SIMILAR PATTERNS OF AMINO ACIDS FOR 5M5K_C_ADNC502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)


(Klebsiella
aerogenes)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 GLN C 208
THR C 171
THR C 490
LEU C 505
None
1.46A 5m5kC-1a5lC:
3.5
5m5kC-1a5lC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1


(Brevibacillus
brevis)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 GLN A 356
THR A  31
THR A 334
LEU A 210
None
1.44A 5m5kC-1amuA:
undetectable
5m5kC-1amuA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 GLN B 210
THR B 173
THR B 492
LEU B 507
None
1.48A 5m5kC-1e9yB:
2.3
5m5kC-1e9yB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 GLN B 342
THR B 343
THR B 251
LEU B 318
None
1.16A 5m5kC-1e9yB:
2.3
5m5kC-1e9yB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l4i SFAE PROTEIN

(Escherichia
coli)
PF00345
(PapD_N)
PF02753
(PapD_C)
4 GLN A 170
THR A 146
THR A 151
LEU A 114
None
1.39A 5m5kC-1l4iA:
undetectable
5m5kC-1l4iA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575


(Aquifex
aeolicus)
PF01709
(Transcrip_reg)
4 GLN A  55
THR A  51
THR A 175
LEU A 187
None
1.46A 5m5kC-1lfpA:
undetectable
5m5kC-1lfpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE


(Pyrococcus
abyssi)
PF00185
(OTCace)
PF02729
(OTCace_N)
4 GLN A 138
THR A 137
THR A  49
LEU A  60
PAL  A 385 (-4.7A)
None
None
None
1.40A 5m5kC-1ml4A:
4.8
5m5kC-1ml4A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd N15 ALPHA-BETA
T-CELL RECEPTOR


(Mus musculus)
PF07686
(V-set)
PF09291
(DUF1968)
4 GLN A   5
THR A   4
THR A  30
LEU A  66
None
1.27A 5m5kC-1nfdA:
undetectable
5m5kC-1nfdA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN


(Salmonella
enterica)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N)
4 GLN A 158
THR A 161
THR A 110
LEU A 103
None
1.38A 5m5kC-1pemA:
undetectable
5m5kC-1pemA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B


(Aspergillus
kawachii)
PF05270
(AbfB)
PF09206
(ArabFuran-catal)
4 GLN A 103
THR A 144
THR A  37
LEU A  52
None
1.15A 5m5kC-1wd3A:
undetectable
5m5kC-1wd3A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xip NUCLEOPORIN NUP159

(Saccharomyces
cerevisiae)
PF16755
(NUP214)
4 GLN A 311
THR A  10
THR A 266
LEU A 227
None
1.49A 5m5kC-1xipA:
undetectable
5m5kC-1xipA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum)
PF00378
(ECH_1)
4 GLN A 220
THR A 221
THR A 148
LEU A  91
None
1.14A 5m5kC-2a81A:
undetectable
5m5kC-2a81A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 GLN A1126
THR A1398
THR A1268
LEU A1483
None
1.38A 5m5kC-2b39A:
undetectable
5m5kC-2b39A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc0 ACETYL-XYLAN
ESTERASE


(Streptomyces
lividans)
PF01522
(Polysacc_deac_1)
4 GLN A 170
THR A 171
THR A 161
LEU A  26
None
1.48A 5m5kC-2cc0A:
2.0
5m5kC-2cc0A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ela ADAPTER PROTEIN
CONTAINING PH
DOMAIN, PTB DOMAIN
AND LEUCINE ZIPPER
MOTIF 1


(Homo sapiens)
PF00640
(PID)
4 GLN A 560
THR A 559
THR A 541
LEU A 564
None
1.23A 5m5kC-2elaA:
undetectable
5m5kC-2elaA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE


(Staphylococcus
carnosus)
PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N)
4 GLN A 510
THR A 511
THR A 454
LEU A 521
None
1.11A 5m5kC-2hroA:
undetectable
5m5kC-2hroA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puq TISSUE FACTOR

(Homo sapiens)
PF01108
(Tissue_fac)
PF09294
(Interfer-bind)
4 GLN T 190
THR T 203
THR T 106
LEU T 143
None
1.34A 5m5kC-2puqT:
undetectable
5m5kC-2puqT:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rk5 PUTATIVE HEMOLYSIN

(Streptococcus
mutans)
PF03471
(CorC_HlyC)
4 GLN A   3
THR A  19
THR A  29
LEU A  70
None
1.36A 5m5kC-2rk5A:
undetectable
5m5kC-2rk5A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsk HEMAGGLUTININ-NEURAM
INIDASE


(Hendra
henipavirus)
PF00423
(HN)
4 GLN A 559
THR A 507
THR A 563
LEU A 551
None
1.24A 5m5kC-2vskA:
undetectable
5m5kC-2vskA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE


(Plesiocystis
pacifica)
PF00561
(Abhydrolase_1)
4 GLN A 236
THR A 235
THR A 241
LEU A 130
None
1.34A 5m5kC-2xt0A:
2.5
5m5kC-2xt0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN


(Escherichia
coli)
PF06751
(EutB)
4 GLN A 405
THR A 366
THR A 325
LEU A 379
None
1.16A 5m5kC-3anyA:
undetectable
5m5kC-3anyA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgk PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
mutans)
PF01256
(Carb_kinase)
4 GLN A 146
THR A 144
THR A 150
LEU A  96
None
1.45A 5m5kC-3bgkA:
6.3
5m5kC-3bgkA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 GLN A  73
THR A  74
THR A 219
LEU A 407
ADN  A 500 (-3.6A)
ADN  A 500 (-4.5A)
NAD  A 550 ( 2.8A)
NAD  A 550 (-4.2A)
0.68A 5m5kC-3ce6A:
57.5
5m5kC-3ce6A:
58.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1


(Streptococcus
pneumoniae)
PF01625
(PMSR)
PF01641
(SelR)
4 GLN A  35
THR A  47
THR A  52
LEU A 128
None
1.28A 5m5kC-3e0mA:
undetectable
5m5kC-3e0mA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE


(Phanerochaete
chrysosporium)
PF12708
(Pectate_lyase_3)
4 GLN A 292
THR A 291
THR A 337
LEU A 332
None
0.84A 5m5kC-3eqnA:
undetectable
5m5kC-3eqnA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 GLN A  56
THR A  57
THR A 156
LEU A 343
ADN  A 438 (-3.8A)
ADN  A 438 (-4.6A)
NAD  A 439 ( 3.0A)
NAD  A 439 ( 4.0A)
0.64A 5m5kC-3g1uA:
54.6
5m5kC-3g1uA:
60.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3glq ADENOSYLHOMOCYSTEINA
SE


(Burkholderia
pseudomallei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 GLN A  66
THR A  67
THR A 200
LEU A 385
RAB  A 602 (-3.9A)
RAB  A 602 (-4.5A)
NAD  A 601 ( 2.9A)
NAD  A 601 ( 4.1A)
0.57A 5m5kC-3glqA:
60.6
5m5kC-3glqA:
65.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h9u ADENOSYLHOMOCYSTEINA
SE


(Trypanosoma
brucei)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 GLN A  56
THR A  57
THR A 156
LEU A 343
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
0.44A 5m5kC-3h9uA:
57.0
5m5kC-3h9uA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING


(Thermotoga
maritima)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 GLN A  74
THR A  75
THR A  87
LEU A  93
None
1.41A 5m5kC-3ip1A:
7.0
5m5kC-3ip1A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jts MHC CLASS I
MAMU-A*02


(Macaca mulatta)
PF00129
(MHC_I)
PF07654
(C1-set)
4 GLN A 218
THR A 216
THR A 187
LEU A 266
None
1.36A 5m5kC-3jtsA:
undetectable
5m5kC-3jtsA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD


(Bacillus
subtilis)
PF07451
(SpoVAD)
4 GLN A   7
THR A 186
THR A 232
LEU A 247
None
1.40A 5m5kC-3lm6A:
undetectable
5m5kC-3lm6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)


(Bacillus
licheniformis)
PF07451
(SpoVAD)
4 GLN A   7
THR A 186
THR A 232
LEU A 247
None
1.35A 5m5kC-3lmaA:
undetectable
5m5kC-3lmaA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n58 ADENOSYLHOMOCYSTEINA
SE


(Brucella
abortus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 GLN A  59
THR A  60
THR A 193
LEU A 378
K  A   2 ( 3.3A)
ADN  A 500 (-4.6A)
NAD  A 550 ( 3.0A)
NAD  A 550 (-4.3A)
0.55A 5m5kC-3n58A:
61.9
5m5kC-3n58A:
69.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 GLN A  66
THR A  67
THR A 206
LEU A 395
ADE  A 506 (-3.8A)
ADE  A 506 (-4.5A)
NAD  A 501 (-2.8A)
NAD  A 501 (-4.2A)
0.36A 5m5kC-3oneA:
57.2
5m5kC-3oneA:
62.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqy BETA CHAIN OF THE
6218-TCR


(Homo sapiens;
Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 GLN E 242
THR E 241
THR E 121
LEU E 126
None
1.38A 5m5kC-3pqyE:
undetectable
5m5kC-3pqyE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2


(Helicobacter
mustelae)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
4 GLN C 209
THR C 172
THR C 491
LEU C 506
None
1.49A 5m5kC-3qgkC:
undetectable
5m5kC-3qgkC:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens)
PF01593
(Amino_oxidase)
4 GLN A 217
THR A  46
THR A  21
LEU A  77
None
FDA  A 483 ( 4.2A)
None
None
1.26A 5m5kC-3rhaA:
undetectable
5m5kC-3rhaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
4 GLN A 245
THR A 237
THR A  72
LEU A  33
None
1.41A 5m5kC-3rw9A:
5.3
5m5kC-3rw9A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus)
PF08337
(Plexin_cytopl)
4 GLN A1528
THR A1527
THR A1573
LEU A1651
None
1.48A 5m5kC-3rytA:
undetectable
5m5kC-3rytA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2s PUTATIVE
PYRAZINAMIDASE/NICOT
INAMIDASE


(Streptococcus
mutans)
PF00857
(Isochorismatase)
4 GLN A 150
THR A 125
THR A 140
LEU A 173
None
1.40A 5m5kC-3s2sA:
3.1
5m5kC-3s2sA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3


(Homo sapiens)
PF01299
(Lamp)
4 GLN A 330
THR A 331
THR A 355
LEU A 292
None
1.35A 5m5kC-4akmA:
undetectable
5m5kC-4akmA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B


(Homo sapiens)
PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW)
4 GLN A 141
THR A 143
THR A 160
LEU A 153
None
1.48A 5m5kC-4hsuA:
3.1
5m5kC-4hsuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN


(Homo sapiens)
PF00129
(MHC_I)
PF07654
(C1-set)
4 GLN A 218
THR A 216
THR A 187
LEU A 266
None
None
NA  A 301 (-2.9A)
None
1.41A 5m5kC-4lcyA:
undetectable
5m5kC-4lcyA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 GLN A  62
THR A  63
THR A 198
LEU A 383
NH4  A 502 ( 3.1A)
ADN  A 501 (-4.5A)
NAD  A 503 ( 2.9A)
NAD  A 503 ( 3.9A)
0.15A 5m5kC-4lvcA:
65.2
5m5kC-4lvcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6k TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Desulfovibrio
salexigens)
PF03480
(DctP)
4 GLN A 159
THR A 229
THR A 235
LEU A 168
None
1.40A 5m5kC-4n6kA:
undetectable
5m5kC-4n6kA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7


(Colwellia
psychrerythraea)
PF03480
(DctP)
4 GLN A 125
THR A 114
THR A 330
LEU A 320
None
1.48A 5m5kC-4petA:
undetectable
5m5kC-4petA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN


(Entamoeba
histolytica)
PF13499
(EF-hand_7)
4 GLN A  87
THR A  88
THR A 184
LEU A 219
None
1.46A 5m5kC-4q04A:
undetectable
5m5kC-4q04A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis)
PF00285
(Citrate_synt)
4 GLN A 111
THR A 195
THR A 204
LEU A 389
None
1.21A 5m5kC-4tvmA:
undetectable
5m5kC-4tvmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txd CSC2

(Thermofilum
pendens)
no annotation 4 GLN A  88
THR A  85
THR A 156
LEU A 331
None
1.43A 5m5kC-4txdA:
undetectable
5m5kC-4txdA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2


(Mycobacterium
tuberculosis)
PF00574
(CLP_protease)
4 GLN A 136
THR A 183
THR A 167
LEU A  86
None
None
None
ZIL  A 301 ( 4.3A)
1.49A 5m5kC-4u0gA:
undetectable
5m5kC-4u0gA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urj PROTEIN FAM83A

(Homo sapiens)
PF07894
(DUF1669)
4 GLN A 140
THR A 141
THR A 136
LEU A 253
None
None
None
EDO  A1305 ( 4.8A)
1.45A 5m5kC-4urjA:
undetectable
5m5kC-4urjA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli)
PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C)
4 GLN A 249
THR A 252
THR A 209
LEU A  40
None
1.48A 5m5kC-4xjxA:
3.0
5m5kC-4xjxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfz MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I


(Macaca mulatta)
PF00129
(MHC_I)
PF07654
(C1-set)
4 GLN A 218
THR A 216
THR A 187
LEU A 266
None
1.43A 5m5kC-4zfzA:
undetectable
5m5kC-4zfzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE


(Danio rerio)
PF07714
(Pkinase_Tyr)
4 GLN A 212
THR A 209
THR A 277
LEU A 246
MG  A 403 (-2.6A)
None
None
None
1.50A 5m5kC-5gzaA:
undetectable
5m5kC-5gzaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6g H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN


(Mus musculus)
PF00129
(MHC_I)
PF07654
(C1-set)
4 GLN A 218
THR A 216
THR A 187
LEU A 266
None
1.48A 5m5kC-5j6gA:
undetectable
5m5kC-5j6gA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
no annotation 4 GLN A 635
THR A 633
THR A 300
LEU A 318
None
1.49A 5m5kC-5ta1A:
undetectable
5m5kC-5ta1A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X


(Streptococcus
thermophilus)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA)
4 GLN A 484
THR A 303
THR A 297
LEU A 270
None
1.38A 5m5kC-5u47A:
undetectable
5m5kC-5u47A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN


(Mus musculus;
Rattus
norvegicus)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd)
4 GLN A1189
THR A1185
THR A1093
LEU A1116
None
1.45A 5m5kC-5welA:
4.2
5m5kC-5welA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0e -

(-)
no annotation 4 GLN A  57
THR A  53
THR A 169
LEU A 153
None
1.36A 5m5kC-5y0eA:
undetectable
5m5kC-5y0eA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 GLN A  62
THR A  63
THR A 162
LEU A 349
ADN  A 501 (-3.8A)
ADN  A 501 (-4.5A)
NAD  A 500 ( 2.9A)
NAD  A 500 ( 4.3A)
0.66A 5m5kC-6aphA:
57.7
5m5kC-6aphA:
60.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 4 GLN B  65
THR B  66
THR B 165
LEU B 373
K  B 504 ( 3.0A)
ADN  B 502 (-4.6A)
NAD  B 501 ( 2.8A)
NAD  B 501 ( 3.9A)
0.22A 5m5kC-6f3mB:
53.0
5m5kC-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-)
no annotation 4 GLN A  60
THR A  61
THR A 160
LEU A 347
NA  A 503 ( 3.2A)
ADN  A 501 (-4.6A)
NAD  A 502 ( 2.8A)
NAD  A 502 (-3.9A)
0.16A 5m5kC-6gbnA:
57.8
5m5kC-6gbnA:
undetectable