SIMILAR PATTERNS OF AMINO ACIDS FOR 5MEW_A_CUA502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  60
HIS A  62
HIS A 104
HIS A 448
HIS A 508
 CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
CU  A 556 (-3.1A)
CU  A 557 ( 3.2A)
CU  A 556 (-3.3A)
 0.27A 5mewA-1asoA:
40.5		 5mewA-1asoA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  60
HIS A 106
HIS A 448
HIS A 506
 CU  A 557 ( 3.1A)
CU  A 555 (-3.3A)
CU  A 557 ( 3.2A)
CU  A 555 (-3.1A)
 0.75A 5mewA-1asoA:
40.5		 5mewA-1asoA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 448
HIS A 450
HIS A 506
HIS A  60
HIS A 106
 CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
CU  A 555 (-3.1A)
CU  A 557 ( 3.1A)
CU  A 555 (-3.3A)
 0.63A 5mewA-1asoA:
40.5		 5mewA-1asoA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 448
HIS A 508
HIS A  60
HIS A 104
 CU  A 557 ( 3.2A)
CU  A 556 (-3.3A)
CU  A 557 ( 3.1A)
CU  A 556 (-3.1A)
 0.75A 5mewA-1asoA:
40.5		 5mewA-1asoA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 508
HIS A 506
HIS A 104
HIS A 106
 CU  A 556 (-3.3A)
CU  A 555 (-3.1A)
CU  A 556 (-3.1A)
CU  A 555 (-3.3A)
 0.78A 5mewA-1asoA:
40.5		 5mewA-1asoA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 398
HIS A 454
 CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
CU  A1500 ( 4.7A)
CU  A1500 (-3.3A)
CU  A1502 ( 3.1A)
CU  A1500 (-3.3A)
 0.11A 5mewA-1gycA:
63.6		 5mewA-1gycA:
68.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 398
HIS A 452
 CU  A1502 (-3.1A)
CU  A1501 (-3.4A)
CU  A1502 ( 3.1A)
CU  A1501 (-3.3A)
 0.77A 5mewA-1gycA:
63.6		 5mewA-1gycA:
68.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 400
HIS A 452
HIS A  64
HIS A 111
 CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
CU  A1501 (-3.3A)
CU  A1502 (-3.1A)
CU  A1501 (-3.4A)
 0.64A 5mewA-1gycA:
63.6		 5mewA-1gycA:
68.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 399
HIS A 453
 CU  A 703 (-4.7A)
CU  A 703 (-3.0A)
CU  A 703 (-4.0A)
CU  A 703 (-3.2A)
CU  A 702 ( 3.7A)
CU  A 703 (-3.3A)
 0.65A 5mewA-1hfuA:
60.5		 5mewA-1hfuA:
59.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 401
HIS A 451
HIS A  64
HIS A 111
 CU  A 702 (-3.2A)
CU  A 702 (-3.2A)
CU  A 703 (-4.7A)
CU  A 702 (-3.2A)
 0.65A 5mewA-1hfuA:
60.5		 5mewA-1hfuA:
59.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 101
HIS A 103
HIS A 161
HIS A 978
HIS A1022
 CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
CU  A1052 ( 3.2A)
CU  A1051 (-3.2A)
 0.62A 5mewA-1kcwA:
18.0		 5mewA-1kcwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 161
HIS A 101
HIS A 103
HIS A 980
HIS A 978
 CU  A1051 (-3.3A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
CU  A1050 (-3.0A)
CU  A1052 ( 3.2A)
 1.44A 5mewA-1kcwA:
18.0		 5mewA-1kcwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 163
HIS A 161
HIS A1020
HIS A1022
 CU  A1050 (-3.3A)
CU  A1051 (-3.3A)
CU  A1050 (-3.2A)
CU  A1051 (-3.2A)
 0.76A 5mewA-1kcwA:
18.0		 5mewA-1kcwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 978
HIS A1020
HIS A 101
HIS A 163
 CU  A1052 ( 3.2A)
CU  A1050 (-3.2A)
CU  A1052 (-3.2A)
CU  A1050 (-3.3A)
 0.39A 5mewA-1kcwA:
18.0		 5mewA-1kcwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 978
HIS A1022
HIS A 101
HIS A 161
 CU  A1052 ( 3.2A)
CU  A1051 (-3.2A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
 0.73A 5mewA-1kcwA:
18.0		 5mewA-1kcwA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 398
HIS A 454
 CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
CU  A 502 ( 4.9A)
CU  A 502 (-3.7A)
CU  A 503 ( 3.2A)
CU  A 502 (-3.4A)
 0.24A 5mewA-1kyaA:
63.0		 5mewA-1kyaA:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 398
HIS A 452
 CU  A 503 (-3.2A)
CU  A 501 (-3.5A)
CU  A 503 ( 3.2A)
CU  A 501 (-3.4A)
 0.77A 5mewA-1kyaA:
63.0		 5mewA-1kyaA:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 400
HIS A 452
HIS A  64
HIS A 111
 CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
CU  A 501 (-3.4A)
CU  A 503 (-3.2A)
CU  A 501 (-3.5A)
 0.66A 5mewA-1kyaA:
63.0		 5mewA-1kyaA:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 399
HIS A 453
 CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
CU  A1500 (-4.2A)
CU  A1500 (-3.3A)
CU  A1502 (-2.9A)
CU  A1500 (-3.4A)
 0.16A 5mewA-1v10A:
61.3		 5mewA-1v10A:
60.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 399
HIS A 451
 CU  A1502 (-3.2A)
CU  A1501 (-3.3A)
CU  A1502 (-2.9A)
CU  A1501 (-2.9A)
 0.69A 5mewA-1v10A:
61.3		 5mewA-1v10A:
60.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 399
HIS A 401
HIS A 451
HIS A  64
HIS A 111
 CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
CU  A1502 (-3.2A)
CU  A1501 (-3.3A)
 0.63A 5mewA-1v10A:
61.3		 5mewA-1v10A:
60.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 416
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  81
HIS A 128
HIS A 416
HIS A 483
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
 0.79A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 128
HIS A 483
HIS A 418
HIS A 485
HIS A 416
 CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
 1.39A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 416
HIS A 418
HIS A 483
HIS A  81
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
 0.65A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 446
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
 0.28A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 446
HIS A 448
HIS A 499
HIS A 101
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
 0.66A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 398
HIS A 454
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 ( 4.4A)
CU  A 603 (-3.4A)
CU  A 604 (-3.1A)
CU  A 603 (-3.3A)
 0.19A 5mewA-2hzhA:
63.0		 5mewA-2hzhA:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 398
HIS A 452
 CU  A 604 ( 3.1A)
CU  A 602 (-3.2A)
CU  A 604 (-3.1A)
CU  A 602 (-3.1A)
 0.78A 5mewA-2hzhA:
63.0		 5mewA-2hzhA:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 400
HIS A 452
HIS A  64
HIS A 111
 CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.1A)
CU  A 604 ( 3.1A)
CU  A 602 (-3.2A)
 0.71A 5mewA-2hzhA:
63.0		 5mewA-2hzhA:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 397
HIS A 453
 CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
CU  A 502 (-4.2A)
CU  A 502 (-3.2A)
CU  A 500 (-3.1A)
CU  A 502 (-3.3A)
 0.14A 5mewA-2qt6A:
63.6		 5mewA-2qt6A:
66.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 397
HIS A 451
 CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 500 (-3.1A)
CU  A 501 (-3.2A)
 0.76A 5mewA-2qt6A:
63.6		 5mewA-2qt6A:
66.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 397
HIS A 399
HIS A 451
HIS A  64
HIS A 111
 CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.2A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
 0.66A 5mewA-2qt6A:
63.6		 5mewA-2qt6A:
66.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 398
HIS A 452
 CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
CU  A 503 ( 4.3A)
CU  A 503 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 503 ( 3.3A)
 0.13A 5mewA-2xybA:
63.6		 5mewA-2xybA:
66.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 398
HIS A 450
 CU  A 504 ( 3.1A)
CU  A 502 (-3.2A)
CU  A 504 (-3.1A)
CU  A 502 ( 3.3A)
 0.77A 5mewA-2xybA:
63.6		 5mewA-2xybA:
66.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 400
HIS A 450
HIS A  64
HIS A 111
 CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.3A)
CU  A 504 ( 3.1A)
CU  A 502 (-3.2A)
 0.67A 5mewA-2xybA:
63.6		 5mewA-2xybA:
66.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  94
HIS A  96
TRP A 132
HIS A 134
HIS A 401
HIS A 458
 CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
CU  A 702 (-4.3A)
CU  A 702 (-3.1A)
CU  A 703 (-3.4A)
CU  A 702 (-3.5A)
 0.34A 5mewA-3abgA:
31.0		 5mewA-3abgA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
HIS A 136
HIS A 401
HIS A 456
 CU  A 703 (-3.0A)
CU  A 701 (-3.2A)
CU  A 703 (-3.4A)
CU  A 701 (-3.3A)
 0.78A 5mewA-3abgA:
31.0		 5mewA-3abgA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 401
HIS A 403
HIS A 456
HIS A  94
HIS A 136
 CU  A 703 (-3.4A)
CU  A 701 ( 3.1A)
CU  A 701 (-3.3A)
CU  A 703 (-3.0A)
CU  A 701 (-3.2A)
 0.75A 5mewA-3abgA:
31.0		 5mewA-3abgA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  92
HIS A  94
HIS A 132
HIS A 394
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
 0.19A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 394
HIS A 396
HIS A 459
HIS A  92
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.65A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 394
HIS A 461
HIS A  92
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.77A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  93
HIS A  95
TRP A 136
HIS A 138
HIS A 434
HIS A 504
 CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
CU  A 603 (-4.2A)
CU  A 603 ( 3.3A)
CU  A 604 (-3.2A)
CU  A 603 ( 3.3A)
 0.31A 5mewA-3dkhA:
42.7		 5mewA-3dkhA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  93
HIS A 140
HIS A 434
HIS A 502
 CU  A 604 (-3.1A)
CU  A 602 ( 3.3A)
CU  A 604 (-3.2A)
CU  A 602 ( 3.2A)
 0.78A 5mewA-3dkhA:
42.7		 5mewA-3dkhA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 140
HIS A 502
HIS A 436
HIS A 504
HIS A 434
 CU  A 602 ( 3.3A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.2A)
CU  A 603 ( 3.3A)
CU  A 604 (-3.2A)
 1.35A 5mewA-3dkhA:
42.7		 5mewA-3dkhA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 434
HIS A 436
HIS A 502
HIS A  93
HIS A 140
 CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
CU  A 602 ( 3.2A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.3A)
 0.65A 5mewA-3dkhA:
42.7		 5mewA-3dkhA:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 102
HIS A 104
TRP A 144
HIS A 146
 None
 0.13A 5mewA-3g5wA:
27.1		 5mewA-3g5wA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 527
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
 0.34A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 161
HIS A 203
HIS A 527
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.77A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 527
HIS A 529
HIS A 602
HIS A 161
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.69A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 403
HIS A 457
 CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
CU  A 604 (-4.1A)
CU  A 604 (-3.2A)
CU  A 602 (-3.0A)
CU  A 604 (-3.1A)
 0.17A 5mewA-3kw7A:
62.4		 5mewA-3kw7A:
67.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 403
HIS A 455
 CU  A 602 (-3.1A)
CU  A 603 (-3.2A)
CU  A 602 (-3.0A)
CU  A 603 (-3.1A)
 0.78A 5mewA-3kw7A:
62.4		 5mewA-3kw7A:
67.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 403
HIS A 405
HIS A 455
HIS A  64
HIS A 111
 CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 602 (-3.1A)
CU  A 603 (-3.2A)
 0.74A 5mewA-3kw7A:
62.4		 5mewA-3kw7A:
67.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  94
HIS A  96
TRP A 137
HIS A 139
HIS A 435
HIS A 505
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 ( 4.5A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.3A)
CU  A 603 ( 3.3A)
 0.22A 5mewA-3ppsA:
41.9		 5mewA-3ppsA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  94
HIS A 141
HIS A 435
HIS A 503
 CU  A 604 ( 3.1A)
CU  A 602 ( 3.3A)
CU  A 604 ( 3.3A)
CU  A 602 ( 3.3A)
 0.79A 5mewA-3ppsA:
41.9		 5mewA-3ppsA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 435
HIS A 437
HIS A 503
HIS A  94
HIS A 141
 CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
CU  A 602 ( 3.3A)
CU  A 604 ( 3.1A)
CU  A 602 ( 3.3A)
 0.59A 5mewA-3ppsA:
41.9		 5mewA-3ppsA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 398
HIS A 454
 CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
CU  A1501 (-4.1A)
CU  A1501 (-3.2A)
CU  A1502 ( 2.9A)
CU  A1501 (-3.3A)
 0.23A 5mewA-3pxlA:
63.7		 5mewA-3pxlA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 400
HIS A 452
HIS A  64
HIS A 111
 CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.1A)
CU  A1502 ( 3.0A)
CU  A1500 (-3.2A)
 0.71A 5mewA-3pxlA:
63.7		 5mewA-3pxlA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 400
HIS A 454
 CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
None
CU  A 502 ( 3.5A)
CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
 0.10A 5mewA-3t6wA:
68.1		 5mewA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  65
HIS A 112
HIS A 400
HIS A 452
 CU  A 504 (-3.1A)
CU  A 503 (-3.4A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
 0.76A 5mewA-3t6wA:
68.1		 5mewA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 400
HIS A 402
HIS A 452
HIS A  65
HIS A 112
 CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
CU  A 504 (-3.1A)
CU  A 503 (-3.4A)
 0.63A 5mewA-3t6wA:
68.1		 5mewA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  87
HIS A  89
TRP A 129
HIS A 131
HIS A 429
HIS A 490
 CU  A 602 ( 4.7A)
CU  A 603 (-2.9A)
CU  A 603 (-4.0A)
CU  A 603 (-3.2A)
CU  A 602 (-3.6A)
CU  A 603 (-3.5A)
 0.34A 5mewA-3v9eA:
44.1		 5mewA-3v9eA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 429
HIS A 488
HIS A  87
HIS A 133
 CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
CU  A 602 ( 4.7A)
CU  A 602 (-3.3A)
 0.42A 5mewA-3v9eA:
44.1		 5mewA-3v9eA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 431
HIS A 488
HIS A  87
HIS A 133
 CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
CU  A 602 ( 4.7A)
CU  A 602 (-3.3A)
 0.66A 5mewA-3v9eA:
44.1		 5mewA-3v9eA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  85
HIS A  87
TRP A 128
HIS A 130
HIS A 420
HIS A 476
 CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
CU  A 615 (-4.2A)
CU  A 615 (-3.2A)
CU  A 614 (-3.1A)
CU  A 615 (-3.2A)
 0.15A 5mewA-3x1bA:
63.2		 5mewA-3x1bA:
63.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  85
HIS A 132
HIS A 420
HIS A 474
 CU  A 614 (-3.1A)
CU  A 616 (-3.2A)
CU  A 614 (-3.1A)
CU  A 616 (-3.2A)
 0.77A 5mewA-3x1bA:
63.2		 5mewA-3x1bA:
63.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 420
HIS A 422
HIS A 474
HIS A  85
HIS A 132
 CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
CU  A 616 (-3.2A)
CU  A 614 (-3.1A)
CU  A 616 (-3.2A)
 0.65A 5mewA-3x1bA:
63.2		 5mewA-3x1bA:
63.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A 139
HIS A 141
TRP A 178
HIS A 180
HIS A 442
HIS A 496
 CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
CU  A 602 ( 4.9A)
CU  A 602 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 602 ( 3.3A)
 0.29A 5mewA-3zx1A:
9.5		 5mewA-3zx1A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 442
HIS A 444
HIS A 494
HIS A 139
HIS A 182
 CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 603 ( 2.8A)
 0.66A 5mewA-3zx1A:
9.5		 5mewA-3zx1A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 494
HIS A 442
HIS A 444
HIS A 141
HIS A 139
 CU  A 603 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 602 (-3.0A)
CU  A 604 ( 3.0A)
 1.38A 5mewA-3zx1A:
9.5		 5mewA-3zx1A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A 105
HIS A 107
TRP A 151
HIS A 153
HIS A 422
HIS A 493
 CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
CU  A 602 ( 4.5A)
CU  A 602 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 602 ( 3.2A)
 0.19A 5mewA-4akoA:
31.8		 5mewA-4akoA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 105
HIS A 155
HIS A 422
HIS A 491
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
 0.78A 5mewA-4akoA:
31.8		 5mewA-4akoA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 422
HIS A 424
HIS A 491
HIS A 105
HIS A 155
 CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.2A)
 0.59A 5mewA-4akoA:
31.8		 5mewA-4akoA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 491
HIS A 422
HIS A 424
HIS A 107
HIS A 105
 CU  A 603 ( 3.1A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 602 (-3.1A)
CU  A 604 ( 3.1A)
 1.42A 5mewA-4akoA:
31.8		 5mewA-4akoA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A1060
HIS A1062
TRP A1102
HIS A1104
 None
CU  A1402 (-3.0A)
CU  A1402 (-4.2A)
CU  A1402 ( 3.2A)
 0.18A 5mewA-4e9xA:
27.1		 5mewA-4e9xA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  82
HIS A  84
TRP A 122
HIS A 124
HIS A 376
 None
 0.46A 5mewA-4f7kA:
32.1		 5mewA-4f7kA:
29.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 397
HIS A 451
 CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
CU  A 502 (-4.2A)
CU  A 502 (-3.2A)
CU  A 504 (-2.7A)
CU  A 502 (-3.3A)
 0.25A 5mewA-4jhvA:
63.1		 5mewA-4jhvA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 397
HIS A 399
HIS A 449
HIS A  64
HIS A 111
 CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.1A)
CU  A 504 ( 2.8A)
CU  A 501 (-3.2A)
 0.72A 5mewA-4jhvA:
63.1		 5mewA-4jhvA:
66.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		5 HIS A 297
HIS A 298
HIS A 294
HIS A 157
HIS A 156
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.1A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.4A)
 1.24A 5mewA-4ymkA:
undetectable		 5mewA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 271
HIS A 272
HIS A 268
HIS A 349
HIS A 348
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.29A 5mewA-4zr0A:
undetectable		 5mewA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 348
HIS A 349
HIS A 345
HIS A 272
HIS A 271
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
 1.24A 5mewA-4zr0A:
undetectable		 5mewA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 271
HIS A 272
HIS A 268
HIS A 349
HIS A 348
 ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
 1.29A 5mewA-4zr1A:
undetectable		 5mewA-4zr1A:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  64
HIS A  66
TRP A 107
HIS A 109
HIS A 398
HIS A 452
 CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
CU  A 508 ( 4.8A)
CU  A 508 (-3.3A)
CU  A 509 ( 3.1A)
CU  A 508 (-3.2A)
 0.16A 5mewA-5ehfA:
63.8		 5mewA-5ehfA:
67.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  64
HIS A 111
HIS A 398
HIS A 450
 CU  A 509 (-3.2A)
CU  A 507 ( 3.3A)
CU  A 509 ( 3.1A)
CU  A 507 (-3.2A)
 0.76A 5mewA-5ehfA:
63.8		 5mewA-5ehfA:
67.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 109
HIS A 111
HIS A  64
HIS A 450
HIS A 400
 CU  A 508 (-3.3A)
CU  A 507 ( 3.3A)
CU  A 509 (-3.2A)
CU  A 507 (-3.2A)
CU  A 507 ( 3.1A)
 1.24A 5mewA-5ehfA:
63.8		 5mewA-5ehfA:
67.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 400
HIS A 450
HIS A  64
HIS A 111
 CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
CU  A 507 (-3.2A)
CU  A 509 (-3.2A)
CU  A 507 ( 3.3A)
 0.67A 5mewA-5ehfA:
63.8		 5mewA-5ehfA:
67.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 450
HIS A 452
HIS A 398
HIS A 109
HIS A  66
 CU  A 507 (-3.2A)
CU  A 508 (-3.2A)
CU  A 509 ( 3.1A)
CU  A 508 (-3.3A)
CU  A 508 ( 3.1A)
 1.27A 5mewA-5ehfA:
63.8		 5mewA-5ehfA:
67.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  95
HIS A  97
TRP A 133
HIS A 135
HIS A 396
HIS A 446
 CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
CU  A1465 (-4.1A)
CU  A1465 (-3.2A)
CU  A1463 ( 4.8A)
CU  A1465 (-3.3A)
 0.29A 5mewA-5g3fA:
35.3		 5mewA-5g3fA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 396
HIS A 398
HIS A 444
HIS A  95
HIS A 137
 CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-3.0A)
CU  A1463 (-4.1A)
CU  A1463 (-3.3A)
 0.81A 5mewA-5g3fA:
35.3		 5mewA-5g3fA:
26.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A 108
HIS A 110
TRP A 150
HIS A 152
HIS A 451
HIS A 517
 CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
CU  A 601 ( 4.4A)
CU  A 601 ( 3.2A)
CU  A 603 (-2.8A)
CU  A 601 ( 3.5A)
 0.27A 5mewA-5lm8A:
43.7		 5mewA-5lm8A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 108
HIS A 154
HIS A 451
HIS A 515
 CU  A 603 ( 3.1A)
CU  A 602 ( 3.4A)
CU  A 603 (-2.8A)
CU  A 602 ( 3.2A)
 0.76A 5mewA-5lm8A:
43.7		 5mewA-5lm8A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 451
HIS A 453
HIS A 515
HIS A 108
HIS A 154
 CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 603 ( 3.1A)
CU  A 602 ( 3.4A)
 0.67A 5mewA-5lm8A:
43.7		 5mewA-5lm8A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		6 HIS A  65
HIS A  67
TRP A 108
HIS A 110
HIS A 400
HIS A 454
 CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
CU  A 502 (-4.2A)
CU  A 502 (-3.1A)
CU  A 503 ( 3.1A)
CU  A 502 ( 3.2A)
 0.00A 5mewA-5mewA:
71.8		 5mewA-5mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A  65
HIS A 112
HIS A 400
HIS A 452
 CU  A 503 (-3.1A)
CU  A 501 (-3.1A)
CU  A 503 ( 3.1A)
CU  A 501 ( 3.0A)
 0.77A 5mewA-5mewA:
71.8		 5mewA-5mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 400
HIS A 402
HIS A 452
HIS A  65
HIS A 112
 CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
CU  A 501 ( 3.0A)
CU  A 503 (-3.1A)
CU  A 501 (-3.1A)
 0.60A 5mewA-5mewA:
71.8		 5mewA-5mewA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 HIS A 101
HIS A 103
HIS A 160
HIS A 972
HIS A1016
 CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
CU  A1104 (-3.6A)
CU  A1105 (-3.3A)
CU  A1104 (-3.1A)
 0.67A 5mewA-5n4lA:
10.8		 5mewA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 HIS A 972
HIS A 974
HIS A1014
HIS A 101
HIS A 162
 CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1101 (-3.2A)
CU  A1105 (-3.1A)
CU  A1101 (-3.3A)
 0.71A 5mewA-5n4lA:
10.8		 5mewA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 HIS A 972
HIS A1016
HIS A 101
HIS A 160
 CU  A1105 (-3.3A)
CU  A1104 (-3.1A)
CU  A1105 (-3.1A)
CU  A1104 (-3.6A)
 0.71A 5mewA-5n4lA:
10.8		 5mewA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 6 HIS A  91
HIS A  93
TRP A 129
HIS A 131
HIS A 437
HIS A 491
 EDO  A 602 ( 4.5A)
None
None
None
None
None
 0.46A 5mewA-6evgA:
33.7		 5mewA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 HIS A 437
HIS A 439
HIS A 489
HIS A  91
HIS A 133
 None
EDO  A 602 (-3.8A)
None
EDO  A 602 ( 4.5A)
EDO  A 602 (-4.1A)
 0.83A 5mewA-6evgA:
33.7		 5mewA-6evgA:
undetectable