SIMILAR PATTERNS OF AMINO ACIDS FOR 5M66_A_ADNA502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		4 GLN A 364
THR A 365
GLU A 334
LEU A 369
 None
 1.39A 5m66A-1itkA:
undetectable		 5m66A-1itkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI

(Chlamydomonas
reinhardtii;
Desulfurococcus
mucosus) 		PF00961
(LAGLIDADG_1)
PF14528
(LAGLIDADG_3) 		4 GLN A 189
THR A 186
GLU A 207
LEU A 138
 None
 1.41A 5m66A-1mowA:
undetectable		 5m66A-1mowA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		4 GLN A   5
THR A   4
GLU A  33
LEU A 318
 None
 1.38A 5m66A-1ps6A:
2.2		 5m66A-1ps6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 GLN B 478
THR B 479
GLU B 227
LEU B 257
 None
 1.23A 5m66A-1qh1B:
3.6		 5m66A-1qh1B:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9i DNA ENDONUCLEASE
I-CREI

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 GLN A  92
THR A  89
GLU A 110
LEU A  41
 None
 1.45A 5m66A-1t9iA:
undetectable		 5m66A-1t9iA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 GLN A 259
THR A 260
GLU A 192
LEU A 189
 NAD  A 600 (-3.5A)
NAD  A 600 (-4.4A)
NAD  A 600 (-2.7A)
None
 1.22A 5m66A-1x87A:
3.3		 5m66A-1x87A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		4 GLN A 499
THR A 498
GLU A 504
LEU A 508
 None
 1.32A 5m66A-2dh3A:
undetectable		 5m66A-2dh3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 GLN A 264
THR A 265
GLU A 197
LEU A 194
 NAD  A3001 (-3.9A)
NAD  A3001 (-4.2A)
NAD  A3001 (-2.7A)
None
 1.18A 5m66A-2v7gA:
7.3		 5m66A-2v7gA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 GLN A 443
THR A 444
GLU A 207
LEU A 235
 None
 1.37A 5m66A-2vsaA:
undetectable		 5m66A-2vsaA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2d BOTULINUM NEUROTOXIN
A HEAVY CHAIN

(Clostridium
botulinum) 		PF07952
(Toxin_trans) 		4 GLN B 557
THR B 584
GLU B 617
LEU B 773
 None
 1.43A 5m66A-2w2dB:
undetectable		 5m66A-2w2dB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w56 VC0508

(Vibrio cholerae) 		PF10980
(DUF2787) 		4 GLN A  66
THR A  67
GLU A  75
LEU A  21
 None
 1.11A 5m66A-2w56A:
undetectable		 5m66A-2w56A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLN A 434
THR A 436
GLU A 432
LEU A 314
 None
 1.44A 5m66A-2yp2A:
undetectable		 5m66A-2yp2A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A

(Homo sapiens) 		PF02373
(JmjC) 		4 GLN A 308
THR A 218
GLU A 315
LEU A 241
 None
 1.45A 5m66A-2yu1A:
undetectable		 5m66A-2yu1A:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLN A  73
THR A  74
GLU A 218
LEU A 407
 ADN  A 500 (-3.6A)
ADN  A 500 (-4.5A)
ADN  A 500 (-2.6A)
NAD  A 550 (-4.2A)
 1.07A 5m66A-3ce6A:
60.8		 5m66A-3ce6A:
58.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 272
THR A 239
GLU A 286
LEU A 217
 None
 1.31A 5m66A-3coiA:
undetectable		 5m66A-3coiA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7n D-RIBOSE
HIGH-AFFINITY
TRANSPORT SYSTEM

(Salmonella
enterica) 		PF05025
(RbsD_FucU) 		4 GLN A 108
THR A 104
GLU A  72
LEU A  31
 None
None
None
EDO  A 300 (-4.3A)
 1.48A 5m66A-3e7nA:
undetectable		 5m66A-3e7nA:
14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLN A  56
THR A  57
GLU A 155
LEU A 343
 ADN  A 438 (-3.8A)
ADN  A 438 (-4.6A)
ADN  A 438 (-3.8A)
NAD  A 439 ( 4.0A)
 0.64A 5m66A-3g1uA:
57.0		 5m66A-3g1uA:
60.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLN A  66
THR A  67
GLU A 199
LEU A 385
 RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
RAB  A 602 (-4.6A)
NAD  A 601 ( 4.1A)
 0.66A 5m66A-3glqA:
61.3		 5m66A-3glqA:
65.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLN A  56
THR A  57
GLU A 155
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-4.0A)
 0.30A 5m66A-3h9uA:
57.4		 5m66A-3h9uA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 GLN A 325
THR A 324
GLU A 312
LEU A 333
 None
 1.37A 5m66A-3kbhA:
undetectable		 5m66A-3kbhA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C

(Homo sapiens) 		PF02828
(L27)
PF09058
(L27_1) 		4 GLN A   9
THR A   8
GLU A  54
LEU A 189
 None
 1.06A 5m66A-3lraA:
undetectable		 5m66A-3lraA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		4 GLN A 181
THR A 182
GLU A 134
LEU A 153
 None
 1.48A 5m66A-3m19A:
undetectable		 5m66A-3m19A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx9 PROTEIN SCV3V2(G19S)

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 GLN A 283
THR A 280
GLU A 301
LEU A 232
 None
 1.37A 5m66A-3mx9A:
undetectable		 5m66A-3mx9A:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLN A  59
THR A  60
GLU A 192
LEU A 378
 K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
ADN  A 500 (-3.6A)
NAD  A 550 (-4.3A)
 0.56A 5m66A-3n58A:
62.2		 5m66A-3n58A:
69.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		4 GLN A  61
THR A  59
GLU A 103
LEU A 111
 None
 1.41A 5m66A-3odmA:
3.0		 5m66A-3odmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 PLEXIN-B1

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		4 GLN B 141
THR B 140
GLU B 201
LEU B 165
 None
 1.32A 5m66A-3ol2B:
undetectable		 5m66A-3ol2B:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLN A  66
THR A  67
GLU A 205
LEU A 395
 ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
None
NAD  A 501 (-4.2A)
 0.36A 5m66A-3oneA:
57.6		 5m66A-3oneA:
62.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4n UNCHARACTERIZED
PROTEIN MJ0754

(Methanocaldococcus
jannaschii) 		PF09968
(DUF2202) 		4 GLN A  55
THR A  56
GLU A  28
LEU A  65
 None
 1.44A 5m66A-3q4nA:
undetectable		 5m66A-3q4nA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 GLN A 115
THR A 118
GLU A 610
LEU A 658
 None
 1.45A 5m66A-3zzuA:
3.4		 5m66A-3zzuA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		4 GLN A 442
THR A 441
GLU A 436
LEU A  64
 None
 1.42A 5m66A-4b3kA:
undetectable		 5m66A-4b3kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 GLN A 211
THR A 212
GLU A 650
LEU A 407
 None
 1.36A 5m66A-4bevA:
2.4		 5m66A-4bevA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		4 GLN A 355
THR A 359
GLU A  80
LEU A 161
 None
 1.08A 5m66A-4dteA:
undetectable		 5m66A-4dteA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jed GLUTATHIONE
S-TRANSFERASE

(Methylobacterium
radiotolerans) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 GLN A 131
THR A 112
GLU A 177
LEU A 139
 None
 1.30A 5m66A-4jedA:
undetectable		 5m66A-4jedA:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLN A  62
THR A  63
GLU A 197
LEU A 383
 NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
ADN  A 501 (-3.6A)
NAD  A 503 ( 3.9A)
 0.15A 5m66A-4lvcA:
68.9		 5m66A-4lvcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A

(Mus musculus) 		PF02373
(JmjC) 		4 GLN A 308
THR A 218
GLU A 315
LEU A 241
 None
 1.49A 5m66A-4qx8A:
undetectable		 5m66A-4qx8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzp ENGINEERED PROTEIN
OR366

(synthetic
construct) 		PF00514
(Arm)
PF13646
(HEAT_2) 		4 GLN A  19
THR A  12
GLU A  51
LEU A  68
 None
 1.50A 5m66A-4rzpA:
undetectable		 5m66A-4rzpA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F

(Staphylococcus
aureus) 		PF01370
(Epimerase) 		4 GLN A  34
THR A  35
GLU A  30
LEU A  53
 None
 1.26A 5m66A-4yrdA:
6.4		 5m66A-4yrdA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 GLN A 127
THR A 128
GLU A  82
LEU A  99
 None
 1.33A 5m66A-4z64A:
undetectable		 5m66A-4z64A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLN A 947
THR A 927
GLU A 860
LEU A 877
 None
 1.08A 5m66A-4zdnA:
undetectable		 5m66A-4zdnA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1

(Fervidobacterium
islandicum) 		PF02074
(Peptidase_M32) 		4 GLN A 105
THR A 101
GLU A  39
LEU A  21
 None
 1.35A 5m66A-5e3xA:
undetectable		 5m66A-5e3xA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04390
(LptE)
PF04453
(OstA_C) 		4 GLN A 553
THR B  66
GLU B  77
LEU B 123
 None
 1.32A 5m66A-5ixmA:
undetectable		 5m66A-5ixmA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLN A 932
THR A 933
GLU A 448
LEU A 921
 None
 1.37A 5m66A-5j6sA:
undetectable		 5m66A-5j6sA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		4 GLN A1126
THR A1122
GLU A1203
LEU A1134
 None
 1.29A 5m66A-5jbeA:
undetectable		 5m66A-5jbeA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 GLN A 227
THR B 104
GLU A 236
LEU A 216
 None
 1.21A 5m66A-5mkkA:
undetectable		 5m66A-5mkkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 GLN A1009
THR A1011
GLU A 838
LEU A1001
 None
 1.41A 5m66A-5t8vA:
undetectable		 5m66A-5t8vA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1b MTRE
PROTEIN,FERRITIN
CHIMERA

(Helicobacter
pylori;
Neisseria
gonorrhoeae) 		no annotation 4 GLN A  69
THR A  71
GLU A  12
LEU A  57
 None
 1.40A 5m66A-5u1bA:
undetectable		 5m66A-5u1bA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6t ENDO-1,4-BETA-MANNAN
ASE

(Eisenia fetida) 		no annotation 4 GLN A  44
THR A  59
GLU A  64
LEU A  78
 None
 1.45A 5m66A-5y6tA:
undetectable		 5m66A-5y6tA:
10.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLN A  62
THR A  63
GLU A 161
LEU A 349
 ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
ADN  A 501 (-2.5A)
NAD  A 500 ( 4.3A)
 1.07A 5m66A-6aphA:
58.1		 5m66A-6aphA:
60.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 4 GLN A 302
THR A 285
GLU A 272
LEU A  34
 None
 1.39A 5m66A-6cj7A:
undetectable		 5m66A-6cj7A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 4 GLN A 302
THR A 285
GLU A 272
LEU A  35
 None
 1.46A 5m66A-6cj7A:
undetectable		 5m66A-6cj7A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 4 GLN B  65
THR B  66
GLU B 164
LEU B 373
 K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
ADN  B 502 (-3.6A)
NAD  B 501 ( 3.9A)
 0.21A 5m66A-6f3mB:
53.4		 5m66A-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 4 GLN A  60
THR A  61
GLU A 159
LEU A 347
 NA  A 503 ( 3.2A)
ADN  A 501 (-4.6A)
ADN  A 501 (-3.9A)
NAD  A 502 (-3.9A)
 0.18A 5m66A-6gbnA:
58.1		 5m66A-6gbnA:
undetectable