SIMILAR PATTERNS OF AMINO ACIDS FOR 5MIE_A_CUA601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 106
HIS A 448
HIS A 450
HIS A 506
 CU  A 555 (-3.3A)
CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
CU  A 555 (-3.1A)
 0.13A 5mieA-1asoA:
40.5		 5mieA-1asoA:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 450
HIS A 508
HIS A 448
HIS A 506
 CU  A 555 ( 3.2A)
CU  A 556 (-3.3A)
CU  A 557 ( 3.2A)
CU  A 555 (-3.1A)
 0.99A 5mieA-1asoA:
40.5		 5mieA-1asoA:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 508
HIS A  60
HIS A  62
HIS A 104
 CU  A 556 (-3.3A)
CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
CU  A 556 (-3.1A)
 0.73A 5mieA-1asoA:
40.5		 5mieA-1asoA:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mieA-1bt2A:
undetectable		 5mieA-1bt2A:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A1501 (-3.4A)
CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
CU  A1501 (-3.3A)
 0.13A 5mieA-1gycA:
63.6		 5mieA-1gycA:
65.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A1500 (-3.3A)
CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.3A)
 0.64A 5mieA-1gycA:
63.6		 5mieA-1gycA:
65.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 198
HIS A 384
HIS A 344
HIS A 224
 CU  A 665 (-3.1A)
CU  A 666 (-3.4A)
CU  A 666 (-3.1A)
CU  A 665 (-3.5A)
 1.00A 5mieA-1hcyA:
undetectable		 5mieA-1hcyA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 401
HIS A 453
HIS A 399
HIS A 451
 CU  A 702 (-3.2A)
CU  A 703 (-3.3A)
CU  A 702 ( 3.7A)
CU  A 702 (-3.2A)
 1.01A 5mieA-1hfuA:
60.5		 5mieA-1hfuA:
56.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 453
HIS A  64
HIS A  66
HIS A 109
 CU  A 703 (-3.3A)
CU  A 703 (-4.7A)
CU  A 703 (-3.0A)
CU  A 703 (-3.2A)
 0.68A 5mieA-1hfuA:
60.5		 5mieA-1hfuA:
56.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 163
HIS A 978
HIS A 980
HIS A1020
 CU  A1050 (-3.3A)
CU  A1052 ( 3.2A)
CU  A1050 (-3.0A)
CU  A1050 (-3.2A)
 0.51A 5mieA-1kcwA:
17.9		 5mieA-1kcwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A1022
HIS A 101
HIS A 103
HIS A 161
 CU  A1051 (-3.2A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
 0.39A 5mieA-1kcwA:
17.9		 5mieA-1kcwA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A 501 (-3.5A)
CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
CU  A 501 (-3.4A)
 0.16A 5mieA-1kyaA:
63.1		 5mieA-1kyaA:
66.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A 502 (-3.4A)
CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
CU  A 502 (-3.7A)
 0.61A 5mieA-1kyaA:
63.1		 5mieA-1kyaA:
66.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A  61
HIS A 212
HIS A  70
HIS A  41
 CU  A5001 (-3.6A)
CU  A5012 (-3.1A)
CU  A5001 ( 3.1A)
CU  A5001 (-2.9A)
 0.94A 5mieA-1lnlA:
undetectable		 5mieA-1lnlA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 399
HIS A 401
HIS A 451
 CU  A1501 (-3.3A)
CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
 0.24A 5mieA-1v10A:
61.4		 5mieA-1v10A:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 453
HIS A  64
HIS A  66
HIS A 109
 CU  A1500 (-3.4A)
CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
CU  A1500 (-3.3A)
 0.62A 5mieA-1v10A:
61.4		 5mieA-1v10A:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.18A 5mieA-1zpuA:
44.1		 5mieA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.73A 5mieA-1zpuA:
44.1		 5mieA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.28A 5mieA-2fqdA:
32.8		 5mieA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.65A 5mieA-2fqdA:
32.8		 5mieA-2fqdA:
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A 602 (-3.2A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.1A)
 0.22A 5mieA-2hzhA:
63.0		 5mieA-2hzhA:
62.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A 603 (-3.3A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 (-3.4A)
 0.70A 5mieA-2hzhA:
63.0		 5mieA-2hzhA:
62.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5mieA-2p3xA:
undetectable		 5mieA-2p3xA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 397
HIS A 399
HIS A 451
 CU  A 501 ( 3.2A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.2A)
 0.19A 5mieA-2qt6A:
63.6		 5mieA-2qt6A:
64.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 453
HIS A  64
HIS A  66
HIS A 109
 CU  A 502 (-3.3A)
CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
CU  A 502 (-3.2A)
 0.68A 5mieA-2qt6A:
63.6		 5mieA-2qt6A:
64.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 398
HIS A 400
HIS A 450
 CU  A 502 (-3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.3A)
 0.20A 5mieA-2xybA:
63.7		 5mieA-2xybA:
63.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 452
HIS A  64
HIS A  66
HIS A 109
 CU  A 503 ( 3.3A)
CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
CU  A 503 ( 3.2A)
 0.67A 5mieA-2xybA:
63.7		 5mieA-2xybA:
63.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS A  85
HIS A 296
HIS A  94
HIS A  61
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
CU  A 400 (-3.2A)
 0.80A 5mieA-2y9xA:
undetectable		 5mieA-2y9xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 136
HIS A 401
HIS A 403
HIS A 456
 CU  A 701 (-3.2A)
CU  A 703 (-3.4A)
CU  A 701 ( 3.1A)
CU  A 701 (-3.3A)
 0.32A 5mieA-3abgA:
31.0		 5mieA-3abgA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 458
HIS A  94
HIS A  96
HIS A 134
 CU  A 702 (-3.5A)
CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
CU  A 702 (-3.1A)
 0.73A 5mieA-3abgA:
31.0		 5mieA-3abgA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.21A 5mieA-3aw5A:
10.5		 5mieA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5mieA-3aw5A:
10.5		 5mieA-3aw5A:
26.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 140
HIS A 434
HIS A 436
HIS A 502
 CU  A 602 ( 3.3A)
CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
CU  A 602 ( 3.2A)
 0.22A 5mieA-3dkhA:
42.7		 5mieA-3dkhA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 504
HIS A  93
HIS A  95
HIS A 138
 CU  A 603 ( 3.3A)
CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
CU  A 603 ( 3.3A)
 0.73A 5mieA-3dkhA:
42.7		 5mieA-3dkhA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.19A 5mieA-3gyrA:
26.1		 5mieA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.68A 5mieA-3gyrA:
26.1		 5mieA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 HIS A  95
HIS A 257
HIS A  93
HIS A 259
 ZN  A 480 (-3.3A)
None
ZN  A 480 (-3.3A)
ZN  A 480 (-3.5A)
 0.95A 5mieA-3hpaA:
undetectable		 5mieA-3hpaA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 403
HIS A 405
HIS A 455
 CU  A 603 (-3.2A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.1A)
 0.29A 5mieA-3kw7A:
62.5		 5mieA-3kw7A:
65.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 457
HIS A  64
HIS A  66
HIS A 109
 CU  A 604 (-3.1A)
CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
CU  A 604 (-3.2A)
 0.70A 5mieA-3kw7A:
62.5		 5mieA-3kw7A:
65.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 HIS A  65
HIS A 236
HIS A  63
HIS A 238
 ZN  A 458 ( 3.2A)
None
ZN  A 458 (-3.3A)
ZN  A 458 (-3.2A)
 1.02A 5mieA-3lscA:
undetectable		 5mieA-3lscA:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 141
HIS A 435
HIS A 437
HIS A 503
 CU  A 602 ( 3.3A)
CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
CU  A 602 ( 3.3A)
 0.22A 5mieA-3ppsA:
42.0		 5mieA-3ppsA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 505
HIS A  94
HIS A  96
HIS A 139
 CU  A 603 ( 3.3A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 ( 3.1A)
 0.69A 5mieA-3ppsA:
42.0		 5mieA-3ppsA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A1500 (-3.2A)
CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.1A)
 0.27A 5mieA-3pxlA:
63.8		 5mieA-3pxlA:
65.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A1501 (-3.3A)
CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
CU  A1501 (-3.2A)
 0.67A 5mieA-3pxlA:
63.8		 5mieA-3pxlA:
65.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 112
HIS A 400
HIS A 402
HIS A 452
 CU  A 503 (-3.4A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
 0.12A 5mieA-3t6wA:
68.1		 5mieA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.70A 5mieA-3t6wA:
68.1		 5mieA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 133
HIS A 429
HIS A 431
HIS A 488
 CU  A 602 (-3.3A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 0.52A 5mieA-3v9eA:
44.2		 5mieA-3v9eA:
33.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 490
HIS A  87
HIS A  89
HIS A 131
 CU  A 603 (-3.5A)
CU  A 602 ( 4.7A)
CU  A 603 (-2.9A)
CU  A 603 (-3.2A)
 0.61A 5mieA-3v9eA:
44.2		 5mieA-3v9eA:
33.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 HIS A  94
HIS A 372
HIS A 103
HIS A  67
 None
 0.95A 5mieA-3w6qA:
undetectable		 5mieA-3w6qA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 132
HIS A 420
HIS A 422
HIS A 474
 CU  A 616 (-3.2A)
CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
CU  A 616 (-3.2A)
 0.10A 5mieA-3x1bA:
63.1		 5mieA-3x1bA:
62.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 476
HIS A  85
HIS A  87
HIS A 130
 CU  A 615 (-3.2A)
CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
CU  A 615 (-3.2A)
 0.69A 5mieA-3x1bA:
63.1		 5mieA-3x1bA:
62.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 182
HIS A 442
HIS A 444
HIS A 494
 CU  A 603 ( 2.8A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 603 ( 3.1A)
 0.34A 5mieA-3zx1A:
31.9		 5mieA-3zx1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 496
HIS A 139
HIS A 141
HIS A 180
 CU  A 602 ( 3.3A)
CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
CU  A 602 ( 3.1A)
 0.62A 5mieA-3zx1A:
31.9		 5mieA-3zx1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 155
HIS A 422
HIS A 424
HIS A 491
 CU  A 603 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.1A)
 0.22A 5mieA-4akoA:
31.8		 5mieA-4akoA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 493
HIS A 105
HIS A 107
HIS A 153
 CU  A 602 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 0.63A 5mieA-4akoA:
31.8		 5mieA-4akoA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A  60
HIS A 210
HIS A  69
HIS A  42
 CUO  A9001 (-3.1A)
CUO  A9001 (-3.3A)
CUO  A9001 (-3.1A)
CUO  A9001 (-3.4A)
 0.93A 5mieA-4bedA:
undetectable		 5mieA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 482
HIS A 633
HIS A 491
HIS A 462
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.3A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.2A)
 0.97A 5mieA-4bedA:
undetectable		 5mieA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 606
HIS A 491
HIS A 462
HIS A 633
 CUO  A9002 (-3.3A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.2A)
CUO  A9002 (-3.3A)
 1.02A 5mieA-4bedA:
undetectable		 5mieA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 896
HIS A1046
HIS A 905
HIS A 876
 CUO  A9003 (-3.4A)
CUO  A9003 (-3.2A)
CUO  A9003 (-3.5A)
CUO  A9003 (-3.3A)
 0.95A 5mieA-4bedA:
undetectable		 5mieA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1019
HIS A 905
HIS A 876
HIS A1046
 CUO  A9003 (-3.4A)
CUO  A9003 (-3.5A)
CUO  A9003 (-3.3A)
CUO  A9003 (-3.2A)
 0.98A 5mieA-4bedA:
undetectable		 5mieA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1311
HIS A1455
HIS A1320
HIS A1293
 CUO  A9004 (-3.4A)
CUO  A9004 (-3.3A)
CUO  A9004 (-3.5A)
CUO  A9004 (-3.2A)
 0.93A 5mieA-4bedA:
undetectable		 5mieA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1428
HIS A1320
HIS A1293
HIS A1455
 CUO  A9004 (-3.4A)
CUO  A9004 (-3.5A)
CUO  A9004 (-3.2A)
CUO  A9004 (-3.3A)
 0.95A 5mieA-4bedA:
undetectable		 5mieA-4bedA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B1725
HIS B1878
HIS B1734
HIS B1705
 CUO  B9005 (-3.1A)
CUO  B9005 (-3.3A)
CUO  B9005 (-3.4A)
CUO  B9005 (-3.2A)
 1.02A 5mieA-4bedB:
3.7		 5mieA-4bedB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2561
HIS B2701
HIS B2570
HIS B2542
 CUO  B9007 (-3.3A)
CUO  B9007 (-3.1A)
CUO  B9007 (-3.3A)
CUO  B9007 (-3.3A)
 0.99A 5mieA-4bedB:
3.7		 5mieA-4bedB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgq NON-HEME
CHLOROPEROXIDASE

(Burkholderia
cenocepacia) 		PF00561
(Abhydrolase_1) 		4 HIS A  55
HIS A  93
HIS A  26
HIS A  28
 None
 0.99A 5mieA-4dgqA:
undetectable		 5mieA-4dgqA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		4 HIS A  80
HIS A 225
HIS A  78
HIS A 227
 ZN  A 504 (-3.1A)
None
ZN  A 504 (-3.3A)
ZN  A 504 (-3.3A)
 0.92A 5mieA-4dzhA:
undetectable		 5mieA-4dzhA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 397
HIS A 399
HIS A 449
 CU  A 501 (-3.2A)
CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.1A)
 0.27A 5mieA-4jhvA:
63.1		 5mieA-4jhvA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 451
HIS A  64
HIS A  66
HIS A 109
 CU  A 502 (-3.3A)
CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
CU  A 502 (-3.2A)
 0.69A 5mieA-4jhvA:
63.1		 5mieA-4jhvA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mieA-4ouaB:
undetectable		 5mieA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mieA-4ouaA:
undetectable		 5mieA-4ouaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 156
HIS A 297
HIS A 298
HIS A 294
 ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.1A)
 1.00A 5mieA-4ymkA:
undetectable		 5mieA-4ymkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 297
HIS A 156
HIS A 157
HIS A 153
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 0.91A 5mieA-4ymkA:
undetectable		 5mieA-4ymkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
HS8  A 252 ( 3.7A)
CU  A 700 (-3.2A)
CU  A 700 (-3.1A)
 0.80A 5mieA-4z0zA:
undetectable		 5mieA-4z0zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 HIS A 116
HIS A 286
HIS A 125
HIS A  93
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
 0.85A 5mieA-4z11A:
undetectable		 5mieA-4z11A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 1.00A 5mieA-4zr0A:
undetectable		 5mieA-4zr0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 348
HIS A 271
HIS A 272
HIS A 268
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.5A)
 0.99A 5mieA-4zr0A:
undetectable		 5mieA-4zr0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.01A 5mieA-4zr1A:
undetectable		 5mieA-4zr1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.00A 5mieA-4zyoA:
undetectable		 5mieA-4zyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 108
HIS A 273
HIS A 117
HIS A  87
 CU  A 402 ( 3.2A)
CU  A 401 ( 3.2A)
CU  A 402 ( 3.2A)
CU  A 402 ( 3.2A)
 0.87A 5mieA-5ce9A:
undetectable		 5mieA-5ce9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.83A 5mieA-5ebbA:
undetectable		 5mieA-5ebbA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 111
HIS A 398
HIS A 400
HIS A 450
 CU  A 507 ( 3.3A)
CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
CU  A 507 (-3.2A)
 0.24A 5mieA-5ehfA:
63.8		 5mieA-5ehfA:
64.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 452
HIS A  64
HIS A  66
HIS A 109
 CU  A 508 (-3.2A)
CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
CU  A 508 (-3.3A)
 0.68A 5mieA-5ehfA:
63.8		 5mieA-5ehfA:
64.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		4 HIS A 292
HIS A 149
HIS A 111
HIS A  44
 ZN  A 501 (-3.4A)
ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.84A 5mieA-5fcaA:
undetectable		 5mieA-5fcaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.2A)
PO4  A 709 (-4.0A)
PO4  A 709 (-3.8A)
ZN  A 701 ( 3.2A)
 0.87A 5mieA-5ficA:
undetectable		 5mieA-5ficA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 137
HIS A 396
HIS A 398
HIS A 444
 CU  A1463 (-3.3A)
CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-3.0A)
 0.48A 5mieA-5g3fA:
35.4		 5mieA-5g3fA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 446
HIS A  95
HIS A  97
HIS A 135
 CU  A1465 (-3.3A)
CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
CU  A1465 (-3.2A)
 0.66A 5mieA-5g3fA:
35.4		 5mieA-5g3fA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		4 HIS A 457
HIS A 317
HIS A 280
HIS A 206
 ZN  A 701 ( 3.1A)
PO4  A 710 (-3.7A)
PO4  A 710 (-4.2A)
ZN  A 701 ( 3.3A)
 0.90A 5mieA-5hqnA:
undetectable		 5mieA-5hqnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.91A 5mieA-5i85A:
undetectable		 5mieA-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.84A 5mieA-5karA:
undetectable		 5mieA-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		4 HIS A 484
HIS A 238
HIS A 183
HIS A 304
 FE2  A 502 (-4.0A)
FE2  A 502 (-4.5A)
FE2  A 502 (-4.0A)
FE2  A 502 (-3.8A)
 0.83A 5mieA-5kjaA:
undetectable		 5mieA-5kjaA:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 154
HIS A 451
HIS A 453
HIS A 515
 CU  A 602 ( 3.4A)
CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 0.23A 5mieA-5lm8A:
43.6		 5mieA-5lm8A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 517
HIS A 108
HIS A 110
HIS A 152
 CU  A 601 ( 3.5A)
CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
CU  A 601 ( 3.2A)
 0.61A 5mieA-5lm8A:
43.6		 5mieA-5lm8A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 112
HIS A 400
HIS A 402
HIS A 452
 CU  A 501 (-3.1A)
CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
CU  A 501 ( 3.0A)
 0.11A 5mieA-5mewA:
71.0		 5mieA-5mewA:
99.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A  65
HIS A  67
HIS A 110
 CU  A 502 ( 3.2A)
CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
CU  A 502 (-3.1A)
 0.67A 5mieA-5mewA:
71.0		 5mieA-5mewA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 162
HIS A 972
HIS A 974
HIS A1014
 CU  A1101 (-3.3A)
CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1101 (-3.2A)
 0.33A 5mieA-5n4lA:
11.8		 5mieA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A1016
HIS A 101
HIS A 103
HIS A 160
 CU  A1104 (-3.1A)
CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
CU  A1104 (-3.6A)
 0.58A 5mieA-5n4lA:
11.8		 5mieA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		4 HIS A   8
HIS A 223
HIS A 179
HIS A   6
 ZN  A 400 (-3.2A)
None
ZN  A 400 (-3.2A)
ZN  A 400 (-3.3A)
 1.01A 5mieA-5vn5A:
undetectable		 5mieA-5vn5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR L
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER
PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER

(Roseiflexus
castenholzii;
Roseiflexus
castenholzii) 		no annotation
no annotation 		4 HIS M 589
HIS L 264
HIS L 229
HIS M 542
 FE  L1005 (-3.2A)
FE  L1005 (-4.4A)
FE  L1005 (-3.1A)
FE  L1005 ( 3.0A)
 1.02A 5mieA-5yq7M:
undetectable		 5mieA-5yq7M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 133
HIS A 437
HIS A 439
HIS A 489
 EDO  A 602 (-4.1A)
None
EDO  A 602 (-3.8A)
None
 0.51A 5mieA-6evgA:
33.7		 5mieA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 491
HIS A  91
HIS A  93
HIS A 131
 None
EDO  A 602 ( 4.5A)
None
None
 0.55A 5mieA-6evgA:
33.7		 5mieA-6evgA:
undetectable