SIMILAR PATTERNS OF AMINO ACIDS FOR 5MEW_A_CUA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  60
HIS A 106
HIS A 448
HIS A 450
HIS A 506
 CU  A 557 ( 3.1A)
CU  A 555 (-3.3A)
CU  A 557 ( 3.2A)
CU  A 555 ( 3.2A)
CU  A 555 (-3.1A)
 0.17A 5mewA-1asoA:
40.5		 5mewA-1asoA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 448
HIS A 508
HIS A  60
HIS A  62
HIS A 104
 CU  A 557 ( 3.2A)
CU  A 556 (-3.3A)
CU  A 557 ( 3.1A)
CU  A 556 ( 3.0A)
CU  A 556 (-3.1A)
 0.64A 5mewA-1asoA:
40.5		 5mewA-1asoA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 506
HIS A 448
HIS A 106
HIS A 450
HIS A  60
 CU  A 555 (-3.1A)
CU  A 557 ( 3.2A)
CU  A 555 (-3.3A)
CU  A 555 ( 3.2A)
CU  A 557 ( 3.1A)
 1.44A 5mewA-1asoA:
40.5		 5mewA-1asoA:
31.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A1502 (-3.1A)
CU  A1501 (-3.4A)
CU  A1502 ( 3.1A)
CU  A1501 ( 3.2A)
CU  A1501 (-3.3A)
 0.14A 5mewA-1gycA:
63.6		 5mewA-1gycA:
68.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 454
HIS A 109
HIS A  66
 CU  A1501 (-3.4A)
CU  A1502 (-3.1A)
CU  A1500 (-3.3A)
CU  A1500 (-3.3A)
CU  A1500 ( 3.2A)
 1.37A 5mewA-1gycA:
63.6		 5mewA-1gycA:
68.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A1502 ( 3.1A)
CU  A1500 (-3.3A)
CU  A1502 (-3.1A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.3A)
 0.58A 5mewA-1gycA:
63.6		 5mewA-1gycA:
68.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 452
HIS A 398
HIS A 111
HIS A 400
HIS A  64
 CU  A1501 (-3.3A)
CU  A1502 ( 3.1A)
CU  A1501 (-3.4A)
CU  A1501 ( 3.2A)
CU  A1502 (-3.1A)
 1.46A 5mewA-1gycA:
63.6		 5mewA-1gycA:
68.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 HIS A 198
HIS A 194
HIS A 344
HIS A 224
HIS A 384
 CU  A 665 (-3.1A)
CU  A 665 (-3.0A)
CU  A 666 (-3.1A)
CU  A 665 (-3.5A)
CU  A 666 (-3.4A)
 1.21A 5mewA-1hcyA:
undetectable		 5mewA-1hcyA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 453
HIS A 109
HIS A  66
 CU  A 702 (-3.2A)
CU  A 703 (-4.7A)
CU  A 703 (-3.3A)
CU  A 703 (-3.2A)
CU  A 703 (-3.0A)
 1.42A 5mewA-1hfuA:
60.5		 5mewA-1hfuA:
59.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 399
HIS A 453
HIS A  64
HIS A  66
HIS A 109
 CU  A 702 ( 3.7A)
CU  A 703 (-3.3A)
CU  A 703 (-4.7A)
CU  A 703 (-3.0A)
CU  A 703 (-3.2A)
 0.86A 5mewA-1hfuA:
60.5		 5mewA-1hfuA:
59.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 101
HIS A 163
HIS A 978
HIS A 980
HIS A1020
 CU  A1052 (-3.2A)
CU  A1050 (-3.3A)
CU  A1052 ( 3.2A)
CU  A1050 (-3.0A)
CU  A1050 (-3.2A)
 0.50A 5mewA-1kcwA:
17.9		 5mewA-1kcwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 978
HIS A1022
HIS A 101
HIS A 103
HIS A 161
 CU  A1052 ( 3.2A)
CU  A1051 (-3.2A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
 0.34A 5mewA-1kcwA:
17.9		 5mewA-1kcwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A1020
HIS A 978
HIS A 163
HIS A 980
HIS A 101
 CU  A1050 (-3.2A)
CU  A1052 ( 3.2A)
CU  A1050 (-3.3A)
CU  A1050 (-3.0A)
CU  A1052 (-3.2A)
 1.32A 5mewA-1kcwA:
17.9		 5mewA-1kcwA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A 503 (-3.2A)
CU  A 501 (-3.5A)
CU  A 503 ( 3.2A)
CU  A 501 ( 3.3A)
CU  A 501 (-3.4A)
 0.23A 5mewA-1kyaA:
63.0		 5mewA-1kyaA:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A 503 ( 3.2A)
CU  A 502 (-3.4A)
CU  A 503 (-3.2A)
CU  A 502 (-3.3A)
CU  A 502 (-3.7A)
 0.58A 5mewA-1kyaA:
63.0		 5mewA-1kyaA:
69.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 399
HIS A 401
HIS A 451
 CU  A1502 (-3.2A)
CU  A1501 (-3.3A)
CU  A1502 (-2.9A)
CU  A1501 ( 3.2A)
CU  A1501 (-2.9A)
 0.26A 5mewA-1v10A:
61.3		 5mewA-1v10A:
60.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 399
HIS A 453
HIS A  64
HIS A  66
HIS A 109
 CU  A1502 (-2.9A)
CU  A1500 (-3.4A)
CU  A1502 (-3.2A)
CU  A1500 ( 2.9A)
CU  A1500 (-3.3A)
 0.55A 5mewA-1v10A:
61.3		 5mewA-1v10A:
60.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 451
HIS A 399
HIS A 111
HIS A 401
HIS A  64
 CU  A1501 (-2.9A)
CU  A1502 (-2.9A)
CU  A1501 (-3.3A)
CU  A1501 ( 3.2A)
CU  A1502 (-3.2A)
 1.44A 5mewA-1v10A:
61.3		 5mewA-1v10A:
60.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  81
HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.25A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 416
HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.67A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 101
HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.26A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 446
HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.63A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A 604 ( 3.1A)
CU  A 602 (-3.2A)
CU  A 604 (-3.1A)
CU  A 602 ( 3.2A)
CU  A 602 (-3.1A)
 0.25A 5mewA-2hzhA:
63.0		 5mewA-2hzhA:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 454
HIS A 109
HIS A  66
 CU  A 602 (-3.2A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.3A)
CU  A 603 (-3.4A)
CU  A 603 ( 3.1A)
 1.42A 5mewA-2hzhA:
63.0		 5mewA-2hzhA:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A 604 (-3.1A)
CU  A 603 (-3.3A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 (-3.4A)
 0.63A 5mewA-2hzhA:
63.0		 5mewA-2hzhA:
65.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 397
HIS A 399
HIS A 451
 CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 500 (-3.1A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.2A)
 0.22A 5mewA-2qt6A:
63.6		 5mewA-2qt6A:
66.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 453
HIS A 109
HIS A  66
 CU  A 501 ( 3.2A)
CU  A 500 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.1A)
 1.38A 5mewA-2qt6A:
63.6		 5mewA-2qt6A:
66.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 397
HIS A 453
HIS A  64
HIS A  66
HIS A 109
 CU  A 500 (-3.1A)
CU  A 502 (-3.3A)
CU  A 500 (-3.1A)
CU  A 502 ( 3.1A)
CU  A 502 (-3.2A)
 0.61A 5mewA-2qt6A:
63.6		 5mewA-2qt6A:
66.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 450
 CU  A 504 ( 3.1A)
CU  A 502 (-3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.3A)
 0.25A 5mewA-2xybA:
63.6		 5mewA-2xybA:
66.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 452
HIS A 109
HIS A  66
 CU  A 502 (-3.2A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.3A)
CU  A 503 ( 3.2A)
CU  A 503 (-3.1A)
 1.38A 5mewA-2xybA:
63.6		 5mewA-2xybA:
66.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 452
HIS A  64
HIS A  66
HIS A 109
 CU  A 504 (-3.1A)
CU  A 503 ( 3.3A)
CU  A 504 ( 3.1A)
CU  A 503 (-3.1A)
CU  A 503 ( 3.2A)
 0.60A 5mewA-2xybA:
63.6		 5mewA-2xybA:
66.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  94
HIS A 136
HIS A 401
HIS A 403
HIS A 456
 CU  A 703 (-3.0A)
CU  A 701 (-3.2A)
CU  A 703 (-3.4A)
CU  A 701 ( 3.1A)
CU  A 701 (-3.3A)
 0.31A 5mewA-3abgA:
31.0		 5mewA-3abgA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 401
HIS A 458
HIS A  94
HIS A  96
HIS A 134
 CU  A 703 (-3.4A)
CU  A 702 (-3.5A)
CU  A 703 (-3.0A)
CU  A 702 ( 3.2A)
CU  A 702 (-3.1A)
 0.65A 5mewA-3abgA:
31.0		 5mewA-3abgA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 456
HIS A 401
HIS A 136
HIS A 403
HIS A  94
 CU  A 701 (-3.3A)
CU  A 703 (-3.4A)
CU  A 701 (-3.2A)
CU  A 701 ( 3.1A)
CU  A 703 (-3.0A)
 1.44A 5mewA-3abgA:
31.0		 5mewA-3abgA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 458
HIS A 401
HIS A 136
HIS A 456
HIS A 403
 CU  A 702 (-3.5A)
CU  A 703 (-3.4A)
CU  A 701 (-3.2A)
CU  A 701 (-3.3A)
CU  A 701 ( 3.1A)
 1.32A 5mewA-3abgA:
31.0		 5mewA-3abgA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  92
HIS A 134
HIS A 394
HIS A 396
HIS A 459
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.14A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 394
HIS A 461
HIS A  92
HIS A  94
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.64A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 459
HIS A 394
HIS A 134
HIS A 396
HIS A  92
 C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
 1.46A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  93
HIS A 140
HIS A 434
HIS A 436
HIS A 502
 CU  A 604 (-3.1A)
CU  A 602 ( 3.3A)
CU  A 604 (-3.2A)
CU  A 602 (-3.2A)
CU  A 602 ( 3.2A)
 0.21A 5mewA-3dkhA:
42.7		 5mewA-3dkhA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 434
HIS A 504
HIS A  93
HIS A  95
HIS A 138
 CU  A 604 (-3.2A)
CU  A 603 ( 3.3A)
CU  A 604 (-3.1A)
CU  A 603 ( 3.2A)
CU  A 603 ( 3.3A)
 0.66A 5mewA-3dkhA:
42.7		 5mewA-3dkhA:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 502
HIS A 434
HIS A 140
HIS A 436
HIS A  93
 CU  A 602 ( 3.2A)
CU  A 604 (-3.2A)
CU  A 602 ( 3.3A)
CU  A 602 (-3.2A)
CU  A 604 (-3.1A)
 1.47A 5mewA-3dkhA:
42.7		 5mewA-3dkhA:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 161
HIS A 203
HIS A 527
HIS A 529
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.20A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 527
HIS A 604
HIS A 161
HIS A 163
HIS A 201
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.67A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 403
HIS A 405
HIS A 455
 CU  A 602 (-3.1A)
CU  A 603 (-3.2A)
CU  A 602 (-3.0A)
CU  A 603 ( 3.0A)
CU  A 603 (-3.1A)
 0.27A 5mewA-3kw7A:
62.4		 5mewA-3kw7A:
67.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 457
HIS A 109
HIS A  66
 CU  A 603 (-3.2A)
CU  A 602 (-3.1A)
CU  A 604 (-3.1A)
CU  A 604 (-3.2A)
CU  A 604 ( 2.9A)
 1.41A 5mewA-3kw7A:
62.4		 5mewA-3kw7A:
67.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 403
HIS A 457
HIS A  64
HIS A  66
HIS A 109
 CU  A 602 (-3.0A)
CU  A 604 (-3.1A)
CU  A 602 (-3.1A)
CU  A 604 ( 2.9A)
CU  A 604 (-3.2A)
 0.64A 5mewA-3kw7A:
62.4		 5mewA-3kw7A:
67.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 455
HIS A 403
HIS A 111
HIS A 405
HIS A  64
 CU  A 603 (-3.1A)
CU  A 602 (-3.0A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.0A)
CU  A 602 (-3.1A)
 1.44A 5mewA-3kw7A:
62.4		 5mewA-3kw7A:
67.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  94
HIS A 141
HIS A 435
HIS A 437
HIS A 503
 CU  A 604 ( 3.1A)
CU  A 602 ( 3.3A)
CU  A 604 ( 3.3A)
CU  A 602 (-3.3A)
CU  A 602 ( 3.3A)
 0.24A 5mewA-3ppsA:
41.9		 5mewA-3ppsA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 435
HIS A 505
HIS A  94
HIS A  96
HIS A 139
 CU  A 604 ( 3.3A)
CU  A 603 ( 3.3A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 603 ( 3.1A)
 0.65A 5mewA-3ppsA:
41.9		 5mewA-3ppsA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 452
 CU  A1502 ( 3.0A)
CU  A1500 (-3.2A)
CU  A1502 ( 2.9A)
CU  A1500 ( 3.2A)
CU  A1500 (-3.1A)
 0.30A 5mewA-3pxlA:
63.7		 5mewA-3pxlA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 454
HIS A 109
HIS A  66
 CU  A1500 (-3.2A)
CU  A1502 ( 3.0A)
CU  A1501 (-3.3A)
CU  A1501 (-3.2A)
CU  A1501 ( 3.0A)
 1.40A 5mewA-3pxlA:
63.7		 5mewA-3pxlA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 454
HIS A  64
HIS A  66
HIS A 109
 CU  A1502 ( 2.9A)
CU  A1501 (-3.3A)
CU  A1502 ( 3.0A)
CU  A1501 ( 3.0A)
CU  A1501 (-3.2A)
 0.65A 5mewA-3pxlA:
63.7		 5mewA-3pxlA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  65
HIS A 112
HIS A 400
HIS A 402
HIS A 452
 CU  A 504 (-3.1A)
CU  A 503 (-3.4A)
CU  A 504 ( 3.1A)
CU  A 503 ( 3.2A)
CU  A 503 ( 3.3A)
 0.12A 5mewA-3t6wA:
68.1		 5mewA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 400
HIS A 454
HIS A  65
HIS A  67
HIS A 110
 CU  A 504 ( 3.1A)
OXY  A 511 ( 3.2A)
CU  A 504 (-3.1A)
CU  A 502 (-3.3A)
CU  A 502 ( 3.5A)
 0.64A 5mewA-3t6wA:
68.1		 5mewA-3t6wA:
79.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  87
HIS A 133
HIS A 429
HIS A 431
HIS A 488
 CU  A 602 ( 4.7A)
CU  A 602 (-3.3A)
CU  A 602 (-3.6A)
CU  A 602 (-3.1A)
CU  A 602 (-3.1A)
 0.49A 5mewA-3v9eA:
44.1		 5mewA-3v9eA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 429
HIS A 490
HIS A  87
HIS A  89
HIS A 131
 CU  A 602 (-3.6A)
CU  A 603 (-3.5A)
CU  A 602 ( 4.7A)
CU  A 603 (-2.9A)
CU  A 603 (-3.2A)
 0.63A 5mewA-3v9eA:
44.1		 5mewA-3v9eA:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 HIS A 372
HIS A 328
HIS A  67
HIS A 103
HIS A  94
 None
 1.34A 5mewA-3w6qA:
undetectable		 5mewA-3w6qA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  85
HIS A 132
HIS A 420
HIS A 422
HIS A 474
 CU  A 614 (-3.1A)
CU  A 616 (-3.2A)
CU  A 614 (-3.1A)
CU  A 616 ( 3.2A)
CU  A 616 (-3.2A)
 0.15A 5mewA-3x1bA:
63.2		 5mewA-3x1bA:
63.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 420
HIS A 476
HIS A  85
HIS A  87
HIS A 130
 CU  A 614 (-3.1A)
CU  A 615 (-3.2A)
CU  A 614 (-3.1A)
CU  A 615 ( 3.1A)
CU  A 615 (-3.2A)
 0.61A 5mewA-3x1bA:
63.2		 5mewA-3x1bA:
63.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 474
HIS A 420
HIS A 132
HIS A 422
HIS A  85
 CU  A 616 (-3.2A)
CU  A 614 (-3.1A)
CU  A 616 (-3.2A)
CU  A 616 ( 3.2A)
CU  A 614 (-3.1A)
 1.47A 5mewA-3x1bA:
63.2		 5mewA-3x1bA:
63.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 139
HIS A 182
HIS A 442
HIS A 444
HIS A 494
 CU  A 604 ( 3.0A)
CU  A 603 ( 2.8A)
CU  A 604 ( 3.0A)
CU  A 603 (-3.1A)
CU  A 603 ( 3.1A)
 0.31A 5mewA-3zx1A:
9.5		 5mewA-3zx1A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 442
HIS A 496
HIS A 139
HIS A 141
HIS A 180
 CU  A 604 ( 3.0A)
CU  A 602 ( 3.3A)
CU  A 604 ( 3.0A)
CU  A 602 (-3.0A)
CU  A 602 ( 3.1A)
 0.55A 5mewA-3zx1A:
9.5		 5mewA-3zx1A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 494
HIS A 442
HIS A 182
HIS A 444
HIS A 139
 CU  A 603 ( 3.1A)
CU  A 604 ( 3.0A)
CU  A 603 ( 2.8A)
CU  A 603 (-3.1A)
CU  A 604 ( 3.0A)
 1.43A 5mewA-3zx1A:
9.5		 5mewA-3zx1A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 105
HIS A 155
HIS A 422
HIS A 424
HIS A 491
 CU  A 604 ( 3.1A)
CU  A 603 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
CU  A 603 ( 3.1A)
 0.18A 5mewA-4akoA:
31.8		 5mewA-4akoA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 107
HIS A 105
HIS A 491
HIS A 422
HIS A 424
 CU  A 602 (-3.1A)
CU  A 604 ( 3.1A)
CU  A 603 ( 3.1A)
CU  A 604 ( 3.1A)
CU  A 603 (-3.2A)
 1.44A 5mewA-4akoA:
31.8		 5mewA-4akoA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 422
HIS A 493
HIS A 105
HIS A 107
HIS A 153
 CU  A 604 ( 3.1A)
CU  A 602 ( 3.2A)
CU  A 604 ( 3.1A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 0.62A 5mewA-4akoA:
31.8		 5mewA-4akoA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS B3106
HIS B3075
HIS B2946
HIS B2974
HIS B2965
 CUO  B9008 (-3.3A)
CUO  B9008 (-2.8A)
CUO  B9008 (-3.1A)
CUO  B9008 (-2.9A)
CUO  B9008 (-3.2A)
 1.31A 5mewA-4bedB:
undetectable		 5mewA-4bedB:
14.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 397
HIS A 399
HIS A 449
 CU  A 504 ( 2.8A)
CU  A 501 (-3.2A)
CU  A 504 (-2.7A)
CU  A 501 ( 3.2A)
CU  A 501 (-3.1A)
 0.34A 5mewA-4jhvA:
63.1		 5mewA-4jhvA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 111
HIS A  64
HIS A 451
HIS A 109
HIS A  66
 CU  A 501 (-3.2A)
CU  A 504 ( 2.8A)
CU  A 502 (-3.3A)
CU  A 502 (-3.2A)
CU  A 502 ( 3.1A)
 1.41A 5mewA-4jhvA:
63.1		 5mewA-4jhvA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 397
HIS A 451
HIS A  64
HIS A  66
HIS A 109
 CU  A 504 (-2.7A)
CU  A 502 (-3.3A)
CU  A 504 ( 2.8A)
CU  A 502 ( 3.1A)
CU  A 502 (-3.2A)
 0.67A 5mewA-4jhvA:
63.1		 5mewA-4jhvA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 449
HIS A 397
HIS A 111
HIS A 399
HIS A  64
 CU  A 501 (-3.1A)
CU  A 504 (-2.7A)
CU  A 501 (-3.2A)
CU  A 501 ( 3.2A)
CU  A 504 ( 2.8A)
 1.45A 5mewA-4jhvA:
63.1		 5mewA-4jhvA:
66.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 HIS A 255
HIS A 251
HIS A  57
HIS A 283
HIS A  91
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
 1.30A 5mewA-4ouaA:
undetectable		 5mewA-4ouaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		5 HIS A 157
HIS A 156
HIS A 297
HIS A 298
HIS A 294
 ZN  A 401 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.1A)
 1.13A 5mewA-4ymkA:
undetectable		 5mewA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		5 HIS A 298
HIS A 297
HIS A 156
HIS A 157
HIS A 153
 ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.01A 5mewA-4ymkA:
undetectable		 5mewA-4ymkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 HIS A 419
HIS A 379
HIS A 223
HIS A 252
HIS A 227
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
 1.37A 5mewA-4yzwA:
undetectable		 5mewA-4yzwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 402 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
 1.10A 5mewA-4zr0A:
undetectable		 5mewA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.5A)
 1.14A 5mewA-4zr0A:
undetectable		 5mewA-4zr0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 244
HIS A 268
HIS A 345
HIS A 348
HIS A 349
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
 1.38A 5mewA-4zr1A:
undetectable		 5mewA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 272
HIS A 271
HIS A 348
HIS A 349
HIS A 345
 ZN  A 402 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.14A 5mewA-4zr1A:
undetectable		 5mewA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 349
HIS A 348
HIS A 271
HIS A 272
HIS A 268
 ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 ( 3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.18A 5mewA-4zr1A:
undetectable		 5mewA-4zr1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 5 HIS A 302
HIS A 301
HIS A 160
HIS A 161
HIS A 157
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
 1.17A 5mewA-4zyoA:
undetectable		 5mewA-4zyoA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  64
HIS A 111
HIS A 398
HIS A 400
HIS A 450
 CU  A 509 (-3.2A)
CU  A 507 ( 3.3A)
CU  A 509 ( 3.1A)
CU  A 507 ( 3.1A)
CU  A 507 (-3.2A)
 0.21A 5mewA-5ehfA:
63.8		 5mewA-5ehfA:
67.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ehf LACCASE

(Antrodiella
faginea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 398
HIS A 452
HIS A  64
HIS A  66
HIS A 109
 CU  A 509 ( 3.1A)
CU  A 508 (-3.2A)
CU  A 509 (-3.2A)
CU  A 508 ( 3.1A)
CU  A 508 (-3.3A)
 0.60A 5mewA-5ehfA:
63.8		 5mewA-5ehfA:
67.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  95
HIS A 137
HIS A 396
HIS A 398
HIS A 444
 CU  A1463 (-4.1A)
CU  A1463 (-3.3A)
CU  A1463 ( 4.8A)
CU  A1463 (-2.9A)
CU  A1463 (-3.0A)
 0.52A 5mewA-5g3fA:
35.3		 5mewA-5g3fA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 396
HIS A 446
HIS A  95
HIS A  97
HIS A 135
 CU  A1463 ( 4.8A)
CU  A1465 (-3.3A)
CU  A1463 (-4.1A)
CU  A1465 (-3.1A)
CU  A1465 (-3.2A)
 0.65A 5mewA-5g3fA:
35.3		 5mewA-5g3fA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 444
HIS A 396
HIS A 137
HIS A 398
HIS A  95
 CU  A1463 (-3.0A)
CU  A1463 ( 4.8A)
CU  A1463 (-3.3A)
CU  A1463 (-2.9A)
CU  A1463 (-4.1A)
 1.46A 5mewA-5g3fA:
35.3		 5mewA-5g3fA:
26.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 108
HIS A 154
HIS A 451
HIS A 453
HIS A 515
 CU  A 603 ( 3.1A)
CU  A 602 ( 3.4A)
CU  A 603 (-2.8A)
CU  A 602 (-3.1A)
CU  A 602 ( 3.2A)
 0.25A 5mewA-5lm8A:
43.7		 5mewA-5lm8A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 451
HIS A 517
HIS A 108
HIS A 110
HIS A 152
 CU  A 603 (-2.8A)
CU  A 601 ( 3.5A)
CU  A 603 ( 3.1A)
CU  A 601 (-2.9A)
CU  A 601 ( 3.2A)
 0.58A 5mewA-5lm8A:
43.7		 5mewA-5lm8A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 515
HIS A 451
HIS A 154
HIS A 453
HIS A 108
 CU  A 602 ( 3.2A)
CU  A 603 (-2.8A)
CU  A 602 ( 3.4A)
CU  A 602 (-3.1A)
CU  A 603 ( 3.1A)
 1.47A 5mewA-5lm8A:
43.7		 5mewA-5lm8A:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A  65
HIS A 112
HIS A 400
HIS A 402
HIS A 452
 CU  A 503 (-3.1A)
CU  A 501 (-3.1A)
CU  A 503 ( 3.1A)
CU  A 501 (-3.2A)
CU  A 501 ( 3.0A)
 0.01A 5mewA-5mewA:
71.8		 5mewA-5mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 112
HIS A  65
HIS A 454
HIS A 110
HIS A  67
 CU  A 501 (-3.1A)
CU  A 503 (-3.1A)
CU  A 502 ( 3.2A)
CU  A 502 (-3.1A)
CU  A 502 ( 2.9A)
 1.42A 5mewA-5mewA:
71.8		 5mewA-5mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 400
HIS A 454
HIS A  65
HIS A  67
HIS A 110
 CU  A 503 ( 3.1A)
CU  A 502 ( 3.2A)
CU  A 503 (-3.1A)
CU  A 502 ( 2.9A)
CU  A 502 (-3.1A)
 0.60A 5mewA-5mewA:
71.8		 5mewA-5mewA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 HIS A 452
HIS A 400
HIS A 112
HIS A 402
HIS A  65
 CU  A 501 ( 3.0A)
CU  A 503 ( 3.1A)
CU  A 501 (-3.1A)
CU  A 501 (-3.2A)
CU  A 503 (-3.1A)
 1.45A 5mewA-5mewA:
71.8		 5mewA-5mewA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 HIS A 101
HIS A 162
HIS A 972
HIS A 974
HIS A1014
 CU  A1105 (-3.1A)
CU  A1101 (-3.3A)
CU  A1105 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1101 (-3.2A)
 0.36A 5mewA-5n4lA:
11.8		 5mewA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 HIS A 972
HIS A1016
HIS A 101
HIS A 103
HIS A 160
 CU  A1105 (-3.3A)
CU  A1104 (-3.1A)
CU  A1105 (-3.1A)
CU  A1104 ( 3.5A)
CU  A1104 (-3.6A)
 0.58A 5mewA-5n4lA:
11.8		 5mewA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 HIS A1014
HIS A 972
HIS A 162
HIS A 974
HIS A 101
 CU  A1101 (-3.2A)
CU  A1105 (-3.3A)
CU  A1101 (-3.3A)
CU  A1101 ( 3.2A)
CU  A1105 (-3.1A)
 1.31A 5mewA-5n4lA:
11.8		 5mewA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 HIS A  91
HIS A 133
HIS A 437
HIS A 439
HIS A 489
 EDO  A 602 ( 4.5A)
EDO  A 602 (-4.1A)
None
EDO  A 602 (-3.8A)
None
 0.57A 5mewA-6evgA:
33.7		 5mewA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 HIS A 131
HIS A  91
HIS A 491
HIS A  93
HIS A 437
 None
EDO  A 602 ( 4.5A)
None
None
None
 1.43A 5mewA-6evgA:
33.7		 5mewA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 HIS A 437
HIS A 491
HIS A  91
HIS A  93
HIS A 131
 None
None
EDO  A 602 ( 4.5A)
None
None
 0.57A 5mewA-6evgA:
33.7		 5mewA-6evgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 HIS A 489
HIS A 437
HIS A 133
HIS A 439
HIS A  91
 None
None
EDO  A 602 (-4.1A)
EDO  A 602 (-3.8A)
EDO  A 602 ( 4.5A)
 1.44A 5mewA-6evgA:
33.7		 5mewA-6evgA:
undetectable