SIMILAR PATTERNS OF AMINO ACIDS FOR 5M8R_C_MMSC516

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 109
HIS A 240
HIS A 244
GLY A 259
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.45A 5m8rC-1bt2A:
16.8		 5m8rC-1bt2A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER

(Thermochromatium
tepidum) 		PF00124
(Photo_RC) 		4 HIS L 238
HIS L 198
LEU L 195
GLY L 199
 None
 0.74A 5m8rC-1eysL:
undetectable		 5m8rC-1eysL:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 HIS A 218
LEU A 217
VAL A 220
SER A 300
 None
 0.93A 5m8rC-1flcA:
undetectable		 5m8rC-1flcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 198
HIS A 344
ASN A 345
HIS A 348
 CU  A 665 (-3.1A)
CU  A 666 (-3.1A)
None
CU  A 666 (-3.8A)
 0.73A 5m8rC-1hcyA:
8.1		 5m8rC-1hcyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 ASN A 387
LEU A 451
GLY A 466
VAL A 468
 None
 1.01A 5m8rC-1iduA:
undetectable		 5m8rC-1iduA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipf TROPINONE
REDUCTASE-II

(Datura
stramonium) 		PF13561
(adh_short_C2) 		4 ASN A  47
LEU A  50
VAL A  64
SER A  40
 None
None
None
NDP  A 261 (-3.8A)
 1.02A 5m8rC-1ipfA:
undetectable		 5m8rC-1ipfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A2562
HIS A2671
ASN A2672
HIS A2675
 CUO  A 888 (-3.4A)
CUO  A 888 (-3.4A)
None
CUO  A 888 (-3.3A)
 0.34A 5m8rC-1js8A:
22.1		 5m8rC-1js8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		4 HIS A  87
LEU A 420
GLY A 418
SER A 175
 ZN  A1002 ( 3.2A)
None
None
None
 1.03A 5m8rC-1lfwA:
0.0		 5m8rC-1lfwA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 HIS A 177
HIS A 324
ASN A 325
HIS A 328
SER A 354
 CU  A 629 (-3.2A)
CU  A 630 (-3.3A)
None
CU  A 630 (-3.2A)
None
 0.74A 5m8rC-1llaA:
3.2		 5m8rC-1llaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A  61
HIS A 181
ASN A 182
HIS A 185
GLY A 197
 CU  A5001 (-3.6A)
CU  A5012 (-3.4A)
None
CU  A5012 (-3.2A)
None
 0.52A 5m8rC-1lnlA:
20.1		 5m8rC-1lnlA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		4 HIS L 230
HIS L 190
LEU L 187
GLY L 191
 FE  M 302 (-3.4A)
FE  M 302 ( 3.3A)
None
None
 0.86A 5m8rC-1pssL:
undetectable		 5m8rC-1pssL:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT

(Bos taurus) 		PF04699
(P16-Arc) 		4 HIS G 129
GLY G 136
VAL G 138
SER G 140
 None
 0.94A 5m8rC-1u2vG:
undetectable		 5m8rC-1u2vG:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vph HYPOTHETICAL PROTEIN
SSO2532

(Sulfolobus
solfataricus) 		PF01894
(UPF0047) 		4 HIS A  79
HIS A  89
LEU A  90
SER A  46
 K  A 138 (-3.5A)
K  A 138 (-3.5A)
None
PO4  A 139 (-2.8A)
 0.91A 5m8rC-1vphA:
undetectable		 5m8rC-1vphA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		5 HIS A  54
HIS A 190
ASN A 191
HIS A 194
SER A 206
 CU  A 400 ( 3.3A)
CU  A 401 ( 3.2A)
None
CU  A 401 ( 3.2A)
PER  A 409 ( 4.1A)
 0.34A 5m8rC-1wx4A:
29.4		 5m8rC-1wx4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13420
(Acetyltransf_4) 		4 HIS A  87
HIS A 135
LEU A 138
SER A 131
 None
 0.99A 5m8rC-1yr0A:
undetectable		 5m8rC-1yr0A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyc GALECTIN-4

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		4 HIS A  63
ASN A  65
HIS A  47
GLY A 140
 None
 0.94A 5m8rC-2dycA:
undetectable		 5m8rC-2dycA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4p HYPOTHETICAL PROTEIN
TM1010

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		4 HIS A  52
HIS A  54
GLY A  57
SER A 109
 UNL  A 136 (-3.3A)
UNL  A 136 (-3.7A)
None
UNL  A 136 ( 4.7A)
 0.87A 5m8rC-2f4pA:
undetectable		 5m8rC-2f4pA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 HIS A  73
HIS A 396
GLY A 157
VAL A 159
 ZN  A 482 ( 3.2A)
SO4  A 491 (-4.0A)
None
None
 0.99A 5m8rC-2i7tA:
undetectable		 5m8rC-2i7tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8)
PF16920
(TPKR_C2) 		4 HIS A 343
LEU A 333
GLY A 344
SER A 304
 None
 0.89A 5m8rC-2ifgA:
undetectable		 5m8rC-2ifgA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 HIS A 108
HIS A 239
ASN A 240
HIS A 243
GLY A 257
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.41A 5m8rC-2p3xA:
3.8		 5m8rC-2p3xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		4 ASN A 254
LEU A 250
GLY A 249
VAL A 189
 None
 0.84A 5m8rC-2q6kA:
undetectable		 5m8rC-2q6kA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 HIS A 747
HIS A 749
GLY A 842
SER A 553
 ZN  A1157 (-3.3A)
ZN  A1157 (-3.3A)
None
None
 0.97A 5m8rC-2qf7A:
undetectable		 5m8rC-2qf7A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rtx PEPTIDYL-TRNA
HYDROLASE YAEJ

(Escherichia
coli) 		PF00472
(RF-1) 		4 HIS A  61
HIS A  62
GLY A 115
SER A 113
 None
 0.88A 5m8rC-2rtxA:
undetectable		 5m8rC-2rtxA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvk YJHT

(Escherichia
coli) 		PF01344
(Kelch_1) 		4 HIS A 290
ASN A 207
GLY A 260
SER A 286
 None
 0.86A 5m8rC-2uvkA:
undetectable		 5m8rC-2uvkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 HIS A 208
LEU A 228
GLY A 275
SER A 272
 None
None
None
OMT  A2473 ( 3.8A)
 0.91A 5m8rC-2vdcA:
undetectable		 5m8rC-2vdcA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wg8 PUTATIVE
PHOSPHOLIPASE A2

(Oryza sativa) 		no annotation 4 HIS A  61
ASN A  78
LEU A  82
VAL A 110
 None
 1.03A 5m8rC-2wg8A:
undetectable		 5m8rC-2wg8A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7v PROBABLE
ENDONUCLEASE 4

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		4 HIS A 230
ASN A 217
GLY A 182
SER A 147
 ZN  A1289 (-3.2A)
ZN  A1288 ( 4.9A)
None
None
 1.03A 5m8rC-2x7vA:
undetectable		 5m8rC-2x7vA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		6 HIS A  85
HIS A 259
ASN A 260
HIS A 263
GLY A 281
VAL A 283
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 ( 4.5A)
0TR  A 410 (-4.0A)
 0.44A 5m8rC-2y9xA:
20.5		 5m8rC-2y9xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 HIS A 165
HIS A 182
LEU A 181
VAL A 184
 ZN  A 378 (-3.3A)
ZN  A 378 (-3.1A)
None
None
 1.01A 5m8rC-3b1bA:
undetectable		 5m8rC-3b1bA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 HIS A 771
HIS A 773
GLY A 868
SER A 576
 MN  A2001 (-3.4A)
MN  A2001 (-3.8A)
None
None
 0.88A 5m8rC-3bg9A:
undetectable		 5m8rC-3bg9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzj UV ENDONUCLEASE

(Thermus
thermophilus) 		PF03851
(UvdE) 		4 HIS A 231
HIS A 143
LEU A 144
VAL A 141
 None
 0.89A 5m8rC-3bzjA:
undetectable		 5m8rC-3bzjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Agrobacterium
fabrum) 		PF00440
(TetR_N) 		4 HIS A 175
ASN A 111
GLY A 104
VAL A 101
 None
 1.01A 5m8rC-3c2bA:
undetectable		 5m8rC-3c2bA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		4 HIS A 101
LEU A  59
GLY A  71
VAL A  69
 None
 0.90A 5m8rC-3dr2A:
undetectable		 5m8rC-3dr2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		4 HIS A  47
HIS A  38
GLY A  11
SER A  14
 None
 0.98A 5m8rC-3g7uA:
undetectable		 5m8rC-3g7uA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbf PHPD

(Streptomyces
viridochromogenes) 		no annotation 4 HIS A 160
ASN A 137
GLY A 145
VAL A 158
 CD  A 508 (-3.4A)
None
None
None
 1.01A 5m8rC-3gbfA:
undetectable		 5m8rC-3gbfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 HIS B 213
HIS B 366
ASN B 367
HIS B 370
GLY B 391
 CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
None
 0.71A 5m8rC-3hhsB:
8.5		 5m8rC-3hhsB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.68A 5m8rC-3hhsA:
5.1		 5m8rC-3hhsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8t GALECTIN-4

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		4 HIS A  75
ASN A  77
HIS A  59
GLY A 152
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
GOL  A 167 (-3.8A)
GOL  A 167 ( 3.7A)
 0.87A 5m8rC-3i8tA:
undetectable		 5m8rC-3i8tA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 HIS A 518
LEU A 784
GLY A 787
SER A 789
 None
 0.95A 5m8rC-3j3iA:
undetectable		 5m8rC-3j3iA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
PPI1

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 ASN d   3
LEU d  17
GLY d 120
VAL d 122
 None
 1.03A 5m8rC-3jb9d:
undetectable		 5m8rC-3jb9d:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		4 HIS A 187
GLY A 193
VAL A 195
SER A 197
 None
None
GP7  A 435 (-4.7A)
None
 0.89A 5m8rC-3k7tA:
undetectable		 5m8rC-3k7tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khp MAOC FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 LEU A 131
GLY A 123
VAL A 100
SER A  98
 None
 0.94A 5m8rC-3khpA:
undetectable		 5m8rC-3khpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
None
AZM  A 264 (-4.7A)
 1.01A 5m8rC-3ml5A:
undetectable		 5m8rC-3ml5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 HIS A 152
LEU A   1
GLY A 153
SER A 282
 None
 0.97A 5m8rC-3n05A:
undetectable		 5m8rC-3n05A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 HIS A 151
ASN A 776
LEU A 464
GLY A 468
 MGD  A1803 ( 4.6A)
MGD  A1803 (-2.9A)
None
None
 0.96A 5m8rC-3o5aA:
undetectable		 5m8rC-3o5aA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 HIS A 375
ASN A  70
GLY A  86
SER A 405
 None
 0.83A 5m8rC-3pocA:
undetectable		 5m8rC-3pocA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prc PHOTOSYNTHETIC
REACTION CENTER

(Blastochloris
viridis) 		PF00124
(Photo_RC) 		4 HIS L 230
HIS L 190
LEU L 187
GLY L 191
 None
 0.75A 5m8rC-3prcL:
undetectable		 5m8rC-3prcL:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 4 HIS A 494
HIS A 130
ASN A 148
HIS A 178
 CUK  A 702 (-3.3A)
CUK  A 702 (-3.2A)
None
CUK  A 702 (-3.1A)
 0.93A 5m8rC-3sbqA:
undetectable		 5m8rC-3sbqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		4 HIS A 120
HIS A 196
GLY A 197
SER A 200
 ZN  A 472 (-3.4A)
None
None
None
 0.86A 5m8rC-3tp9A:
undetectable		 5m8rC-3tp9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 HIS A 125
HIS A 112
GLY A 113
SER A 115
 None
 0.79A 5m8rC-3uszA:
undetectable		 5m8rC-3uszA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv1 PROTEIN LEC-6

(Caenorhabditis
elegans) 		PF00337
(Gal-bind_lectin) 		4 HIS A  60
ASN A  62
HIS A  48
GLY A 135
 GAL  A 201 (-3.8A)
GAL  A 201 (-3.9A)
None
None
 0.92A 5m8rC-3vv1A:
undetectable		 5m8rC-3vv1A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 HIS A  94
HIS A 328
ASN A 329
HIS A 332
VAL A 359
 None
 0.56A 5m8rC-3w6qA:
14.5		 5m8rC-3w6qA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		6 HIS A 203
HIS A 357
ASN A 358
HIS A 361
GLY A 382
VAL A 384
 CUO  A 708 (-3.5A)
CUO  A 708 (-3.3A)
None
CUO  A 708 (-3.2A)
None
None
 0.71A 5m8rC-3wkyA:
8.6		 5m8rC-3wkyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Pseudomonas sp.
VM15C) 		no annotation 4 HIS A 296
HIS A 298
LEU A 254
SER A 196
 None
 0.99A 5m8rC-3wweA:
undetectable		 5m8rC-3wweA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli) 		PF01728
(FtsJ) 		4 HIS A 149
LEU A 137
GLY A 100
VAL A 147
 None
 1.02A 5m8rC-4aukA:
undetectable		 5m8rC-4aukA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B1725
ASN B1848
HIS B1851
GLY B1863
 CUO  B9005 (-3.1A)
None
CUO  B9005 (-3.2A)
None
 0.41A 5m8rC-4bedB:
19.5		 5m8rC-4bedB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B1725
HIS B1847
HIS B1851
GLY B1863
 CUO  B9005 (-3.1A)
CUO  B9005 (-3.2A)
CUO  B9005 (-3.2A)
None
 0.85A 5m8rC-4bedB:
19.5		 5m8rC-4bedB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B3075
ASN B3076
HIS B3079
SER B3096
 CUO  B9008 (-2.8A)
None
CUO  B9008 (-3.5A)
CUO  B9008 ( 4.7A)
 0.35A 5m8rC-4bedB:
19.5		 5m8rC-4bedB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B3106
HIS B2965
GLY B2947
SER B3096
 CUO  B9008 (-3.3A)
CUO  B9008 (-3.2A)
None
CUO  B9008 ( 4.7A)
 0.87A 5m8rC-4bedB:
19.5		 5m8rC-4bedB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		4 HIS B 563
LEU B 566
VAL B 599
SER B 602
 None
 1.03A 5m8rC-4ci6B:
undetectable		 5m8rC-4ci6B:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		4 HIS B 416
ASN B 620
HIS B 453
SER B 455
 None
 0.89A 5m8rC-4etpB:
undetectable		 5m8rC-4etpB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
 0.63A 5m8rC-4gpgA:
undetectable		 5m8rC-4gpgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl0 GALECTIN

(Toxascaris
leonina) 		PF00337
(Gal-bind_lectin) 		4 HIS A 192
ASN A 194
HIS A 179
GLY A 268
 None
 0.93A 5m8rC-4hl0A:
undetectable		 5m8rC-4hl0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1001 ( 4.9A)
 0.79A 5m8rC-4j3qA:
26.8		 5m8rC-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 HIS A 273
HIS A  76
HIS A  11
GLY A 283
 SO4  A 505 (-4.0A)
None
None
None
 0.88A 5m8rC-4lbwA:
undetectable		 5m8rC-4lbwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes) 		PF13365
(Trypsin_2) 		4 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
2OY  A 301 ( 4.2A)
None
None
 0.59A 5m8rC-4nsyA:
undetectable		 5m8rC-4nsyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
LEU A 118
GLY A 145
VAL A 143
 ZN  A 301 (-3.2A)
None
None
None
 1.03A 5m8rC-4qk3A:
undetectable		 5m8rC-4qk3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		4 HIS A 178
HIS A 184
GLY A 246
SER A 274
 None
 0.88A 5m8rC-4rk1A:
undetectable		 5m8rC-4rk1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 LEU A 322
GLY A  54
VAL A 273
SER A 276
 None
 0.92A 5m8rC-4rs3A:
undetectable		 5m8rC-4rs3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 HIS A1761
LEU A1749
GLY A1746
VAL A1716
 None
 1.01A 5m8rC-4uclA:
undetectable		 5m8rC-4uclA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		4 HIS A 339
ASN A  60
GLY A  35
VAL A  33
 None
 0.84A 5m8rC-4w5zA:
undetectable		 5m8rC-4w5zA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 HIS A 581
LEU A 575
VAL A 596
SER A 550
 None
 0.93A 5m8rC-4wjlA:
undetectable		 5m8rC-4wjlA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI

(Escherichia
coli) 		PF05861
(PhnI)
PF06007
(PhnJ) 		4 HIS D 108
HIS C 333
HIS C 328
GLY D  47
 None
ZN  C 402 (-3.3A)
ZN  C 402 (-3.1A)
SO4  D 301 (-3.3A)
 1.03A 5m8rC-4xb6D:
undetectable		 5m8rC-4xb6D:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5

(Rattus
norvegicus) 		PF00083
(Sugar_tr) 		4 ASN A 342
LEU A 343
GLY A 347
SER A 349
 None
 0.93A 5m8rC-4ybqA:
undetectable		 5m8rC-4ybqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		6 HIS A 227
HIS A 379
ASN A 380
HIS A 383
GLY A 404
VAL A 406
 CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
None
 0.69A 5m8rC-4yzwA:
7.1		 5m8rC-4yzwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 HIS A 116
HIS A 252
HIS A 256
GLY A 271
 CU  A 700 (-3.2A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 0.33A 5m8rC-4z11A:
17.3		 5m8rC-4z11A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 326
HIS A 349
HIS A 272
GLY A 269
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.4A)
None
 0.84A 5m8rC-4zr0A:
undetectable		 5m8rC-4zr0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 326
HIS A 349
HIS A 272
GLY A 269
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.5A)
None
 0.91A 5m8rC-4zr1A:
undetectable		 5m8rC-4zr1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxc HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Pseudomonas sp.
WBC-3) 		no annotation 4 HIS W  59
LEU W 100
GLY W  90
VAL W  88
 None
 1.01A 5m8rC-4zxcW:
undetectable		 5m8rC-4zxcW:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 4 HIS A 215
HIS A 157
HIS A  95
SER A 100
 ZN  A2002 ( 3.0A)
ZN  A2001 ( 3.3A)
ZN  A2001 ( 3.4A)
None
 0.96A 5m8rC-5b3rA:
undetectable		 5m8rC-5b3rA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		6 HIS A 108
HIS A 239
ASN A 240
HIS A 243
LEU A 244
GLY A 258
 CU  A 402 ( 3.2A)
CU  A 401 ( 3.2A)
None
CU  A 401 ( 3.2A)
None
None
 0.31A 5m8rC-5ce9A:
16.5		 5m8rC-5ce9A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
None
520  A 302 ( 4.9A)
 1.03A 5m8rC-5cjfA:
undetectable		 5m8rC-5cjfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A

(Homo sapiens) 		PF06105
(Aph-1) 		4 HIS C 197
HIS C 171
GLY C 126
SER C 129
 None
 0.98A 5m8rC-5fn4C:
undetectable		 5m8rC-5fn4C:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		6 HIS A  60
HIS A 204
ASN A 205
HIS A 208
GLY A 216
VAL A 218
 ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
None
HQE  A 303 (-3.3A)
 0.22A 5m8rC-5i3aA:
33.4		 5m8rC-5i3aA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		4 HIS A 413
ASN A 289
GLY A 389
SER A 384
 NI  A 501 (-3.6A)
NI  A 501 ( 2.9A)
None
None
 0.86A 5m8rC-5jjtA:
undetectable		 5m8rC-5jjtA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		8 HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
GLY A 389
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
 0.29A 5m8rC-5m8tA:
68.7		 5m8rC-5m8tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 HIS A 215
HIS A 377
HIS A 381
GLY A 388
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
None
 0.88A 5m8rC-5m8tA:
68.7		 5m8rC-5m8tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t FLAVIN-BINDING
SUBUNIT OF SULFIDE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 HIS A 210
HIS A 206
LEU A 239
GLY A 369
 None
 0.96A 5m8rC-5n1tA:
undetectable		 5m8rC-5n1tA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 5 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
None
 0.73A 5m8rC-5or4A:
26.5		 5m8rC-5or4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy9 GLYCOPROTEIN G

(Indiana
vesiculovirus) 		no annotation 4 LEU A 374
GLY A 372
VAL A 300
SER A 303
 None
 0.93A 5m8rC-5oy9A:
undetectable		 5m8rC-5oy9A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 4 HIS B 280
LEU B 321
GLY B 319
VAL B 314
 GOL  B 502 ( 4.7A)
None
None
None
 0.96A 5m8rC-5thzB:
undetectable		 5m8rC-5thzB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 HIS A 321
LEU A 322
GLY A  85
VAL A  81
 None
 0.70A 5m8rC-5tx7A:
undetectable		 5m8rC-5tx7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		4 HIS A 271
HIS A 320
LEU A 319
GLY A 364
 CA  A 703 (-3.2A)
CA  A 703 (-3.3A)
None
None
 0.79A 5m8rC-5wzrA:
undetectable		 5m8rC-5wzrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR L
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER

(Roseiflexus
castenholzii) 		no annotation 4 HIS L 264
HIS L 229
LEU L 226
GLY L 230
 FE  L1005 (-4.4A)
FE  L1005 (-3.1A)
None
None
 0.80A 5m8rC-5yq7L:
undetectable		 5m8rC-5yq7L:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER

(Roseiflexus
castenholzii) 		no annotation 4 HIS M 589
HIS M 542
LEU M 539
GLY M 543
 FE  L1005 (-3.2A)
FE  L1005 ( 3.0A)
None
None
 0.74A 5m8rC-5yq7M:
undetectable		 5m8rC-5yq7M:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 UNCHARACTERIZED
PROTEIN

(Thermobifida
fusca) 		no annotation 4 HIS I 162
LEU I 139
GLY I 140
VAL I 214
 None
 0.94A 5m8rC-6c66I:
undetectable		 5m8rC-6c66I:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 4 HIS A 181
LEU A 184
GLY A 180
SER A 177
 None
 0.96A 5m8rC-6c93A:
undetectable		 5m8rC-6c93A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 4 HIS B 220
HIS B 379
GLY B 417
SER B 422
 None
 0.76A 5m8rC-6eysB:
7.3		 5m8rC-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 4 HIS B 375
HIS B 379
GLY B 417
SER B 422
 None
 0.40A 5m8rC-6eysB:
7.3		 5m8rC-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 4 HIS A 181
LEU A 278
GLY A 280
VAL A 251
 QPS  A 602 (-4.1A)
None
None
QPS  A 602 ( 4.6A)
 0.83A 5m8rC-6gnfA:
undetectable		 5m8rC-6gnfA:
undetectable