SIMILAR PATTERNS OF AMINO ACIDS FOR 5M8R_A_MMSA511

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 HIS S 695
HIS S 700
LEU S 640
VAL S 624
 None
 1.01A 5m8rA-1bkdS:
undetectable		 5m8rA-1bkdS:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 HIS A 197
HIS A 139
HIS A  77
SER A  82
 ZN  A 501 ( 3.4A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.4A)
None
 1.02A 5m8rA-1ddkA:
undetectable		 5m8rA-1ddkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 HIS A 218
LEU A 217
VAL A 220
SER A 300
 None
 0.93A 5m8rA-1flcA:
undetectable		 5m8rA-1flcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		4 HIS A 437
HIS A  80
ASN A  98
HIS A 128
 CUZ  A4801 (-3.0A)
CUZ  A4801 (-3.3A)
None
CUZ  A4801 (-3.2A)
 0.94A 5m8rA-1fwxA:
0.0		 5m8rA-1fwxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 198
HIS A 344
ASN A 345
HIS A 348
 CU  A 665 (-3.1A)
CU  A 666 (-3.1A)
None
CU  A 666 (-3.8A)
 0.67A 5m8rA-1hcyA:
7.6		 5m8rA-1hcyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipf TROPINONE
REDUCTASE-II

(Datura
stramonium) 		PF13561
(adh_short_C2) 		4 ASN A  47
LEU A  50
VAL A  64
SER A  40
 None
None
None
NDP  A 261 (-3.8A)
 1.05A 5m8rA-1ipfA:
0.0		 5m8rA-1ipfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
None
AZM  A1400 (-4.6A)
 1.05A 5m8rA-1jd0A:
undetectable		 5m8rA-1jd0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A2562
HIS A2671
ASN A2672
HIS A2675
 CUO  A 888 (-3.4A)
CUO  A 888 (-3.4A)
None
CUO  A 888 (-3.3A)
 0.44A 5m8rA-1js8A:
22.1		 5m8rA-1js8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 HIS A 636
ASN A  48
LEU A  59
SER A 449
 None
 1.05A 5m8rA-1kqfA:
0.0		 5m8rA-1kqfA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 HIS A 177
HIS A 324
ASN A 325
HIS A 328
SER A 354
 CU  A 629 (-3.2A)
CU  A 630 (-3.3A)
None
CU  A 630 (-3.2A)
None
 0.68A 5m8rA-1llaA:
7.1		 5m8rA-1llaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 328
HIS A 173
HIS A 177
LEU A 178
 CU  A 630 (-3.2A)
CU  A 629 (-3.2A)
CU  A 629 (-3.2A)
None
 1.07A 5m8rA-1llaA:
7.1		 5m8rA-1llaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A  61
HIS A 181
ASN A 182
HIS A 185
 CU  A5001 (-3.6A)
CU  A5012 (-3.4A)
None
CU  A5012 (-3.2A)
 0.54A 5m8rA-1lnlA:
20.1		 5m8rA-1lnlA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 HIS A 437
HIS A  80
ASN A  98
HIS A 128
 CUZ  A 801 (-3.0A)
CUZ  A 801 (-3.3A)
None
CUZ  A 801 (-3.1A)
 0.94A 5m8rA-1qniA:
undetectable		 5m8rA-1qniA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN

(Pseudomonas
aeruginosa) 		PF13433
(Peripla_BP_5) 		4 HIS A 158
HIS A 162
LEU A 163
VAL A 368
 None
 1.06A 5m8rA-1qnlA:
undetectable		 5m8rA-1qnlA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 HIS A 287
HIS A 320
LEU A 319
SER A 372
 None
SO4  A 474 (-3.8A)
None
SO4  A 474 (-4.1A)
 1.03A 5m8rA-1svdA:
undetectable		 5m8rA-1svdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vph HYPOTHETICAL PROTEIN
SSO2532

(Sulfolobus
solfataricus) 		PF01894
(UPF0047) 		4 HIS A  79
HIS A  89
LEU A  90
SER A  46
 K  A 138 (-3.5A)
K  A 138 (-3.5A)
None
PO4  A 139 (-2.8A)
 0.87A 5m8rA-1vphA:
undetectable		 5m8rA-1vphA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		5 HIS A  54
HIS A 190
ASN A 191
HIS A 194
SER A 206
 CU  A 400 ( 3.3A)
CU  A 401 ( 3.2A)
None
CU  A 401 ( 3.2A)
PER  A 409 ( 4.1A)
 0.30A 5m8rA-1wx4A:
29.4		 5m8rA-1wx4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 HIS A 190
HIS A  54
HIS A  38
SER A 206
 CU  A 401 ( 3.2A)
CU  A 400 ( 3.3A)
CU  A 400 ( 3.3A)
PER  A 409 ( 4.1A)
 1.04A 5m8rA-1wx4A:
29.4		 5m8rA-1wx4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 HIS A 420
LEU A 417
VAL A 347
SER A 350
 None
 0.99A 5m8rA-1wzaA:
undetectable		 5m8rA-1wzaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 HIS A 695
HIS A 700
LEU A 640
VAL A 624
 None
 1.01A 5m8rA-1xdvA:
undetectable		 5m8rA-1xdvA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY

(Escherichia
coli) 		PF02130
(UPF0054) 		5 HIS A1124
HIS A1118
LEU A1117
VAL A1067
SER A1069
 NI  A5001 (-3.3A)
NI  A5001 (-3.4A)
None
None
None
 1.42A 5m8rA-1xm5A:
undetectable		 5m8rA-1xm5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		4 HIS A 117
HIS A 135
LEU A 134
VAL A 137
 ZN  A 283 (-3.2A)
ZN  A 283 ( 3.1A)
None
ACY  A 279 ( 4.7A)
 1.07A 5m8rA-1y7wA:
undetectable		 5m8rA-1y7wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		4 HIS A  96
LEU A  76
VAL A  83
SER A  84
 None
 1.04A 5m8rA-1yd9A:
undetectable		 5m8rA-1yd9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynb HYPOTHETICAL PROTEIN
AF1432

(Archaeoglobus
fulgidus) 		PF13023
(HD_3) 		4 HIS A  74
HIS A  42
ASN A  43
VAL A 120
 None
 1.02A 5m8rA-1ynbA:
undetectable		 5m8rA-1ynbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13420
(Acetyltransf_4) 		4 HIS A  87
HIS A 135
LEU A 138
SER A 131
 None
 0.99A 5m8rA-1yr0A:
undetectable		 5m8rA-1yr0A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1w ENDOU PROTEIN

(Xenopus laevis) 		PF09412
(XendoU) 		4 HIS A 272
ASN A 270
HIS A 162
SER A 168
 PO4  A1290 (-3.8A)
PO4  A1290 (-4.3A)
PO4  A1290 (-3.7A)
None
 1.06A 5m8rA-2c1wA:
undetectable		 5m8rA-2c1wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		4 HIS A 108
LEU A 100
VAL A 192
SER A  87
 MG  A 506 (-4.6A)
None
None
None
 0.99A 5m8rA-2dqbA:
undetectable		 5m8rA-2dqbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 4 HIS I 204
HIS I 202
HIS I 318
LEU I 317
 None
 0.95A 5m8rA-2gk1I:
undetectable		 5m8rA-2gk1I:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8m ACETYLTRANSFERASE
PA4866 FROM P.
AERUGINOSA

(Pseudomonas
aeruginosa) 		PF13420
(Acetyltransf_4) 		4 HIS A  86
HIS A 134
LEU A 137
SER A 130
 None
None
None
AZI  A1174 ( 3.9A)
 0.97A 5m8rA-2j8mA:
undetectable		 5m8rA-2j8mA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		5 HIS A 329
HIS A 332
ASN A  15
LEU A  19
SER A 149
 None
 1.32A 5m8rA-2jbwA:
undetectable		 5m8rA-2jbwA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jlm PUTATIVE
PHOSPHINOTHRICIN
N-ACETYLTRANSFERASE

(Acinetobacter
baylyi) 		PF13420
(Acetyltransf_4) 		4 HIS A  94
HIS A 142
LEU A 145
SER A 138
 None
 1.03A 5m8rA-2jlmA:
undetectable		 5m8rA-2jlmA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lef PROTEIN (LYMPHOID
ENHANCER-BINDING
FACTOR)

(Mus musculus) 		PF00505
(HMG_box) 		4 ASN A  34
LEU A  37
VAL A  22
SER A  25
 None
 1.00A 5m8rA-2lefA:
undetectable		 5m8rA-2lefA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.35A 5m8rA-2p3xA:
20.4		 5m8rA-2p3xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 HIS A 189
HIS A 279
LEU A 278
SER A 320
 FMN  A7401 (-4.4A)
None
None
FMN  A7401 ( 4.2A)
 0.74A 5m8rA-2q3oA:
undetectable		 5m8rA-2q3oA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wg8 PUTATIVE
PHOSPHOLIPASE A2

(Oryza sativa) 		no annotation 4 HIS A  61
ASN A  78
LEU A  82
VAL A 110
 None
 1.05A 5m8rA-2wg8A:
undetectable		 5m8rA-2wg8A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 HIS A  85
HIS A 259
ASN A 260
HIS A 263
VAL A 283
 CU  A 400 (-3.3A)
CU  A 401 (-3.2A)
0TR  A 410 (-4.1A)
0TR  A 410 ( 3.1A)
0TR  A 410 (-4.0A)
 0.33A 5m8rA-2y9xA:
20.5		 5m8rA-2y9xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 HIS A 165
HIS A 182
LEU A 181
VAL A 184
 ZN  A 378 (-3.3A)
ZN  A 378 (-3.1A)
None
None
 1.04A 5m8rA-3b1bA:
undetectable		 5m8rA-3b1bA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzj UV ENDONUCLEASE

(Thermus
thermophilus) 		PF03851
(UvdE) 		4 HIS A 231
HIS A 143
LEU A 144
VAL A 141
 None
 0.91A 5m8rA-3bzjA:
undetectable		 5m8rA-3bzjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzj UV ENDONUCLEASE

(Thermus
thermophilus) 		PF03851
(UvdE) 		5 HIS A 231
HIS A 203
ASN A 176
HIS A 143
VAL A 141
 None
MN  A 281 (-3.3A)
None
None
None
 0.99A 5m8rA-3bzjA:
undetectable		 5m8rA-3bzjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c19 UNCHARACTERIZED
PROTEIN MK0293

(Methanopyrus
kandleri) 		PF01969
(DUF111) 		4 HIS A  42
HIS A  55
LEU A  17
VAL A  44
 PO4  A 185 (-4.2A)
None
None
PO4  A 185 ( 4.5A)
 1.06A 5m8rA-3c19A:
undetectable		 5m8rA-3c19A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr8 YNCA

(Salmonella
enterica) 		PF13420
(Acetyltransf_4) 		4 HIS A  83
HIS A 131
LEU A 134
SER A 127
 ACO  A1423 (-4.3A)
ACO  A1423 ( 4.5A)
None
ACO  A1423 (-3.4A)
 0.99A 5m8rA-3dr8A:
undetectable		 5m8rA-3dr8A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		4 HIS A 237
HIS A 287
LEU A 295
SER A 298
 None
 1.05A 5m8rA-3fgbA:
undetectable		 5m8rA-3fgbA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS B 213
HIS B 366
ASN B 367
HIS B 370
 CU  B 686 (-3.3A)
CU  B   1 (-3.3A)
None
CU  B   1 (-3.2A)
 0.67A 5m8rA-3hhsB:
8.3		 5m8rA-3hhsB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 219
HIS A 368
ASN A 369
HIS A 372
 CU  A 696 (-3.3A)
CU  A 697 (-3.2A)
None
CU  A 697 (-3.2A)
 0.63A 5m8rA-3hhsA:
5.1		 5m8rA-3hhsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 174
HIS A 321
ASN A 322
HIS A 325
 None
 0.92A 5m8rA-3ixwA:
6.8		 5m8rA-3ixwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 321
ASN A 322
HIS A 325
SER A 351
 None
 0.73A 5m8rA-3ixwA:
6.8		 5m8rA-3ixwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
None
AZM  A 264 (-4.7A)
 1.04A 5m8rA-3ml5A:
undetectable		 5m8rA-3ml5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o85 RIBOSOMAL PROTEIN
L7AE

(Giardia
intestinalis) 		PF01248
(Ribosomal_L7Ae) 		4 HIS A 104
HIS A  25
LEU A  22
SER A  28
 None
 1.00A 5m8rA-3o85A:
undetectable		 5m8rA-3o85A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi) 		PF04264
(YceI) 		4 ASN A  27
HIS A  52
LEU A  25
VAL A  65
 GOL  A   3 (-4.3A)
None
None
None
 0.85A 5m8rA-3q34A:
undetectable		 5m8rA-3q34A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 4 HIS A 494
HIS A 130
ASN A 148
HIS A 178
 CUK  A 702 (-3.3A)
CUK  A 702 (-3.2A)
None
CUK  A 702 (-3.1A)
 0.93A 5m8rA-3sbqA:
undetectable		 5m8rA-3sbqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 HIS A  94
HIS A 328
ASN A 329
HIS A 332
VAL A 359
 None
 0.55A 5m8rA-3w6qA:
14.3		 5m8rA-3w6qA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 HIS A 203
HIS A 357
ASN A 358
HIS A 361
VAL A 384
 CUO  A 708 (-3.5A)
CUO  A 708 (-3.3A)
None
CUO  A 708 (-3.2A)
None
 0.69A 5m8rA-3wkyA:
8.4		 5m8rA-3wkyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 361
HIS A 199
HIS A 203
LEU A 204
 CUO  A 708 (-3.2A)
CUO  A 708 (-3.3A)
CUO  A 708 (-3.5A)
None
 1.01A 5m8rA-3wkyA:
8.4		 5m8rA-3wkyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311

(Methanocaldococcus
jannaschii) 		PF01261
(AP_endonuc_2) 		4 HIS A 195
HIS A 222
ASN A 224
HIS A 231
 MN  A1001 (-3.5A)
MN  A1001 ( 4.9A)
None
MN  A1001 (-3.6A)
 1.02A 5m8rA-3wqoA:
undetectable		 5m8rA-3wqoA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A  60
HIS A 179
ASN A 180
HIS A 183
 CUO  A9001 (-3.1A)
CUO  A9001 (-3.4A)
None
CUO  A9001 (-3.4A)
 1.00A 5m8rA-4bedA:
20.5		 5m8rA-4bedA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 482
HIS A 602
ASN A 603
HIS A 606
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.4A)
None
CUO  A9002 (-3.3A)
 0.96A 5m8rA-4bedA:
20.5		 5m8rA-4bedA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 896
HIS A1015
ASN A1016
HIS A1019
 CUO  A9003 (-3.4A)
CUO  A9003 (-3.1A)
None
CUO  A9003 (-3.4A)
 1.02A 5m8rA-4bedA:
20.5		 5m8rA-4bedA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B1725
HIS B1847
ASN B1848
HIS B1851
 CUO  B9005 (-3.1A)
CUO  B9005 (-3.2A)
None
CUO  B9005 (-3.2A)
 0.84A 5m8rA-4bedB:
19.5		 5m8rA-4bedB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2141
HIS B2260
ASN B2261
HIS B2264
 CUO  B9006 (-3.1A)
CUO  B9006 (-3.2A)
None
CUO  B9006 (-3.2A)
 0.89A 5m8rA-4bedB:
19.5		 5m8rA-4bedB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2561
HIS B2670
ASN B2671
HIS B2674
 CUO  B9007 (-3.3A)
CUO  B9007 (-3.4A)
None
CUO  B9007 (-3.4A)
 0.88A 5m8rA-4bedB:
19.5		 5m8rA-4bedB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2965
HIS B3075
HIS B3079
SER B3096
 CUO  B9008 (-3.2A)
CUO  B9008 (-2.8A)
CUO  B9008 (-3.5A)
CUO  B9008 ( 4.7A)
 0.61A 5m8rA-4bedB:
19.5		 5m8rA-4bedB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS B2974
HIS B3075
ASN B3076
HIS B3079
SER B3096
 CUO  B9008 (-2.9A)
CUO  B9008 (-2.8A)
None
CUO  B9008 (-3.5A)
CUO  B9008 ( 4.7A)
 1.28A 5m8rA-4bedB:
19.5		 5m8rA-4bedB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		4 HIS B 416
ASN B 620
HIS B 453
SER B 455
 None
 0.91A 5m8rA-4etpB:
undetectable		 5m8rA-4etpB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
 0.64A 5m8rA-4gpgA:
undetectable		 5m8rA-4gpgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h14 SPIKE GLYCOPROTEIN

(Betacoronavirus
1) 		PF16451
(Spike_NTD) 		4 HIS A 143
LEU A 155
VAL A 139
SER A 158
 NAG  A1005 ( 4.1A)
None
None
None
 1.01A 5m8rA-4h14A:
undetectable		 5m8rA-4h14A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1001 ( 4.9A)
 0.76A 5m8rA-4j3qA:
15.9		 5m8rA-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 HIS A 110
HIS A 312
HIS A 288
VAL A 299
SER A 302
 CU  A1001 (-3.3A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1001 ( 4.9A)
 1.32A 5m8rA-4j3qA:
15.9		 5m8rA-4j3qA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 ASN A 771
LEU A 772
VAL A 190
SER A 193
 None
 0.96A 5m8rA-4k0eA:
undetectable		 5m8rA-4k0eA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kiw 3-DEHYDROQUINATE
DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01220
(DHquinase_II) 		4 HIS A  81
HIS A 101
LEU A  74
SER A 118
 KIW  A 500 (-3.6A)
KIW  A 500 (-4.2A)
None
None
 1.06A 5m8rA-4kiwA:
undetectable		 5m8rA-4kiwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		4 HIS A  73
HIS A 152
VAL A 153
SER A 156
 MN  A 302 ( 3.4A)
MN  A 302 (-3.4A)
None
None
 1.03A 5m8rA-4lomA:
undetectable		 5m8rA-4lomA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 ASN E 794
LEU E 797
VAL E 670
SER E 711
 None
 1.04A 5m8rA-4mh0E:
undetectable		 5m8rA-4mh0E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes) 		PF13365
(Trypsin_2) 		4 HIS A 148
LEU A 209
VAL A 188
SER A 158
 None
2OY  A 301 ( 4.2A)
None
None
 0.61A 5m8rA-4nsyA:
undetectable		 5m8rA-4nsyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oje EFF-1A

(Caenorhabditis
elegans) 		PF14884
(EFF-AFF) 		4 HIS H 405
HIS H  39
LEU H 463
SER H 408
 None
None
NAG  H1101 ( 4.5A)
None
 0.98A 5m8rA-4ojeH:
undetectable		 5m8rA-4ojeH:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF02112
(PDEase_II) 		4 HIS A 128
HIS A 326
HIS A 294
LEU A 295
 ZN  A 403 (-3.4A)
ZN  A 404 ( 3.3A)
G  A 402 (-3.6A)
None
 0.91A 5m8rA-4ojxA:
undetectable		 5m8rA-4ojxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF02112
(PDEase_II) 		4 HIS A 213
HIS A 133
HIS A 326
SER A 281
 ZN  A 403 ( 3.3A)
ZN  A 404 (-3.3A)
ZN  A 404 ( 3.3A)
None
 0.98A 5m8rA-4ojxA:
undetectable		 5m8rA-4ojxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
 1.07A 5m8rA-4qk3A:
undetectable		 5m8rA-4qk3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 HIS A  90
HIS A 178
VAL A 254
SER A 258
 None
3YN  A 503 (-4.3A)
None
None
 1.03A 5m8rA-4rvhA:
undetectable		 5m8rA-4rvhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubq BETA-LACTAMASE

(Acinetobacter
baumannii) 		no annotation 4 HIS A 198
HIS A 140
HIS A  78
SER A  83
 ZN  A 302 ( 3.8A)
ZN  A 301 ( 3.3A)
ZN  A 301 (-3.4A)
None
 1.00A 5m8rA-4ubqA:
undetectable		 5m8rA-4ubqA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 HIS A 581
LEU A 575
VAL A 596
SER A 550
 None
 0.92A 5m8rA-4wjlA:
undetectable		 5m8rA-4wjlA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 HIS A 227
HIS A 379
ASN A 380
HIS A 383
VAL A 406
 CU  A 801 (-3.2A)
CU  A 802 (-3.2A)
None
CU  A 802 (-3.2A)
None
 0.61A 5m8rA-4yzwA:
7.2		 5m8rA-4yzwA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 326
HIS A 268
HIS A 244
LEU A 243
VAL A 359
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.7A)
None
None
 1.39A 5m8rA-4zr0A:
undetectable		 5m8rA-4zr0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		5 HIS A 326
HIS A 268
HIS A 244
LEU A 243
VAL A 359
 ZN  A 401 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
None
None
 1.40A 5m8rA-4zr1A:
undetectable		 5m8rA-4zr1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		4 HIS A 205
ASN A  45
LEU A  43
VAL A  49
 None
 1.04A 5m8rA-4zwvA:
undetectable		 5m8rA-4zwvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE

(Streptomyces
hygroscopicus) 		no annotation 5 HIS A 195
HIS A 193
LEU A 224
VAL A 126
SER A 125
 None
 1.46A 5m8rA-5a3kA:
undetectable		 5m8rA-5a3kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 4 HIS A 215
HIS A 157
HIS A  95
SER A 100
 ZN  A2002 ( 3.0A)
ZN  A2001 ( 3.3A)
ZN  A2001 ( 3.4A)
None
 0.96A 5m8rA-5b3rA:
undetectable		 5m8rA-5b3rA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 HIS A 108
HIS A 239
ASN A 240
HIS A 243
LEU A 244
 CU  A 402 ( 3.2A)
CU  A 401 ( 3.2A)
None
CU  A 401 ( 3.2A)
None
 0.28A 5m8rA-5ce9A:
20.3		 5m8rA-5ce9A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
None
520  A 302 ( 4.9A)
 1.06A 5m8rA-5cjfA:
undetectable		 5m8rA-5cjfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1u 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00701
(DHDPS) 		4 HIS A 122
LEU A 119
VAL A 107
SER A 106
 None
 0.98A 5m8rA-5f1uA:
undetectable		 5m8rA-5f1uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		5 HIS A  60
HIS A 204
ASN A 205
HIS A 208
VAL A 218
 ZN  A 301 ( 3.2A)
ZN  A 302 ( 3.4A)
HQE  A 303 (-3.4A)
HQE  A 303 ( 3.0A)
HQE  A 303 (-3.3A)
 0.15A 5m8rA-5i3aA:
33.4		 5m8rA-5i3aA:
25.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		7 HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
 0.25A 5m8rA-5m8tA:
69.1		 5m8rA-5m8tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 5 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
None
 0.69A 5m8rA-5or4A:
26.5		 5m8rA-5or4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 5 HIS A 110
HIS A 312
HIS A 288
VAL A 299
SER A 302
 CU  A2001 (-3.3A)
CU  A2002 (-3.1A)
CU  A2002 (-3.2A)
None
None
 1.37A 5m8rA-5or4A:
26.5		 5m8rA-5or4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		4 HIS A 320
ASN A 321
HIS A 324
LEU A 325
 None
 0.80A 5m8rA-5wayA:
undetectable		 5m8rA-5wayA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp0 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Aliivibrio
fischeri) 		PF02540
(NAD_synthase) 		4 HIS A 120
ASN A 119
HIS A 116
VAL A 139
 None
 0.74A 5m8rA-5wp0A:
undetectable		 5m8rA-5wp0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhz PROBABLE
ENDONUCLEASE 4

(Mycobacterium
tuberculosis) 		no annotation 4 HIS A 191
HIS A 165
ASN A 130
HIS A  96
 ZN  A 305 (-3.2A)
ZN  A 306 ( 3.2A)
None
ZN  A 304 ( 3.1A)
 1.01A 5m8rA-5zhzA:
undetectable		 5m8rA-5zhzA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6auj THYMIDYLATE SYNTHASE

(Elizabethkingia
anophelis) 		PF00303
(Thymidylat_synt) 		4 HIS A 155
HIS A 209
LEU A 169
SER A 188
 M0H  A 154 ( 4.1A)
None
None
None
 1.05A 5m8rA-6aujA:
undetectable		 5m8rA-6aujA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 HIS A 818
LEU A 820
VAL A 829
SER A 826
 None
 1.04A 5m8rA-6b3eA:
undetectable		 5m8rA-6b3eA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 4 HIS B 220
HIS B 375
HIS B 379
SER B 422
 None
 0.65A 5m8rA-6eysB:
undetectable		 5m8rA-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 4 HIS A  66
HIS A 138
VAL A 139
SER A 142
 MN  A 202 ( 3.4A)
MN  A 202 (-3.5A)
None
None
 1.04A 5m8rA-6fwhA:
undetectable		 5m8rA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-) 		no annotation 4 HIS A 253
LEU A 252
VAL A 349
SER A 352
 None
 1.05A 5m8rA-6g3uA:
undetectable		 5m8rA-6g3uA:
undetectable