SIMILAR PATTERNS OF AMINO ACIDS FOR 5M6G_A_SORA711_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		7 GLY A  57
ASP A  95
ARG A 158
LYS A 206
HIS A 207
MET A 250
GLU A 491
 None
IDD  A 621 (-2.7A)
IDD  A 621 (-2.9A)
IDD  A 621 (-3.1A)
IDD  A 621 (-3.7A)
IDD  A 621 (-3.8A)
IDD  A 621 (-2.8A)
 0.95A 5m6gA-1lq2A:
57.3		 5m6gA-1lq2A:
46.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		11 LEU A  54
GLY A  56
ASP A  95
PHE A 144
ARG A 158
LYS A 206
HIS A 207
MET A 250
MET A 316
TRP A 430
GLU A 491
 None
IDD  A 621 ( 4.0A)
IDD  A 621 (-2.7A)
IDD  A 621 ( 4.7A)
IDD  A 621 (-2.9A)
IDD  A 621 (-3.1A)
IDD  A 621 (-3.7A)
IDD  A 621 (-3.8A)
IDD  A 621 ( 4.3A)
None
IDD  A 621 (-2.8A)
 0.31A 5m6gA-1lq2A:
57.3		 5m6gA-1lq2A:
46.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 ASP A  58
ARG A 130
LYS A 163
HIS A 164
MET A 207
GLU A 458
 GOL  A1726 (-3.1A)
GOL  A1726 ( 3.9A)
GOL  A1726 (-2.9A)
GOL  A1726 (-4.6A)
GOL  A1726 ( 4.0A)
GOL  A1726 ( 4.7A)
 0.37A 5m6gA-2x40A:
35.3		 5m6gA-2x40A:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		6 ASP A  45
ARG A 113
LYS A 146
HIS A 147
MET A 190
GLU A 590
 GOL  A5001 (-3.1A)
None
GOL  A5001 (-2.9A)
None
GOL  A5001 (-3.8A)
GOL  A5001 ( 4.6A)
 0.43A 5m6gA-3abzA:
34.6		 5m6gA-3abzA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		5 ASP A  62
PHE A 114
LYS A 160
HIS A 161
MET A 204
 NP6  A 341 (-3.0A)
None
NP6  A 341 (-3.0A)
NP6  A 341 (-3.6A)
NP6  A 341 (-3.5A)
 0.52A 5m6gA-3gs6A:
24.8		 5m6gA-3gs6A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ASP A 123
PHE A 173
ARG A 191
LYS A 221
HIS A 222
 None
None
PEG  A 645 ( 3.5A)
None
PEG  A 645 (-3.3A)
 1.18A 5m6gA-3lk6A:
33.5		 5m6gA-3lk6A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ASP A 123
PHE A 173
LYS A 221
HIS A 222
MET A 267
 None
None
None
PEG  A 645 (-3.3A)
None
 0.73A 5m6gA-3lk6A:
33.5		 5m6gA-3lk6A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Salmonella
enterica) 		PF00290
(Trp_syntA) 		5 LEU A 209
GLY A 230
PHE A   8
ARG A  14
GLU A  16
 None
 1.28A 5m6gA-3pr2A:
9.0		 5m6gA-3pr2A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3

(Deinococcus
radiodurans) 		PF00933
(Glyco_hydro_3) 		6 ASP A  77
PHE A 127
LYS A 175
HIS A 176
MET A 220
MET A 288
 None
 0.79A 5m6gA-3tevA:
28.9		 5m6gA-3tevA:
23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		10 ASP A  84
PHE A 128
ARG A 142
LYS A 181
HIS A 182
MET A 225
TYR A 262
MET A 292
TRP A 400
GLU A 488
 BGC  A 776 (-2.8A)
BGC  A 776 (-4.4A)
BGC  A 776 (-2.9A)
BGC  A 776 (-2.7A)
BGC  A 776 (-4.1A)
BGC  A 776 (-3.7A)
None
BGC  A 776 ( 3.8A)
None
BGC  A 776 ( 3.1A)
 0.48A 5m6gA-3u4aA:
38.1		 5m6gA-3u4aA:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		9 LEU A  63
ASP A 109
PHE A 158
ARG A 172
HIS A 215
MET A 258
MET A 320
TRP A 432
GLU A 493
 None
 1.00A 5m6gA-3uszA:
36.1		 5m6gA-3uszA:
37.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		6 LEU A  63
ASP A 109
PHE A 158
LYS A 214
HIS A 215
MET A 258
 None
 1.03A 5m6gA-3uszA:
36.1		 5m6gA-3uszA:
37.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		7 LEU A  63
GLY A  65
PHE A 158
ARG A 172
HIS A 215
MET A 258
MET A 320
 None
 0.79A 5m6gA-3uszA:
36.1		 5m6gA-3uszA:
37.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		5 ASP A  63
PHE A 112
ARG A 130
LYS A 160
MET A 207
 None
 1.18A 5m6gA-3wo8A:
29.7		 5m6gA-3wo8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		5 ASP A  63
PHE A 112
LYS A 160
HIS A 161
MET A 207
 None
 0.51A 5m6gA-3wo8A:
29.7		 5m6gA-3wo8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		5 LEU A  33
PHE A 112
ARG A 130
LYS A 160
MET A 207
 None
 1.21A 5m6gA-3wo8A:
29.7		 5m6gA-3wo8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		5 LEU A  33
PHE A 112
LYS A 160
HIS A 161
MET A 207
 None
 0.90A 5m6gA-3wo8A:
29.7		 5m6gA-3wo8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 ASP A  61
ARG A 125
LYS A 158
HIS A 159
MET A 201
GLU A 441
 None
 0.46A 5m6gA-3zz1A:
30.5		 5m6gA-3zz1A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		5 ASP A  62
PHE A 117
LYS A 163
HIS A 164
MET A 210
 NDG  A 401 ( 3.0A)
NDG  A 401 ( 4.7A)
NDG  A 401 ( 2.9A)
NDG  A 401 ( 3.6A)
NDG  A 401 ( 4.3A)
 0.71A 5m6gA-4gvfA:
25.3		 5m6gA-4gvfA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		7 ASP A  98
ARG A 162
LYS A 195
HIS A 196
MET A 238
MET A 291
GLU A 578
 BGC  A 901 (-2.9A)
BGC  A 901 (-3.0A)
BGC  A 901 (-2.8A)
BGC  A 901 (-4.0A)
BGC  A 901 (-4.1A)
BGC  A 901 ( 4.0A)
BGC  A 901 (-3.2A)
 0.41A 5m6gA-4i3gA:
32.2		 5m6gA-4i3gA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 ASP A  92
ARG A 156
LYS A 189
HIS A 190
MET A 245
GLU A 509
 BGC  A 942 (-2.8A)
BGC  A 942 (-2.9A)
BGC  A 942 (-2.8A)
BGC  A 942 (-4.1A)
BGC  A 942 (-4.0A)
BGC  A 942 (-3.1A)
 0.42A 5m6gA-4iigA:
32.9		 5m6gA-4iigA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		5 ASP A 126
PHE A 177
LYS A 225
HIS A 226
MET A 270
 FMT  A 404 (-4.0A)
None
None
ACT  A 401 (-3.5A)
None
 0.44A 5m6gA-4yyfA:
29.4		 5m6gA-4yyfA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		5 ASP A  80
LYS A 179
HIS A 180
MET A 229
MET A 297
 None
 0.39A 5m6gA-4zm6A:
33.7		 5m6gA-4zm6A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		10 LEU A  61
ASP A  91
PHE A 135
ARG A 149
LYS A 191
HIS A 192
MET A 235
MET A 302
TRP A 409
GLU A 473
 None
BGC  A 802 (-3.0A)
BGC  A 802 (-4.3A)
BGC  A 802 (-2.7A)
BGC  A 802 (-2.7A)
BGC  A 802 (-4.0A)
BGC  A 802 (-3.8A)
BGC  A 802 ( 3.7A)
BGC  A 803 (-3.4A)
BGC  A 801 ( 2.8A)
 0.66A 5m6gA-4zo6A:
37.8		 5m6gA-4zo6A:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		7 LEU A  61
GLY A  62
ASP A  91
PHE A 135
LYS A 191
MET A 235
MET A 302
 None
None
BGC  A 802 (-3.0A)
BGC  A 802 (-4.3A)
BGC  A 802 (-2.7A)
BGC  A 802 (-3.8A)
BGC  A 802 ( 3.7A)
 1.46A 5m6gA-4zo6A:
37.8		 5m6gA-4zo6A:
29.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ARG A 166
LYS A 206
HIS A 207
MET A 254
GLU A 492
 GOL  A1922 (-2.8A)
GOL  A1922 (-3.0A)
GOL  A1922 (-3.9A)
GOL  A1922 ( 3.7A)
TRS  A1920 (-2.9A)
 0.63A 5m6gA-5a7mA:
11.7		 5m6gA-5a7mA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		5 ASP A  63
PHE A 112
ARG A 130
LYS A 160
MET A 207
 None
None
CD  A 501 ( 4.5A)
None
None
 1.18A 5m6gA-5bzaA:
29.1		 5m6gA-5bzaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		5 ASP A  63
PHE A 112
LYS A 160
HIS A 161
MET A 207
 None
None
None
CD  A 501 (-4.0A)
None
 0.45A 5m6gA-5bzaA:
29.1		 5m6gA-5bzaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxu FERULIC ACID
ESTERASE AMCE1/FAE1A

(Anaeromyces
mucronatus) 		PF00756
(Esterase) 		5 LEU A  65
GLY A  64
PHE A 114
HIS A 196
TYR A 122
 None
 1.40A 5m6gA-5cxuA:
undetectable		 5m6gA-5cxuA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 ASP A  93
ARG A 157
LYS A 190
HIS A 191
MET A 246
GLU A 510
 EDO  A1881 (-2.9A)
None
EDO  A1881 (-3.1A)
None
EDO  A1881 (-3.8A)
EDO  A1872 ( 4.9A)
 0.43A 5m6gA-5fjiA:
30.1		 5m6gA-5fjiA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 ASP A  93
ARG A 157
LYS A 190
HIS A 191
MET A 246
GLU A 510
 PEG  A6002 (-3.3A)
None
None
None
None
None
 0.43A 5m6gA-5fjjA:
28.0		 5m6gA-5fjjA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A 144
GLY A 140
ARG A  10
TYR A 181
GLU A 169
 None
 1.49A 5m6gA-5fkuA:
undetectable		 5m6gA-5fkuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5u BETA-HEXOSAMINIDASE

(Pseudomonas
aeruginosa) 		PF00933
(Glyco_hydro_3) 		5 ASP A  62
PHE A 114
LYS A 161
HIS A 162
MET A 206
 None
 0.84A 5m6gA-5g5uA:
22.0		 5m6gA-5g5uA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		10 LEU A  94
ASP A 131
PHE A 180
ARG A 194
LYS A 235
HIS A 236
MET A 279
MET A 347
TRP A 454
GLU A 534
 None
BGC  A 801 (-3.0A)
BGC  A 801 ( 4.7A)
BGC  A 801 (-2.9A)
BGC  A 801 (-2.8A)
BGC  A 801 (-4.1A)
BGC  A 801 (-3.6A)
BGC  A 801 ( 3.7A)
None
BGC  A 801 (-2.6A)
 0.42A 5m6gA-5jp0A:
41.9		 5m6gA-5jp0A:
32.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 ASP A  92
ARG A 156
LYS A 189
HIS A 190
MET A 242
GLU A 505
 BGC  A 946 (-3.0A)
BGC  A 946 (-2.9A)
BGC  A 946 (-2.5A)
BGC  A 946 (-3.7A)
BGC  A 946 (-3.9A)
BGC  A 946 (-3.3A)
 0.47A 5m6gA-5ju6A:
31.0		 5m6gA-5ju6A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 ASP A 532
ARG A 597
LYS A 630
HIS A 631
MET A 674
GLU A 143
 GAL  A1000 (-3.1A)
GAL  A1000 (-3.1A)
GAL  A1000 (-3.0A)
GAL  A1000 (-4.3A)
GAL  A1000 ( 3.9A)
GAL  A1000 (-3.4A)
 0.35A 5m6gA-5k6oA:
18.6		 5m6gA-5k6oA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 LEU A 690
GLY A 691
PHE A 658
HIS A 660
MET A 682
 None
 1.32A 5m6gA-5k8dA:
undetectable		 5m6gA-5k8dA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 5 ASP A 129
PHE A 178
MET A 275
TRP A 448
GLU A 195
 SOR  A 711 (-3.1A)
SOR  A 711 (-4.6A)
SOR  A 711 (-3.9A)
None
None
 1.43A 5m6gA-5m6gA:
70.0		 5m6gA-5m6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 7 GLY A  92
ASP A 129
ARG A 192
LYS A 231
HIS A 232
MET A 275
GLU A 505
 SOR  A 711 (-4.1A)
SOR  A 711 (-3.1A)
SOR  A 711 ( 3.0A)
SOR  A 711 (-2.5A)
GOL  A 709 ( 3.4A)
SOR  A 711 (-3.9A)
SOR  A 711 (-3.5A)
 0.93A 5m6gA-5m6gA:
70.0		 5m6gA-5m6gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 12 LEU A  89
GLY A  91
ASP A 129
PHE A 178
ARG A 192
LYS A 231
HIS A 232
MET A 275
TYR A 311
MET A 340
TRP A 448
GLU A 505
 None
SOR  A 711 (-3.5A)
SOR  A 711 (-3.1A)
SOR  A 711 (-4.6A)
SOR  A 711 ( 3.0A)
SOR  A 711 (-2.5A)
GOL  A 709 ( 3.4A)
SOR  A 711 (-3.9A)
SOR  A 711 ( 4.6A)
SOR  A 711 ( 3.7A)
None
SOR  A 711 (-3.5A)
 0.00A 5m6gA-5m6gA:
70.0		 5m6gA-5m6gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 6 ASP A  88
ARG A 152
LYS A 185
HIS A 186
MET A 241
GLU A 505
 None
 0.47A 5m6gA-5nbsA:
32.9		 5m6gA-5nbsA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		10 LEU A  82
ASP A 112
PHE A 156
ARG A 170
LYS A 213
HIS A 214
MET A 257
MET A 323
TRP A 437
GLU A 525
 None
EDO  A 802 (-2.9A)
EDO  A 802 (-4.0A)
None
EDO  A 802 ( 3.8A)
None
EDO  A 802 (-3.5A)
EDO  A 802 (-3.6A)
None
None
 0.45A 5m6gA-5tf0A:
38.4		 5m6gA-5tf0A:
32.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 5 ASP A  44
ARG A 120
LYS A 153
HIS A 154
MET A 197
 GOL  A 801 (-3.0A)
GOL  A 801 (-3.6A)
GOL  A 801 (-3.4A)
GOL  A 801 (-4.0A)
GOL  A 801 (-3.7A)
 0.60A 5m6gA-5wabA:
31.6		 5m6gA-5wabA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 6 ASP A 570
ARG A 635
LYS A 668
HIS A 669
MET A 712
GLU A 168
 None
 0.58A 5m6gA-5wugA:
19.2		 5m6gA-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 LEU A  18
GLY A 242
PHE A 414
HIS A 386
MET A 390
 None
 1.30A 5m6gA-5xwbA:
undetectable		 5m6gA-5xwbA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 10 ASP A 110
PHE A 154
ARG A 168
LYS A 207
HIS A 208
MET A 251
TYR A 287
MET A 317
TRP A 435
GLU A 523
 BGC  A 802 (-3.0A)
BGC  A 802 (-4.4A)
BGC  A 802 (-3.0A)
BGC  A 802 (-2.9A)
BGC  A 802 (-4.1A)
BGC  A 802 (-3.7A)
None
BGC  A 802 ( 3.8A)
None
BGC  A 802 (-2.6A)
 0.43A 5m6gA-5xxoA:
43.5		 5m6gA-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 10 LEU A  67
ASP A  96
PHE A 145
ARG A 159
LYS A 202
HIS A 203
MET A 246
MET A 314
TRP A 422
GLU A 524
 None
BGC  A 801 (-3.0A)
BGC  A 801 (-4.6A)
BGC  A 801 (-2.6A)
BGC  A 801 (-2.8A)
BGC  A 801 (-3.9A)
BGC  A 801 (-3.7A)
BGC  A 801 (-4.3A)
None
BGC  A 801 (-2.6A)
 0.56A 5m6gA-5z9sA:
37.9		 5m6gA-5z9sA:
undetectable