SIMILAR PATTERNS OF AMINO ACIDS FOR 5M50_B_TA1B502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4y ADENYLATE KINASE

(Escherichia
coli) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 ASP A 159
THR A  60
ARG A 156
GLY A  32
LEU A  35
 None
None
AP5  A 215 (-2.8A)
AP5  A 215 (-3.1A)
None
 1.37A 5m50B-1e4yA:
2.1		 5m50B-1e4yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 ASP A 204
HIS A 470
THR A 480
GLY A 877
LEU A 878
 SWA  A1103 ( 3.0A)
None
None
None
None
 1.21A 5m50B-1hwwA:
undetectable		 5m50B-1hwwA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioa ARCELIN-5A

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 ASP A 134
THR A 156
PRO A 204
GLY A  86
LEU A  87
 None
 1.40A 5m50B-1ioaA:
undetectable		 5m50B-1ioaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixx COAGULATION FACTORS
IX/X-BINDING PROTEIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		5 GLU A  47
SER A  44
GLN A  73
GLY A  69
LEU A  70
 CA  A 130 ( 2.9A)
None
None
None
None
 1.40A 5m50B-1ixxA:
undetectable		 5m50B-1ixxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		5 VAL A 114
ASP A 113
SER A  90
THR A  55
GLY A  63
 None
 1.44A 5m50B-1j71A:
undetectable		 5m50B-1j71A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jb7 TELOMERE-BINDING
PROTEIN BETA SUBUNIT

(Sterkiella nova) 		PF07404
(TEBP_beta) 		5 VAL B 100
SER B 102
THR B  19
ARG B 140
LEU B 138
 None
 1.44A 5m50B-1jb7B:
undetectable		 5m50B-1jb7B:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5y SURVIVAL PROTEIN
SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N)
PF13616
(Rotamase_3) 		5 ASP A  26
GLU A  39
ARG A  67
GLY A  44
LEU A  45
 None
 1.05A 5m50B-1m5yA:
2.4		 5m50B-1m5yA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phj TELOMERE-BINDING
PROTEIN BETA SUBUNIT

(Sterkiella nova) 		PF07404
(TEBP_beta) 		5 VAL B 100
SER B 102
THR B  19
ARG B 140
LEU B 138
 None
 1.45A 5m50B-1phjB:
undetectable		 5m50B-1phjB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 VAL A  43
ASP A  42
SER A 123
THR A  52
ARG A 105
 None
 1.36A 5m50B-1q1qA:
undetectable		 5m50B-1q1qA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 VAL A  58
ASP A  57
SER A 138
THR A  67
ARG A 120
 None
None
None
A3P  A 314 ( 4.9A)
None
 1.34A 5m50B-1q20A:
undetectable		 5m50B-1q20A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 VAL A 610
GLU A 612
THR A 107
GLY A 589
LEU A 633
 None
 1.39A 5m50B-1qb4A:
3.3		 5m50B-1qb4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qp8 FORMATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 VAL A 236
ASP A 235
GLN A 273
ARG A  39
GLY A 264
 NDP  A 310 (-4.2A)
NDP  A 310 (-4.4A)
None
None
None
 1.39A 5m50B-1qp8A:
2.2		 5m50B-1qp8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrc POLYNUCLEOTIDE
KINASE

(Escherichia
virus T4) 		PF13671
(AAA_33) 		5 VAL A 256
ASP A 255
GLU A 259
ARG A 288
LEU A 147
 None
CA  A 701 ( 4.1A)
None
CA  A 701 ( 4.4A)
None
 0.97A 5m50B-1rrcA:
3.2		 5m50B-1rrcA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1
ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 144
GLU B 160
ARG B 332
GLY B 336
LEU B 333
 None
 1.45A 5m50B-1tqyA:
2.1		 5m50B-1tqyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu7 GLUTATHIONE
S-TRANSFERASE 2

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A  30
PRO A  16
ARG A  18
GLY A  12
LEU A  13
 None
None
None
None
GSH  A1001 (-4.4A)
 1.42A 5m50B-1tu7A:
undetectable		 5m50B-1tu7A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ueb ELONGATION FACTOR P

(Thermus
thermophilus) 		PF01132
(EFP)
PF08207
(EFP_N)
PF09285
(Elong-fact-P_C) 		5 VAL A 132
GLU A 169
THR A 143
GLY A 138
LEU A 163
 None
 1.29A 5m50B-1uebA:
undetectable		 5m50B-1uebA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLU A 674
SER A 632
THR A 156
ARG A 210
LEU A 249
 None
 1.35A 5m50B-1xkhA:
undetectable		 5m50B-1xkhA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT
D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		5 VAL B 135
ASP B 138
THR A  35
ARG A 184
GLY A 264
 B12  B 800 (-3.7A)
None
None
PLP  B 801 (-2.9A)
None
 1.17A 5m50B-1xrsB:
4.8		 5m50B-1xrsB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y17 ANTICOAGULANT
PROTEIN A

(Deinagkistrodon
acutus) 		PF00059
(Lectin_C) 		5 GLU A  47
SER A  44
GLN A  73
GLY A  69
LEU A  70
 CA  A1001 (-2.7A)
None
None
None
None
 1.43A 5m50B-1y17A:
undetectable		 5m50B-1y17A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		5 VAL A 288
ASP A 287
SER A 338
THR A 247
GLN A 245
 None
 1.44A 5m50B-1yt8A:
undetectable		 5m50B-1yt8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 VAL A 114
ASP A 113
SER A  90
THR A  55
GLY A  63
 None
None
None
ZN  A 400 ( 4.7A)
None
 1.37A 5m50B-1zapA:
undetectable		 5m50B-1zapA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcw AROMATIC
PRENYLTRANSFERASE

(Streptomyces
sp. CL190) 		PF11468
(PTase_Orf2) 		5 GLU A 266
GLN A 161
ARG A 296
GLY A 297
LEU A 298
 None
None
NO3  A 601 ( 4.7A)
None
None
 1.33A 5m50B-1zcwA:
undetectable		 5m50B-1zcwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1

(Bos taurus) 		PF02274
(Amidinotransf) 		6 VAL A  76
ASP A  78
GLU A 100
PRO A  71
ARG A  97
LEU A  24
 None
ZN  A1281 ( 4.1A)
None
None
None
None
 1.49A 5m50B-2ci6A:
undetectable		 5m50B-2ci6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d40 PUTATIVE GENTISATE
1,2-DIOXYGENASE

(Escherichia
coli) 		PF07883
(Cupin_2) 		5 VAL A 124
ASP A 125
GLU A 127
THR A 248
ARG A 186
 None
 1.38A 5m50B-2d40A:
undetectable		 5m50B-2d40A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0q TELOMERE-BINDING
PROTEIN BETA SUBUNIT

(Sterkiella nova) 		PF07404
(TEBP_beta) 		5 VAL B 100
SER B 102
THR B  19
ARG B 140
LEU B 138
 None
 1.43A 5m50B-2i0qB:
undetectable		 5m50B-2i0qB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 VAL A 128
GLU A 210
SER A 213
THR A 450
GLY A 578
 None
 1.41A 5m50B-2ipcA:
undetectable		 5m50B-2ipcA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iss GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermotoga
maritima) 		PF01174
(SNO) 		5 VAL D  12
ASP D  11
GLN D  93
GLY D  80
LEU D  83
 None
 1.04A 5m50B-2issD:
undetectable		 5m50B-2issD:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		5 ASP A  22
PRO A 338
ARG A 339
GLY A 335
LEU A 334
 None
 1.44A 5m50B-2jbwA:
2.6		 5m50B-2jbwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0q HYPOTHETICAL PROTEIN
CC0527

(Caulobacter
vibrioides) 		PF06108
(DUF952) 		5 VAL A  93
GLU A  96
GLN A  43
ARG A  10
LEU A  99
 None
 1.40A 5m50B-2o0qA:
undetectable		 5m50B-2o0qA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 KIT LIGAND
MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Mus musculus) 		PF02404
(SCF)
no annotation 		5 VAL X  76
GLU X  74
SER A 101
ARG A 104
LEU X 120
 None
 1.29A 5m50B-2o26X:
undetectable		 5m50B-2o26X:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 THR A  33
GLN A  52
ARG A  42
PRO A  46
GLY A  48
 None
 1.14A 5m50B-2o6sA:
undetectable		 5m50B-2o6sA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1w PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		5 VAL A 215
ASP A 216
ARG A  24
GLY A  25
LEU A  22
 None
 1.44A 5m50B-2q1wA:
6.6		 5m50B-2q1wA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A  55
ASP A 113
SER A  34
THR A 373
ARG A  69
 None
 1.34A 5m50B-2x40A:
4.6		 5m50B-2x40A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyb HYPOTHETICAL PROTEIN
TTHA1606

(Thermus
thermophilus) 		PF01784
(NIF3) 		5 VAL A 163
ASP A 183
THR A 213
GLY A 130
LEU A 168
 None
 1.49A 5m50B-2yybA:
undetectable		 5m50B-2yybA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF08839
(CDT1) 		5 VAL C 349
ASP C 350
THR C 254
ARG C 311
LEU C 206
 None
 1.39A 5m50B-2zxxC:
undetectable		 5m50B-2zxxC:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		5 VAL A 588
ASP A 212
HIS A 120
ARG A 285
LEU A 283
 None
 1.37A 5m50B-3cf4A:
3.0		 5m50B-3cf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		5 VAL A   7
THR A 156
PRO A 171
GLY A 192
LEU A 191
 None
 1.35A 5m50B-3ddhA:
5.2		 5m50B-3ddhA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eat PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCB

(Pseudomonas
aeruginosa) 		PF02668
(TauD) 		5 GLU X 121
GLN X   8
ARG X  51
GLY X  48
LEU X  49
 None
 1.48A 5m50B-3eatX:
undetectable		 5m50B-3eatX:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec2 DNA REPLICATION
PROTEIN DNAC

(Aquifex
aeolicus) 		PF01695
(IstB_IS21) 		5 ASP A 198
THR A 177
ARG A 202
GLY A 151
LEU A 150
 None
 1.45A 5m50B-3ec2A:
undetectable		 5m50B-3ec2A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpn GEOBACILLUS
STEAROTHERMOPHILUS
UVRA INTERACTION
DOMAIN
GEOBACILLUS
STEAROTHERMOPHILUS
UVRB INTERACTION
DOMAIN

(Geobacillus
stearothermophilus) 		no annotation 5 ASP B 198
GLU B 215
THR A 165
ARG A 176
LEU A 186
 None
 1.31A 5m50B-3fpnB:
undetectable		 5m50B-3fpnB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpn GEOBACILLUS
STEAROTHERMOPHILUS
UVRA INTERACTION
DOMAIN
GEOBACILLUS
STEAROTHERMOPHILUS
UVRB INTERACTION
DOMAIN

(Geobacillus
stearothermophilus) 		no annotation 5 VAL B 199
ASP B 198
GLU B 215
THR A 165
ARG A 176
 None
 1.14A 5m50B-3fpnB:
undetectable		 5m50B-3fpnB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 GLU A 313
THR A 189
ARG A 263
GLY A 173
LEU A 174
 None
 1.37A 5m50B-3h7lA:
undetectable		 5m50B-3h7lA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw PSEUDOURIDINE
SYNTHASE CBF5

(Pyrococcus
furiosus) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		5 VAL A  91
ASP A  55
GLU A 213
ARG A 174
ARG A 204
 None
 1.45A 5m50B-3hjwA:
undetectable		 5m50B-3hjwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo) 		5 ASP W 742
SER W 753
ARG W 740
GLY W 728
LEU W 731
 None
 1.50A 5m50B-3mwyW:
undetectable		 5m50B-3mwyW:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 GLU A 278
SER A 276
ARG A 267
GLY A 266
LEU A 262
 None
 1.40A 5m50B-3nksA:
undetectable		 5m50B-3nksA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 VAL A  13
GLU A  12
THR A  60
ARG A 193
GLY A  51
 None
4CT  A 233 ( 4.0A)
None
4CT  A 233 ( 4.7A)
None
 1.34A 5m50B-3o4vA:
3.6		 5m50B-3o4vA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0l STEROIDOGENIC ACUTE
REGULATORY PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF01852
(START) 		5 VAL A 116
ASP A 115
SER A 244
GLY A  88
LEU A  90
 None
 1.43A 5m50B-3p0lA:
undetectable		 5m50B-3p0lA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxg NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N) 		5 VAL A  64
GLU A  65
GLN A  76
GLY A  25
LEU A  22
 None
 1.49A 5m50B-3pxgA:
undetectable		 5m50B-3pxgA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxi NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF00004
(AAA)
PF02151
(UVR)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 VAL A  64
GLU A  65
GLN A  76
GLY A  25
LEU A  22
 None
 1.49A 5m50B-3pxiA:
undetectable		 5m50B-3pxiA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		5 ASP A  66
GLU A  88
PRO A  59
ARG A  85
LEU A  14
 HM3  A 255 (-4.3A)
None
None
HM3  A 255 ( 4.7A)
None
 1.40A 5m50B-3rhyA:
undetectable		 5m50B-3rhyA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		5 VAL A  10
SER A  44
THR A 169
GLN A 178
GLY A 164
 None
 1.47A 5m50B-3si9A:
3.0		 5m50B-3si9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A

(Arabidopsis
thaliana) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 ASP A 142
GLU A  52
SER A  53
ARG A 243
GLY A  63
 MG  A1002 ( 3.9A)
None
None
None
GDP  A1000 ( 3.5A)
 1.23A 5m50B-3t34A:
3.0		 5m50B-3t34A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 ASP A 329
THR A  90
ARG A 366
GLY A 377
LEU A 378
 None
 1.23A 5m50B-4cpnA:
undetectable		 5m50B-4cpnA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 GLU A 196
SER A 200
PRO A 156
GLY A 146
LEU A 145
 None
 1.29A 5m50B-4eziA:
4.5		 5m50B-4eziA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3l BMAL1B
CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		5 ASP B 156
HIS B 321
ARG A 256
GLY A 120
LEU A 141
 None
 1.47A 5m50B-4f3lB:
undetectable		 5m50B-4f3lB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gio PUTATIVE LIPOPROTEIN

(Campylobacter
jejuni) 		PF07233
(DUF1425) 		5 VAL A  84
ASP A  83
SER A 107
THR A  28
ARG A 110
 None
 1.43A 5m50B-4gioA:
undetectable		 5m50B-4gioA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		5 ASP A 246
GLU A 223
HIS A 128
PRO A 221
ARG A 220
 None
 1.38A 5m50B-4gx8A:
undetectable		 5m50B-4gx8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h18 CMT1

(Corynebacterium
glutamicum) 		PF00756
(Esterase) 		5 THR A 146
GLN A 159
ARG A 233
GLY A 234
LEU A 231
 None
 1.41A 5m50B-4h18A:
3.4		 5m50B-4h18A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-RELATED
PROTEIN 7

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 VAL A  71
ASP A  72
SER A  33
THR A 395
GLY A 163
 None
 1.46A 5m50B-4i6mA:
undetectable		 5m50B-4i6mA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 5 GLU D 315
HIS D 342
SER D 335
GLY D 407
LEU D 168
 None
 1.39A 5m50B-4jrmD:
undetectable		 5m50B-4jrmD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1

(Homo sapiens) 		PF00400
(WD40) 		5 ASP A 246
HIS A 213
SER A 230
GLY A 263
LEU A 262
 None
 1.44A 5m50B-4lg9A:
undetectable		 5m50B-4lg9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 VAL A1479
HIS A1459
ARG A 974
PRO A1501
LEU A1455
 None
 1.37A 5m50B-4wxxA:
5.0		 5m50B-4wxxA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 ASP A 575
GLU A1159
HIS A 824
GLY A1154
LEU A1274
 None
 1.41A 5m50B-5a22A:
undetectable		 5m50B-5a22A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		5 VAL A  59
THR A 355
GLN A 357
GLY A 379
LEU A 410
 None
 1.35A 5m50B-5b48A:
3.3		 5m50B-5b48A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pectobacterium
atrosepticum) 		PF01867
(Cas_Cas1) 		5 VAL A 267
ASP A 266
SER A 241
PRO A 248
GLY A 250
 None
 1.48A 5m50B-5fclA:
undetectable		 5m50B-5fclA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLU A 262
GLN A  69
ARG A 287
GLY A 289
LEU A 292
 None
 1.32A 5m50B-5gmsA:
undetectable		 5m50B-5gmsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5l GLUTATHIONE
S-TRANSFERASE S2

(Nilaparvata
lugens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A  31
PRO A  17
ARG A  19
GLY A  13
LEU A  14
 None
None
None
PEG  A 302 (-3.5A)
GSH  A 301 (-4.2A)
 1.24A 5m50B-5h5lA:
undetectable		 5m50B-5h5lA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 5 VAL A 275
HIS A 258
THR A 151
ARG A 226
GLY A 156
 None
MN  A 602 (-3.2A)
None
None
None
 1.30A 5m50B-5hrmA:
undetectable		 5m50B-5hrmA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 5 VAL A 275
HIS A 258
THR A 151
ARG A 226
GLY A 156
 None
 1.36A 5m50B-5iojA:
undetectable		 5m50B-5iojA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		5 VAL A  88
ASP A  86
THR A 111
GLY A  67
LEU A  68
 None
 1.42A 5m50B-5iysA:
undetectable		 5m50B-5iysA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 ASP A 667
GLN A 428
PRO A 500
ARG A 499
LEU A 422
 EDO  A1007 (-3.4A)
None
None
None
None
 1.31A 5m50B-5kdxA:
undetectable		 5m50B-5kdxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 ASP A 667
PRO A 500
ARG A 499
GLY A 423
LEU A 422
 EDO  A1007 (-3.4A)
None
None
None
None
 1.37A 5m50B-5kdxA:
undetectable		 5m50B-5kdxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx0 FIBROMODULIN

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASP A 240
PRO A 243
ARG A 220
GLY A 221
LEU A 222
 None
 1.42A 5m50B-5mx0A:
undetectable		 5m50B-5mx0A:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 ASP B  26
GLU B  27
GLN B 281
ARG B 320
PRO B 360
GLY B 370
 None
 1.22A 5m50B-5n5nB:
58.0		 5m50B-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 ASP B  26
GLU B  27
GLN B 281
PRO B 360
GLY B 370
LEU B 371
 None
 1.20A 5m50B-5n5nB:
58.0		 5m50B-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 ASP B  26
GLU B  27
THR B 276
GLN B 281
GLY B 370
LEU B 371
 None
 1.25A 5m50B-5n5nB:
58.0		 5m50B-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 ASP B  26
SER B 236
GLN B 281
PRO B 360
GLY B 370
LEU B 371
 None
 1.13A 5m50B-5n5nB:
58.0		 5m50B-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 ASP B  26
SER B 236
THR B 276
GLN B 281
GLY B 370
LEU B 371
 None
 1.12A 5m50B-5n5nB:
58.0		 5m50B-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
ASP B  26
GLU B  27
GLN B 281
PRO B 360
GLY B 370
 None
 1.14A 5m50B-5n5nB:
58.0		 5m50B-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
ASP B  26
GLU B  27
HIS B 229
THR B 276
GLN B 281
GLY B 370
 None
 1.12A 5m50B-5n5nB:
58.0		 5m50B-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 7 VAL B  23
ASP B  26
HIS B 229
SER B 236
THR B 276
GLN B 281
GLY B 370
 None
 0.98A 5m50B-5n5nB:
58.0		 5m50B-5n5nB:
97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 VAL B  23
ASP B  26
SER B 236
GLN B 281
PRO B 360
GLY B 370
 None
 1.06A 5m50B-5n5nB:
58.0		 5m50B-5n5nB:
97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 5 ASP A 565
GLU A 267
GLN A 122
ARG A 532
GLY A 558
 None
 1.42A 5m50B-5oc1A:
undetectable		 5m50B-5oc1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 VAL A  76
ASP A  75
THR A 227
ARG A 124
GLY A 125
 None
 1.50A 5m50B-5t2uA:
6.3		 5m50B-5t2uA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tky PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 VAL A 324
ASP A 327
SER A 212
PRO A 403
ARG A 421
 None
 1.46A 5m50B-5tkyA:
undetectable		 5m50B-5tkyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 HIS 7 334
SER 7 249
THR 7 352
GLY 7 337
LEU 7 339
 None
 1.22A 5m50B-5v8f7:
undetectable		 5m50B-5v8f7:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 VAL A 737
ASP A 738
PRO A  29
ARG A 412
GLY A  27
 None
 1.49A 5m50B-5vm9A:
undetectable		 5m50B-5vm9A:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 SER B 234
THR B 274
GLN B 279
ARG B 318
PRO B 358
GLY B 360
LEU B 361
 TA1  B 502 ( 4.9A)
TA1  B 502 (-4.7A)
TA1  B 502 ( 4.3A)
None
None
TA1  B 502 (-3.6A)
TA1  B 502 (-3.7A)
 1.31A 5m50B-5w3jB:
58.0		 5m50B-5w3jB:
77.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
GLU B  27
THR B 274
GLN B 279
ARG B 318
GLY B 360
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 (-3.6A)
TA1  B 502 (-4.7A)
TA1  B 502 ( 4.3A)
None
TA1  B 502 (-3.6A)
 1.05A 5m50B-5w3jB:
58.0		 5m50B-5w3jB:
77.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
ASP B  26
SER B 234
THR B 274
GLN B 279
ARG B 318
GLY B 360
 TA1  B 502 (-3.9A)
TA1  B 502 (-4.1A)
TA1  B 502 ( 4.9A)
TA1  B 502 (-4.7A)
TA1  B 502 ( 4.3A)
None
TA1  B 502 (-3.6A)
 1.09A 5m50B-5w3jB:
58.0		 5m50B-5w3jB:
77.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
GLU B  27
THR B 274
GLN B 279
ARG B 318
PRO B 358
GLY B 360
 TA1  B 502 (-3.9A)
TA1  B 502 (-3.6A)
TA1  B 502 (-4.7A)
TA1  B 502 ( 4.3A)
None
None
TA1  B 502 (-3.6A)
 1.03A 5m50B-5w3jB:
58.0		 5m50B-5w3jB:
77.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		7 VAL B  23
SER B 234
THR B 274
GLN B 279
ARG B 318
PRO B 358
GLY B 360
 TA1  B 502 (-3.9A)
TA1  B 502 ( 4.9A)
TA1  B 502 (-4.7A)
TA1  B 502 ( 4.3A)
None
None
TA1  B 502 (-3.6A)
 1.10A 5m50B-5w3jB:
58.0		 5m50B-5w3jB:
77.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 5 THR A 783
GLN A 780
ARG A  36
GLY A  35
LEU A 413
 None
 1.44A 5m50B-5weaA:
undetectable		 5m50B-5weaA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqg ISOMERASE TRT14

(Aspergillus
terreus) 		no annotation 5 VAL A  79
ASP A  80
GLU A  81
THR A  32
PRO A   3
 None
 1.41A 5m50B-5wqgA:
undetectable		 5m50B-5wqgA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 5 VAL A  87
HIS A 229
SER A 276
GLY A  22
LEU A  20
 None
 1.19A 5m50B-5wslA:
undetectable		 5m50B-5wslA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		5 VAL A 410
ASP A 407
GLU A 409
GLY A 185
LEU A 216
 None
None
None
FLC  A 501 (-3.5A)
None
 1.50A 5m50B-5x9rA:
undetectable		 5m50B-5x9rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		5 VAL A 392
THR A 430
GLN A 438
GLY A 407
LEU A 406
 None
 1.26A 5m50B-5xfaA:
undetectable		 5m50B-5xfaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6daw NON-HEME IRON
HYDROXYLASE

(Streptomyces
lusitanus) 		no annotation 5 ASP A  74
SER A  93
PRO A  81
ARG A 165
GLY A 304
 None
 1.47A 5m50B-6dawA:
undetectable		 5m50B-6dawA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 5 VAL A 183
ASP A 186
THR A 101
GLY A  81
LEU A  84
 None
 0.96A 5m50B-6frvA:
undetectable		 5m50B-6frvA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdt -

(-) 		no annotation 5 GLU A 313
THR A 189
ARG A 263
GLY A 173
LEU A 174
 None
 1.35A 5m50B-6gdtA:
undetectable		 5m50B-6gdtA:
undetectable