SIMILAR PATTERNS OF AMINO ACIDS FOR 5MAF_A_XINA403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  62
GLY A  63
VAL A  70
ALA A  83
LYS A  85
GLU A  97
LEU A 132
TYR A 134
 None
 0.57A 5mafA-1gngA:
24.6		 5mafA-1gngA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
GLY A 202
VAL A 209
ALA A 220
LYS A 222
GLU A 236
TYR A 268
GLY A 272
 None
 0.82A 5mafA-1k9aA:
26.0		 5mafA-1k9aA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 GLU A 209
ILE A 211
GLY A 212
VAL A 219
ALA A 230
LYS A 232
GLU A 245
GLY A 286
 None
PY1  A 700 (-3.6A)
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.6A)
 0.85A 5mafA-1py5A:
18.3		 5mafA-1py5A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 ILE A 211
GLY A 212
VAL A 219
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
 PY1  A 700 (-3.6A)
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
 0.77A 5mafA-1py5A:
18.3		 5mafA-1py5A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
 None
 0.71A 5mafA-1rjbA:
22.1		 5mafA-1rjbA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 596
VAL A 603
ALA A 621
LYS A 623
GLU A 640
TYR A 672
GLY A 676
 None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
 0.81A 5mafA-1t46A:
23.0		 5mafA-1t46A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 ILE A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLU A  76
TYR A 107
GLY A 110
 None
 0.88A 5mafA-1u5qA:
27.2		 5mafA-1u5qA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY A  16
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  84
TYR A  86
GLY A  90
GLU A  91
 HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.2A)
HYM  A 400 (-4.7A)
None
HYM  A 400 ( 4.7A)
 0.65A 5mafA-1zltA:
27.5		 5mafA-1zltA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ILE A 251
GLY A 252
VAL A 259
ALA A 272
LYS A 274
GLU A 293
TYR A 325
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.6A)
BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 ( 4.9A)
BI1  A1000 (-4.2A)
 0.56A 5mafA-1zrzA:
28.8		 5mafA-1zrzA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  93
 None
 0.64A 5mafA-1zwsA:
29.2		 5mafA-1zwsA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  93
 None
None
None
GOL  A3001 (-3.5A)
None
None
GOL  A3001 ( 4.5A)
 0.65A 5mafA-2a2aA:
29.0		 5mafA-2a2aA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  93
GLY A  99
ILE A 160
 None
None
GOL  A3001 (-3.5A)
None
GOL  A3001 ( 4.5A)
None
GOL  A3001 ( 3.9A)
 0.76A 5mafA-2a2aA:
29.0		 5mafA-2a2aA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  27
VAL A  34
ALA A  47
LYS A  49
GLU A  65
LEU A  98
GLY A 104
 STU  A1301 ( 3.8A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.7A)
STU  A1301 ( 4.0A)
 0.76A 5mafA-2bujA:
26.9		 5mafA-2bujA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY X  18
VAL X  25
ALA X  37
LYS X  39
GLU X  54
TYR X  84
GLY X  88
 STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
 0.59A 5mafA-2dq7X:
26.3		 5mafA-2dq7X:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
GLY A  35
VAL A  42
ALA A  55
GLU A  76
TYR A 107
GLY A 110
 STU  A 400 (-4.2A)
STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
STU  A 400 (-4.5A)
STU  A 400 (-3.4A)
 0.78A 5mafA-2gcdA:
28.2		 5mafA-2gcdA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLU A  76
TYR A 107
 STU  A 400 (-4.2A)
STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.5A)
 0.71A 5mafA-2gcdA:
28.2		 5mafA-2gcdA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 428
GLY A 429
VAL A 436
ALA A 452
LYS A 454
GLU A 471
GLY A 505
 BII  A1687 (-3.8A)
BII  A1687 ( 3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
BII  A1687 (-3.6A)
 0.79A 5mafA-2jkmA:
24.2		 5mafA-2jkmA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 589
VAL A 596
ALA A 614
LYS A 616
GLU A 633
TYR A 665
GLY A 669
 None
 0.75A 5mafA-2ogvA:
22.1		 5mafA-2ogvA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 GLU A  23
VAL A  33
ALA A  46
LYS A  48
GLU A  73
GLY A 109
GLU A 110
 None
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 (-3.3A)
 0.80A 5mafA-2phkA:
30.6		 5mafA-2phkA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 GLY A  26
VAL A  33
ALA A  46
LYS A  48
GLU A  73
GLY A 109
GLU A 110
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 (-3.3A)
 0.75A 5mafA-2phkA:
30.6		 5mafA-2phkA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		8 ILE B  47
GLY B  48
VAL B  55
ALA B  67
LYS B  69
GLU B  85
TYR B 116
GLY B 120
 None
 0.60A 5mafA-2qkwB:
23.5		 5mafA-2qkwB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ILE A 681
GLY A 682
VAL A 689
ALA A 705
LYS A 707
GLU A 724
TYR A 755
GLY A 759
 None
 0.86A 5mafA-2r2pA:
21.1		 5mafA-2r2pA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
GLU A 124
TYR A 155
GLY A 159
 None
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 ( 4.9A)
None
 0.58A 5mafA-2v55A:
26.9		 5mafA-2v55A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		7 ILE A 490
GLY A 491
VAL A 498
ALA A 509
LYS A 511
GLU A 535
ILE A 686
 None
5ID  A1800 (-3.5A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
None
IOD  A1799 (-4.2A)
 0.67A 5mafA-2vuwA:
17.8		 5mafA-2vuwA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  93
 None
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
ADP  A1303 ( 4.1A)
 0.56A 5mafA-2w4kA:
29.2		 5mafA-2w4kA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  93
GLY A  99
ILE A 160
 ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
None
ADP  A1303 ( 4.1A)
 0.74A 5mafA-2w4kA:
29.2		 5mafA-2w4kA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLU A 110
VAL A 120
ALA A 133
LYS A 135
TYR A 182
GLY A 186
ILE A 246
 None
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 ( 4.3A)
16X  A1374 (-4.1A)
16X  A1374 (-4.0A)
16X  A1374 (-4.1A)
 0.78A 5mafA-2x4fA:
26.8		 5mafA-2x4fA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 627
GLY A 628
VAL A 635
ALA A 651
LYS A 653
TYR A 701
GLY A 705
 None
None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
 0.69A 5mafA-2xyuA:
24.3		 5mafA-2xyuA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  30
GLY A  31
VAL A  38
ALA A  51
LYS A  53
GLY A 113
GLU A 114
 B49  A1294 (-3.9A)
B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 ( 4.7A)
 0.72A 5mafA-2y7jA:
31.3		 5mafA-2y7jA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  30
GLY A  31
VAL A  38
LYS A  53
GLU A  77
GLY A 113
GLU A 114
 B49  A1294 (-3.9A)
B49  A1294 (-4.0A)
None
None
None
B49  A1294 (-3.6A)
B49  A1294 ( 4.7A)
 0.80A 5mafA-2y7jA:
31.3		 5mafA-2y7jA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		8 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LEU A  93
GLY A  99
GLU A 100
ILE A 160
 None
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 ( 3.6A)
None
None
AMP  A1302 (-4.0A)
 0.98A 5mafA-2yabA:
29.1		 5mafA-2yabA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		8 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  93
GLY A  99
 None
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
AMP  A1302 ( 3.6A)
None
 0.83A 5mafA-2yabA:
29.1		 5mafA-2yabA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		8 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  93
GLY A  99
ILE A 160
 None
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.6A)
None
AMP  A1302 (-4.0A)
 0.87A 5mafA-2yabA:
29.1		 5mafA-2yabA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLU A 303
ILE A 305
GLY A 306
VAL A 313
ALA A 326
LYS A 328
GLU A 346
TYR A 378
 None
770  A 901 (-3.8A)
770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
 0.98A 5mafA-2z2wA:
28.0		 5mafA-2z2wA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 305
GLY A 306
VAL A 313
ALA A 326
GLU A 346
TYR A 378
GLY A 382
 770  A 901 (-3.8A)
770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.60A 5mafA-2z2wA:
28.0		 5mafA-2z2wA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  98
VAL A 105
ALA A 121
GLU A 143
LEU A 172
TYR A 174
GLY A 178
GLU A 179
 STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.1A)
STU  A 400 (-4.7A)
STU  A 400 ( 4.4A)
STU  A 400 (-3.6A)
 0.92A 5mafA-3a62A:
28.7		 5mafA-3a62A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 488
VAL A 495
ALA A 515
LYS A 517
GLU A 534
TYR A 566
GLY A 570
 M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
 0.79A 5mafA-3b2tA:
26.3		 5mafA-3b2tA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  93
GLU A 100
 None
4RB  A 401 (-3.6A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
GOL  A 503 (-2.8A)
4RB  A 401 ( 4.1A)
4RB  A 401 (-3.8A)
 0.83A 5mafA-3bqrA:
28.5		 5mafA-3bqrA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  93
GLY A  99
GLU A 100
ILE A 160
 None
4RB  A 401 (-3.6A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
4RB  A 401 ( 4.1A)
None
4RB  A 401 (-3.8A)
4RB  A 401 (-3.5A)
 0.80A 5mafA-3bqrA:
28.5		 5mafA-3bqrA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A1084
GLY A1085
VAL A1092
ALA A1108
LEU A1157
TYR A1159
GLY A1163
 CKK  A1500 ( 4.4A)
None
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-4.7A)
CKK  A1500 (-4.5A)
CKK  A1500 ( 4.5A)
 0.66A 5mafA-3c1xA:
22.4		 5mafA-3c1xA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
GLY A 202
VAL A 209
ALA A 220
LYS A 222
GLU A 236
TYR A 268
GLY A 272
 None
 0.82A 5mafA-3d7uA:
26.9		 5mafA-3d7uA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 639
GLY A 640
VAL A 647
ALA A 663
LYS A 665
GLU A 682
GLY A 717
 IHZ  A1001 ( 4.8A)
None
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 3.9A)
 0.77A 5mafA-3dkoA:
23.1		 5mafA-3dkoA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 ILE A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLY A 108
GLU A 109
ILE A 168
 DRK  A   1 (-4.2A)
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.2A)
 0.59A 5mafA-3f3zA:
30.8		 5mafA-3f3zA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 432
VAL A 439
ALA A 455
LYS A 457
GLU A 474
GLY A 508
GLU A 509
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-3.8A)
 0.76A 5mafA-3fzpA:
23.7		 5mafA-3fzpA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLU A 207
ILE A 209
GLY A 210
VAL A 217
ALA A 228
LYS A 230
GLU A 243
TYR A 281
GLY A 285
 None
ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
None
ADP  A 900 ( 4.2A)
 0.83A 5mafA-3g2fA:
24.2		 5mafA-3g2fA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 834
VAL A 841
ALA A 859
LYS A 861
GLU A 878
TYR A 911
GLY A 915
 None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
None
 0.69A 5mafA-3hngA:
23.0		 5mafA-3hngA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 ILE A  59
GLY A  60
VAL A  67
ALA A  80
LYS A  82
TYR A 131
GLY A 135
GLU A 136
 None
 0.71A 5mafA-3iecA:
36.1		 5mafA-3iecA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 ILE A  59
GLY A  60
VAL A  67
LYS A  82
GLU A 100
TYR A 131
GLY A 135
GLU A 136
 None
 0.89A 5mafA-3iecA:
36.1		 5mafA-3iecA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 GLY A  83
VAL A  90
ALA A 103
LYS A 105
GLY A 158
GLU A 159
ILE A 218
 ANP  A 610 (-3.5A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
ANP  A 610 (-2.8A)
None
None
ANP  A 610 ( 4.4A)
 0.78A 5mafA-3igoA:
25.6		 5mafA-3igoA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 GLY A 559
VAL A 566
ALA A 579
LYS A 581
GLU A 596
GLY A 634
ILE A 719
 ANP  A 877 (-3.8A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
ANP  A 877 ( 4.3A)
 0.82A 5mafA-3lltA:
25.1		 5mafA-3lltA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  40
VAL A  47
ALA A  60
GLU A  80
LEU A 110
TYR A 112
GLY A 116
GLU A 117
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
None
 0.74A 5mafA-3lm5A:
29.4		 5mafA-3lm5A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 ILE A 210
GLY A 211
VAL A 218
ALA A 229
LYS A 231
GLU A 244
TYR A 281
GLY A 285
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
 0.79A 5mafA-3mdyA:
24.0		 5mafA-3mdyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  50
VAL A  57
ALA A  70
LYS A  72
GLU A  91
TYR A 122
GLY A 126
GLU A 127
 XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.2A)
 0.87A 5mafA-3mvjA:
29.7		 5mafA-3mvjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		7 ILE A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLU A  75
LEU A 109
 GOL  A 434 ( 4.5A)
None
None
GOL  A 434 ( 4.1A)
GOL  A 433 (-3.2A)
GOL  A 433 ( 4.8A)
GOL  A 433 (-4.3A)
 0.70A 5mafA-3n9xA:
24.6		 5mafA-3n9xA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ILE A  36
GLY A  37
VAL A  44
ALA A  57
LYS A  59
GLU A  77
LEU A 111
 ANP  A 430 (-4.4A)
ANP  A 430 (-3.5A)
ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
ANP  A 430 ( 4.4A)
ANP  A 430 ( 4.1A)
 0.57A 5mafA-3nieA:
25.9		 5mafA-3nieA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY A  89
VAL A  96
ALA A 109
LYS A 111
GLU A 130
LEU A 159
TYR A 161
GLY A 165
GLU A 166
 JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
JOZ  A 361 (-4.0A)
None
None
None
 0.75A 5mafA-3nuuA:
31.7		 5mafA-3nuuA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 193
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 263
GLY A 269
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.7A)
None
 0.49A 5mafA-3nyoA:
29.1		 5mafA-3nyoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 GLU A 555
ILE A 557
GLY A 558
VAL A 565
ALA A 576
LYS A 578
GLU A 596
GLY A 631
 None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.2A)
 1.03A 5mafA-3ppzA:
26.0		 5mafA-3ppzA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ILE A 557
GLY A 558
VAL A 565
ALA A 576
LYS A 578
GLU A 596
TYR A 627
GLY A 631
 STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
 0.80A 5mafA-3ppzA:
26.0		 5mafA-3ppzA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
GLU A 124
TYR A 155
 None
NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
 0.68A 5mafA-3qfvA:
26.7		 5mafA-3qfvA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 GLY A  58
VAL A  65
ALA A  78
LYS A  80
GLY A 134
GLU A 135
ILE A 194
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
None
None
BK5  A 701 ( 3.5A)
 0.82A 5mafA-3sxfA:
26.2		 5mafA-3sxfA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 485
VAL A 492
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
 07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
 0.67A 5mafA-3tt0A:
23.6		 5mafA-3tt0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLU A 623
ILE A 625
GLY A 626
VAL A 633
ALA A 649
LYS A 651
GLU A 668
GLY A 703
 None
 0.83A 5mafA-3zfxA:
26.0		 5mafA-3zfxA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  84
VAL A  91
ALA A 104
LYS A 106
LEU A 154
TYR A 156
GLY A 160
GLU A 161
 VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
None
VX6  A 500 (-4.2A)
VX6  A 500 (-3.3A)
VX6  A 500 ( 4.6A)
 0.97A 5mafA-4af3A:
24.7		 5mafA-4af3A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ILE A  83
GLY A  84
VAL A  91
ALA A 104
LYS A 106
GLU A 125
TYR A 156
 None
None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
 0.69A 5mafA-4aw2A:
27.1		 5mafA-4aw2A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ILE A  83
VAL A  91
ALA A 104
LYS A 106
GLU A 125
TYR A 156
GLY A 160
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
 0.81A 5mafA-4aw2A:
27.1		 5mafA-4aw2A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLU A  95
ILE A  97
GLY A  98
VAL A 105
ALA A 121
LYS A 123
GLU A 140
GLY A 175
 None
30K  A1365 (-4.5A)
30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
 0.74A 5mafA-4aw5A:
17.0		 5mafA-4aw5A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		9 GLY A 247
VAL A 254
ALA A 267
LYS A 269
GLU A 288
LEU A 318
TYR A 320
GLY A 324
GLU A 325
 None
 0.65A 5mafA-4c0tA:
30.7		 5mafA-4c0tA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 GLY A  23
VAL A  30
ALA A  43
LYS A  45
GLU A  64
TYR A  95
GLY A  99
 STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
 0.81A 5mafA-4cfhA:
32.1		 5mafA-4cfhA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLU A 614
GLY A 617
VAL A 624
ALA A 653
LYS A 655
GLU A 672
TYR A 703
 None
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.0A)
 0.71A 5mafA-4ckrA:
22.5		 5mafA-4ckrA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		7 ILE A  44
GLY A  45
VAL A  52
ALA A  64
LYS A  66
GLU A  78
LEU A 113
 None
 0.66A 5mafA-4e7wA:
23.9		 5mafA-4e7wA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 ILE A 567
GLY A 568
VAL A 575
ALA A 588
LYS A 590
GLU A 607
GLY A 642
 GUI  A 901 (-4.0A)
GUI  A 901 ( 4.3A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
GUI  A 901 (-3.5A)
 0.80A 5mafA-4e93A:
27.0		 5mafA-4e93A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  64
GLY A  65
VAL A  72
ALA A  88
LYS A  90
GLU A 104
TYR A 136
 None
ADP  A 601 ( 3.8A)
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
None
ADP  A 601 (-4.1A)
 0.50A 5mafA-4f99A:
24.5		 5mafA-4f99A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 856
VAL A 863
ALA A 880
LYS A 882
GLU A 898
TYR A 931
GLY A 935
 IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 (-3.3A)
 0.81A 5mafA-4gl9A:
25.0		 5mafA-4gl9A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 GLY A 157
VAL A 164
ALA A 177
LYS A 179
GLU A 198
TYR A 229
GLY A 233
GLU A 234
 GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
0XZ  A 501 ( 4.9A)
None
GOL  A 505 ( 2.9A)
 0.44A 5mafA-4gv1A:
30.7		 5mafA-4gv1A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 479
VAL A 486
ALA A 506
LYS A 508
GLU A 525
TYR A 557
GLY A 561
 ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 ( 4.6A)
 0.72A 5mafA-4k33A:
26.0		 5mafA-4k33A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLU A  40
GLY A  43
VAL A  50
ALA A  61
LYS A  63
GLU A  77
TYR A 106
GLY A 110
 None
1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
 1.02A 5mafA-4l52A:
24.2		 5mafA-4l52A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLU A  31
GLY A  34
VAL A  41
ALA A  54
LYS A  56
GLU A  70
TYR A 101
GLY A 105
 None
None
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
 0.79A 5mafA-4lg4A:
26.4		 5mafA-4lg4A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 ILE A 197
GLY A 198
VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 271
 29X  A 702 (-4.7A)
29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 ( 4.7A)
 0.49A 5mafA-4mk0A:
29.2		 5mafA-4mk0A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 ILE A 197
VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 271
GLY A 277
 29X  A 702 (-4.7A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 ( 4.7A)
None
 0.81A 5mafA-4mk0A:
29.2		 5mafA-4mk0A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLU B  28
GLY B  31
VAL B  38
ALA B  51
LYS B  53
GLU B  70
TYR B 101
GLY B 105
 None
ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
 0.83A 5mafA-4o27B:
29.2		 5mafA-4o27B:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ILE A 619
GLY A 620
VAL A 627
ALA A 644
LYS A 646
GLU A 663
TYR A 694
GLY A 698
 None
 1.13A 5mafA-4p2kA:
26.1		 5mafA-4p2kA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
 None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
 0.66A 5mafA-4rt7A:
23.2		 5mafA-4rt7A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 193
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 263
GLY A 269
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-4.5A)
None
 0.57A 5mafA-4tnbA:
26.8		 5mafA-4tnbA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 GLY A  15
VAL A  22
ALA A  35
LYS A  37
GLU A  52
TYR A  83
GLY A  87
 ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
 0.72A 5mafA-4ueuA:
26.5		 5mafA-4ueuA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		8 GLY A 105
VAL A 112
ALA A 125
LYS A 127
GLU A 146
TYR A 177
GLY A 181
GLU A 182
 ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-3.5A)
 0.83A 5mafA-4wb7A:
30.1		 5mafA-4wb7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
 None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
 0.76A 5mafA-4xufA:
23.3		 5mafA-4xufA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 469
GLY A 470
VAL A 477
ALA A 488
LYS A 490
GLU A 509
TYR A 541
 4CV  A 801 (-4.3A)
4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-3.9A)
 0.53A 5mafA-4yffA:
22.9		 5mafA-4yffA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 194
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 264
GLY A 270
 AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
AN2  A 601 ( 4.8A)
None
 0.46A 5mafA-4yhjA:
27.1		 5mafA-4yhjA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLU A  76
GLY A 111
GLU A 112
ILE A 171
 ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 (-3.5A)
ADP  A 506 (-4.5A)
 0.63A 5mafA-4ysjA:
31.2		 5mafA-4ysjA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 485
VAL A 492
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
 38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
 0.51A 5mafA-5a46A:
23.8		 5mafA-5a46A:
11.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  22
GLY A  23
VAL A  30
ALA A  44
LYS A  46
GLU A  63
TYR A  94
GLY A  98
 51W  A 401 (-3.9A)
51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-3.7A)
 0.59A 5mafA-5ci7A:
29.3		 5mafA-5ci7A:
36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ILE A  62
GLY A  63
VAL A  70
ALA A  83
LYS A  85
GLU A 103
TYR A 134
 5RC  A4000 (-4.0A)
5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
 0.65A 5mafA-5es1A:
37.1		 5mafA-5es1A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 ILE A  62
GLY A  63
VAL A  70
ALA A  83
LYS A  85
TYR A 134
GLY A 138
GLU A 139
 5RC  A4000 (-4.0A)
5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
 0.72A 5mafA-5es1A:
37.1		 5mafA-5es1A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 170
GLY A 176
GLU A 177
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.4A)
5U5  A 401 (-3.3A)
 0.47A 5mafA-5eykA:
30.3		 5mafA-5eykA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 904
VAL A 911
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
 0.76A 5mafA-5f1zA:
24.9		 5mafA-5f1zA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 731
VAL A 738
ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
 0.64A 5mafA-5fm2A:
26.3		 5mafA-5fm2A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 600
VAL A 607
ALA A 625
LYS A 627
GLU A 644
TYR A 676
GLY A 680
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
 0.73A 5mafA-5grnA:
23.1		 5mafA-5grnA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 GLU A  18
VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
GLU A  97
 None
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-3.5A)
 0.81A 5mafA-5hu3A:
31.8		 5mafA-5hu3A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		8 ILE A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
GLU A  65
TYR A  96
GLY A 100
 None
None
None
None
None
None
PO4  A 401 (-4.8A)
None
 0.83A 5mafA-5ig1A:
29.7		 5mafA-5ig1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aua PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
SEC14P

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 LEU A  37
CYH A  17
LEU A 169
ASP A  54
 None
 1.31A 5mafA-1auaA:
undetectable		 5mafA-1auaA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 179
CYH A 154
LEU A 124
ASP A 126
 None
 1.35A 5mafA-1dj3A:
undetectable		 5mafA-1dj3A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  55
CYH A  83
LEU A 133
ASP A 144
 None
 0.82A 5mafA-1h4lA:
26.7		 5mafA-1h4lA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j7q CALCIUM VECTOR
PROTEIN

(Branchiostoma
lanceolatum) 		no annotation 4 CYH A  78
CYH A  16
LEU A  75
ASP A  85
 None
 1.32A 5mafA-1j7qA:
undetectable		 5mafA-1j7qA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6n PROBABLE
ATP-DEPENDENT RNA
HELICASE

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A 231
CYH A  87
CYH A  75
ASP A 196
 None
 1.22A 5mafA-1t6nA:
undetectable		 5mafA-1t6nA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LEU A  80
CYH A 108
LEU A 158
ASP A 169
 None
 0.86A 5mafA-1u5qA:
27.2		 5mafA-1u5qA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfc ALANINE RACEMASE

(Mycobacterium
tuberculosis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 341
CYH A 255
LEU A  11
ASP A 292
 None
 0.88A 5mafA-1xfcA:
undetectable		 5mafA-1xfcA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		4 LEU A 724
CYH A 689
CYH A 755
LEU A 762
 None
SF4  A2233 (-2.3A)
SF4  A2233 (-2.3A)
SF4  A2233 (-4.3A)
 1.02A 5mafA-2c3oA:
undetectable		 5mafA-2c3oA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecl RING-BOX PROTEIN 2

(Homo sapiens) 		PF12678
(zf-rbx1) 		4 CYH A  48
CYH A  70
LEU A  69
ASP A  16
 ZN  A 601 (-2.3A)
ZN  A 601 (-2.2A)
ZN  A 601 ( 4.6A)
None
 1.50A 5mafA-2eclA:
undetectable		 5mafA-2eclA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0d UBIQUITIN LIGASE
PROTEIN RING2

(Homo sapiens) 		PF13923
(zf-C3HC4_2) 		4 LEU B 100
CYH B  51
LEU B  58
ASP B 103
 None
ZN  B 203 (-2.3A)
None
None
 1.22A 5mafA-2h0dB:
undetectable		 5mafA-2h0dB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgq BRAZZEIN

(Pentadiplandra
brazzeana) 		no annotation 4 CYH A  47
CYH A  16
LEU A  45
ASP A  40
 None
 1.35A 5mafA-2kgqA:
undetectable		 5mafA-2kgqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol3 ALLOGENEIC H-2KBM8
MHC CLASS I MOLECULE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 CYH H 101
CYH H 164
LEU H   5
ASP H  29
 None
 1.30A 5mafA-2ol3H:
undetectable		 5mafA-2ol3H:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP

(Homo sapiens) 		PF01853
(MOZ_SAS) 		4 LEU A 185
CYH A 211
CYH A 231
LEU A 233
 None
ZN  A 490 (-2.3A)
ZN  A 490 (-2.4A)
None
 1.37A 5mafA-2ou2A:
undetectable		 5mafA-2ou2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0y HYPOTHETICAL PROTEIN
LP_0780

(Lactobacillus
plantarum) 		PF01933
(UPF0052) 		4 LEU A 199
CYH A 296
LEU A 291
ASP A 243
 None
 1.36A 5mafA-2p0yA:
undetectable		 5mafA-2p0yA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b74 UNCHARACTERIZED
PROTEIN YKL091C

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 LEU A  33
CYH A  13
LEU A 171
ASP A  50
 None
 1.17A 5mafA-3b74A:
undetectable		 5mafA-3b74A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		4 LEU A 282
CYH A 251
LEU A 232
ASP A 258
 None
 1.45A 5mafA-3bwsA:
3.0		 5mafA-3bwsA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 LEU A 175
CYH A 117
LEU A 119
ASP A 182
 None
 1.38A 5mafA-3clwA:
2.3		 5mafA-3clwA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A  36
CYH A   5
LEU A  91
ASP A  62
 None
 1.31A 5mafA-3ghyA:
undetectable		 5mafA-3ghyA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU B 114
CYH B 177
LEU B 178
ASP B 168
 None
 1.43A 5mafA-3gtuB:
undetectable		 5mafA-3gtuB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcj PEPTIDE METHIONINE
SULFOXIDE REDUCTASE

(Xanthomonas
campestris) 		PF01641
(SelR) 		4 CYH A  56
CYH A 102
LEU A  58
ASP A   5
 ZN  A1000 (-2.3A)
ZN  A1000 (-2.2A)
None
None
 1.49A 5mafA-3hcjA:
undetectable		 5mafA-3hcjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 LEU A 541
CYH A 545
LEU A 645
ASP A 552
 None
 1.10A 5mafA-3j04A:
undetectable		 5mafA-3j04A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kav UNCHARACTERIZED
PROTEIN PA2107

(Pseudomonas
aeruginosa) 		PF03860
(DUF326) 		4 LEU A  52
CYH A  48
CYH A 119
ASP A  68
 None
 1.34A 5mafA-3kavA:
undetectable		 5mafA-3kavA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kav UNCHARACTERIZED
PROTEIN PA2107

(Pseudomonas
aeruginosa) 		PF03860
(DUF326) 		4 LEU A  52
CYH A  48
CYH A 119
ASP A  71
 None
 1.47A 5mafA-3kavA:
undetectable		 5mafA-3kavA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldz SIGNAL TRANSDUCING
ADAPTER MOLECULE 1

(Homo sapiens) 		PF00790
(VHS) 		4 CYH A  46
CYH A  72
LEU A  68
ASP A  12
 None
 1.36A 5mafA-3ldzA:
undetectable		 5mafA-3ldzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 LEU A 719
CYH A 748
LEU A 804
ASP A 828
 None
ADP  A2101 (-4.2A)
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.90A 5mafA-3lj0A:
25.7		 5mafA-3lj0A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lke ENOYL-COA HYDRATASE

(Bacillus
halodurans) 		PF00378
(ECH_1) 		4 LEU A  28
CYH A  74
LEU A  83
ASP A 146
 None
 1.31A 5mafA-3lkeA:
undetectable		 5mafA-3lkeA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmf UNCHARACTERIZED
PROTEIN

(Nitrosospira
multiformis) 		no annotation 4 LEU A  48
CYH A  52
CYH A  21
ASP A  82
 None
 1.21A 5mafA-3lmfA:
undetectable		 5mafA-3lmfA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 753
CYH A 751
LEU A 820
ASP A 831
 ITI  A   1 (-3.8A)
ITI  A   1 (-3.7A)
ITI  A   1 (-4.6A)
ITI  A   1 ( 4.6A)
 1.46A 5mafA-3lzbA:
22.9		 5mafA-3lzbA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  70
CYH A 106
LEU A 156
ASP A 167
 None
 0.80A 5mafA-3mi9A:
25.4		 5mafA-3mi9A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF02581
(TMP-TENI) 		4 LEU A 111
CYH A  64
LEU A  61
ASP A  85
 None
 1.50A 5mafA-3o63A:
undetectable		 5mafA-3o63A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		4 LEU A  40
CYH A 275
CYH A 224
LEU A 271
 None
 1.33A 5mafA-3ufgA:
undetectable		 5mafA-3ufgA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uko ALCOHOL
DEHYDROGENASE
CLASS-3

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 375
CYH A 373
CYH A 370
ASP A  50
 None
 1.47A 5mafA-3ukoA:
undetectable		 5mafA-3ukoA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 889
CYH A 919
LEU A1035
ASP A1046
 LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.43A 5mafA-3wzdA:
23.1		 5mafA-3wzdA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  85
CYH A 113
LEU A 164
ASP A 175
 None
XZN  A1317 (-3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
 0.42A 5mafA-4bc6A:
14.2		 5mafA-4bc6A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6y CITRATE SYNTHASE

(Vibrio
vulnificus) 		PF00285
(Citrate_synt) 		4 LEU A 327
CYH A 272
LEU A 276
ASP A 334
 None
 1.47A 5mafA-4e6yA:
undetectable		 5mafA-4e6yA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz PROTEIN E6

(Alphapapillomavirus
9) 		PF00518
(E6) 		4 LEU C  67
CYH C 106
CYH C 136
ASP C  44
 None
ZN  C 201 (-2.3A)
ZN  C 201 (-2.2A)
None
 1.44A 5mafA-4gizC:
undetectable		 5mafA-4gizC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		4 LEU A1608
CYH A1610
CYH A1653
ASP A1529
 None
ZN  A1719 (-2.3A)
ZN  A1719 (-2.3A)
MES  A1718 (-3.9A)
 1.45A 5mafA-4guaA:
undetectable		 5mafA-4guaA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyv PYRUVATE KINASE 1

(Trypanosoma
brucei) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 460
CYH A 429
LEU A 426
ASP A 444
 None
 1.34A 5mafA-4hyvA:
undetectable		 5mafA-4hyvA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Mycobacterium
tuberculosis) 		PF02126
(PTE) 		4 LEU A 220
CYH A 146
LEU A 161
ASP A 188
 None
KCX  A 145 ( 4.0A)
None
None
 1.21A 5mafA-4if2A:
undetectable		 5mafA-4if2A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 CYH A 505
CYH A 534
LEU A 365
ASP A 499
 None
None
None
GOL  A 606 (-3.8A)
 1.20A 5mafA-4jgvA:
undetectable		 5mafA-4jgvA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		4 LEU A 747
CYH A 675
LEU A 671
ASP A 709
 None
 1.41A 5mafA-4k6jA:
undetectable		 5mafA-4k6jA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LEU A 406
CYH A 435
LEU A 489
ASP A 500
 None
 0.87A 5mafA-4o1oA:
18.1		 5mafA-4o1oA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LEU B 408
CYH B 437
LEU B 492
ASP B 503
 None
ACP  B 801 (-4.5A)
ACP  B 801 (-4.5A)
MG  B 803 (-1.8A)
 0.86A 5mafA-4oavB:
19.4		 5mafA-4oavB:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 LEU A 485
CYH A 490
LEU A 373
ASP A 425
 None
 1.49A 5mafA-4ogzA:
2.2		 5mafA-4ogzA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A1012
CYH A1015
LEU A1007
ASP A 569
 None
 1.46A 5mafA-4ptfA:
undetectable		 5mafA-4ptfA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		4 LEU A 205
CYH A 176
LEU A 315
ASP A 312
 None
 1.44A 5mafA-4pviA:
3.0		 5mafA-4pviA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tum ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 2

(Arabidopsis
thaliana) 		PF13637
(Ank_4) 		4 LEU A 234
CYH A 299
LEU A 302
ASP A 272
 None
 1.35A 5mafA-4tumA:
undetectable		 5mafA-4tumA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxl PEPTIDE DEFORMYLASE

(Haemophilus
influenzae) 		PF01327
(Pep_deformylase) 		4 LEU A 142
CYH A  18
LEU A  55
ASP A  11
 None
 1.45A 5mafA-4wxlA:
undetectable		 5mafA-4wxlA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 LEU A 616
CYH A 645
LEU A 695
ASP A 711
 None
 0.88A 5mafA-4z7gA:
21.9		 5mafA-4z7gA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Aquifex
aeolicus;
Pseudomonas
aeruginosa) 		PF06557
(DUF1122) 		4 LEU A 218
CYH A 214
CYH A 285
ASP A 234
 None
 1.50A 5mafA-4zsxA:
3.0		 5mafA-4zsxA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 LEU A 250
CYH A 490
CYH A 501
LEU A 500
 None
 1.33A 5mafA-4zzhA:
undetectable		 5mafA-4zzhA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqk ICP27

(Human
alphaherpesvirus
1) 		PF05459
(Herpes_UL69) 		4 LEU A 472
CYH A 414
LEU A 413
ASP A 424
 None
 1.20A 5mafA-5bqkA:
undetectable		 5mafA-5bqkA:
16.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  67
CYH A  95
LEU A 145
ASP A 165
 None
51W  A 401 (-3.9A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 0.56A 5mafA-5ci7A:
29.3		 5mafA-5ci7A:
36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doi TELOMERASE
ASSOCIATED PROTEIN
P45
TELOMERASE-ASSOCIATE
D PROTEIN 19

(Tetrahymena
thermophila) 		no annotation 4 LEU A  10
CYH E  96
LEU E  13
ASP E  54
 None
 1.22A 5mafA-5doiA:
undetectable		 5mafA-5doiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eid ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 2

(Arabidopsis
thaliana) 		PF13637
(Ank_4) 		4 LEU A 234
CYH A 299
LEU A 302
ASP A 272
 None
 1.42A 5mafA-5eidA:
undetectable		 5mafA-5eidA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr8 E3 UBIQUITIN-PROTEIN
LIGASE TRIM33

(Homo sapiens) 		no annotation 4 LEU A1060
CYH A 966
LEU A 958
ASP A1022
 None
 1.36A 5mafA-5mr8A:
undetectable		 5mafA-5mr8A:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 LEU A  61
CYH A  70
CYH A  89
ASP A 150
 None
7LV  A 401 ( 3.7A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.2A)
 0.72A 5mafA-5tvtA:
45.6		 5mafA-5tvtA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 LEU A  61
CYH A  70
CYH A  89
LEU A 139
 None
7LV  A 401 ( 3.7A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.9A)
 0.19A 5mafA-5tvtA:
45.6		 5mafA-5tvtA:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn SUPPRESSOR OF HU
SENSITIVITY INVOLVED
IN RECOMBINATION
PROTEIN 1
SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU C 114
CYH D 176
LEU D 179
ASP D 108
 None
ZN  D 301 (-2.3A)
None
None
 1.37A 5mafA-5xynC:
undetectable		 5mafA-5xynC:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0e -

(-) 		no annotation 4 LEU A 301
CYH A 193
LEU A 257
ASP A 265
 None
None
SO4  A 501 (-4.1A)
SO4  A 501 (-3.9A)
 1.33A 5mafA-5y0eA:
undetectable		 5mafA-5y0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 4 LEU A 194
CYH A 440
LEU A 441
ASP A 224
 None
 1.39A 5mafA-6c62A:
undetectable		 5mafA-6c62A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dnh CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 4

(Homo sapiens) 		no annotation 4 LEU C  28
CYH C  55
CYH C  49
ASP C  80
 None
ZN  C 301 (-2.8A)
ZN  C 301 (-2.4A)
None
 1.26A 5mafA-6dnhC:
undetectable		 5mafA-6dnhC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A1593
CYH A1616
LEU A1615
ASP A1587
 None
 1.28A 5mafA-6emkA:
undetectable		 5mafA-6emkA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 4 LEU U  66
CYH U  94
LEU U 144
ASP U 157
 None
DB8  U 301 (-4.2A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.80A 5mafA-6fdyU:
28.6		 5mafA-6fdyU:
undetectable