SIMILAR PATTERNS OF AMINO ACIDS FOR 5MFX_A_ACTA701_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8m HUMAN RHINOVIRUS 16
COAT PROTEIN

(Rhinovirus A) 		PF00073
(Rhv) 		4 ARG 2 103
THR 2  43
ALA 2  47
ASP 2  46
 None
 1.26A 5mfxA-1c8m2:
0.0		 5mfxA-1c8m2:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7b CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF16010
(CDH-cyt) 		4 THR A 175
HIS A 177
ALA A 176
ASP A 172
 None
 1.39A 5mfxA-1d7bA:
0.0		 5mfxA-1d7bA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ARG A  21
THR A  33
ALA A 172
ASP A  17
 None
 1.34A 5mfxA-1e5dA:
2.4		 5mfxA-1e5dA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 THR A 317
HIS A 316
ALA A 318
ASP A 319
 None
 0.94A 5mfxA-1f4hA:
0.0		 5mfxA-1f4hA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 X-LINKED INHIBITOR
OF APOPTOSIS PROTEIN

(Homo sapiens) 		no annotation 4 THR E 135
HIS E 136
ALA E 137
ASP E 138
 None
 1.39A 5mfxA-1i51E:
undetectable		 5mfxA-1i51E:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 THR A 252
HIS A 251
ALA A 253
ASP A  87
 None
 1.32A 5mfxA-1i9gA:
2.9		 5mfxA-1i9gA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A

(Spinacia
oleracea) 		no annotation 4 THR O 138
HIS O 139
ALA O 140
ASP O 141
 None
 1.36A 5mfxA-1jn0O:
undetectable		 5mfxA-1jn0O:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01135
(PCMT) 		4 ARG A  36
HIS A  64
ALA A  60
ASP A  47
 None
SAH  A 300 (-4.2A)
None
None
 1.36A 5mfxA-1kr5A:
2.2		 5mfxA-1kr5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A  46
HIS A  49
ALA A  50
ASP A  47
 EDO  A1260 ( 2.9A)
NAD  A1250 (-3.9A)
None
None
 1.31A 5mfxA-1lluA:
2.2		 5mfxA-1lluA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n2o PANTOTHENATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF02569
(Pantoate_ligase) 		4 ARG A 132
THR A 134
HIS A 135
ALA A  75
 None
 1.33A 5mfxA-1n2oA:
undetectable		 5mfxA-1n2oA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		4 ARG A  91
THR A  31
ALA A 110
ASP A 112
 None
 1.08A 5mfxA-1nrkA:
undetectable		 5mfxA-1nrkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		4 THR A 249
HIS A 248
ALA A 250
ASP A  88
 None
 1.32A 5mfxA-1o54A:
3.1		 5mfxA-1o54A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ARG B 477
THR B 400
HIS B 402
ASP B 398
 None
 1.39A 5mfxA-1ovlB:
undetectable		 5mfxA-1ovlB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		4 ARG A 267
THR A 294
HIS A 293
ALA A 297
 None
 1.45A 5mfxA-1q0zA:
undetectable		 5mfxA-1q0zA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 THR A 309
HIS A 310
ALA A 311
ASP A 312
 None
 1.31A 5mfxA-1qpaA:
undetectable		 5mfxA-1qpaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r18 PROTEIN-L-ISOASPARTA
TE(D-ASPARTATE)-O-ME
THYLTRANSFERASE

(Drosophila
melanogaster) 		PF01135
(PCMT) 		4 ARG A  37
HIS A  65
ALA A  61
ASP A  48
 None
SAH  A 300 (-3.9A)
None
None
 1.38A 5mfxA-1r18A:
2.1		 5mfxA-1r18A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A  40
HIS A  43
ALA A  44
ASP A  41
 ETF  A 501 ( 3.3A)
None
None
None
 1.26A 5mfxA-1rjwA:
3.1		 5mfxA-1rjwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 ARG A 218
THR A 251
HIS A 252
ASP A 248
 None
 1.37A 5mfxA-1w9xA:
undetectable		 5mfxA-1w9xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 ARG A  64
THR A 266
ALA A 267
ASP A 264
 None
NO3  A 408 ( 4.9A)
None
None
 1.40A 5mfxA-1wx4A:
undetectable		 5mfxA-1wx4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ARG A  22
THR A  35
ALA A 174
ASP A  18
 None
 1.30A 5mfxA-1ycgA:
undetectable		 5mfxA-1ycgA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		4 THR A  33
HIS A  28
ALA A  29
ASP A  31
 None
 1.33A 5mfxA-1zc6A:
undetectable		 5mfxA-1zc6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhv HYPOTHETICAL PROTEIN
ATU0741

(Agrobacterium
fabrum) 		PF13840
(ACT_7) 		4 ARG A  18
THR A  40
ALA A  21
ASP A  42
 None
 1.10A 5mfxA-1zhvA:
undetectable		 5mfxA-1zhvA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		4 THR A 320
HIS A 319
ALA A 321
ASP A  91
 None
 1.24A 5mfxA-2b25A:
2.0		 5mfxA-2b25A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ARG A 274
THR A 196
HIS A 195
ALA A 192
 None
 1.33A 5mfxA-2bwsA:
2.3		 5mfxA-2bwsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipq HYPOTHETICAL PROTEIN
STY4665

(Salmonella
enterica) 		PF07515
(TraI_2_C) 		4 THR X 422
HIS X 428
ALA X 423
ASP X 424
 None
 1.38A 5mfxA-2ipqX:
undetectable		 5mfxA-2ipqX:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j63 AP-ENDONUCLEASE

(Leishmania
major) 		PF03372
(Exo_endo_phos) 		4 THR A 310
HIS A 328
ALA A 309
ASP A 306
 None
 1.35A 5mfxA-2j63A:
undetectable		 5mfxA-2j63A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lli PROTEIN AIR2

(Saccharomyces
cerevisiae) 		PF00098
(zf-CCHC) 		4 THR A  31
HIS A  34
ALA A  30
ASP A  19
 None
ZN  A 204 (-3.7A)
None
None
 1.36A 5mfxA-2lliA:
undetectable		 5mfxA-2lliA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		4 THR A 274
HIS A 275
ALA A 276
ASP A 277
 None
 1.44A 5mfxA-2o36A:
undetectable		 5mfxA-2o36A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		4 THR A 275
HIS A 276
ALA A 277
ASP A 278
 None
 1.42A 5mfxA-2o3eA:
undetectable		 5mfxA-2o3eA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovi HYPOTHETICAL PROTEIN
CHUX

(Escherichia
coli) 		PF06228
(ChuX_HutX) 		4 THR A  66
HIS A  65
ALA A  67
ASP A  68
 None
 1.30A 5mfxA-2oviA:
undetectable		 5mfxA-2oviA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 ARG A  39
HIS A  67
ALA A  63
ASP A  50
 None
SAH  A 301 (-3.9A)
None
None
 1.42A 5mfxA-2pbfA:
undetectable		 5mfxA-2pbfA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph0 UNCHARACTERIZED
PROTEIN

(Pectobacterium
carotovorum) 		PF06228
(ChuX_HutX) 		4 THR A  67
HIS A  66
ALA A  68
ASP A  69
 None
 1.26A 5mfxA-2ph0A:
undetectable		 5mfxA-2ph0A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 THR A 108
HIS A 107
ALA A  87
ASP A  85
 None
None
None
P3T  A 501 ( 4.6A)
 1.16A 5mfxA-2pljA:
undetectable		 5mfxA-2pljA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		4 ARG A1222
THR A1073
HIS A1225
ALA A1072
 None
 1.27A 5mfxA-2po3A:
undetectable		 5mfxA-2po3A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 THR A 288
HIS A 291
ALA A 287
ASP A 318
 None
 1.44A 5mfxA-2q8hA:
undetectable		 5mfxA-2q8hA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Listeria
monocytogenes) 		PF06751
(EutB) 		4 THR A 230
HIS A 227
ALA A 226
ASP A 197
 None
 1.43A 5mfxA-2qezA:
undetectable		 5mfxA-2qezA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5v PCZA361.1

(Amycolatopsis
orientalis) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 THR A 125
HIS A 124
ALA A  79
ASP A  77
 None
 1.44A 5mfxA-2r5vA:
undetectable		 5mfxA-2r5vA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		4 ARG A 431
THR A 394
HIS A 397
ALA A 393
 None
 1.43A 5mfxA-2vroA:
undetectable		 5mfxA-2vroA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvf MAJOR CAPSID PROTEIN
P2

(Pseudoalteromonas
virus PM2) 		no annotation 4 ARG A 195
THR A 220
ALA A 174
ASP A 222
 None
 1.25A 5mfxA-2vvfA:
undetectable		 5mfxA-2vvfA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		4 THR A   9
HIS A  48
ALA A  10
ASP A 284
 None
None
ANP  A1531 ( 4.0A)
ANP  A1531 (-2.7A)
 1.14A 5mfxA-2vwbA:
undetectable		 5mfxA-2vwbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 THR A 381
HIS A 382
ALA A 349
ASP A 347
 None
None
PLP  A1386 (-3.4A)
PLP  A1386 (-2.8A)
 1.33A 5mfxA-2vycA:
3.3		 5mfxA-2vycA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		4 ARG A 189
THR A 201
ALA A 183
ASP A 247
 None
 1.27A 5mfxA-2w9mA:
undetectable		 5mfxA-2w9mA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waw MOBA RELATE PROTEIN

(Mycobacterium
sp. DSM 3803) 		PF12804
(NTP_transf_3) 		4 ARG A   3
THR A   7
ALA A  96
ASP A  93
 None
 1.06A 5mfxA-2wawA:
undetectable		 5mfxA-2wawA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		4 THR A  27
HIS A  24
ALA A 235
ASP A 236
 None
 1.30A 5mfxA-2xj9A:
3.0		 5mfxA-2xj9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus musculus) 		PF00640
(PID)
PF10515
(APP_amyloid) 		4 ARG A 129
THR A 110
ALA A 109
ASP A 108
 None
 1.41A 5mfxA-2yt0A:
undetectable		 5mfxA-2yt0A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		4 THR A 237
HIS A 236
ALA A 238
ASP A  79
 None
 1.33A 5mfxA-2yvlA:
2.6		 5mfxA-2yvlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ARG A 334
THR A 329
ALA A 333
ASP A 330
 None
 1.44A 5mfxA-2zu6A:
9.7		 5mfxA-2zu6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 THR A 235
HIS A 234
ALA A  64
ASP A 172
 None
SO4  A   1 (-3.7A)
None
None
 1.16A 5mfxA-3a3jA:
undetectable		 5mfxA-3a3jA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		no annotation 4 ARG A 128
THR A 168
ALA A 166
ASP A 171
 None
 1.33A 5mfxA-3b8oA:
undetectable		 5mfxA-3b8oA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 THR A 675
HIS A 585
ALA A 671
ASP A 672
 None
 1.36A 5mfxA-3c10A:
3.1		 5mfxA-3c10A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc7 PUTATIVE
UNCHARACTERIZED
PROTEIN LP_3323

(Lactobacillus
plantarum) 		PF13472
(Lipase_GDSL_2) 		4 THR A  32
HIS A  41
ALA A  33
ASP A  29
 None
 1.10A 5mfxA-3dc7A:
undetectable		 5mfxA-3dc7A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 4 THR A 177
HIS A 176
ALA A 178
ASP A 245
 None
None
NDP  A 401 ( 3.8A)
None
 1.44A 5mfxA-3iupA:
3.8		 5mfxA-3iupA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 4 THR A 177
HIS A 176
ALA A 246
ASP A 245
 None
None
NDP  A 401 ( 3.8A)
None
 1.27A 5mfxA-3iupA:
3.8		 5mfxA-3iupA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		4 THR A1984
HIS A1988
ALA A1986
ASP A1947
 None
 1.13A 5mfxA-3jbzA:
undetectable		 5mfxA-3jbzA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr2 HEXULOSE-6-PHOSPHATE
SYNTHASE SGBH

(Vibrio cholerae) 		PF00215
(OMPdecase) 		4 THR A  94
HIS A  91
ALA A  90
ASP A  67
 SO4  A 501 (-2.9A)
None
None
SO4  A 501 (-4.4A)
 1.42A 5mfxA-3jr2A:
undetectable		 5mfxA-3jr2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		4 THR A  59
HIS A  79
ALA A 108
ASP A 111
 None
 1.37A 5mfxA-3lm3A:
2.3		 5mfxA-3lm3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 ARG A 249
THR A 247
ALA A 248
ASP A 245
 None
 1.32A 5mfxA-3m8uA:
undetectable		 5mfxA-3m8uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkv PUTATIVE
AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ARG A 262
THR A 260
ALA A 261
ASP A 257
 None
 1.33A 5mfxA-3mkvA:
undetectable		 5mfxA-3mkvA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A 217
HIS A 367
ALA A 218
ASP A 214
 None
 1.25A 5mfxA-3o04A:
undetectable		 5mfxA-3o04A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oes GTPASE RHEBL1

(Homo sapiens) 		PF00071
(Ras) 		4 THR A  20
HIS A  24
ALA A  23
ASP A  60
 MG  A 202 ( 3.2A)
None
None
MG  A 202 ( 3.7A)
 1.25A 5mfxA-3oesA:
3.0		 5mfxA-3oesA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 THR A 111
HIS A 115
ALA A 142
ASP A 139
 None
None
None
EDO  A 264 (-4.1A)
 1.04A 5mfxA-3qxzA:
undetectable		 5mfxA-3qxzA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		4 ARG A 176
THR A 199
HIS A 174
ASP A 177
 None
 1.24A 5mfxA-3r9uA:
undetectable		 5mfxA-3r9uA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr6 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacteroides
abscessus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 ARG A 160
HIS A 164
ALA A 148
ASP A 150
 EDO  A 265 (-4.0A)
EDO  A 265 (-4.8A)
None
None
 1.35A 5mfxA-3rr6A:
undetectable		 5mfxA-3rr6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		4 ARG A 421
THR A 288
HIS A 287
ALA A 305
 None
 1.31A 5mfxA-3s6pA:
undetectable		 5mfxA-3s6pA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sok FIMBRIAL PROTEIN

(Dichelobacter
nodosus) 		PF00114
(Pilin)
PF07963
(N_methyl) 		4 ARG A  46
THR A  79
ALA A  78
ASP A  70
 None
 1.17A 5mfxA-3sokA:
undetectable		 5mfxA-3sokA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uko ALCOHOL
DEHYDROGENASE
CLASS-3

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 166
HIS A  90
ALA A 167
ASP A 164
 None
 1.35A 5mfxA-3ukoA:
2.7		 5mfxA-3ukoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woy CLIP-ASSOCIATING
PROTEIN 2

(Homo sapiens) 		PF12348
(CLASP_N) 		4 ARG A 154
THR A 195
ALA A 199
ASP A  66
 None
 1.31A 5mfxA-3woyA:
undetectable		 5mfxA-3woyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zig SEPF-LIKE PROTEIN

(Pyrococcus
furiosus) 		PF04472
(SepF) 		4 THR A  60
HIS A  61
ALA A  62
ASP A  63
 None
 1.33A 5mfxA-3zigA:
undetectable		 5mfxA-3zigA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		4 THR A 110
HIS A 105
ALA A 107
ASP A 109
 None
 1.29A 5mfxA-3zs6A:
undetectable		 5mfxA-3zs6A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 THR A 436
HIS A 481
ALA A 355
ASP A 374
 None
 1.39A 5mfxA-3zz1A:
2.1		 5mfxA-3zz1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		4 THR A1198
HIS A1172
ALA A1169
ASP A1170
 EDO  A2370 (-4.2A)
None
None
None
 1.26A 5mfxA-4bkwA:
undetectable		 5mfxA-4bkwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4coy EPITHELIAL ADHESIN 6

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 THR A 154
HIS A 157
ALA A 213
ASP A 212
 None
 1.33A 5mfxA-4coyA:
undetectable		 5mfxA-4coyA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		4 ARG A 469
THR A 406
HIS A  46
ALA A 405
 None
 1.44A 5mfxA-4cxkA:
2.1		 5mfxA-4cxkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE

(Mycobacterium
avium) 		PF04909
(Amidohydro_2) 		4 ARG A 205
HIS A 212
ALA A 171
ASP A 172
 None
 1.44A 5mfxA-4dziA:
undetectable		 5mfxA-4dziA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6c AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		PF07993
(NAD_binding_4) 		4 ARG A2228
HIS A2298
ALA A2191
ASP A2192
 None
 1.35A 5mfxA-4f6cA:
undetectable		 5mfxA-4f6cA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		no annotation 4 ARG B2228
HIS B2298
ALA B2191
ASP B2192
 None
 1.41A 5mfxA-4f6lB:
undetectable		 5mfxA-4f6lB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 ARG A 148
THR A 183
ALA A 184
ASP A 185
 None
 1.45A 5mfxA-4ghkA:
3.0		 5mfxA-4ghkA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvm TLMII

(Streptoalloteichus
hindustanus) 		PF00668
(Condensation) 		4 ARG A 296
THR A 412
ALA A 351
ASP A 410
 None
 1.32A 5mfxA-4hvmA:
undetectable		 5mfxA-4hvmA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 119
THR A 306
HIS A 307
ALA A 310
 None
 1.30A 5mfxA-4izgA:
undetectable		 5mfxA-4izgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks9 MALONYL-COA
DECARBOXYLASE

(Cupriavidus
metallidurans) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 ARG A 398
THR A 390
HIS A 394
ALA A 393
 None
 1.26A 5mfxA-4ks9A:
undetectable		 5mfxA-4ks9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ARG A 337
THR A 340
ALA A 272
ASP A 343
 None
 1.29A 5mfxA-4mruA:
undetectable		 5mfxA-4mruA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		4 ARG A 445
THR A 443
ALA A 444
ASP A 441
 GOL  A 606 ( 4.4A)
None
None
None
 1.30A 5mfxA-4oerA:
undetectable		 5mfxA-4oerA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ARG A 272
THR A 194
HIS A 193
ALA A 190
 None
 1.32A 5mfxA-4pv4A:
undetectable		 5mfxA-4pv4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		4 THR A 486
HIS A 464
ALA A 501
ASP A 498
 None
 1.35A 5mfxA-4s28A:
undetectable		 5mfxA-4s28A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uww STRUTHIOCALCIN-1

(Struthio
camelus) 		PF00059
(Lectin_C) 		4 ARG A  35
THR A 131
ALA A 132
ASP A   1
 None
 1.14A 5mfxA-4uwwA:
undetectable		 5mfxA-4uwwA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A  45
HIS A  48
ALA A  49
ASP A  46
 ETF  A 404 (-2.6A)
8ID  A 403 (-4.0A)
None
None
 1.30A 5mfxA-4w6zA:
undetectable		 5mfxA-4w6zA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 ARG A 263
THR A 211
HIS A 231
ALA A 232
 None
 1.42A 5mfxA-4wjsA:
undetectable		 5mfxA-4wjsA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB

(Escherichia
coli) 		PF00814
(Peptidase_M22) 		4 THR C  10
HIS C  34
ALA C  12
ASP C   7
 None
ACT  C 301 (-4.6A)
None
None
 1.30A 5mfxA-4wq5C:
undetectable		 5mfxA-4wq5C:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x00 PUTATIVE HYDROLASE

(Burkholderia
cenocepacia) 		PF12697
(Abhydrolase_6) 		4 THR A 164
HIS A 165
ALA A 159
ASP A 161
 None
 1.32A 5mfxA-4x00A:
undetectable		 5mfxA-4x00A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xax CARD

(Thermus
thermophilus) 		PF02559
(CarD_CdnL_TRCF) 		4 THR B  93
HIS B  90
ALA B 128
ASP B 125
 None
 1.42A 5mfxA-4xaxB:
undetectable		 5mfxA-4xaxB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		4 ARG A 232
THR A 394
ALA A 396
ASP A 401
 None
None
GDP  A1104 (-3.8A)
None
 1.37A 5mfxA-5cjuA:
2.1		 5mfxA-5cjuA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		4 THR A 319
HIS A 318
ALA A 320
ASP A 321
 None
 1.18A 5mfxA-5cqfA:
2.6		 5mfxA-5cqfA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		4 ARG A 283
THR A 205
ALA A 206
ASP A 203
 None
 1.14A 5mfxA-5dldA:
2.6		 5mfxA-5dldA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		4 ARG A 397
THR A 395
ALA A 396
ASP A 393
 None
 1.36A 5mfxA-5e7pA:
4.6		 5mfxA-5e7pA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		4 ARG A 100
THR A  34
HIS A  32
ASP A  82
 None
 1.45A 5mfxA-5h05A:
undetectable		 5mfxA-5h05A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Myxococcus
xanthus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 THR A 312
HIS A 250
ALA A 313
ASP A 145
 CSO  A 115 ( 3.9A)
CSO  A 115 (-3.5A)
None
None
 1.30A 5mfxA-5hwqA:
undetectable		 5mfxA-5hwqA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22) 		4 THR A   9
HIS A  48
ALA A  10
ASP A 284
 None
None
None
MG  A 402 ( 2.7A)
 1.15A 5mfxA-5jmvA:
undetectable		 5mfxA-5jmvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4y SUSC HOMOLOG

(Bacteroides
thetaiotaomicron) 		no annotation 4 THR D 800
HIS D 799
ALA D 803
ASP D 854
 None
 0.97A 5mfxA-5t4yD:
undetectable		 5mfxA-5t4yD:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 ARG A 662
HIS A 760
ALA A 761
ASP A 690
 None
PO4  A 902 (-3.9A)
None
None
 1.29A 5mfxA-5te1A:
undetectable		 5mfxA-5te1A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 4 ARG A 517
THR A 520
ALA A 524
ASP A 268
 SO4  A 720 (-3.1A)
None
None
None
 1.11A 5mfxA-5y6rA:
undetectable		 5mfxA-5y6rA:
undetectable