SIMILAR PATTERNS OF AMINO ACIDS FOR 5M5C_E_TA1E502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE

(Leuconostoc
mesenteroides) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 VAL A  19
ASP A  18
LEU A 320
SER A 186
THR A 110
 None
None
None
PHY  A 782 ( 3.8A)
None
 1.22A 5m5cE-1ehiA:
undetectable		 5m5cE-1ehiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		5 VAL A 200
HIS A 206
THR A 252
GLY A 283
LEU A 284
 None
 1.23A 5m5cE-1epxA:
undetectable		 5m5cE-1epxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3o HYPOTHETICAL ABC
TRANSPORTER
ATP-BINDING PROTEIN
MJ0796

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		5 ASP A 170
LEU A  94
ALA A 155
GLY A 174
LEU A 176
 MG  A 301 ( 4.5A)
None
None
None
None
 1.24A 5m5cE-1f3oA:
undetectable		 5m5cE-1f3oA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi9 DIPEPTIDE TRANSPORT
PROTEIN DPPA

(Bacillus
subtilis) 		PF04951
(Peptidase_M55) 		5 LEU A  99
SER A  59
THR A 170
GLY A 135
LEU A 134
 None
 1.13A 5m5cE-1hi9A:
4.3		 5m5cE-1hi9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivh ISOVALERYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 175
ASP A 174
LEU A 103
GLY A 127
LEU A  61
 None
 1.26A 5m5cE-1ivhA:
undetectable		 5m5cE-1ivhA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		5 VAL A 159
ASP A 161
LEU A 187
ALA A 157
THR A 143
 None
 1.22A 5m5cE-1k7hA:
undetectable		 5m5cE-1k7hA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ASP A  29
LEU A  73
ALA A  76
SER A  79
THR A  88
 None
 1.06A 5m5cE-1q51A:
undetectable		 5m5cE-1q51A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 VAL A 112
GLU A 111
LEU A 129
ALA A 132
THR A 168
 None
 1.27A 5m5cE-1s4eA:
undetectable		 5m5cE-1s4eA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		5 ASP A  59
ALA A  44
SER A  54
THR A 211
LEU A 220
 EDO  A1217 (-3.5A)
None
None
None
None
 1.25A 5m5cE-1u60A:
undetectable		 5m5cE-1u60A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A 124
GLU A 125
ALA A 120
GLY A 172
LEU A 317
 None
 1.23A 5m5cE-1ub7A:
undetectable		 5m5cE-1ub7A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 VAL A 340
ALA A 282
THR A 306
GLY A 252
LEU A 335
 None
 1.16A 5m5cE-1w5eA:
23.6		 5m5cE-1w5eA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcj HYPOTHETICAL PROTEIN
TM0487

(Thermotoga
maritima) 		PF01883
(FeS_assembly_P) 		5 VAL A  18
ASP A  26
LEU A  62
ALA A  65
THR A  83
 None
 1.18A 5m5cE-1wcjA:
undetectable		 5m5cE-1wcjA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 VAL A  50
HIS B  83
THR B 267
GLY B 341
LEU B 342
 None
 1.08A 5m5cE-1wytA:
undetectable		 5m5cE-1wytA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		5 VAL A 218
HIS A 226
LEU A 224
THR A 166
GLY A 181
 None
 1.26A 5m5cE-1wzcA:
undetectable		 5m5cE-1wzcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xco PHOSPHATE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF01515
(PTA_PTB) 		5 LEU A  36
ALA A  32
THR A 318
GLY A 124
LEU A 302
 None
 1.18A 5m5cE-1xcoA:
undetectable		 5m5cE-1xcoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1j DNA EXCISION REPAIR
PROTEIN ERCC-1

(Homo sapiens) 		PF14520
(HHH_5) 		5 VAL B 288
ASP B 287
LEU B 260
THR B 256
LEU B 277
 None
None
None
None
HG  B   1 ( 3.8A)
 1.20A 5m5cE-2a1jB:
undetectable		 5m5cE-2a1jB:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens) 		PF08704
(GCD14) 		5 ASP A 192
LEU A 119
SER A 133
GLY A  83
LEU A 143
 SAM  A 601 (-3.5A)
None
None
None
None
 1.23A 5m5cE-2b25A:
2.5		 5m5cE-2b25A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		5 LEU A 269
ALA A 312
THR A 327
GLY A 349
LEU A 347
 None
 1.24A 5m5cE-2dpyA:
2.7		 5m5cE-2dpyA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enj PROTEIN KINASE C
THETA TYPE

(Homo sapiens) 		no annotation 5 ASP A  61
LEU A  32
THR A  85
GLY A   8
LEU A   9
 None
 1.23A 5m5cE-2enjA:
undetectable		 5m5cE-2enjA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 VAL A 188
GLU A 225
LEU A 139
ALA A 164
GLY A 222
 None
 1.16A 5m5cE-2gkoA:
undetectable		 5m5cE-2gkoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		5 ASP A 169
GLU A 102
LEU A  15
SER A 182
GLY A  74
 None
 1.17A 5m5cE-2greA:
undetectable		 5m5cE-2greA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		5 VAL A 320
ASP A 306
ALA A 251
GLY A  31
LEU A  32
 None
 1.11A 5m5cE-2iy9A:
2.6		 5m5cE-2iy9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		5 GLU A 481
ALA A 404
SER A 401
GLY A 307
LEU A 346
 None
None
G6Q  A1610 (-4.1A)
None
None
 1.23A 5m5cE-2j6hA:
4.4		 5m5cE-2j6hA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD

(Aquifex
aeolicus) 		PF00005
(ABC_tran) 		5 ASP A 165
LEU A  93
ALA A 150
GLY A 169
LEU A 171
 None
 1.24A 5m5cE-2pclA:
undetectable		 5m5cE-2pclA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 VAL A 194
ASP A 198
GLU A 195
LEU A 188
THR A 674
 None
 1.13A 5m5cE-2po4A:
undetectable		 5m5cE-2po4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ASP A 221
ALA A 199
SER A 200
GLY A 225
LEU A 190
 None
None
None
PLP  A 406 (-3.3A)
None
 1.03A 5m5cE-2qghA:
undetectable		 5m5cE-2qghA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 273
ALA A 224
THR A 127
GLY A 152
LEU A 151
 None
 1.12A 5m5cE-2qo3A:
undetectable		 5m5cE-2qo3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2d ZN-DEPENDENT
HYDROLASES

(Agrobacterium
fabrum) 		PF00753
(Lactamase_B) 		5 ALA A  45
SER A  44
THR A 106
GLY A 197
LEU A 198
 None
 1.18A 5m5cE-2r2dA:
undetectable		 5m5cE-2r2dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		5 ASP A 361
LEU A 295
SER A 368
GLY A 358
LEU A 357
 None
HBI  A 500 (-4.2A)
HBI  A 500 ( 4.1A)
None
None
 1.11A 5m5cE-2tohA:
undetectable		 5m5cE-2tohA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfa HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE,
HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens;
Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		5 VAL A  61
ASP A  60
LEU A  87
GLY A 188
LEU A 171
 None
 1.15A 5m5cE-2vfaA:
2.7		 5m5cE-2vfaA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 VAL A 267
ALA A 197
THR A 248
GLY A 271
LEU A 272
 None
 1.25A 5m5cE-2xd4A:
undetectable		 5m5cE-2xd4A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 VAL X 381
HIS X 297
LEU X 298
ALA X 349
THR X 289
 None
 1.22A 5m5cE-2y9eX:
undetectable		 5m5cE-2y9eX:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 VAL A  20
ALA A  38
SER A  42
GLY A 164
LEU A 165
 None
 1.24A 5m5cE-2z0mA:
undetectable		 5m5cE-2z0mA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1

(Homo sapiens) 		PF01380
(SIS) 		5 GLU A 553
ALA A 476
SER A 473
GLY A 380
LEU A 419
 None
 1.22A 5m5cE-2zj4A:
4.0		 5m5cE-2zj4A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 VAL A 604
LEU A 609
ALA A 596
GLY A 635
LEU A 397
 None
 1.27A 5m5cE-3a2fA:
undetectable		 5m5cE-3a2fA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adf MONOMERIC AZAMI
GREEN

(Galaxea
fascicularis) 		PF01353
(GFP) 		5 VAL A 157
ASP A 156
GLU A 144
LEU A 161
SER A 142
 None
None
None
None
CRQ  A  64 ( 2.8A)
 1.21A 5m5cE-3adfA:
undetectable		 5m5cE-3adfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aex THREONINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 VAL A 153
LEU A 102
ALA A  81
GLY A  86
LEU A 107
 None
None
None
AN7  A1001 (-4.2A)
None
 1.25A 5m5cE-3aexA:
2.1		 5m5cE-3aexA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 VAL A 642
GLU A 641
ALA A 761
GLY A 666
LEU A 665
 None
 1.14A 5m5cE-3ai7A:
undetectable		 5m5cE-3ai7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		5 VAL A 195
LEU A 232
THR A 273
GLY A 281
LEU A 282
 None
 1.22A 5m5cE-3bwsA:
undetectable		 5m5cE-3bwsA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		5 VAL A  33
GLU A  35
LEU A  45
ALA A  40
GLY A  10
 None
 1.17A 5m5cE-3d0qA:
2.0		 5m5cE-3d0qA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		5 VAL A 189
GLU A 226
LEU A 140
ALA A 165
GLY A 223
 None
 1.17A 5m5cE-3d43A:
2.1		 5m5cE-3d43A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dev SH1221

(Staphylococcus
haemolyticus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 VAL A 258
ASP A 259
GLU A 260
ALA A 238
SER A 239
 None
 1.26A 5m5cE-3devA:
undetectable		 5m5cE-3devA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 GLU A 217
LEU A  55
THR A 409
GLY A 225
LEU A 412
 PLP  A 450 (-4.2A)
None
None
None
None
 1.21A 5m5cE-3du4A:
undetectable		 5m5cE-3du4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 ASP A 198
LEU A 446
ALA A 373
THR A 457
GLY A 418
 None
 1.25A 5m5cE-3fahA:
undetectable		 5m5cE-3fahA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 VAL A 324
ASP A 323
LEU A 328
GLY A 315
LEU A 318
 None
 1.00A 5m5cE-3fjoA:
3.9		 5m5cE-3fjoA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpn GEOBACILLUS
STEAROTHERMOPHILUS
UVRA INTERACTION
DOMAIN
GEOBACILLUS
STEAROTHERMOPHILUS
UVRB INTERACTION
DOMAIN

(Geobacillus
stearothermophilus) 		no annotation 5 VAL B 199
ASP B 198
GLU B 215
THR A 165
LEU A 186
 None
 1.24A 5m5cE-3fpnB:
undetectable		 5m5cE-3fpnB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 VAL A 399
LEU A 163
ALA A 185
GLY A 410
LEU A 413
 None
None
None
FLC  A 451 ( 4.3A)
None
 1.23A 5m5cE-3ie1A:
undetectable		 5m5cE-3ie1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 VAL A 159
LEU A 362
ALA A 153
GLY A 131
LEU A 130
 None
 1.28A 5m5cE-3k1dA:
undetectable		 5m5cE-3k1dA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcp GLUCOKINASE

(Parabacteroides
distasonis) 		PF00480
(ROK) 		5 HIS A 362
LEU A 363
ALA A 359
SER A  70
GLY A 123
 None
 1.22A 5m5cE-3mcpA:
undetectable		 5m5cE-3mcpA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		5 LEU A 182
ALA A 185
SER A 188
GLY A 247
LEU A 222
 None
 1.19A 5m5cE-3nf2A:
undetectable		 5m5cE-3nf2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyf D-ARGININE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		5 VAL A1030
GLU A1032
ALA A1016
THR A1337
GLY A1200
 None
FAD  A1500 (-2.6A)
None
None
FAD  A1500 (-3.5A)
 1.08A 5m5cE-3nyfA:
2.1		 5m5cE-3nyfA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		5 ASP A 446
LEU A 371
ALA A 377
THR A 334
GLY A 230
 None
 1.26A 5m5cE-3ohnA:
undetectable		 5m5cE-3ohnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfs NADPH--CYTOCHROME
P450 REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		5 VAL A 347
ASP A 346
LEU A 351
GLY A 338
LEU A 341
 None
 1.06A 5m5cE-3qfsA:
4.3		 5m5cE-3qfsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9u THIOREDOXIN
REDUCTASE

(Campylobacter
jejuni) 		PF07992
(Pyr_redox_2) 		5 VAL A 230
GLU A 146
LEU A 150
ALA A 148
THR A 199
 None
 1.25A 5m5cE-3r9uA:
undetectable		 5m5cE-3r9uA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc4 SHORT CHAIN
DEHYDROGENASE
(A0QTM2 HOMOLOG)

(Mycolicibacterium
thermoresistibile) 		PF00106
(adh_short) 		5 VAL A 127
LEU A 144
SER A  11
THR A 238
GLY A 168
 None
 1.18A 5m5cE-3sc4A:
6.7		 5m5cE-3sc4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 186
ASP A 185
ALA A 115
GLY A 138
LEU A  73
 None
 1.15A 5m5cE-3sf6A:
undetectable		 5m5cE-3sf6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujk PROTEIN PHOSPHATASE
2C 77

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 VAL A 235
ALA A 254
SER A 266
GLY A 338
LEU A 339
 None
None
None
MG  A 424 ( 4.8A)
None
 1.18A 5m5cE-3ujkA:
undetectable		 5m5cE-3ujkA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 VAL A 211
ASP A 210
GLU A 229
LEU A  78
SER A 227
 ATP  A 501 (-4.1A)
None
None
None
None
 1.09A 5m5cE-3wquA:
undetectable		 5m5cE-3wquA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 VAL A 211
ASP A 210
GLU A 229
LEU A  78
SER A 227
 ATP  A 400 (-4.0A)
None
None
None
None
 1.09A 5m5cE-3wt0A:
undetectable		 5m5cE-3wt0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aez WD REPEAT-CONTAINING
PROTEIN SLP1

(Schizosaccharomyces
pombe) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 ASP A 325
ALA A 284
SER A 282
GLY A 309
LEU A 310
 None
 1.23A 5m5cE-4aezA:
undetectable		 5m5cE-4aezA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cti OSMOLARITY SENSOR
PROTEIN ENVZ, AF1503

(Archaeoglobus
fulgidus;
Escherichia
coli) 		PF00512
(HisKA)
PF00672
(HAMP)
PF02518
(HATPase_c) 		5 ASP A 385
GLU A 381
LEU A 335
ALA A 338
SER A 341
 None
 1.20A 5m5cE-4ctiA:
undetectable		 5m5cE-4ctiA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		5 ASP A 210
LEU A 341
ALA A 258
GLY A 265
LEU A 266
 None
 1.18A 5m5cE-4e3eA:
undetectable		 5m5cE-4e3eA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 VAL B  23
ALA B 100
SER B 104
GLY B  77
LEU B 118
 None
 1.09A 5m5cE-4k7gB:
undetectable		 5m5cE-4k7gB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0g PROTEIN PHOSPHATASE
2C 37

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 VAL A 225
ALA A 244
SER A 256
GLY A 328
LEU A 329
 None
 1.17A 5m5cE-4n0gA:
undetectable		 5m5cE-4n0gA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic PROBABLE PROTEIN
PHOSPHATASE 2C 6

(Oryza sativa) 		PF00481
(PP2C) 		5 VAL B 284
ALA B 303
SER B 315
GLY B 387
LEU B 388
 None
 1.18A 5m5cE-4oicB:
undetectable		 5m5cE-4oicB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovx XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		5 ASP A 165
LEU A 175
ALA A 171
SER A 160
THR A 218
 None
 1.26A 5m5cE-4ovxA:
2.7		 5m5cE-4ovxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01148
(CTP_transf_1) 		5 VAL A 156
LEU A 272
ALA A 275
SER A 278
LEU A 142
 None
 1.08A 5m5cE-4q2eA:
undetectable		 5m5cE-4q2eA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 LEU A 352
ALA A 408
THR A 415
GLY A 396
LEU A  58
 None
None
EDO  A 507 (-4.3A)
None
None
 1.12A 5m5cE-4w1wA:
undetectable		 5m5cE-4w1wA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Helicobacter
pylori) 		PF00793
(DAHP_synth_1) 		5 VAL A 233
ALA A 229
THR A 203
GLY A 237
LEU A 238
 None
 1.08A 5m5cE-4z1aA:
undetectable		 5m5cE-4z1aA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		5 VAL A  51
ASP A  52
GLU A 120
HIS A 123
GLY A  27
 None
None
SO4  A 401 ( 4.2A)
None
SO4  A 401 (-3.2A)
 1.13A 5m5cE-5b3fA:
undetectable		 5m5cE-5b3fA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP57

(Chaetomium
thermophilum) 		PF05064
(Nsp1_C)
PF13874
(Nup54) 		5 LEU E 287
ALA E 283
THR C 617
GLY E 276
LEU E 275
 None
None
OS  C 701 (-3.2A)
None
None
 1.04A 5m5cE-5cwsE:
undetectable		 5m5cE-5cwsE:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 183
ALA A 136
SER A 135
GLY A 103
LEU A 102
 None
None
None
None
ATP  A1691 ( 4.9A)
 1.19A 5m5cE-5fwmA:
undetectable		 5m5cE-5fwmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA

(Homo sapiens) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 183
ALA A 136
THR A 179
GLY A 103
LEU A 102
 None
None
ATP  A1691 (-4.4A)
None
ATP  A1691 ( 4.9A)
 1.16A 5m5cE-5fwmA:
undetectable		 5m5cE-5fwmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN

(Lavandula
lanata) 		PF01255
(Prenyltransf) 		5 LEU A 283
ALA A 286
SER A 289
THR A 116
LEU A 246
 None
 1.08A 5m5cE-5hc8A:
undetectable		 5m5cE-5hc8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 VAL A 641
LEU A 625
ALA A 624
THR A 417
GLY A 646
 None
 1.26A 5m5cE-5i4eA:
undetectable		 5m5cE-5i4eA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A  89
LEU A  44
SER A  95
THR A 212
GLY A  18
 None
 0.95A 5m5cE-5i68A:
undetectable		 5m5cE-5i68A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbe MOPR

(Acinetobacter
calcoaceticus) 		PF02830
(V4R)
PF06505
(XylR_N) 		5 ASP A  82
LEU A 159
ALA A 162
SER A 166
GLY A 107
 None
None
IPH  A 602 ( 3.9A)
IPH  A 602 (-3.6A)
None
 1.14A 5m5cE-5kbeA:
undetectable		 5m5cE-5kbeA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00146
(NADHdh)
PF00499
(Oxidored_q3) 		5 GLU H 143
LEU J  54
ALA H 107
SER H 109
GLY J  63
 None
 1.11A 5m5cE-5lc5H:
undetectable		 5m5cE-5lc5H:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 ASP A  26
HIS A 227
LEU A 228
ALA A 231
LEU A 360
 None
 0.70A 5m5cE-5mjsA:
56.7		 5m5cE-5mjsA:
58.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
ASP B  26
HIS B 229
LEU B 230
ALA B 233
THR B 276
GLY B 370
 None
 1.06A 5m5cE-5n5nB:
58.6		 5m5cE-5n5nB:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
ASP B  26
HIS B 229
SER B 236
THR B 276
GLY B 370
 None
 0.95A 5m5cE-5n5nB:
58.6		 5m5cE-5n5nB:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
ASP B  26
LEU B 230
ALA B 233
THR B 276
GLY B 370
LEU B 371
 None
 1.04A 5m5cE-5n5nB:
58.6		 5m5cE-5n5nB:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
ASP B  26
SER B 236
THR B 276
GLY B 370
LEU B 371
 None
 1.04A 5m5cE-5n5nB:
58.6		 5m5cE-5n5nB:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
GLU B  27
HIS B 229
LEU B 230
ALA B 233
THR B 276
 None
 0.99A 5m5cE-5n5nB:
58.6		 5m5cE-5n5nB:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
GLU B  27
LEU B 230
ALA B 233
THR B 276
LEU B 371
 None
 1.11A 5m5cE-5n5nB:
58.6		 5m5cE-5n5nB:
97.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyr BACTERIOPHYTOCHROME

(Xanthomonas
campestris) 		no annotation 5 VAL A 355
ASP A 354
HIS A 493
LEU A 494
GLY A 360
 None
 1.20A 5m5cE-5uyrA:
undetectable		 5m5cE-5uyrA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 5 LEU A  88
SER A 205
THR A 144
GLY A 181
LEU A 184
 None
 1.27A 5m5cE-5v9xA:
2.2		 5m5cE-5v9xA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxv PEROXISOMAL MEMBRANE
PROTEIN PEX15

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 240
SER A 244
THR A 225
GLY A 186
LEU A 187
 None
 1.24A 5m5cE-5vxvA:
undetectable		 5m5cE-5vxvA:
9.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLU B  27
LEU B 228
THR B 274
GLY B 360
LEU B 361
 TA1  B 502 (-3.6A)
None
TA1  B 502 (-4.7A)
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
 1.16A 5m5cE-5w3jB:
58.5		 5m5cE-5w3jB:
77.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		6 VAL B  23
ASP B  26
GLU B  27
LEU B 228
THR B 274
GLY B 360
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
None
TA1  B 502 (-4.7A)
TA1  B 502 (-3.6A)
 1.17A 5m5cE-5w3jB:
58.5		 5m5cE-5w3jB:
77.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL B  23
ASP B  26
SER B 234
THR B 274
GLY B 360
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 ( 4.9A)
TA1  B 502 (-4.7A)
TA1  B 502 (-3.6A)
 0.97A 5m5cE-5w3jB:
58.5		 5m5cE-5w3jB:
77.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 5 VAL A  27
ALA A 460
THR A  37
GLY A 449
LEU A 451
 None
 1.12A 5m5cE-5x8oA:
undetectable		 5m5cE-5x8oA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		5 VAL A 178
ALA A 155
SER A 156
THR A 394
GLY A 431
 None
 1.19A 5m5cE-5x9rA:
undetectable		 5m5cE-5x9rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arr ACETYL-COA
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		no annotation 5 VAL A  88
LEU A  96
ALA A  98
THR A 365
GLY A  33
 None
 1.14A 5m5cE-6arrA:
undetectable		 5m5cE-6arrA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfp VCA0883

(Vibrio cholerae) 		no annotation 5 ASP A 152
ALA A  57
SER A  56
THR A  26
GLY A 144
 None
 1.20A 5m5cE-6dfpA:
undetectable		 5m5cE-6dfpA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpd PROTEIN AB21

(Agaricus
bisporus) 		no annotation 5 VAL A 128
ALA A 134
THR A  18
GLY A  85
LEU A 187
 None
 1.20A 5m5cE-6fpdA:
undetectable		 5m5cE-6fpdA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 5 VAL A 183
ASP A 186
THR A 101
GLY A  81
LEU A  84
 None
 1.01A 5m5cE-6frvA:
undetectable		 5m5cE-6frvA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 VAL A 297
ALA A  45
THR A 287
GLY A  56
LEU A  55
 None
None
HEM  A 401 (-3.8A)
None
None
 1.16A 5m5cE-6fshA:
undetectable		 5m5cE-6fshA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-) 		no annotation 5 ALA A 524
SER A 528
THR A 381
GLY A 543
LEU A 546
 None
 1.25A 5m5cE-6g3uA:
undetectable		 5m5cE-6g3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9rub RIBULOSE-1,5-BISPHOS
PHATE CARBOXYLASE

(Rhodospirillum
rubrum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 VAL A 262
ASP A 263
THR A 250
GLY A 197
LEU A 204
 None
 1.25A 5m5cE-9rubA:
undetectable		 5m5cE-9rubA:
22.57