SIMILAR PATTERNS OF AMINO ACIDS FOR 5M66_D_ADND502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amy 1,4-ALPHA-D-GLUCAN
GLUCANOHYDROLASE

(Hordeum vulgare) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		3 THR A 248
THR A 242
LEU A   3
 None
 0.59A 5m66D-1amyA:
undetectable		 5m66D-1amyA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		3 THR A 179
THR A 205
LEU A 244
 None
 0.56A 5m66D-1dl2A:
undetectable		 5m66D-1dl2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		3 THR A 179
THR A 209
LEU A 244
 None
 0.69A 5m66D-1dl2A:
undetectable		 5m66D-1dl2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 THR C  83
THR C   5
LEU C 292
 None
 0.57A 5m66D-1n8yC:
undetectable		 5m66D-1n8yC:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		3 THR A 100
THR A  91
LEU A  76
 None
 0.70A 5m66D-1tf1A:
undetectable		 5m66D-1tf1A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugk SYNAPTOTAGMIN IV

(Homo sapiens) 		PF00168
(C2) 		3 THR A  68
THR A  62
LEU A  11
 None
 0.58A 5m66D-1ugkA:
undetectable		 5m66D-1ugkA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		3 THR A 183
THR A  21
LEU A 176
 None
 0.68A 5m66D-1ulsA:
8.9		 5m66D-1ulsA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w15 SYNAPTOTAGMIN IV

(Rattus
norvegicus) 		PF00168
(C2) 		3 THR A 349
THR A 343
LEU A 291
 None
 0.63A 5m66D-1w15A:
undetectable		 5m66D-1w15A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 THR A 516
THR A 533
LEU A 170
 None
 0.69A 5m66D-1wkbA:
undetectable		 5m66D-1wkbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		3 THR A 366
THR A 484
LEU A 384
 None
 0.60A 5m66D-1xocA:
undetectable		 5m66D-1xocA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		3 THR A1339
THR A1356
LEU A1293
 None
 0.57A 5m66D-1xv5A:
4.1		 5m66D-1xv5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318

(Archaeoglobus
fulgidus) 		PF02171
(Piwi) 		3 THR A 265
THR A 250
LEU A 292
 None
 0.60A 5m66D-1ytuA:
2.4		 5m66D-1ytuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 THR A 424
THR A 241
LEU A 318
 None
None
NAG  A2005 (-4.7A)
 0.65A 5m66D-1zpuA:
undetectable		 5m66D-1zpuA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btw ALR0975 PROTEIN

(Nostoc sp. PCC
7120) 		PF05023
(Phytochelatin) 		3 THR A  89
THR A 109
LEU A  79
 None
 0.63A 5m66D-2btwA:
undetectable		 5m66D-2btwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN

(Thermus
thermophilus) 		PF00890
(FAD_binding_2)
PF07992
(Pyr_redox_2) 		3 THR A 106
THR A  92
LEU A  28
 FAD  A2304 (-4.3A)
None
None
 0.71A 5m66D-2cvjA:
3.1		 5m66D-2cvjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 THR A 468
THR A 492
LEU A 481
 None
 0.71A 5m66D-2db3A:
undetectable		 5m66D-2db3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enp B/K PROTEIN

(Homo sapiens) 		PF00168
(C2) 		3 THR A  78
THR A  72
LEU A  15
 None
 0.59A 5m66D-2enpA:
undetectable		 5m66D-2enpA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		3 THR A 204
THR A 193
LEU A 120
 None
 0.68A 5m66D-2j0wA:
undetectable		 5m66D-2j0wA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzb ADENOSYLCOBINAMIDE-P
HOSPHATE
GUANYLYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF12804
(NTP_transf_3) 		3 THR A  56
THR A  75
LEU A   4
 None
 0.56A 5m66D-2mzbA:
2.4		 5m66D-2mzbA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE

(Homo sapiens) 		PF00168
(C2) 		3 THR A  60
THR A  54
LEU A 135
 None
 0.55A 5m66D-2nq3A:
undetectable		 5m66D-2nq3A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsq E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
PROTEIN

(Homo sapiens) 		PF00168
(C2) 		3 THR A  69
THR A  63
LEU A 146
 None
 0.53A 5m66D-2nsqA:
undetectable		 5m66D-2nsqA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR

(Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS)
PF07924
(NuiA) 		3 THR B 135
THR A 200
LEU A 234
 MG  A 303 ( 2.9A)
None
None
 0.70A 5m66D-2o3bB:
undetectable		 5m66D-2o3bB:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2

(Homo sapiens) 		PF00293
(NUDIX) 		3 THR A 194
THR A 168
LEU A  66
 None
 0.32A 5m66D-2pnyA:
undetectable		 5m66D-2pnyA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 THR B  57
THR B  93
LEU B 215
 None
 0.70A 5m66D-2po2B:
undetectable		 5m66D-2po2B:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		3 THR A 206
THR A 170
LEU A  30
 FAD  A 600 (-4.0A)
None
None
 0.57A 5m66D-2r4jA:
3.1		 5m66D-2r4jA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzp PROTEIN KINASE C
GAMMA TYPE

(Homo sapiens) 		PF00168
(C2) 		3 THR A 218
THR A 212
LEU A 161
 None
 0.63A 5m66D-2uzpA:
undetectable		 5m66D-2uzpA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		3 THR A  31
THR A 329
LEU A 208
 None
 0.47A 5m66D-2uzzA:
2.8		 5m66D-2uzzA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		3 THR A 702
THR A 389
LEU A 734
 None
 0.63A 5m66D-2yn9A:
3.9		 5m66D-2yn9A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 THR A  14
THR A 124
LEU A 200
 None
 0.71A 5m66D-2yv2A:
2.4		 5m66D-2yv2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a58 EXOCYST COMPLEX
COMPONENT SEC3

(Saccharomyces
cerevisiae) 		PF15277
(Sec3-PIP2_bind) 		3 THR A 110
THR A 200
LEU A  78
 None
 0.70A 5m66D-3a58A:
undetectable		 5m66D-3a58A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czq PUTATIVE
POLYPHOSPHATE KINASE
2

(Sinorhizobium
meliloti) 		PF03976
(PPK2) 		3 THR A 104
THR A 272
LEU A 292
 None
 0.71A 5m66D-3czqA:
2.1		 5m66D-3czqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 3 THR A 221
THR A 203
LEU A 187
 None
 0.66A 5m66D-3dadA:
undetectable		 5m66D-3dadA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 THR A1257
THR A1301
LEU A1413
 None
 0.58A 5m66D-3ecqA:
undetectable		 5m66D-3ecqA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		3 THR A 329
THR A 356
LEU A 506
 None
 0.69A 5m66D-3eo7A:
undetectable		 5m66D-3eo7A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		3 THR A 291
THR A 337
LEU A 332
 None
 0.66A 5m66D-3eqnA:
undetectable		 5m66D-3eqnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f00 SYNAPTOTAGMIN-1

(Homo sapiens) 		PF00168
(C2) 		3 THR A 201
THR A 195
LEU A 145
 None
 0.65A 5m66D-3f00A:
undetectable		 5m66D-3f00A:
16.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 THR A  67
THR A 200
LEU A 385
 RAB  A 602 (-4.5A)
NAD  A 601 ( 2.9A)
NAD  A 601 ( 4.1A)
 0.69A 5m66D-3glqA:
60.9		 5m66D-3glqA:
65.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 THR A  57
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.50A 5m66D-3h9uA:
57.4		 5m66D-3h9uA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn8 SYNAPTOTAGMIN-3

(Rattus
norvegicus) 		PF00168
(C2) 		3 THR A 491
THR A 485
LEU A 433
 None
 0.65A 5m66D-3hn8A:
undetectable		 5m66D-3hn8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz8 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Neisseria
meningitidis) 		PF13462
(Thioredoxin_4) 		3 THR A 198
THR A 178
LEU A  35
 None
 0.68A 5m66D-3hz8A:
undetectable		 5m66D-3hz8A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jts MHC CLASS I
MAMU-A*02

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 THR A 240
THR A 187
LEU A 266
 None
 0.64A 5m66D-3jtsA:
undetectable		 5m66D-3jtsA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3leq UNCHARACTERIZED
PROTEIN CVNB5

(Streptomyces
avermitilis) 		PF03259
(Robl_LC7) 		3 THR A  56
THR A 103
LEU A  80
 None
 0.69A 5m66D-3leqA:
undetectable		 5m66D-3leqA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljn HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF00023
(Ank)
PF12796
(Ank_2) 		3 THR A 256
THR A 241
LEU A 216
 None
 0.51A 5m66D-3ljnA:
undetectable		 5m66D-3ljnA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		3 THR A  36
THR A  53
LEU A  65
 None
 0.49A 5m66D-3m19A:
undetectable		 5m66D-3m19A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mez MANNOSE-SPECIFIC
LECTIN 3 CHAIN 2

(Crocus vernus) 		PF01453
(B_lectin) 		3 THR B  78
THR B  84
LEU B  63
 None
 0.62A 5m66D-3mezB:
undetectable		 5m66D-3mezB:
13.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 THR A  60
THR A 193
LEU A 378
 ADN  A 500 (-4.6A)
NAD  A 550 ( 3.0A)
NAD  A 550 (-4.3A)
 0.67A 5m66D-3n58A:
61.9		 5m66D-3n58A:
69.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0p SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		3 THR A 215
THR A 220
LEU A 252
 None
 0.52A 5m66D-3o0pA:
undetectable		 5m66D-3o0pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oit OS07G0271500 PROTEIN

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 THR A 204
THR A  54
LEU A 219
 None
 0.68A 5m66D-3oitA:
undetectable		 5m66D-3oitA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okf 3-DEHYDROQUINATE
SYNTHASE

(Vibrio cholerae) 		PF01761
(DHQ_synthase) 		3 THR A 175
THR A 220
LEU A  26
 None
 0.66A 5m66D-3okfA:
4.0		 5m66D-3okfA:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 THR A  67
THR A 206
LEU A 395
 ADE  A 506 (-4.5A)
NAD  A 501 (-2.8A)
NAD  A 501 (-4.2A)
 0.44A 5m66D-3oneA:
57.1		 5m66D-3oneA:
62.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5t DUF3298 FAMILY
PROTEIN

(Bacteroides
fragilis) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		3 THR A 232
THR A 252
LEU A 206
 None
 0.70A 5m66D-3s5tA:
undetectable		 5m66D-3s5tA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		3 THR A 781
THR A 631
LEU A 796
 None
 0.61A 5m66D-3tsyA:
5.2		 5m66D-3tsyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 THR A  41
THR A  82
LEU A 240
 None
 0.71A 5m66D-3ttsA:
2.1		 5m66D-3ttsA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		3 THR A 143
THR A 110
LEU A  36
 FAD  A 551 ( 4.3A)
None
None
 0.62A 5m66D-3up4A:
2.8		 5m66D-3up4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wn6 ALPHA-AMYLASE

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF07821
(Alpha-amyl_C2) 		3 THR A 273
THR A 267
LEU A  28
 None
 0.45A 5m66D-3wn6A:
undetectable		 5m66D-3wn6A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woy CLIP-ASSOCIATING
PROTEIN 2

(Homo sapiens) 		PF12348
(CLASP_N) 		3 THR A 181
THR A 159
LEU A  99
 None
 0.69A 5m66D-3woyA:
undetectable		 5m66D-3woyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		3 THR A  77
THR A  94
LEU A 106
 None
 0.50A 5m66D-3zyiA:
undetectable		 5m66D-3zyiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		3 THR A  90
THR A 107
LEU A 119
 None
 0.58A 5m66D-3zynA:
undetectable		 5m66D-3zynA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		3 THR B 489
THR B 469
LEU B 514
 None
 0.47A 5m66D-4bwcB:
undetectable		 5m66D-4bwcB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0m RAS-RELATED PROTEIN
RAB-11A

(Homo sapiens) 		PF00071
(Ras) 		3 THR B  98
THR B 153
LEU B  88
 None
 0.69A 5m66D-4d0mB:
undetectable		 5m66D-4d0mB:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Clostridioides
difficile) 		PF00590
(TP_methylase) 		3 THR A 195
THR A 221
LEU A  37
 None
 0.69A 5m66D-4e16A:
undetectable		 5m66D-4e16A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imv RICIN

(Ricinus
communis) 		PF00161
(RIP) 		3 THR A 163
THR A 156
LEU A  68
 None
 0.69A 5m66D-4imvA:
undetectable		 5m66D-4imvA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 THR A  46
THR A  83
LEU A 121
 None
 0.65A 5m66D-4jhmA:
undetectable		 5m66D-4jhmA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkz TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		3 THR A  99
THR A 108
LEU A  26
 None
 0.62A 5m66D-4jkzA:
undetectable		 5m66D-4jkzA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf9 GLUTATHIONE
S-TRANSFERASE
PROTEIN

(Ralstonia
solanacearum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 THR A 200
THR A  13
LEU A 125
 None
ACT  A 408 (-4.7A)
None
 0.59A 5m66D-4kf9A:
undetectable		 5m66D-4kf9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		3 THR A  88
THR A  97
LEU A 272
 None
 0.55A 5m66D-4knaA:
4.5		 5m66D-4knaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcv DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA

(Rattus
norvegicus) 		PF00168
(C2) 		3 THR A 188
THR A 182
LEU A 130
 None
 0.70A 5m66D-4lcvA:
undetectable		 5m66D-4lcvA:
15.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 THR A  63
THR A 198
LEU A 383
 ADN  A 501 (-4.5A)
NAD  A 503 ( 2.9A)
NAD  A 503 ( 3.9A)
 0.23A 5m66D-4lvcA:
68.3		 5m66D-4lvcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjj DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN ALPHA

(Homo sapiens) 		PF00168
(C2) 		3 THR A 151
THR A 145
LEU A  93
 None
 0.65A 5m66D-4mjjA:
undetectable		 5m66D-4mjjA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4np9 RABPHILIN-3A

(Rattus
norvegicus) 		PF00168
(C2) 		3 THR A 444
THR A 438
LEU A 386
 None
 0.63A 5m66D-4np9A:
undetectable		 5m66D-4np9A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN

(Vibrio cholerae) 		PF00501
(AMP-binding) 		3 THR A 346
THR A 103
LEU A 409
 None
 0.59A 5m66D-4oxiA:
5.2		 5m66D-4oxiA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa8 PUTATIVE LIPOPROTEIN
LPRF

(Mycobacterium
bovis) 		PF07161
(LppX_LprAFG) 		3 THR A 220
THR A  69
LEU A 215
 None
 0.65A 5m66D-4qa8A:
undetectable		 5m66D-4qa8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq2 PUTATIVE
PHYCOERYTHRIN LYASE

(Guillardia
theta) 		PF09367
(CpeS) 		3 THR A  53
THR A  85
LEU A  99
 None
 0.54A 5m66D-4tq2A:
undetectable		 5m66D-4tq2A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2

(Drosophila
melanogaster) 		PF00168
(C2) 		3 THR A 900
THR A 894
LEU A 842
 None
 0.59A 5m66D-4ts6A:
undetectable		 5m66D-4ts6A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui1 HEMOJUVELIN

(Homo sapiens) 		PF06535
(RGM_N) 		3 THR C 125
THR C  50
LEU C 113
 None
 0.64A 5m66D-4ui1C:
undetectable		 5m66D-4ui1C:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 THR A1257
THR A1301
LEU A1413
 None
 0.63A 5m66D-5a55A:
undetectable		 5m66D-5a55A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		3 THR A 693
THR A 380
LEU A 725
 None
 0.55A 5m66D-5aw4A:
3.6		 5m66D-5aw4A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		3 THR A 196
THR A 256
LEU A 233
 None
 0.69A 5m66D-5bwiA:
undetectable		 5m66D-5bwiA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus) 		PF08241
(Methyltransf_11) 		3 THR A  91
THR A  72
LEU A 228
 SAH  A 301 (-4.2A)
None
None
 0.69A 5m66D-5gm2A:
2.3		 5m66D-5gm2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		3 THR A 268
THR A 230
LEU A 164
 None
 0.69A 5m66D-5hmqA:
undetectable		 5m66D-5hmqA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 THR A 173
THR A 392
LEU A 406
 ATP  A 601 (-3.3A)
None
ATP  A 601 (-4.5A)
 0.69A 5m66D-5ie2A:
4.6		 5m66D-5ie2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 3 THR B  67
THR B  61
LEU B 134
 None
 0.68A 5m66D-5iz5B:
2.8		 5m66D-5iz5B:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8h ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Psychrobacter
arcticus) 		PF13393
(tRNA-synt_His) 		3 THR A 160
THR A 305
LEU A 241
 None
MPD  A 406 (-3.8A)
None
 0.62A 5m66D-5m8hA:
undetectable		 5m66D-5m8hA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6

(Schizosaccharomyces
pombe) 		no annotation 3 THR A 597
THR B 602
LEU B 644
 None
 0.66A 5m66D-5mg8A:
undetectable		 5m66D-5mg8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n48 FIBRONECTIN
NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		no annotation 3 THR A 104
THR B1301
LEU A   7
 None
 0.62A 5m66D-5n48A:
undetectable		 5m66D-5n48A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L24,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL

(Homo sapiens) 		PF00181
(Ribosomal_L2)
PF00467
(KOW)
PF03947
(Ribosomal_L2_C)
PF17136
(ribosomal_L24) 		3 THR d 263
THR V 107
LEU d  78
 None
 0.70A 5m66D-5oold:
undetectable		 5m66D-5oold:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owc -

(-) 		no annotation 3 THR A 101
THR A  16
LEU A 108
 None
PEG  A 208 (-4.0A)
None
 0.63A 5m66D-5owcA:
undetectable		 5m66D-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		3 THR A  92
THR A 101
LEU A 276
 None
 0.57A 5m66D-5u0lA:
4.5		 5m66D-5u0lA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 3 THR A 194
THR A  44
LEU A 209
 None
 0.68A 5m66D-5uc5A:
undetectable		 5m66D-5uc5A:
9.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 THR A  58
THR A 212
LEU A 401
 SAH  A 502 (-4.2A)
NAD  A 501 ( 4.1A)
NAD  A 501 (-4.1A)
 0.50A 5m66D-5utuA:
54.1		 5m66D-5utuA:
51.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		3 THR B2639
THR B2584
LEU B2594
 None
 0.58A 5m66D-5v4bB:
undetectable		 5m66D-5v4bB:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 THR A  64
THR A 198
LEU A 386
 ADN  A 502 (-4.4A)
NAD  A 501 ( 2.9A)
NAD  A 501 (-3.9A)
 0.22A 5m66D-5v96A:
62.1		 5m66D-5v96A:
62.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 THR A 557
THR A 337
LEU A 218
 None
 0.69A 5m66D-5vocA:
undetectable		 5m66D-5vocA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxv ISOCHORISMATE LYASE

(Vibrio
anguillarum) 		no annotation 3 THR A 140
THR A 131
LEU A  36
 None
 0.64A 5m66D-5wxvA:
2.7		 5m66D-5wxvA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Homo sapiens) 		no annotation 3 THR i 132
THR i 333
LEU i 218
 PLX  g 201 (-4.0A)
None
None
 0.65A 5m66D-5xtci:
undetectable		 5m66D-5xtci:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1 -

(-) 		no annotation 3 THR C  98
THR C 171
LEU C 127
 None
 0.67A 5m66D-6dw1C:
undetectable		 5m66D-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1 -

(-) 		no annotation 3 THR C 214
THR C  98
LEU C 132
 None
 0.65A 5m66D-6dw1C:
undetectable		 5m66D-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 3 THR C 627
THR C 612
LEU C 600
 None
 0.49A 5m66D-6en4C:
undetectable		 5m66D-6en4C:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 3 THR B  66
THR B 165
LEU B 373
 ADN  B 502 (-4.6A)
NAD  B 501 ( 2.8A)
NAD  B 501 ( 3.9A)
 0.28A 5m66D-6f3mB:
53.3		 5m66D-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 3 THR A  61
THR A 160
LEU A 347
 ADN  A 501 (-4.6A)
NAD  A 502 ( 2.8A)
NAD  A 502 (-3.9A)
 0.25A 5m66D-6gbnA:
31.5		 5m66D-6gbnA:
undetectable