SIMILAR PATTERNS OF AMINO ACIDS FOR 5MIE_A_CUA604_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aso | ASCORBATE OXIDASE (Cucurbita pepo) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 445CYH A 507ILE A 509HIS A 512 | CU A 554 (-3.2A) CU A 554 (-2.1A) CU A 554 ( 4.1A) CU A 554 (-3.1A) | 0.14A | 5mieA-1asoA:40.5 | 5mieA-1asoA:29.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1do6 | SUPEROXIDE REDUCTASE (Pyrococcusfuriosus) |
PF01880(Desulfoferrodox) | 4 | HIS A 47CYH A 111ILE A 113HIS A 114 | FE A 200 (-3.4A) FE A 200 (-2.4A)None FE A 200 (-3.2A) | 1.23A | 5mieA-1do6A:undetectable | 5mieA-1do6A:11.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fhq | PROTEIN KINASE SPK1 (Saccharomycescerevisiae) |
PF00498(FHA) | 4 | HIS A 651CYH A 623ILE A 680HIS A 622 | None | 1.20A | 5mieA-1fhqA:undetectable | 5mieA-1fhqA:13.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gyc | LACCASE 2 (Trametesversicolor) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 395CYH A 453ILE A 455HIS A 458 | CU A1503 (-3.1A) CU A1503 (-2.1A) CU A1503 ( 3.8A) CU A1503 (-3.1A) | 0.09A | 5mieA-1gycA:63.6 | 5mieA-1gycA:65.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hfu | LACCASE 1 (Coprinopsiscinerea) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 396CYH A 452ILE A 454HIS A 457 | CU A 701 (-3.2A) CU A 701 (-2.1A) CU A 701 ( 3.8A) CU A 701 (-3.1A) | 0.10A | 5mieA-1hfuA:60.5 | 5mieA-1hfuA:56.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kya | LACCASE (Trametesversicolor) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 395CYH A 453ILE A 455HIS A 458 | CU A 500 (-3.4A) CU A 500 (-2.2A) CU A 500 (-3.7A) CU A 500 ( 3.3A) | 0.18A | 5mieA-1kyaA:63.1 | 5mieA-1kyaA:66.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rcy | RUSTICYANIN (Acidithiobacillusferrooxidans) |
PF00127(Copper-bind) | 4 | HIS A 85CYH A 138ILE A 140HIS A 143 | CU A 156 ( 3.1A) CU A 156 ( 2.2A) CU A 156 ( 4.1A) CU A 156 ( 3.0A) | 0.45A | 5mieA-1rcyA:7.5 | 5mieA-1rcyA:13.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1v10 | LACCASE (Rigidoporusmicroporus) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 396CYH A 452ILE A 454HIS A 457 | CU A1503 (-3.2A) CU A1503 (-2.1A) CU A1503 (-3.4A) CU A1503 (-3.2A) | 0.24A | 5mieA-1v10A:61.4 | 5mieA-1v10A:57.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vzh | DESULFOFERRODOXIN (Desulfarculusbaarsii) |
PF01880(Desulfoferrodox)PF06397(Desulfoferrod_N) | 4 | HIS A 49CYH A 116ILE A 118HIS A 119 | FE A1129 ( 3.4A) FE A1129 (-2.7A)None FE A1129 ( 3.2A) | 1.50A | 5mieA-1vzhA:undetectable | 5mieA-1vzhA:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vzh | DESULFOFERRODOXIN (Desulfarculusbaarsii) |
PF01880(Desulfoferrodox)PF06397(Desulfoferrod_N) | 4 | HIS A 75CYH A 116ILE A 118HIS A 119 | FE A1129 ( 3.4A) FE A1129 (-2.7A)None FE A1129 ( 3.2A) | 1.11A | 5mieA-1vzhA:undetectable | 5mieA-1vzhA:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ws7 | MAVICYANIN (Cucurbita pepo) |
PF02298(Cu_bind_like) | 4 | HIS A 45CYH A 86ILE A 88HIS A 91 | CU1 A1001 (-3.1A)CU1 A1001 (-2.2A)CU1 A1001 ( 4.5A)CU1 A1001 (-3.1A) | 0.49A | 5mieA-1ws7A:3.0 | 5mieA-1ws7A:12.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xj5 | SPERMIDINE SYNTHASE1 (Arabidopsisthaliana) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 4 | HIS A 141CYH A 116ILE A 296HIS A 112 | None | 1.31A | 5mieA-1xj5A:undetectable | 5mieA-1xj5A:20.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zpu | IRON TRANSPORTMULTICOPPER OXIDASEFET3 (Saccharomycescerevisiae) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 413CYH A 484ILE A 486HIS A 489 | CU1 A1001 (-3.1A)CU1 A1001 (-2.1A)CU1 A1001 (-3.9A)CU1 A1001 (-3.1A) | 0.13A | 5mieA-1zpuA:44.2 | 5mieA-1zpuA:31.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dv6 | NITRITE REDUCTASE (Hyphomicrobiumdenitrificans) |
PF07732(Cu-oxidase_3) | 4 | HIS A 77CYH A 114ILE A 116HIS A 119 | CU A 502 (-3.2A) CU A 502 (-2.2A) CU A 502 ( 4.6A) CU A 502 (-3.1A) | 0.55A | 5mieA-2dv6A:21.1 | 5mieA-2dv6A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eos | B-CELL LYMPHOMA 6PROTEIN (Homo sapiens) |
PF00096(zf-C2H2) | 4 | HIS A 30CYH A 14ILE A 16HIS A 34 | ZN A 201 ( 3.2A) ZN A 201 ( 2.3A) ZN A 201 ( 4.1A) ZN A 201 ( 3.1A) | 1.39A | 5mieA-2eosA:undetectable | 5mieA-2eosA:8.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hvb | SUPEROXIDE REDUCTASE (Pyrococcushorikoshii) |
PF01880(Desulfoferrodox) | 4 | HIS A 56CYH A 111ILE A 113HIS A 114 | FE A 201 (-3.4A) FE A 201 (-2.2A)None FE A 201 (-3.2A) | 1.23A | 5mieA-2hvbA:undetectable | 5mieA-2hvbA:11.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hzh | LACCASE (Trametesochracea) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 395CYH A 453ILE A 455HIS A 458 | CU A 601 (-3.6A) CU A 601 (-2.1A) CU A 601 (-3.7A) CU A 601 (-3.4A) | 0.24A | 5mieA-2hzhA:63.0 | 5mieA-2hzhA:62.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qt6 | LACCASE (Lentinustigrinus) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 394CYH A 452ILE A 454HIS A 457 | CU A 499 (-3.1A) CU A 499 (-2.2A) CU A 499 (-3.7A) CU A 499 (-3.1A) | 0.06A | 5mieA-2qt6A:63.6 | 5mieA-2qt6A:64.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyb | LACCASE (Trametescinnabarina) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 395CYH A 451ILE A 453HIS A 456 | CU A 501 (-3.1A) CU A 501 (-2.2A) CU A 501 (-3.7A) CU A 501 ( 3.1A) | 0.08A | 5mieA-2xybA:63.7 | 5mieA-2xybA:63.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dkh | LACCASE-1 (Melanocarpusalbomyces) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 431CYH A 503ILE A 505HIS A 508 | CU A 601 (-3.0A) CU A 601 (-2.1A) CU A 601 ( 4.0A) CU A 601 (-3.3A) | 0.29A | 5mieA-3dkhA:42.7 | 5mieA-3dkhA:30.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2s | COAGULATION FACTORVIII LIGHT CHAIN (Homo sapiens) |
PF00754(F5_F8_type_C)PF07731(Cu-oxidase_2) | 4 | HIS B1954CYH B2000ILE B2002HIS B2005 | None | 0.38A | 5mieA-3j2sB:17.5 | 5mieA-3j2sB:23.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kw7 | LACCASE B (Trametes sp.AH28-2) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 400CYH A 456ILE A 458HIS A 461 | CU A 601 (-3.2A) CU A 601 (-2.1A) CU A 601 (-3.7A) CU A 601 (-3.1A) | 0.12A | 5mieA-3kw7A:62.5 | 5mieA-3kw7A:65.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pps | LACCASE (Thielaviaarenaria) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 432CYH A 504ILE A 506HIS A 509 | CU A 601 (-3.1A) CU A 601 (-2.1A) CU A 601 ( 4.1A) CU A 601 (-3.1A) | 0.32A | 5mieA-3ppsA:41.9 | 5mieA-3ppsA:30.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pxl | LACCASE (Trameteshirsuta) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 395CYH A 453ILE A 455HIS A 458 | CU A1503 (-3.1A) CU A1503 (-2.1A) CU A1503 (-3.7A) CU A1503 (-3.1A) | 0.06A | 5mieA-3pxlA:63.8 | 5mieA-3pxlA:65.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qzb | PUTATIVE SUPEROXIDEREDUCTASE (Thermotogamaritima) |
PF01880(Desulfoferrodox) | 4 | HIS A 51CYH A 115ILE A 117HIS A 118 | FE A 132 (-3.4A) FE A 132 (-2.3A)None FE A 132 (-3.3A) | 1.18A | 5mieA-3qzbA:undetectable | 5mieA-3qzbA:13.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t6w | LACCASE (Steccherinumochraceum) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 397CYH A 453ILE A 455HIS A 458 | CU A 501 (-3.1A) CU A 501 (-2.0A) CU A 501 (-3.8A) CU A 501 (-3.3A) | 0.09A | 5mieA-3t6wA:68.1 | 5mieA-3t6wA:79.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v9e | LACCASE (Botrytis aclada) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 426CYH A 489ILE A 491HIS A 494 | CU A 601 (-3.1A) CU A 601 (-2.2A) CU A 601 (-4.0A) CU A 601 (-3.1A) | 0.12A | 5mieA-3v9eA:44.2 | 5mieA-3v9eA:33.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3x1b | LACCASE (Lentinus) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 417CYH A 475ILE A 477HIS A 480 | CU A 617 (-3.1A) CU A 617 (-2.2A) CU A 617 ( 3.8A) CU A 617 (-3.1A) | 0.06A | 5mieA-3x1bA:63.1 | 5mieA-3x1bA:62.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zx1 | OXIDOREDUCTASE,PUTATIVE (Campylobacterjejuni) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 439CYH A 495ILE A 497HIS A 500 | CU A 601 (-3.1A) CU A 601 (-2.2A) CU A 601 ( 3.9A) CU A 601 (-3.1A) | 0.15A | 5mieA-3zx1A:31.9 | 5mieA-3zx1A:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ako | SPORE COAT PROTEIN A (Bacillussubtilis) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 419CYH A 492ILE A 494HIS A 497 | CU A 601 (-3.1A) CU A 601 (-2.2A) CU A 601 ( 4.0A) CU A 601 (-3.1A) | 0.08A | 5mieA-4akoA:31.8 | 5mieA-4akoA:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c4b | SUPEROXIDE REDUCTASE (Archaeoglobusfulgidus) |
PF01880(Desulfoferrodox) | 4 | HIS A 46CYH A 110ILE A 112HIS A 113 | FE2 A1001 (-3.4A)FE2 A1001 (-2.4A)NoneFE2 A1001 (-3.2A) | 1.20A | 5mieA-4c4bA:undetectable | 5mieA-4c4bA:11.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4jhv | LACCASE (Coriolopsiscaperata) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 394CYH A 450ILE A 452HIS A 455 | CU A 503 (-3.1A) CU A 503 (-2.2A) CU A 503 (-3.7A) CU A 503 (-3.1A) | 0.07A | 5mieA-4jhvA:63.1 | 5mieA-4jhvA:62.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a31 | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 1 (Homo sapiens) |
PF12859(ANAPC1) | 4 | HIS A 31CYH A 28ILE A 101HIS A 27 | None | 1.39A | 5mieA-5a31A:undetectable | 5mieA-5a31A:16.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ehf | LACCASE (Antrodiellafaginea) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 395CYH A 451ILE A 453HIS A 456 | CU A 510 (-3.1A) CU A 510 (-2.0A) CU A 510 (-3.7A) CU A 510 (-3.1A) | 0.11A | 5mieA-5ehfA:63.8 | 5mieA-5ehfA:64.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g3f | THERMUS THERMOPHILUSMULTICOPPER OXIDASE (Thermusthermophilus) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 393CYH A 445ILE A 447HIS A 450 | CU A1464 (-3.1A) CU A1464 (-2.1A) CU A1464 ( 3.9A) CU A1464 (-3.2A) | 0.13A | 5mieA-5g3fA:35.4 | 5mieA-5g3fA:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8d | COAGULATION FACTORVIII (Homo sapiens) |
PF00394(Cu-oxidase)PF07732(Cu-oxidase_3) | 4 | HIS A 267CYH A 310ILE A 312HIS A 315 | CU A 808 (-2.5A) CU A 808 (-2.2A) CU A 808 ( 4.9A) CU A 808 (-2.7A) | 0.68A | 5mieA-5k8dA:10.8 | 5mieA-5k8dA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8d | COAGULATION FACTORVIII,IG GAMMA-1CHAIN C REGION (Homo sapiens) |
PF00754(F5_F8_type_C)PF07731(Cu-oxidase_2) | 4 | HIS B1954CYH B2000ILE B2002HIS B2005 | CU B2610 (-3.0A) CU B2610 (-1.9A) CU B2610 (-3.3A) CU B2610 (-3.6A) | 0.59A | 5mieA-5k8dB:13.1 | 5mieA-5k8dB:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lcw | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 1 (Homo sapiens) |
PF12859(ANAPC1) | 4 | HIS A 31CYH A 28ILE A 101HIS A 27 | None | 1.40A | 5mieA-5lcwA:undetectable | 5mieA-5lcwA:14.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5lm8 | 'MULTICOPPER OXIDASE (Aspergillusniger) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 448CYH A 516ILE A 518HIS A 521 | CU A 604 (-3.1A) CU A 604 (-2.1A) CU A 604 (-3.8A) CU A 604 (-3.0A) | 0.13A | 5mieA-5lm8A:43.6 | 5mieA-5lm8A:31.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mew | LACCASE 2 (Steccherinummurashkinskyi) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 397CYH A 453ILE A 455HIS A 458 | CU A 504 (-3.1A) CU A 504 (-2.1A) CU A 504 (-3.8A) CU A 504 (-3.1A) | 0.05A | 5mieA-5mewA:71.0 | 5mieA-5mewA:99.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 7paz | PSEUDOAZURIN (Alcaligenesfaecalis) |
PF00127(Copper-bind) | 4 | HIS A 40CYH A 78ILE A 80HIS A 81 | CU A 124 ( 3.1A) CU A 124 ( 2.1A) CU A 124 ( 4.3A) CU A 124 ( 3.2A) | 0.51A | 5mieA-7pazA:3.7 | 5mieA-7pazA:13.55 |