SIMILAR PATTERNS OF AMINO ACIDS FOR 5MHW_A_CUA602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  60
HIS A  62
HIS A 104
HIS A 508
 CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
CU  A 556 (-3.1A)
CU  A 556 (-3.3A)
 0.29A 5mhwA-1asoA:
40.4		 5mhwA-1asoA:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 448
HIS A 450
HIS A 506
HIS A 106
 CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
CU  A 555 (-3.1A)
CU  A 555 (-3.3A)
 0.70A 5mhwA-1asoA:
40.4		 5mhwA-1asoA:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 508
HIS A 448
HIS A 506
HIS A 450
 CU  A 556 (-3.3A)
CU  A 557 ( 3.2A)
CU  A 555 (-3.1A)
CU  A 555 ( 3.2A)
 0.85A 5mhwA-1asoA:
40.4		 5mhwA-1asoA:
29.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 454
 CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
CU  A1500 ( 4.7A)
CU  A1500 (-3.3A)
CU  A1500 (-3.3A)
 0.11A 5mhwA-1gycA:
63.6		 5mhwA-1gycA:
65.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A 452
HIS A 111
 CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
CU  A1501 (-3.3A)
CU  A1501 (-3.4A)
 0.70A 5mhwA-1gycA:
63.6		 5mhwA-1gycA:
65.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A 398
HIS A 452
HIS A 400
 CU  A1500 (-3.3A)
CU  A1502 ( 3.1A)
CU  A1501 (-3.3A)
CU  A1501 ( 3.2A)
 0.86A 5mhwA-1gycA:
63.6		 5mhwA-1gycA:
65.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 453
 CU  A 703 (-4.7A)
CU  A 703 (-3.0A)
CU  A 703 (-4.0A)
CU  A 703 (-3.2A)
CU  A 703 (-3.3A)
 0.21A 5mhwA-1hfuA:
60.5		 5mhwA-1hfuA:
56.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 101
HIS A 103
HIS A 161
HIS A1022
 CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
CU  A1051 (-3.2A)
 0.72A 5mhwA-1kcwA:
17.9		 5mhwA-1kcwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 163
HIS A 101
HIS A 161
HIS A 103
 CU  A1050 (-3.3A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
 0.97A 5mhwA-1kcwA:
17.9		 5mhwA-1kcwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A1022
HIS A 978
HIS A1020
HIS A 980
 CU  A1051 (-3.2A)
CU  A1052 ( 3.2A)
CU  A1050 (-3.2A)
CU  A1050 (-3.0A)
 0.81A 5mhwA-1kcwA:
17.9		 5mhwA-1kcwA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 454
 CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
CU  A 502 ( 4.9A)
CU  A 502 (-3.7A)
CU  A 502 (-3.4A)
 0.24A 5mhwA-1kyaA:
63.0		 5mhwA-1kyaA:
66.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A 452
HIS A 111
 CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
CU  A 501 (-3.4A)
CU  A 501 (-3.5A)
 0.71A 5mhwA-1kyaA:
63.0		 5mhwA-1kyaA:
66.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A 398
HIS A 452
HIS A 400
 CU  A 502 (-3.4A)
CU  A 503 ( 3.2A)
CU  A 501 (-3.4A)
CU  A 501 ( 3.3A)
 0.88A 5mhwA-1kyaA:
63.0		 5mhwA-1kyaA:
66.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 453
 CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
CU  A1500 (-4.2A)
CU  A1500 (-3.3A)
CU  A1500 (-3.4A)
 0.17A 5mhwA-1v10A:
61.3		 5mhwA-1v10A:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 399
HIS A 401
HIS A 451
HIS A 111
 CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
CU  A1501 (-3.3A)
 0.69A 5mhwA-1v10A:
61.3		 5mhwA-1v10A:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 453
HIS A 399
HIS A 451
HIS A 401
 CU  A1500 (-3.4A)
CU  A1502 (-2.9A)
CU  A1501 (-2.9A)
CU  A1501 ( 3.2A)
 0.91A 5mhwA-1v10A:
61.3		 5mhwA-1v10A:
57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mhwA-1zpuA:
44.2		 5mhwA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5mhwA-1zpuA:
44.2		 5mhwA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5mhwA-1zpuA:
44.2		 5mhwA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.26A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.71A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.88A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 454
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 ( 4.4A)
CU  A 603 (-3.4A)
CU  A 603 (-3.3A)
 0.18A 5mhwA-2hzhA:
63.0		 5mhwA-2hzhA:
62.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A 452
HIS A 111
 CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.1A)
CU  A 602 (-3.2A)
 0.77A 5mhwA-2hzhA:
63.0		 5mhwA-2hzhA:
62.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A 398
HIS A 452
HIS A 400
 CU  A 603 (-3.3A)
CU  A 604 (-3.1A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 0.87A 5mhwA-2hzhA:
63.0		 5mhwA-2hzhA:
62.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 453
 CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
CU  A 502 (-4.2A)
CU  A 502 (-3.2A)
CU  A 502 (-3.3A)
 0.11A 5mhwA-2qt6A:
63.6		 5mhwA-2qt6A:
64.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
HIS A 399
HIS A 451
HIS A 111
 CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.2A)
CU  A 501 ( 3.2A)
 0.73A 5mhwA-2qt6A:
63.6		 5mhwA-2qt6A:
64.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 453
HIS A 397
HIS A 451
HIS A 399
 CU  A 502 (-3.3A)
CU  A 500 (-3.1A)
CU  A 501 (-3.2A)
CU  A 501 ( 3.2A)
 0.86A 5mhwA-2qt6A:
63.6		 5mhwA-2qt6A:
64.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 452
 CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
CU  A 503 ( 4.3A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
 0.09A 5mhwA-2xybA:
63.6		 5mhwA-2xybA:
63.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A 450
HIS A 111
 CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.3A)
CU  A 502 (-3.2A)
 0.73A 5mhwA-2xybA:
63.6		 5mhwA-2xybA:
63.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 452
HIS A 398
HIS A 450
HIS A 400
 CU  A 503 ( 3.3A)
CU  A 504 (-3.1A)
CU  A 502 ( 3.3A)
CU  A 502 (-3.2A)
 0.87A 5mhwA-2xybA:
63.6		 5mhwA-2xybA:
63.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  94
HIS A  96
TRP A 132
HIS A 134
HIS A 458
 CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
CU  A 702 (-4.3A)
CU  A 702 (-3.1A)
CU  A 702 (-3.5A)
 0.35A 5mhwA-3abgA:
30.9		 5mhwA-3abgA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 458
HIS A 401
HIS A 456
HIS A 403
 CU  A 702 (-3.5A)
CU  A 703 (-3.4A)
CU  A 701 (-3.3A)
CU  A 701 ( 3.1A)
 0.85A 5mhwA-3abgA:
30.9		 5mhwA-3abgA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.18A 5mhwA-3aw5A:
31.5		 5mhwA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.72A 5mhwA-3aw5A:
31.5		 5mhwA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.87A 5mhwA-3aw5A:
31.5		 5mhwA-3aw5A:
26.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  93
HIS A  95
TRP A 136
HIS A 138
HIS A 504
 CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
CU  A 603 (-4.2A)
CU  A 603 ( 3.3A)
CU  A 603 ( 3.3A)
 0.33A 5mhwA-3dkhA:
42.7		 5mhwA-3dkhA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 434
HIS A 436
HIS A 502
HIS A 140
 CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
CU  A 602 ( 3.2A)
CU  A 602 ( 3.3A)
 0.73A 5mhwA-3dkhA:
42.7		 5mhwA-3dkhA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 504
HIS A 434
HIS A 502
HIS A 436
 CU  A 603 ( 3.3A)
CU  A 604 (-3.2A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.2A)
 0.86A 5mhwA-3dkhA:
42.7		 5mhwA-3dkhA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 102
HIS A 104
TRP A 144
HIS A 146
 None
 0.13A 5mhwA-3g5wA:
27.1		 5mhwA-3g5wA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 296
HIS A 246
HIS A 294
HIS A 248
 None
C1O  A   2 ( 3.1A)
None
C1O  A   2 ( 3.5A)
 0.89A 5mhwA-3g5wA:
27.1		 5mhwA-3g5wA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 282
HIS A 233
HIS A 280
HIS A 235
 None
CU  A 302 (-3.0A)
CU  A 304 (-3.1A)
CU  A 304 ( 3.1A)
 0.95A 5mhwA-3gdcA:
24.1		 5mhwA-3gdcA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.34A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.73A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.91A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 457
 CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
CU  A 604 (-4.1A)
CU  A 604 (-3.2A)
CU  A 604 (-3.1A)
 0.16A 5mhwA-3kw7A:
62.4		 5mhwA-3kw7A:
65.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 403
HIS A 405
HIS A 455
HIS A 111
 CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 603 (-3.2A)
 0.82A 5mhwA-3kw7A:
62.4		 5mhwA-3kw7A:
65.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 457
HIS A 403
HIS A 455
HIS A 405
 CU  A 604 (-3.1A)
CU  A 602 (-3.0A)
CU  A 603 (-3.1A)
CU  A 603 ( 3.0A)
 0.86A 5mhwA-3kw7A:
62.4		 5mhwA-3kw7A:
65.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 289
HIS A 234
HIS A 287
HIS A 236
 CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.5A)
CU  A 403 ( 3.2A)
 0.90A 5mhwA-3kw8A:
11.6		 5mhwA-3kw8A:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  94
HIS A  96
TRP A 137
HIS A 139
HIS A 505
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 ( 4.5A)
CU  A 603 ( 3.1A)
CU  A 603 ( 3.3A)
 0.23A 5mhwA-3ppsA:
41.9		 5mhwA-3ppsA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 435
HIS A 437
HIS A 503
HIS A 141
 CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
CU  A 602 ( 3.3A)
CU  A 602 ( 3.3A)
 0.66A 5mhwA-3ppsA:
41.9		 5mhwA-3ppsA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 505
HIS A 435
HIS A 503
HIS A 437
 CU  A 603 ( 3.3A)
CU  A 604 ( 3.3A)
CU  A 602 ( 3.3A)
CU  A 602 (-3.3A)
 0.89A 5mhwA-3ppsA:
41.9		 5mhwA-3ppsA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 454
 CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
CU  A1501 (-4.1A)
CU  A1501 (-3.2A)
CU  A1501 (-3.3A)
 0.18A 5mhwA-3pxlA:
63.8		 5mhwA-3pxlA:
65.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A 452
HIS A 111
 CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.1A)
CU  A1500 (-3.2A)
 0.80A 5mhwA-3pxlA:
63.8		 5mhwA-3pxlA:
65.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A 398
HIS A 452
HIS A 400
 CU  A1501 (-3.3A)
CU  A1502 ( 2.9A)
CU  A1500 (-3.1A)
CU  A1500 ( 3.2A)
 0.87A 5mhwA-3pxlA:
63.8		 5mhwA-3pxlA:
65.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
OXY  A 511 ( 3.2A)
 0.11A 5mhwA-3t6wA:
68.0		 5mhwA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 402
HIS A 452
HIS A 112
 CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
CU  A 503 (-3.4A)
 0.71A 5mhwA-3t6wA:
68.0		 5mhwA-3t6wA:
79.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 OXY  A 511 ( 3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
 0.84A 5mhwA-3t6wA:
68.0		 5mhwA-3t6wA:
79.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 277
HIS A 222
HIS A 275
HIS A 224
 CU  A 309 ( 3.2A)
CU  A 308 ( 3.4A)
CU  A 310 ( 3.3A)
CU  A 310 ( 3.3A)
 0.88A 5mhwA-3t9wA:
10.7		 5mhwA-3t9wA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbb SMALL LACCASE,
OXIDOREDUCTASE

(Streptomyces
viridosporus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 284
HIS A 229
HIS A 282
HIS A 231
 OXY  A   2 ( 3.9A)
CU  A   7 ( 3.2A)
CU  A   8 ( 3.3A)
CU  A   8 (-3.3A)
 0.91A 5mhwA-3tbbA:
11.6		 5mhwA-3tbbA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  87
HIS A  89
TRP A 129
HIS A 131
HIS A 490
 CU  A 602 ( 4.7A)
CU  A 603 (-2.9A)
CU  A 603 (-4.0A)
CU  A 603 (-3.2A)
CU  A 603 (-3.5A)
 0.23A 5mhwA-3v9eA:
44.2		 5mhwA-3v9eA:
33.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 490
HIS A 429
HIS A 488
HIS A 431
 CU  A 603 (-3.5A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 0.95A 5mhwA-3v9eA:
44.2		 5mhwA-3v9eA:
33.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  85
HIS A  87
TRP A 128
HIS A 130
HIS A 476
 CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
CU  A 615 (-4.2A)
CU  A 615 (-3.2A)
CU  A 615 (-3.2A)
 0.13A 5mhwA-3x1bA:
63.1		 5mhwA-3x1bA:
62.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 420
HIS A 422
HIS A 474
HIS A 132
 CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
CU  A 616 (-3.2A)
CU  A 616 (-3.2A)
 0.72A 5mhwA-3x1bA:
63.1		 5mhwA-3x1bA:
62.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 476
HIS A 420
HIS A 474
HIS A 422
 CU  A 615 (-3.2A)
CU  A 614 (-3.1A)
CU  A 616 (-3.2A)
CU  A 616 ( 3.2A)
 0.84A 5mhwA-3x1bA:
63.1		 5mhwA-3x1bA:
62.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 139
HIS A 141
TRP A 178
HIS A 180
HIS A 496
 CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
CU  A 602 ( 4.9A)
CU  A 602 ( 3.1A)
CU  A 602 ( 3.3A)
 0.33A 5mhwA-3zx1A:
31.9		 5mhwA-3zx1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 496
HIS A 442
HIS A 494
HIS A 444
 CU  A 602 ( 3.3A)
CU  A 604 ( 3.0A)
CU  A 603 ( 3.1A)
CU  A 603 (-3.1A)
 0.85A 5mhwA-3zx1A:
31.9		 5mhwA-3zx1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 105
HIS A 107
TRP A 151
HIS A 153
HIS A 493
 CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
CU  A 602 ( 4.5A)
CU  A 602 ( 3.2A)
CU  A 602 ( 3.2A)
 0.18A 5mhwA-4akoA:
31.9		 5mhwA-4akoA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 422
HIS A 424
HIS A 491
HIS A 155
 CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.1A)
CU  A 603 ( 3.2A)
 0.65A 5mhwA-4akoA:
31.9		 5mhwA-4akoA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 493
HIS A 422
HIS A 491
HIS A 424
 CU  A 602 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 (-3.2A)
 0.88A 5mhwA-4akoA:
31.9		 5mhwA-4akoA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A1060
HIS A1062
TRP A1102
HIS A1104
 None
CU  A1402 (-3.0A)
CU  A1402 (-4.2A)
CU  A1402 ( 3.2A)
 0.18A 5mhwA-4e9xA:
27.1		 5mhwA-4e9xA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A1254
HIS A1204
HIS A1252
HIS A1206
 OXY  A1405 ( 3.8A)
CU  A1404 ( 3.0A)
CU  A1403 ( 3.2A)
CU  A1403 (-3.1A)
 0.85A 5mhwA-4e9xA:
27.1		 5mhwA-4e9xA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  82
HIS A  84
TRP A 122
HIS A 124
 None
 0.38A 5mhwA-4f7kA:
32.1		 5mhwA-4f7kA:
27.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 289
HIS A 234
HIS A 287
HIS A 236
 CU  A 402 (-3.2A)
CU  A 404 (-3.1A)
CU  A 403 (-3.4A)
CU  A 403 ( 3.2A)
 0.92A 5mhwA-4gybA:
11.6		 5mhwA-4gybA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		4 HIS A 228
HIS A 177
HIS A   9
HIS A  11
 ZN  A 401 ( 4.7A)
ZN  A 401 (-3.6A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.4A)
 1.04A 5mhwA-4ifrA:
undetectable		 5mhwA-4ifrA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 451
 CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
CU  A 502 (-4.2A)
CU  A 502 (-3.2A)
CU  A 502 (-3.3A)
 0.19A 5mhwA-4jhvA:
63.0		 5mhwA-4jhvA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 397
HIS A 399
HIS A 449
HIS A 111
 CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.1A)
CU  A 501 (-3.2A)
 0.80A 5mhwA-4jhvA:
63.0		 5mhwA-4jhvA:
62.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 451
HIS A 397
HIS A 449
HIS A 399
 CU  A 502 (-3.3A)
CU  A 504 (-2.7A)
CU  A 501 (-3.1A)
CU  A 501 ( 3.2A)
 0.88A 5mhwA-4jhvA:
63.0		 5mhwA-4jhvA:
62.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 286
HIS A 231
HIS A 284
HIS A 233
 CU  A 406 (-3.2A)
CU  A 406 ( 4.9A)
CU  A 403 (-3.2A)
CU  A 403 (-3.3A)
 0.93A 5mhwA-4w1tA:
18.9		 5mhwA-4w1tA:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 452
 CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
CU  A 508 ( 4.8A)
CU  A 508 (-3.3A)
CU  A 508 (-3.2A)
 0.18A 5mhwA-5ehfA:
63.7		 5mhwA-5ehfA:
64.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 400
HIS A 450
HIS A 111
 CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
CU  A 507 (-3.2A)
CU  A 507 ( 3.3A)
 0.73A 5mhwA-5ehfA:
63.7		 5mhwA-5ehfA:
64.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 452
HIS A 398
HIS A 450
HIS A 400
 CU  A 508 (-3.2A)
CU  A 509 ( 3.1A)
CU  A 507 (-3.2A)
CU  A 507 ( 3.1A)
 0.87A 5mhwA-5ehfA:
63.7		 5mhwA-5ehfA:
64.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  95
HIS A  97
TRP A 133
HIS A 135
HIS A 446
 CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
CU  A1465 (-4.1A)
CU  A1465 (-3.2A)
CU  A1465 (-3.3A)
 0.23A 5mhwA-5g3fA:
35.3		 5mhwA-5g3fA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 396
HIS A 398
HIS A 444
HIS A 137
 CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-3.0A)
CU  A1463 (-3.3A)
 0.85A 5mhwA-5g3fA:
35.3		 5mhwA-5g3fA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 446
HIS A 396
HIS A 444
HIS A 398
 CU  A1465 (-3.3A)
CU  A1463 ( 4.8A)
CU  A1463 (-3.0A)
CU  A1463 (-2.9A)
 0.91A 5mhwA-5g3fA:
35.3		 5mhwA-5g3fA:
25.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 108
HIS A 110
TRP A 150
HIS A 152
HIS A 517
 CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
CU  A 601 ( 4.4A)
CU  A 601 ( 3.2A)
CU  A 601 ( 3.5A)
 0.25A 5mhwA-5lm8A:
43.6		 5mhwA-5lm8A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 451
HIS A 453
HIS A 515
HIS A 154
 CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 602 ( 3.4A)
 0.74A 5mhwA-5lm8A:
43.6		 5mhwA-5lm8A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 517
HIS A 451
HIS A 515
HIS A 453
 CU  A 601 ( 3.5A)
CU  A 603 (-2.8A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.1A)
 0.90A 5mhwA-5lm8A:
43.6		 5mhwA-5lm8A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 454
 CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
CU  A 502 (-4.2A)
CU  A 502 (-3.1A)
CU  A 502 ( 3.2A)
 0.05A 5mhwA-5mewA:
71.2		 5mhwA-5mewA:
99.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 400
HIS A 402
HIS A 452
HIS A 112
 CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
CU  A 501 ( 3.0A)
CU  A 501 (-3.1A)
 0.67A 5mhwA-5mewA:
71.2		 5mhwA-5mewA:
99.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 454
HIS A 400
HIS A 452
HIS A 402
 CU  A 502 ( 3.2A)
CU  A 503 ( 3.1A)
CU  A 501 ( 3.0A)
CU  A 501 (-3.2A)
 0.85A 5mhwA-5mewA:
71.2		 5mhwA-5mewA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkm TWO-DOMAIN LACCASE

(Streptomyces
griseoflavus) 		no annotation 4 HIS A 290
HIS A 235
HIS A 288
HIS A 237
 None
 0.87A 5mhwA-5mkmA:
11.6		 5mhwA-5mkmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 101
HIS A 103
HIS A 160
HIS A1016
 CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
CU  A1104 (-3.6A)
CU  A1104 (-3.1A)
 0.71A 5mhwA-5n4lA:
12.6		 5mhwA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 160
HIS A 162
HIS A 101
HIS A 974
 CU  A1104 (-3.6A)
CU  A1101 (-3.3A)
CU  A1105 (-3.1A)
CU  A1101 ( 3.2A)
 1.05A 5mhwA-5n4lA:
12.6		 5mhwA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 972
HIS A 974
HIS A1014
HIS A 162
 CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1101 (-3.2A)
CU  A1101 (-3.3A)
 0.76A 5mhwA-5n4lA:
12.6		 5mhwA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A1016
HIS A 972
HIS A1014
HIS A 974
 CU  A1104 (-3.1A)
CU  A1105 (-3.3A)
CU  A1101 (-3.2A)
CU  A1101 ( 3.2A)
 0.95A 5mhwA-5n4lA:
12.6		 5mhwA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		4 HIS A 223
HIS A 179
HIS A   6
HIS A   8
 None
ZN  A 400 (-3.2A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
 1.03A 5mhwA-5vn5A:
undetectable		 5mhwA-5vn5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 HIS A  91
HIS A  93
TRP A 129
HIS A 131
HIS A 491
 EDO  A 602 ( 4.5A)
None
None
None
None
 0.43A 5mhwA-6evgA:
33.7		 5mhwA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 437
HIS A 439
HIS A 489
HIS A 133
 None
EDO  A 602 (-3.8A)
None
EDO  A 602 (-4.1A)
 0.89A 5mhwA-6evgA:
33.7		 5mhwA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 HIS A 491
HIS A 437
HIS A 489
HIS A 439
 None
None
None
EDO  A 602 (-3.8A)
 0.83A 5mhwA-6evgA:
33.7		 5mhwA-6evgA:
undetectable