SIMILAR PATTERNS OF AMINO ACIDS FOR 5M5K_C_ADNC502_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5l | UREASE (ALPHASUBUNIT) (Klebsiellaaerogenes) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | GLN C 208THR C 171THR C 490LEU C 505 | None | 1.46A | 5m5kC-1a5lC:3.5 | 5m5kC-1a5lC:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1amu | GRAMICIDINSYNTHETASE 1 (Brevibacillusbrevis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | GLN A 356THR A 31THR A 334LEU A 210 | None | 1.44A | 5m5kC-1amuA:undetectable | 5m5kC-1amuA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | GLN B 210THR B 173THR B 492LEU B 507 | None | 1.48A | 5m5kC-1e9yB:2.3 | 5m5kC-1e9yB:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | GLN B 342THR B 343THR B 251LEU B 318 | None | 1.16A | 5m5kC-1e9yB:2.3 | 5m5kC-1e9yB:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l4i | SFAE PROTEIN (Escherichiacoli) |
PF00345(PapD_N)PF02753(PapD_C) | 4 | GLN A 170THR A 146THR A 151LEU A 114 | None | 1.39A | 5m5kC-1l4iA:undetectable | 5m5kC-1l4iA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lfp | HYPOTHETICAL PROTEINAQ_1575 (Aquifexaeolicus) |
PF01709(Transcrip_reg) | 4 | GLN A 55THR A 51THR A 175LEU A 187 | None | 1.46A | 5m5kC-1lfpA:undetectable | 5m5kC-1lfpA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ml4 | ASPARTATETRANSCARBAMOYLASE (Pyrococcusabyssi) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | GLN A 138THR A 137THR A 49LEU A 60 | PAL A 385 (-4.7A)NoneNoneNone | 1.40A | 5m5kC-1ml4A:4.8 | 5m5kC-1ml4A:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nfd | N15 ALPHA-BETAT-CELL RECEPTOR (Mus musculus) |
PF07686(V-set)PF09291(DUF1968) | 4 | GLN A 5THR A 4THR A 30LEU A 66 | None | 1.27A | 5m5kC-1nfdA:undetectable | 5m5kC-1nfdA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pem | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2ALPHA CHAIN (Salmonellaenterica) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF08343(RNR_N) | 4 | GLN A 158THR A 161THR A 110LEU A 103 | None | 1.38A | 5m5kC-1pemA:undetectable | 5m5kC-1pemA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wd3 | ALPHA-L-ARABINOFURANOSIDASE B (Aspergilluskawachii) |
PF05270(AbfB)PF09206(ArabFuran-catal) | 4 | GLN A 103THR A 144THR A 37LEU A 52 | None | 1.15A | 5m5kC-1wd3A:undetectable | 5m5kC-1wd3A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xip | NUCLEOPORIN NUP159 (Saccharomycescerevisiae) |
PF16755(NUP214) | 4 | GLN A 311THR A 10THR A 266LEU A 227 | None | 1.49A | 5m5kC-1xipA:undetectable | 5m5kC-1xipA:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a81 | CARB (Pectobacteriumcarotovorum) |
PF00378(ECH_1) | 4 | GLN A 220THR A 221THR A 148LEU A 91 | None | 1.14A | 5m5kC-2a81A:undetectable | 5m5kC-2a81A:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | GLN A1126THR A1398THR A1268LEU A1483 | None | 1.38A | 5m5kC-2b39A:undetectable | 5m5kC-2b39A:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cc0 | ACETYL-XYLANESTERASE (Streptomyceslividans) |
PF01522(Polysacc_deac_1) | 4 | GLN A 170THR A 171THR A 161LEU A 26 | None | 1.48A | 5m5kC-2cc0A:2.0 | 5m5kC-2cc0A:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ela | ADAPTER PROTEINCONTAINING PHDOMAIN, PTB DOMAINAND LEUCINE ZIPPERMOTIF 1 (Homo sapiens) |
PF00640(PID) | 4 | GLN A 560THR A 559THR A 541LEU A 564 | None | 1.23A | 5m5kC-2elaA:undetectable | 5m5kC-2elaA:16.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hro | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Staphylococcuscarnosus) |
PF00391(PEP-utilizers)PF02896(PEP-utilizers_C)PF05524(PEP-utilisers_N) | 4 | GLN A 510THR A 511THR A 454LEU A 521 | None | 1.11A | 5m5kC-2hroA:undetectable | 5m5kC-2hroA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2puq | TISSUE FACTOR (Homo sapiens) |
PF01108(Tissue_fac)PF09294(Interfer-bind) | 4 | GLN T 190THR T 203THR T 106LEU T 143 | None | 1.34A | 5m5kC-2puqT:undetectable | 5m5kC-2puqT:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rk5 | PUTATIVE HEMOLYSIN (Streptococcusmutans) |
PF03471(CorC_HlyC) | 4 | GLN A 3THR A 19THR A 29LEU A 70 | None | 1.36A | 5m5kC-2rk5A:undetectable | 5m5kC-2rk5A:12.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsk | HEMAGGLUTININ-NEURAMINIDASE (Hendrahenipavirus) |
PF00423(HN) | 4 | GLN A 559THR A 507THR A 563LEU A 551 | None | 1.24A | 5m5kC-2vskA:undetectable | 5m5kC-2vskA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xt0 | HALOALKANEDEHALOGENASE (Plesiocystispacifica) |
PF00561(Abhydrolase_1) | 4 | GLN A 236THR A 235THR A 241LEU A 130 | None | 1.34A | 5m5kC-2xt0A:2.5 | 5m5kC-2xt0A:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3any | ETHANOLAMINEAMMONIA-LYASE HEAVYCHAIN (Escherichiacoli) |
PF06751(EutB) | 4 | GLN A 405THR A 366THR A 325LEU A 379 | None | 1.16A | 5m5kC-3anyA:undetectable | 5m5kC-3anyA:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bgk | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcusmutans) |
PF01256(Carb_kinase) | 4 | GLN A 146THR A 144THR A 150LEU A 96 | None | 1.45A | 5m5kC-3bgkA:6.3 | 5m5kC-3bgkA:20.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLN A 73THR A 74THR A 219LEU A 407 | ADN A 500 (-3.6A)ADN A 500 (-4.5A)NAD A 550 ( 2.8A)NAD A 550 (-4.2A) | 0.68A | 5m5kC-3ce6A:57.5 | 5m5kC-3ce6A:58.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0m | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRA/MSRB 1 (Streptococcuspneumoniae) |
PF01625(PMSR)PF01641(SelR) | 4 | GLN A 35THR A 47THR A 52LEU A 128 | None | 1.28A | 5m5kC-3e0mA:undetectable | 5m5kC-3e0mA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqn | GLUCAN1,3-BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF12708(Pectate_lyase_3) | 4 | GLN A 292THR A 291THR A 337LEU A 332 | None | 0.84A | 5m5kC-3eqnA:undetectable | 5m5kC-3eqnA:22.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLN A 56THR A 57THR A 156LEU A 343 | ADN A 438 (-3.8A)ADN A 438 (-4.6A)NAD A 439 ( 3.0A)NAD A 439 ( 4.0A) | 0.64A | 5m5kC-3g1uA:54.6 | 5m5kC-3g1uA:60.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLN A 66THR A 67THR A 200LEU A 385 | RAB A 602 (-3.9A)RAB A 602 (-4.5A)NAD A 601 ( 2.9A)NAD A 601 ( 4.1A) | 0.57A | 5m5kC-3glqA:60.6 | 5m5kC-3glqA:65.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLN A 56THR A 57THR A 156LEU A 343 | ADN A 439 (-3.6A)ADN A 439 (-4.7A)NAD A 438 (-3.8A)NAD A 438 (-4.0A) | 0.44A | 5m5kC-3h9uA:57.0 | 5m5kC-3h9uA:58.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ip1 | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Thermotogamaritima) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | GLN A 74THR A 75THR A 87LEU A 93 | None | 1.41A | 5m5kC-3ip1A:7.0 | 5m5kC-3ip1A:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jts | MHC CLASS IMAMU-A*02 (Macaca mulatta) |
PF00129(MHC_I)PF07654(C1-set) | 4 | GLN A 218THR A 216THR A 187LEU A 266 | None | 1.36A | 5m5kC-3jtsA:undetectable | 5m5kC-3jtsA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm6 | STAGE V SPORULATIONPROTEIN AD (Bacillussubtilis) |
PF07451(SpoVAD) | 4 | GLN A 7THR A 186THR A 232LEU A 247 | None | 1.40A | 5m5kC-3lm6A:undetectable | 5m5kC-3lm6A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lma | STAGE V SPORULATIONPROTEIN AD (SPOVAD) (Bacilluslicheniformis) |
PF07451(SpoVAD) | 4 | GLN A 7THR A 186THR A 232LEU A 247 | None | 1.35A | 5m5kC-3lmaA:undetectable | 5m5kC-3lmaA:21.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLN A 59THR A 60THR A 193LEU A 378 | K A 2 ( 3.3A)ADN A 500 (-4.6A)NAD A 550 ( 3.0A)NAD A 550 (-4.3A) | 0.55A | 5m5kC-3n58A:61.9 | 5m5kC-3n58A:69.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLN A 66THR A 67THR A 206LEU A 395 | ADE A 506 (-3.8A)ADE A 506 (-4.5A)NAD A 501 (-2.8A)NAD A 501 (-4.2A) | 0.36A | 5m5kC-3oneA:57.2 | 5m5kC-3oneA:62.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqy | BETA CHAIN OF THE6218-TCR (Homo sapiens;Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | GLN E 242THR E 241THR E 121LEU E 126 | None | 1.38A | 5m5kC-3pqyE:undetectable | 5m5kC-3pqyE:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgk | UREASE SUBUNIT BETA2 (Helicobactermustelae) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | GLN C 209THR C 172THR C 491LEU C 506 | None | 1.49A | 5m5kC-3qgkC:undetectable | 5m5kC-3qgkC:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rha | PUTRESCINE OXIDASE (Paenarthrobacteraurescens) |
PF01593(Amino_oxidase) | 4 | GLN A 217THR A 46THR A 21LEU A 77 | NoneFDA A 483 ( 4.2A)NoneNone | 1.26A | 5m5kC-3rhaA:undetectable | 5m5kC-3rhaA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rw9 | SPERMIDINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 4 | GLN A 245THR A 237THR A 72LEU A 33 | None | 1.41A | 5m5kC-3rw9A:5.3 | 5m5kC-3rw9A:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ryt | PLEXIN-A1 (Mus musculus) |
PF08337(Plexin_cytopl) | 4 | GLN A1528THR A1527THR A1573LEU A1651 | None | 1.48A | 5m5kC-3rytA:undetectable | 5m5kC-3rytA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s2s | PUTATIVEPYRAZINAMIDASE/NICOTINAMIDASE (Streptococcusmutans) |
PF00857(Isochorismatase) | 4 | GLN A 150THR A 125THR A 140LEU A 173 | None | 1.40A | 5m5kC-3s2sA:3.1 | 5m5kC-3s2sA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4akm | LYSOSOME-ASSOCIATEDMEMBRANEGLYCOPROTEIN 3 (Homo sapiens) |
PF01299(Lamp) | 4 | GLN A 330THR A 331THR A 355LEU A 292 | None | 1.35A | 5m5kC-4akmA:undetectable | 5m5kC-4akmA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hsu | LYSINE-SPECIFICHISTONE DEMETHYLASE1B (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM)PF07496(zf-CW) | 4 | GLN A 141THR A 143THR A 160LEU A 153 | None | 1.48A | 5m5kC-4hsuA:3.1 | 5m5kC-4hsuA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lcy | HLA CLASS IHISTOCOMPATIBILITYANTIGEN, B-46 ALPHACHAIN (Homo sapiens) |
PF00129(MHC_I)PF07654(C1-set) | 4 | GLN A 218THR A 216THR A 187LEU A 266 | NoneNone NA A 301 (-2.9A)None | 1.41A | 5m5kC-4lcyA:undetectable | 5m5kC-4lcyA:20.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLN A 62THR A 63THR A 198LEU A 383 | NH4 A 502 ( 3.1A)ADN A 501 (-4.5A)NAD A 503 ( 2.9A)NAD A 503 ( 3.9A) | 0.15A | 5m5kC-4lvcA:65.2 | 5m5kC-4lvcA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6k | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Desulfovibriosalexigens) |
PF03480(DctP) | 4 | GLN A 159THR A 229THR A 235LEU A 168 | None | 1.40A | 5m5kC-4n6kA:undetectable | 5m5kC-4n6kA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pet | EXTRACELLULARSOLUTE-BINDINGPROTEIN, FAMILY 7 (Colwelliapsychrerythraea) |
PF03480(DctP) | 4 | GLN A 125THR A 114THR A 330LEU A 320 | None | 1.48A | 5m5kC-4petA:undetectable | 5m5kC-4petA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q04 | URE3-BP SEQUENCESPECIFIC DNA BINDINGPROTEIN (Entamoebahistolytica) |
PF13499(EF-hand_7) | 4 | GLN A 87THR A 88THR A 184LEU A 219 | None | 1.46A | 5m5kC-4q04A:undetectable | 5m5kC-4q04A:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvm | CITRATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00285(Citrate_synt) | 4 | GLN A 111THR A 195THR A 204LEU A 389 | None | 1.21A | 5m5kC-4tvmA:undetectable | 5m5kC-4tvmA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txd | CSC2 (Thermofilumpendens) |
no annotation | 4 | GLN A 88THR A 85THR A 156LEU A 331 | None | 1.43A | 5m5kC-4txdA:undetectable | 5m5kC-4txdA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u0g | ATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT 2 (Mycobacteriumtuberculosis) |
PF00574(CLP_protease) | 4 | GLN A 136THR A 183THR A 167LEU A 86 | NoneNoneNoneZIL A 301 ( 4.3A) | 1.49A | 5m5kC-4u0gA:undetectable | 5m5kC-4u0gA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4urj | PROTEIN FAM83A (Homo sapiens) |
PF07894(DUF1669) | 4 | GLN A 140THR A 141THR A 136LEU A 253 | NoneNoneNoneEDO A1305 ( 4.8A) | 1.45A | 5m5kC-4urjA:undetectable | 5m5kC-4urjA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xjx | HSDR (Escherichiacoli) |
PF04313(HSDR_N)PF04851(ResIII)PF12008(EcoR124_C) | 4 | GLN A 249THR A 252THR A 209LEU A 40 | None | 1.48A | 5m5kC-4xjxA:3.0 | 5m5kC-4xjxA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zfz | MAJORHISTOCOMPATIBILITYCOMPLEX CLASS I (Macaca mulatta) |
PF00129(MHC_I)PF07654(C1-set) | 4 | GLN A 218THR A 216THR A 187LEU A 266 | None | 1.43A | 5m5kC-4zfzA:undetectable | 5m5kC-4zfzA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gza | PROTEIN O-MANNOSEKINASE (Danio rerio) |
PF07714(Pkinase_Tyr) | 4 | GLN A 212THR A 209THR A 277LEU A 246 | MG A 403 (-2.6A)NoneNoneNone | 1.50A | 5m5kC-5gzaA:undetectable | 5m5kC-5gzaA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6g | H-2 CLASS IHISTOCOMPATIBILITYANTIGEN, Q10 ALPHACHAIN (Mus musculus) |
PF00129(MHC_I)PF07654(C1-set) | 4 | GLN A 218THR A 216THR A 187LEU A 266 | None | 1.48A | 5m5kC-5j6gA:undetectable | 5m5kC-5j6gA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ta1 | GLYCOSIDE HYDROLASE (Bacteroidesuniformis) |
no annotation | 4 | GLN A 635THR A 633THR A 300LEU A 318 | None | 1.49A | 5m5kC-5ta1A:undetectable | 5m5kC-5ta1A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u47 | PENICILLIN BINDINGPROTEIN 2X (Streptococcusthermophilus) |
PF00905(Transpeptidase)PF03717(PBP_dimer)PF03793(PASTA) | 4 | GLN A 484THR A 303THR A 297LEU A 270 | None | 1.38A | 5m5kC-5u47A:undetectable | 5m5kC-5u47A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wel | CHIMERA OF GLUTAMATERECEPTOR 2, GERMCELL-SPECIFIC GENE1-LIKE PROTEIN (Mus musculus;Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF07803(GSG-1)PF10613(Lig_chan-Glu_bd) | 4 | GLN A1189THR A1185THR A1093LEU A1116 | None | 1.45A | 5m5kC-5welA:4.2 | 5m5kC-5welA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y0e | - (-) |
no annotation | 4 | GLN A 57THR A 53THR A 169LEU A 153 | None | 1.36A | 5m5kC-5y0eA:undetectable | 5m5kC-5y0eA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLN A 62THR A 63THR A 162LEU A 349 | ADN A 501 (-3.8A)ADN A 501 (-4.5A)NAD A 500 ( 2.9A)NAD A 500 ( 4.3A) | 0.66A | 5m5kC-6aphA:57.7 | 5m5kC-6aphA:60.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 4 | GLN B 65THR B 66THR B 165LEU B 373 | K B 504 ( 3.0A)ADN B 502 (-4.6A)NAD B 501 ( 2.8A)NAD B 501 ( 3.9A) | 0.22A | 5m5kC-6f3mB:53.0 | 5m5kC-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbn | - (-) |
no annotation | 4 | GLN A 60THR A 61THR A 160LEU A 347 | NA A 503 ( 3.2A)ADN A 501 (-4.6A)NAD A 502 ( 2.8A)NAD A 502 (-3.9A) | 0.16A | 5m5kC-6gbnA:57.8 | 5m5kC-6gbnA:undetectable |