SIMILAR PATTERNS OF AMINO ACIDS FOR 5M54_E_TA1E502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djp GLUTAMINASE-ASPARAGI
NASE

(Pseudomonas sp.
7A) 		PF00710
(Asparaginase) 		5 VAL A1192
ASP A1163
ALA A1145
GLY A1136
LEU A1140
 None
 1.22A 5m54E-1djpA:
2.6		 5m54E-1djpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00266
(Aminotran_5) 		5 VAL A  17
ASP A  14
ALA A 247
GLN A 180
GLY A 183
 None
None
None
PLP  A 500 (-4.0A)
None
 1.00A 5m54E-1ecxA:
undetectable		 5m54E-1ecxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gom ENDO-1,4-BETA-XYLANA
SE

(Thermoascus
aurantiacus) 		PF00331
(Glyco_hydro_10) 		5 VAL A 218
ASP A 177
ALA A 254
GLN A  42
GLY A 205
 None
 1.25A 5m54E-1gomA:
undetectable		 5m54E-1gomA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioa ARCELIN-5A

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 ASP A 134
PHE A  71
THR A 156
GLY A  86
LEU A  87
 None
 1.07A 5m54E-1ioaA:
undetectable		 5m54E-1ioaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		5 VAL A 410
ALA A 487
SER A 408
GLN A 320
GLY A 297
 None
 1.24A 5m54E-1jqkA:
4.5		 5m54E-1jqkA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		5 VAL A 133
ALA A  67
PHE A  60
THR A  71
GLY A  13
 None
 1.13A 5m54E-1mbmA:
undetectable		 5m54E-1mbmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		5 VAL A 133
PHE A  60
THR A  71
GLY A  13
LEU A  49
 None
 1.15A 5m54E-1mbmA:
undetectable		 5m54E-1mbmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n07 PUTATIVE RIBOFLAVIN
KINASE

(Schizosaccharomyces
pombe) 		PF01687
(Flavokinase) 		5 VAL A  97
ALA A  69
PHE A 161
GLY A 118
LEU A 117
 None
 1.15A 5m54E-1n07A:
undetectable		 5m54E-1n07A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		5 ALA A 149
PHE A 140
THR A 497
ARG A 426
GLN A 427
 None
None
None
SO4  A1505 (-4.1A)
None
 1.26A 5m54E-1obhA:
2.7		 5m54E-1obhA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 VAL A 340
ALA A 282
THR A 306
GLY A 252
LEU A 335
 None
 1.15A 5m54E-1w5eA:
23.9		 5m54E-1w5eA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 ASP A  50
ALA A  81
THR A 115
GLN A 112
GLY A  21
 MG  A 701 ( 4.2A)
None
None
None
GTP  A 700 (-3.3A)
 1.18A 5m54E-1wdtA:
2.7		 5m54E-1wdtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 VAL A  50
HIS B  83
THR B 267
GLY B 341
LEU B 342
 None
 1.11A 5m54E-1wytA:
undetectable		 5m54E-1wytA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		5 ASP A 226
HIS A 299
PHE A 291
ARG A 182
GLY A 186
 None
None
None
SAZ  A 709 ( 3.8A)
SAZ  A 709 (-3.8A)
 1.29A 5m54E-1yyrA:
undetectable		 5m54E-1yyrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z00 DNA EXCISION REPAIR
PROTEIN ERCC-1

(Homo sapiens) 		PF14520
(HHH_5) 		5 ALA A 266
PHE A 257
ARG A 283
GLY A 278
LEU A 277
 None
 1.29A 5m54E-1z00A:
undetectable		 5m54E-1z00A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhn CD1D1 ANTIGEN

(Mus musculus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		5 SER A 114
GLN A  55
ARG A 173
GLY A 174
LEU A 175
 FUC  A 287 (-4.4A)
None
None
None
None
 1.09A 5m54E-1zhnA:
undetectable		 5m54E-1zhnA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		5 VAL A  56
ASP A  51
ALA A   0
THR A 302
GLY A   4
 None
 0.89A 5m54E-2ap1A:
undetectable		 5m54E-2ap1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		5 VAL A 108
ALA A 130
THR A 122
GLY A 156
LEU A 159
 None
 1.21A 5m54E-2c7bA:
3.7		 5m54E-2c7bA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN

(Aeropyrum
pernix) 		no annotation 5 VAL A 191
ALA A 141
PHE A 142
GLY A 185
LEU A 184
 None
 1.24A 5m54E-2cxhA:
undetectable		 5m54E-2cxhA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		5 VAL A 158
ASP A 159
THR A 188
GLY A 183
LEU A 179
 None
 1.24A 5m54E-2ef4A:
3.6		 5m54E-2ef4A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE

(Enterococcus
faecalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 VAL A 113
ASP A 112
ALA A  81
ARG A 284
GLY A 280
 None
 1.19A 5m54E-2ew2A:
undetectable		 5m54E-2ew2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtr CHROMODOMAIN Y-LIKE
PROTEIN

(Homo sapiens) 		PF00378
(ECH_1) 		5 ALA A 132
THR A 136
ARG A 170
GLY A 181
LEU A 182
 None
 1.23A 5m54E-2gtrA:
undetectable		 5m54E-2gtrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhg HYPOTHETICAL PROTEIN
RPA3614

(Rhodopseudomonas
palustris) 		PF00581
(Rhodanese) 		5 ALA A 101
PHE A  90
GLN A  83
GLY A 109
LEU A 110
 None
 1.24A 5m54E-2hhgA:
undetectable		 5m54E-2hhgA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihm DNA POLYMERASE MU

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		5 ALA A 474
SER A 476
PHE A 431
GLY A 485
LEU A 484
 None
 1.12A 5m54E-2ihmA:
undetectable		 5m54E-2ihmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermotoga
maritima) 		PF01174
(SNO) 		5 VAL D  12
ASP D  11
GLN D  93
GLY D  80
LEU D  83
 None
 1.10A 5m54E-2issD:
undetectable		 5m54E-2issD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		5 ALA A 192
PHE A 193
GLN A 115
GLY A 175
LEU A 121
 None
 1.24A 5m54E-2iy8A:
5.9		 5m54E-2iy8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		5 VAL A 320
ASP A 306
ALA A 251
GLY A  31
LEU A  32
 None
 1.20A 5m54E-2iy9A:
2.5		 5m54E-2iy9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kym BUD EMERGENCE
PROTEIN 1

(Lodderomyces
elongisporus) 		PF00018
(SH3_1) 		5 VAL A  20
ASP A  19
ALA A  39
ARG A  43
GLY A  45
 None
 1.17A 5m54E-2kymA:
undetectable		 5m54E-2kymA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 ALA A  81
SER A  84
THR A 128
ARG A 111
GLY A 109
 None
None
None
SO4  A 451 ( 3.0A)
None
 1.28A 5m54E-2pvsA:
3.9		 5m54E-2pvsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		5 HIS A  78
ALA A  38
PHE A  75
THR A  34
LEU A  20
 None
 1.23A 5m54E-2v6jA:
2.6		 5m54E-2v6jA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 195
ALA A 307
SER A 310
THR A 336
ARG A 340
 None
None
None
GOL  A1497 (-3.3A)
ADP  A1490 (-3.6A)
 1.17A 5m54E-2vosA:
4.1		 5m54E-2vosA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		5 VAL A 228
ASP A 227
ALA A 172
GLY A  53
LEU A  57
 None
 1.27A 5m54E-2vroA:
2.2		 5m54E-2vroA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		5 VAL A 228
ASP A 227
ALA A 172
GLY A  54
LEU A  57
 None
 0.96A 5m54E-2vroA:
2.2		 5m54E-2vroA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2r MATRIX PROTEIN

(Vesicular
stomatitis
virus) 		PF06326
(Vesiculo_matrix) 		5 VAL A  88
ALA A 109
SER A 113
GLY A 209
LEU A 210
 None
 1.27A 5m54E-2w2rA:
undetectable		 5m54E-2w2rA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 176
ALA A 189
THR A 362
GLY A 217
LEU A 216
 None
 1.10A 5m54E-2wekA:
3.6		 5m54E-2wekA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 VAL A 177
ALA A 170
THR A 165
GLY A  79
LEU A 126
 None
 1.22A 5m54E-2wnrA:
undetectable		 5m54E-2wnrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		5 ASP A 350
HIS A 510
THR A 411
GLN A 125
GLY A 379
 None
PO4  A1527 (-4.1A)
None
None
None
 1.28A 5m54E-2yeqA:
undetectable		 5m54E-2yeqA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abi PUTATIVE
UNCHARACTERIZED
PROTEIN PH1688

(Pyrococcus
horikoshii) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 VAL A  89
ASP A  90
ALA A 304
SER A 307
GLY A   7
 None
None
None
None
NAD  A1001 ( 3.8A)
 1.25A 5m54E-3abiA:
3.6		 5m54E-3abiA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		5 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.17A 5m54E-3axiA:
2.4		 5m54E-3axiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bni PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 VAL A  84
PHE A 163
ARG A 197
GLY A  94
LEU A 151
 None
PG4  A 301 ( 4.9A)
None
None
None
 1.03A 5m54E-3bniA:
undetectable		 5m54E-3bniA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		5 ASP A 205
ALA A 191
SER A 232
ARG A 202
GLY A 290
 None
 1.15A 5m54E-3d43A:
2.8		 5m54E-3d43A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
fragilis) 		PF13419
(HAD_2) 		5 HIS A 123
ALA A  15
PHE A  10
ARG A  19
GLY A  20
 None
 1.13A 5m54E-3d6jA:
undetectable		 5m54E-3d6jA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3el6 ERYTHROMYCIN
DEHYDRATASE

(Saccharopolyspora
erythraea) 		PF14765
(PS-DH) 		5 VAL A  21
ASP A  20
ALA A  97
GLY A  69
LEU A  70
 None
CL  A 290 (-4.1A)
None
None
None
 1.05A 5m54E-3el6A:
undetectable		 5m54E-3el6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fob BROMOPEROXIDASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		5 ALA A 262
PHE A 182
THR A 165
GLY A  32
LEU A  35
 None
None
None
CL  A 401 ( 4.1A)
None
 1.16A 5m54E-3fobA:
4.5		 5m54E-3fobA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9a MINIMIZER

(Camelus
dromedarius) 		PF07686
(V-set) 		5 VAL B  78
ALA B  35
THR B  98
GLY B  55
LEU B  52
 None
 1.14A 5m54E-3g9aB:
undetectable		 5m54E-3g9aB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iln LAMINARINASE

(Rhodothermus
marinus) 		PF00722
(Glyco_hydro_16) 		5 ALA A  66
SER A  78
PHE A 241
GLN A 234
GLY A 228
 None
 1.18A 5m54E-3ilnA:
undetectable		 5m54E-3ilnA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		5 ALA A 819
THR A 932
ARG A 767
GLY A1109
LEU A1110
 None
 1.26A 5m54E-3jclA:
2.8		 5m54E-3jclA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1i FLAGELLAR PROTEIN

(Helicobacter
pylori) 		PF02561
(FliS) 		5 SER A  35
PHE A  61
ARG A 111
GLY A 112
LEU A 113
 None
 0.95A 5m54E-3k1iA:
2.8		 5m54E-3k1iA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 VAL A 243
ASP A 242
ALA A 312
GLN A 385
GLY A 171
 None
 1.29A 5m54E-3lijA:
undetectable		 5m54E-3lijA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		5 HIS A 198
SER A 215
PHE A 227
ARG A 269
GLY A 209
 None
 1.17A 5m54E-3lm3A:
undetectable		 5m54E-3lm3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0l STEROIDOGENIC ACUTE
REGULATORY PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF01852
(START) 		5 VAL A 116
ASP A 115
SER A 244
GLY A  88
LEU A  90
 None
 1.29A 5m54E-3p0lA:
undetectable		 5m54E-3p0lA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N) 		5 VAL A  64
ALA A 120
THR A 105
GLY A  56
LEU A  50
 None
 1.16A 5m54E-3pxgA:
undetectable		 5m54E-3pxgA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL A  64
ALA A 120
THR A 105
GLY A  56
LEU A  50
 None
 1.16A 5m54E-3pxiA:
undetectable		 5m54E-3pxiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ALA A 352
SER A 351
PHE A 327
GLY A 485
LEU A 489
 None
 1.26A 5m54E-3qfkA:
undetectable		 5m54E-3qfkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 VAL A 424
ASP A 427
PHE A 377
GLY A 408
LEU A 388
 None
 1.19A 5m54E-3syjA:
undetectable		 5m54E-3syjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Listeria
monocytogenes) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 VAL A 181
ALA A 184
PHE A 186
GLY A 124
LEU A 101
 FAD  A 299 (-3.8A)
None
None
FAD  A 299 (-3.6A)
None
 1.20A 5m54E-3tx1A:
undetectable		 5m54E-3tx1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		5 ALA A 150
SER A 153
ARG A  74
GLN A  64
GLY A  85
 None
 1.18A 5m54E-3zizA:
undetectable		 5m54E-3zizA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aez WD REPEAT-CONTAINING
PROTEIN SLP1

(Schizosaccharomyces
pombe) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 ASP A 325
ALA A 284
SER A 282
GLY A 309
LEU A 310
 None
 1.25A 5m54E-4aezA:
undetectable		 5m54E-4aezA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 ALA A 204
ARG A  31
GLN A  27
GLY A 240
LEU A 241
 None
 1.07A 5m54E-4awnA:
undetectable		 5m54E-4awnA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N) 		5 ALA A 284
PHE A 313
ARG A 248
GLN A 269
GLY A 320
 None
None
None
GOL  A1365 (-4.5A)
None
 1.12A 5m54E-4b43A:
undetectable		 5m54E-4b43A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bub UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--LD-LYSINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 395
ASP A 394
ALA A 438
GLY A 445
LEU A 339
 None
 1.25A 5m54E-4bubA:
4.4		 5m54E-4bubA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		5 VAL A  45
HIS A  81
ALA A  85
SER A  89
GLY A  72
 None
 1.20A 5m54E-4ddqA:
3.7		 5m54E-4ddqA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 VAL A  65
ALA A  60
THR A 144
GLY A 135
LEU A 136
 None
 1.28A 5m54E-4efcA:
2.3		 5m54E-4efcA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 VAL A1187
ALA A1229
THR A1163
GLY A1176
LEU A 291
 None
 1.12A 5m54E-4f4cA:
3.2		 5m54E-4f4cA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd4 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
LIKE 5B

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		5 VAL A 117
ASP A 116
ALA A 126
SER A 164
GLY A  84
 GOL  A 301 (-4.3A)
GOL  A 301 ( 4.7A)
None
None
None
 1.15A 5m54E-4fd4A:
undetectable		 5m54E-4fd4A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf0 GLUTATHIONE
S-TRANSFERASE

(Sulfitobacter
sp. NAS-14.1) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 VAL A 143
ALA A  97
THR A  89
GLY A 155
LEU A 154
 None
None
None
CL  A 301 ( 3.9A)
None
 1.21A 5m54E-4gf0A:
undetectable		 5m54E-4gf0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 5 ALA B 432
PHE B  82
THR B 151
GLN B 197
GLY B 155
 None
 1.25A 5m54E-4gt2B:
undetectable		 5m54E-4gt2B:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 VAL B  23
ALA B 100
SER B 104
GLY B  77
LEU B 118
 None
 1.09A 5m54E-4k7gB:
undetectable		 5m54E-4k7gB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00657
(Lipase_GDSL) 		5 VAL A 120
HIS A 122
PHE A 217
THR A 130
GLY A  84
 None
 1.12A 5m54E-4k9sA:
4.4		 5m54E-4k9sA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		5 VAL A  22
ALA A 443
THR A  31
GLY A 432
LEU A 434
 None
 1.20A 5m54E-4mz1A:
2.4		 5m54E-4mz1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 HIS A 272
ALA A 515
SER A 275
THR A 388
GLY A  32
 None
 1.26A 5m54E-4pfwA:
undetectable		 5m54E-4pfwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Helicobacter
pylori) 		PF00793
(DAHP_synth_1) 		5 VAL A 233
ALA A 229
THR A 203
GLY A 237
LEU A 238
 None
 1.14A 5m54E-4z1aA:
undetectable		 5m54E-4z1aA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c12 GENE 2 PROTEIN

(Shigella virus
Sf6) 		PF17288
(Terminase_3C) 		5 ASP A 247
ALA A 445
THR A 282
GLN A 307
GLY A 301
 MG  A 801 (-4.1A)
None
None
None
None
 1.26A 5m54E-5c12A:
undetectable		 5m54E-5c12A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 VAL B 198
HIS B 104
PHE B 142
GLN B  59
ARG B 195
 BGC  B 601 ( 4.6A)
BGC  B 601 (-4.0A)
BGC  B 601 (-4.9A)
None
BGC  B 601 (-3.4A)
 1.19A 5m54E-5do8B:
2.7		 5m54E-5do8B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1u 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00701
(DHDPS) 		5 VAL A  90
ALA A 125
SER A 129
GLN A 116
LEU A 155
 None
 1.27A 5m54E-5f1uA:
2.4		 5m54E-5f1uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsh CSM6

(Thermus
thermophilus) 		PF09670
(Cas_Cas02710) 		5 VAL A 162
ALA A  67
ARG A  90
GLY A  58
LEU A  57
 None
 1.22A 5m54E-5fshA:
2.8		 5m54E-5fshA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		5 ASP A  89
HIS A  85
SER A 228
THR A 648
GLY A  67
 None
 1.01A 5m54E-5jxkA:
undetectable		 5m54E-5jxkA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		5 ALA A 672
THR A 658
ARG A 585
GLY A 760
LEU A 763
 None
 1.18A 5m54E-5loiA:
2.1		 5m54E-5loiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpq TRANSGLYCOSYLASE

(Neisseria
meningitidis) 		PF01464
(SLT)
PF14718
(SLT_L) 		5 ALA A 170
THR A 133
ARG A 155
GLY A 156
LEU A 157
 None
 1.26A 5m54E-5mpqA:
2.0		 5m54E-5mpqA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrj BETA-XYLANASE

(Acremonium
chrysogenum) 		no annotation 5 VAL A 313
ASP A 267
ALA A 349
GLN A 132
GLY A 296
 None
 1.20A 5m54E-5mrjA:
undetectable		 5m54E-5mrjA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 5 ASP A 119
ALA A 719
SER A 720
GLY A 675
LEU A 674
 None
 1.20A 5m54E-5mzsA:
undetectable		 5m54E-5mzsA:
9.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 9 VAL B  23
ASP B  26
ALA B 233
SER B 236
PHE B 272
THR B 276
GLN B 281
GLY B 370
LEU B 371
 None
 1.00A 5m54E-5n5nB:
58.0		 5m54E-5n5nB:
97.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 9 VAL B  23
ASP B  26
HIS B 229
ALA B 233
SER B 236
PHE B 272
THR B 276
GLN B 281
GLY B 370
 None
 0.95A 5m54E-5n5nB:
58.0		 5m54E-5n5nB:
97.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 VAL A 286
GLN A 726
ARG A 283
GLY A 719
LEU A 791
 None
MGD  A2002 ( 3.3A)
MGD  A2002 (-3.8A)
MGD  A2002 (-3.3A)
None
 1.22A 5m54E-5nqdA:
undetectable		 5m54E-5nqdA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 HIS A  73
ALA A  81
SER A 275
PHE A 198
ARG A  59
 None
 1.26A 5m54E-5od2A:
3.4		 5m54E-5od2A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 VAL A 241
ASP A 240
PHE A  79
ARG A 211
GLY A  17
 ADP  A 602 (-3.9A)
ADP  A 602 (-3.9A)
None
ADP  A 602 (-3.4A)
ADP  A 602 (-3.2A)
 1.16A 5m54E-5u3cA:
4.0		 5m54E-5u3cA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 5 VAL A 738
ASP A 819
HIS A 719
ALA A 722
ARG A 731
 None
 1.12A 5m54E-5vanA:
2.6		 5m54E-5vanA:
11.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
SER B 230
THR B 274
GLN B 279
GLY B 360
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
None
TA1  B 502 (-4.7A)
TA1  B 502 ( 4.3A)
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
 1.49A 5m54E-5w3jB:
58.4		 5m54E-5w3jB:
77.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
SER B 234
THR B 274
GLN B 279
GLY B 360
LEU B 361
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 ( 4.9A)
TA1  B 502 (-4.7A)
TA1  B 502 ( 4.3A)
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
 1.20A 5m54E-5w3jB:
58.4		 5m54E-5w3jB:
77.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 5 ASP A 139
ALA A 188
THR A  33
GLY A  24
LEU A  28
 GDP  A 404 (-2.3A)
None
None
GDP  A 404 (-3.1A)
None
 1.18A 5m54E-5w76A:
5.1		 5m54E-5w76A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8o INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 5 VAL A  27
ALA A 460
THR A  37
GLY A 449
LEU A 451
 None
 1.00A 5m54E-5x8oA:
2.0		 5m54E-5x8oA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		5 VAL A 178
ALA A 155
SER A 156
THR A 394
GLY A 431
 None
 1.27A 5m54E-5x9rA:
undetectable		 5m54E-5x9rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED

(Oryza sativa) 		no annotation 5 HIS A 162
ARG A 170
GLN A 173
GLY A 301
LEU A 300
 None
 1.28A 5m54E-5xoiA:
undetectable		 5m54E-5xoiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2d -

(-) 		no annotation 5 VAL A 193
ASP A 173
ALA A 252
GLY A 231
LEU A 232
 None
 1.25A 5m54E-5y2dA:
undetectable		 5m54E-5y2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoo MALATE DEHYDROGENASE

(Haemophilus
influenzae) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  42
ASP A  45
ALA A   8
GLN A 229
LEU A  20
 None
 1.22A 5m54E-6aooA:
2.5		 5m54E-6aooA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0d AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Paraburkholderia
phymatum) 		no annotation 5 VAL A  77
ASP A 119
ALA A 183
ARG A 180
GLY A  73
 None
 1.24A 5m54E-6c0dA:
3.0		 5m54E-6c0dA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co2 NUDT16-TUDOR-INTERAC
TING (NUDT16TI)

(Homo sapiens) 		no annotation 5 ASP A  63
ARG A  50
GLN A  48
ARG A  75
LEU A  77
 None
 1.04A 5m54E-6co2A:
undetectable		 5m54E-6co2A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 5 ALA A 709
SER A 767
PHE A 725
ARG A 738
GLY A 705
 None
None
None
G39  A 908 (-3.0A)
None
 1.15A 5m54E-6eksA:
undetectable		 5m54E-6eksA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9g METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
MCPU

(Pseudomonas
putida) 		no annotation 5 ASP A 129
PHE A  83
ARG A 104
GLY A 142
LEU A 151
 None
 0.99A 5m54E-6f9gA:
undetectable		 5m54E-6f9gA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 VAL A 297
ALA A  45
THR A 287
GLY A  56
LEU A  55
 None
None
HEM  A 401 (-3.8A)
None
None
 1.15A 5m54E-6fshA:
undetectable		 5m54E-6fshA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 5 HIS A 577
ALA A 601
THR A 502
GLY A 648
LEU A 645
 None
 1.29A 5m54E-6fwfA:
undetectable		 5m54E-6fwfA:
10.77