SIMILAR PATTERNS OF AMINO ACIDS FOR 5MHY_A_CUA604

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 445
CYH A 507
ILE A 509
HIS A 512
 CU  A 554 (-3.2A)
CU  A 554 (-2.1A)
CU  A 554 ( 4.1A)
CU  A 554 (-3.1A)
 0.14A 5mhyA-1asoA:
40.5		 5mhyA-1asoA:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do6 SUPEROXIDE REDUCTASE

(Pyrococcus
furiosus) 		PF01880
(Desulfoferrodox) 		4 HIS A  47
CYH A 111
ILE A 113
HIS A 114
 FE  A 200 (-3.4A)
FE  A 200 (-2.4A)
None
FE  A 200 (-3.2A)
 1.23A 5mhyA-1do6A:
undetectable		 5mhyA-1do6A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhq PROTEIN KINASE SPK1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		4 HIS A 651
CYH A 623
ILE A 680
HIS A 622
 None
 1.20A 5mhyA-1fhqA:
undetectable		 5mhyA-1fhqA:
13.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A1503 (-3.1A)
CU  A1503 (-2.1A)
CU  A1503 ( 3.8A)
CU  A1503 (-3.1A)
 0.08A 5mhyA-1gycA:
63.6		 5mhyA-1gycA:
65.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 396
CYH A 452
ILE A 454
HIS A 457
 CU  A 701 (-3.2A)
CU  A 701 (-2.1A)
CU  A 701 ( 3.8A)
CU  A 701 (-3.1A)
 0.09A 5mhyA-1hfuA:
60.5		 5mhyA-1hfuA:
56.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A 500 (-3.4A)
CU  A 500 (-2.2A)
CU  A 500 (-3.7A)
CU  A 500 ( 3.3A)
 0.18A 5mhyA-1kyaA:
63.0		 5mhyA-1kyaA:
66.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcy RUSTICYANIN

(Acidithiobacillus
ferrooxidans) 		PF00127
(Copper-bind) 		4 HIS A  85
CYH A 138
ILE A 140
HIS A 143
 CU  A 156 ( 3.1A)
CU  A 156 ( 2.2A)
CU  A 156 ( 4.1A)
CU  A 156 ( 3.0A)
 0.44A 5mhyA-1rcyA:
7.6		 5mhyA-1rcyA:
13.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 396
CYH A 452
ILE A 454
HIS A 457
 CU  A1503 (-3.2A)
CU  A1503 (-2.1A)
CU  A1503 (-3.4A)
CU  A1503 (-3.2A)
 0.25A 5mhyA-1v10A:
61.3		 5mhyA-1v10A:
57.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  75
CYH A 116
ILE A 118
HIS A 119
 FE  A1129 ( 3.4A)
FE  A1129 (-2.7A)
None
FE  A1129 ( 3.2A)
 1.11A 5mhyA-1vzhA:
undetectable		 5mhyA-1vzhA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws7 MAVICYANIN

(Cucurbita pepo) 		PF02298
(Cu_bind_like) 		4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5mhyA-1ws7A:
3.1		 5mhyA-1ws7A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mhyA-1xj5A:
undetectable		 5mhyA-1xj5A:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5mhyA-1zpuA:
44.2		 5mhyA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		4 HIS A  77
CYH A 114
ILE A 116
HIS A 119
 CU  A 502 (-3.2A)
CU  A 502 (-2.2A)
CU  A 502 ( 4.6A)
CU  A 502 (-3.1A)
 0.55A 5mhyA-2dv6A:
20.9		 5mhyA-2dv6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eos B-CELL LYMPHOMA 6
PROTEIN

(Homo sapiens) 		PF00096
(zf-C2H2) 		4 HIS A  30
CYH A  14
ILE A  16
HIS A  34
 ZN  A 201 ( 3.2A)
ZN  A 201 ( 2.3A)
ZN  A 201 ( 4.1A)
ZN  A 201 ( 3.1A)
 1.40A 5mhyA-2eosA:
undetectable		 5mhyA-2eosA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		4 HIS A  56
CYH A 111
ILE A 113
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
None
FE  A 201 (-3.2A)
 1.23A 5mhyA-2hvbA:
undetectable		 5mhyA-2hvbA:
11.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A 601 (-3.6A)
CU  A 601 (-2.1A)
CU  A 601 (-3.7A)
CU  A 601 (-3.4A)
 0.25A 5mhyA-2hzhA:
63.0		 5mhyA-2hzhA:
62.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
CYH A 452
ILE A 454
HIS A 457
 CU  A 499 (-3.1A)
CU  A 499 (-2.2A)
CU  A 499 (-3.7A)
CU  A 499 (-3.1A)
 0.05A 5mhyA-2qt6A:
63.6		 5mhyA-2qt6A:
64.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 451
ILE A 453
HIS A 456
 CU  A 501 (-3.1A)
CU  A 501 (-2.2A)
CU  A 501 (-3.7A)
CU  A 501 ( 3.1A)
 0.08A 5mhyA-2xybA:
63.6		 5mhyA-2xybA:
63.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 431
CYH A 503
ILE A 505
HIS A 508
 CU  A 601 (-3.0A)
CU  A 601 (-2.1A)
CU  A 601 ( 4.0A)
CU  A 601 (-3.3A)
 0.30A 5mhyA-3dkhA:
42.7		 5mhyA-3dkhA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 None
 0.38A 5mhyA-3j2sB:
10.2		 5mhyA-3j2sB:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
CYH A 456
ILE A 458
HIS A 461
 CU  A 601 (-3.2A)
CU  A 601 (-2.1A)
CU  A 601 (-3.7A)
CU  A 601 (-3.1A)
 0.12A 5mhyA-3kw7A:
62.4		 5mhyA-3kw7A:
65.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 432
CYH A 504
ILE A 506
HIS A 509
 CU  A 601 (-3.1A)
CU  A 601 (-2.1A)
CU  A 601 ( 4.1A)
CU  A 601 (-3.1A)
 0.32A 5mhyA-3ppsA:
41.9		 5mhyA-3ppsA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 453
ILE A 455
HIS A 458
 CU  A1503 (-3.1A)
CU  A1503 (-2.1A)
CU  A1503 (-3.7A)
CU  A1503 (-3.1A)
 0.05A 5mhyA-3pxlA:
63.7		 5mhyA-3pxlA:
65.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzb PUTATIVE SUPEROXIDE
REDUCTASE

(Thermotoga
maritima) 		PF01880
(Desulfoferrodox) 		4 HIS A  51
CYH A 115
ILE A 117
HIS A 118
 FE  A 132 (-3.4A)
FE  A 132 (-2.3A)
None
FE  A 132 (-3.3A)
 1.17A 5mhyA-3qzbA:
2.4		 5mhyA-3qzbA:
13.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
CYH A 453
ILE A 455
HIS A 458
 CU  A 501 (-3.1A)
CU  A 501 (-2.0A)
CU  A 501 (-3.8A)
CU  A 501 (-3.3A)
 0.09A 5mhyA-3t6wA:
68.0		 5mhyA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 426
CYH A 489
ILE A 491
HIS A 494
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 (-4.0A)
CU  A 601 (-3.1A)
 0.12A 5mhyA-3v9eA:
44.1		 5mhyA-3v9eA:
33.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 417
CYH A 475
ILE A 477
HIS A 480
 CU  A 617 (-3.1A)
CU  A 617 (-2.2A)
CU  A 617 ( 3.8A)
CU  A 617 (-3.1A)
 0.06A 5mhyA-3x1bA:
63.1		 5mhyA-3x1bA:
62.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 439
CYH A 495
ILE A 497
HIS A 500
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 ( 3.9A)
CU  A 601 (-3.1A)
 0.15A 5mhyA-3zx1A:
9.5		 5mhyA-3zx1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 419
CYH A 492
ILE A 494
HIS A 497
 CU  A 601 (-3.1A)
CU  A 601 (-2.2A)
CU  A 601 ( 4.0A)
CU  A 601 (-3.1A)
 0.08A 5mhyA-4akoA:
31.8		 5mhyA-4akoA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4b SUPEROXIDE REDUCTASE

(Archaeoglobus
fulgidus) 		PF01880
(Desulfoferrodox) 		4 HIS A  46
CYH A 110
ILE A 112
HIS A 113
 FE2  A1001 (-3.4A)
FE2  A1001 (-2.4A)
None
FE2  A1001 (-3.2A)
 1.20A 5mhyA-4c4bA:
undetectable		 5mhyA-4c4bA:
11.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
CYH A 450
ILE A 452
HIS A 455
 CU  A 503 (-3.1A)
CU  A 503 (-2.2A)
CU  A 503 (-3.7A)
CU  A 503 (-3.1A)
 0.07A 5mhyA-4jhvA:
63.0		 5mhyA-4jhvA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.39A 5mhyA-5a31A:
undetectable		 5mhyA-5a31A:
16.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 395
CYH A 451
ILE A 453
HIS A 456
 CU  A 510 (-3.1A)
CU  A 510 (-2.0A)
CU  A 510 (-3.7A)
CU  A 510 (-3.1A)
 0.10A 5mhyA-5ehfA:
63.7		 5mhyA-5ehfA:
64.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 393
CYH A 445
ILE A 447
HIS A 450
 CU  A1464 (-3.1A)
CU  A1464 (-2.1A)
CU  A1464 ( 3.9A)
CU  A1464 (-3.2A)
 0.13A 5mhyA-5g3fA:
35.4		 5mhyA-5g3fA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.67A 5mhyA-5k8dA:
10.8		 5mhyA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.60A 5mhyA-5k8dB:
13.1		 5mhyA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 HIS A  31
CYH A  28
ILE A 101
HIS A  27
 None
 1.40A 5mhyA-5lcwA:
undetectable		 5mhyA-5lcwA:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 448
CYH A 516
ILE A 518
HIS A 521
 CU  A 604 (-3.1A)
CU  A 604 (-2.1A)
CU  A 604 (-3.8A)
CU  A 604 (-3.0A)
 0.13A 5mhyA-5lm8A:
43.6		 5mhyA-5lm8A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
CYH A 453
ILE A 455
HIS A 458
 CU  A 504 (-3.1A)
CU  A 504 (-2.1A)
CU  A 504 (-3.8A)
CU  A 504 (-3.1A)
 0.04A 5mhyA-5mewA:
71.1		 5mhyA-5mewA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7paz PSEUDOAZURIN

(Alcaligenes
faecalis) 		PF00127
(Copper-bind) 		4 HIS A  40
CYH A  78
ILE A  80
HIS A  81
 CU  A 124 ( 3.1A)
CU  A 124 ( 2.1A)
CU  A 124 ( 4.3A)
CU  A 124 ( 3.2A)
 0.51A 5mhyA-7pazA:
3.7		 5mhyA-7pazA:
13.55