SIMILAR PATTERNS OF AMINO ACIDS FOR 5M67_B_ACTB505

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ASP A 211
ILE A 215
ARG A 638
ARG A 562
 None
 1.02A 5m67B-1nl3A:
1.0		 5m67B-1nl3A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 ASP A 836
ILE A 834
ARG A 672
ARG A 808
 None
 1.02A 5m67B-2q1fA:
0.0		 5m67B-2q1fA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		4 ASP A 284
ILE A 288
ARG A 158
ARG A 287
 None
None
SO4  A 802 (-4.1A)
SO4  A 802 ( 4.0A)
 1.02A 5m67B-2q4aA:
0.0		 5m67B-2q4aA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		4 ASP A 308
ILE A 307
ARG A  12
ARG A 304
 None
 1.40A 5m67B-3hbaA:
2.9		 5m67B-3hbaA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm PRE-MRNA-SPLICING
FACTOR 6

(Saccharomyces
cerevisiae) 		PF06424
(PRP1_N) 		4 ASP G 712
ILE G 725
ARG G 728
ARG G 721
 None
 1.36A 5m67B-3jcmG:
0.0		 5m67B-3jcmG:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ny7 SULFATE TRANSPORTER

(Escherichia
coli) 		PF01740
(STAS) 		4 ASP A 449
ILE A 480
ARG A 513
ARG A 479
 None
 1.42A 5m67B-3ny7A:
0.0		 5m67B-3ny7A:
13.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ASP A 344
ILE A 349
ARG A 353
ARG A 382
 None
 0.11A 5m67B-4lvcA:
68.8		 5m67B-4lvcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 ASP A  19
ILE A  17
ARG A 185
ARG A   6
 None
 0.99A 5m67B-4qfeA:
1.5		 5m67B-4qfeA:
21.52