SIMILAR PATTERNS OF AMINO ACIDS FOR 5M67_C_ACTC504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		4 ASP A 260
ILE A 191
ARG A 193
ARG A 262
 None
 1.43A 5m67C-2q4aA:
0.0		 5m67C-2q4aA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9i PUTATIVE PHAGE
CAPSID PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 4 ASP A  51
ILE A  54
ARG A  58
ARG A  10
 None
 1.34A 5m67C-2r9iA:
undetectable		 5m67C-2r9iA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 ASP A 230
ILE A 231
ARG A 225
ARG A  19
 None
 1.29A 5m67C-3eq1A:
0.0		 5m67C-3eq1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		4 ASP A 321
ILE A 272
ARG A 276
ARG A 324
 None
 1.42A 5m67C-3hgqA:
undetectable		 5m67C-3hgqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilw DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF00521
(DNA_topoisoIV) 		4 ASP A 454
ILE A 451
ARG A 442
ARG A 387
 None
 1.09A 5m67C-3ilwA:
0.0		 5m67C-3ilwA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ASP A 474
ILE A 477
ARG A  72
ARG A 476
 None
 1.32A 5m67C-3mcxA:
0.0		 5m67C-3mcxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9r UNCHARACTERIZED
PROTEIN YOL086W-A
UNCHARACTERIZED
PROTEIN YDL160C-A

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF15630
(CENP-S)
PF09415
(CENP-X) 		4 ASP B  35
ILE B  36
ARG A  86
ARG A  21
 None
 1.28A 5m67C-3v9rB:
undetectable		 5m67C-3v9rB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A 227
ILE A 207
ARG A 205
ARG A 253
 None
 1.37A 5m67C-4rcnA:
0.5		 5m67C-4rcnA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrf TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Bacillus cereus) 		PF01047
(MarR) 		4 ASP A  77
ILE A  76
ARG A  83
ARG A  74
 None
GOL  A 207 ( 4.5A)
GOL  A 207 (-4.5A)
None
 1.23A 5m67C-4xrfA:
0.6		 5m67C-4xrfA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f84 O-GLUCOSYLTRANSFERAS
E RUMI

(Drosophila
melanogaster) 		PF05686
(Glyco_transf_90) 		4 ASP A 238
ILE A 241
ARG A 245
ARG A 232
 None
 1.26A 5m67C-5f84A:
2.6		 5m67C-5f84A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ASP A 113
ILE A  93
ARG A  81
ARG A  92
 None
 1.43A 5m67C-5facA:
1.1		 5m67C-5facA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASP A 690
ILE A 695
ARG A 654
ARG A 450
 None
None
None
SO4  A1001 (-3.7A)
 1.37A 5m67C-5k6oA:
1.3		 5m67C-5k6oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0v PROTEIN
O-GLUCOSYLTRANSFERAS
E 1

(Homo sapiens) 		PF05686
(Glyco_transf_90) 		4 ASP A 219
ILE A 222
ARG A 226
ARG A 213
 None
 1.34A 5m67C-5l0vA:
2.4		 5m67C-5l0vA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 4 ASP A 138
ILE A 137
ARG A  80
ARG A 140
 None
 1.45A 5m67C-5wmmA:
5.4		 5m67C-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 ASP A 728
ILE A 733
ARG A 692
ARG A 488
 None
 1.46A 5m67C-5wugA:
2.2		 5m67C-5wugA:
undetectable