SIMILAR PATTERNS OF AMINO ACIDS FOR 5M45_J_ACTJ803_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 510
PRO A 511
ILE A 509
LEU A 513
 None
None
CU  A 554 ( 4.1A)
None
 0.93A 5m45J-1asoA:
0.0		 5m45J-1asoA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f45 INTERLEUKIN-12 ALPHA
CHAIN

(Homo sapiens) 		PF03039
(IL12) 		4 GLU B  67
PRO B  65
ILE B  82
LEU B  66
 None
 1.20A 5m45J-1f45B:
undetectable		 5m45J-1f45B:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj8 PROLINE-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09181
(ProRS-C_2) 		4 GLU A 398
PRO A 419
ILE A 400
LEU A 397
 None
 1.26A 5m45J-1nj8A:
0.0		 5m45J-1nj8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q60 GENERAL
TRANSCRIPTION FACTOR
II-I

(Mus musculus) 		PF02946
(GTF2I) 		4 GLU A  67
PRO A  64
ILE A  63
LEU A   8
 None
 1.14A 5m45J-1q60A:
undetectable		 5m45J-1q60A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r71 TRANSCRIPTIONAL
REPRESSOR PROTEIN
KORB

(Escherichia
coli) 		PF08535
(KorB) 		4 GLU A 156
PRO A 154
ILE A 157
LEU A 152
 None
 1.24A 5m45J-1r71A:
0.0		 5m45J-1r71A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tye INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		4 GLU B  65
PRO B  85
ILE B  88
LEU B  64
 None
 1.31A 5m45J-1tyeB:
0.0		 5m45J-1tyeB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz6 PUTATIVE SUGAR
KINASE

(Salmonella
enterica) 		PF00294
(PfkB) 		4 GLU A 174
PRO A 173
ILE A 176
LEU A 175
 None
 1.25A 5m45J-1tz6A:
0.0		 5m45J-1tz6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pseudomonas sp.
ACP) 		PF00291
(PALP) 		4 GLU A  61
PRO A  60
ILE A  59
LEU A  58
 None
 1.22A 5m45J-1tzmA:
0.0		 5m45J-1tzmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukx GCN2 EIF2ALPHA
KINASE

(Mus musculus) 		PF05773
(RWD) 		4 GLU A  46
PRO A  45
ILE A  47
LEU A  33
 None
 1.19A 5m45J-1ukxA:
0.0		 5m45J-1ukxA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLU A 110
PRO A 108
ILE A 111
LEU A 106
 None
 1.29A 5m45J-1v26A:
0.0		 5m45J-1v26A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 GLU A 336
PRO A 350
ILE A 353
LEU A 351
 None
 1.08A 5m45J-1vpkA:
undetectable		 5m45J-1vpkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		4 GLU A 213
PRO A 211
ILE A 214
LEU A 209
 None
 1.23A 5m45J-1vzyA:
undetectable		 5m45J-1vzyA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxq GTP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF08438
(MMR_HSR1_C) 		4 GLU A  63
PRO A  72
ILE A  71
LEU A  70
 None
 1.22A 5m45J-1wxqA:
undetectable		 5m45J-1wxqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2k OSTEOCLAST
STIMULATING FACTOR 1

(Homo sapiens) 		PF00018
(SH3_1) 		4 GLU A  23
PRO A  55
ILE A  54
LEU A  53
 None
 1.09A 5m45J-1x2kA:
undetectable		 5m45J-1x2kA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6g MEGAKARYOCYTE-ASSOCI
ATED
TYROSINE-PROTEIN
KINASE

(Homo sapiens) 		PF00018
(SH3_1) 		4 GLU A  46
PRO A  16
ILE A  44
LEU A  45
 None
 1.05A 5m45J-1x6gA:
undetectable		 5m45J-1x6gA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 GLU A 210
PRO A 211
ILE A 212
LEU A 213
 PLP  A 434 (-3.8A)
None
None
None
 1.00A 5m45J-1z3zA:
undetectable		 5m45J-1z3zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlm OSTEOCLAST
STIMULATING FACTOR 1

(Homo sapiens) 		PF00018
(SH3_1) 		4 GLU A  30
PRO A  62
ILE A  61
LEU A  60
 GLU  A  30 ( 0.6A)
PRO  A  62 ( 1.1A)
ILE  A  61 ( 0.5A)
LEU  A  60 ( 0.6A)
 1.20A 5m45J-1zlmA:
undetectable		 5m45J-1zlmA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLU A   9
PRO A  23
ILE A  22
LEU A  21
 None
 0.92A 5m45J-2e8yA:
undetectable		 5m45J-2e8yA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 GLU A 197
PRO A 195
ILE A 198
LEU A 193
 None
 1.21A 5m45J-2eb0A:
undetectable		 5m45J-2eb0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 GLU A 266
PRO A 309
ILE A 264
LEU A 265
 None
 1.19A 5m45J-2fmtA:
undetectable		 5m45J-2fmtA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 GLU A 478
PRO A 464
ILE A 463
LEU A 462
 None
 1.14A 5m45J-2hnhA:
undetectable		 5m45J-2hnhA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsn METHIONYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		PF09635
(MetRS-N) 		4 GLU A  41
PRO A  40
ILE A   7
LEU A   6
 None
 1.10A 5m45J-2hsnA:
undetectable		 5m45J-2hsnA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im5 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Porphyromonas
gingivalis) 		PF04095
(NAPRTase) 		4 GLU A 120
PRO A 122
ILE A 123
LEU A 124
 None
 1.07A 5m45J-2im5A:
undetectable		 5m45J-2im5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l11 CHROMOBOX PROTEIN
HOMOLOG 3

(Homo sapiens) 		PF00385
(Chromo) 		4 GLU A  44
PRO A  43
ILE A  46
LEU A  45
 None
 1.19A 5m45J-2l11A:
undetectable		 5m45J-2l11A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mj3 IRON-SULFUR CLUSTER
BINDING PROTEIN

(Ehrlichia
chaffeensis) 		PF00111
(Fer2) 		4 GLU A  17
PRO A   2
ILE A   4
LEU A   3
 None
 1.28A 5m45J-2mj3A:
undetectable		 5m45J-2mj3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		4 GLU A 123
PRO A 121
ILE A 115
LEU A 114
 None
 1.17A 5m45J-2obmA:
undetectable		 5m45J-2obmA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE

(Bacteroides
thetaiotaomicron) 		PF00596
(Aldolase_II) 		4 GLU A 198
PRO A 196
ILE A 199
LEU A 194
 None
 1.12A 5m45J-2opiA:
undetectable		 5m45J-2opiA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 GLU A  32
PRO A  30
ILE A  33
LEU A  27
 None
 1.33A 5m45J-2oq2A:
undetectable		 5m45J-2oq2A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vh3 RANASMURFIN

(Polypedates
leucomystax) 		no annotation 4 GLU B  77
PRO B  76
ILE B  79
LEU B  78
 None
None
None
SO4  B1116 (-4.7A)
 1.27A 5m45J-2vh3B:
undetectable		 5m45J-2vh3B:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 GLU C 105
PRO C 123
ILE C 122
LEU C 198
 None
 1.28A 5m45J-2wbeC:
undetectable		 5m45J-2wbeC:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqd PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
aureus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 GLU A  86
PRO A  85
ILE A  88
LEU A  87
 None
 1.24A 5m45J-2wqdA:
undetectable		 5m45J-2wqdA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 GLU A  94
PRO A  92
ILE A  95
LEU A  90
 None
 1.26A 5m45J-2wzfA:
0.1		 5m45J-2wzfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		4 GLU A  94
PRO A  92
ILE A  95
LEU A  90
 None
 1.20A 5m45J-2wzgA:
0.0		 5m45J-2wzgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvp MUTT/NUDIX FAMILY
PROTEIN

(Thermus
thermophilus) 		PF00293
(NUDIX) 		4 GLU A  84
PRO A 104
ILE A 103
LEU A 102
 None
 1.21A 5m45J-2yvpA:
undetectable		 5m45J-2yvpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 GLU A 254
PRO A 253
ILE A 252
LEU A 251
 None
 1.26A 5m45J-3clwA:
undetectable		 5m45J-3clwA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5l REGULATORY PROTEIN
RECX

(Lactobacillus
reuteri) 		PF02631
(RecX) 		4 GLU A  94
PRO A  95
ILE A  96
LEU A  97
 None
 1.22A 5m45J-3d5lA:
0.4		 5m45J-3d5lA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9y PROFILIN

(Schizosaccharomyces
pombe) 		PF00235
(Profilin) 		4 GLU A  42
PRO A  40
ILE A  43
LEU A  38
 None
 1.28A 5m45J-3d9yA:
undetectable		 5m45J-3d9yA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db0 LIN2891 PROTEIN

(Listeria
innocua) 		PF16242
(Pyrid_ox_like) 		4 GLU A 120
PRO A 119
ILE A 117
LEU A  82
 None
 1.07A 5m45J-3db0A:
undetectable		 5m45J-3db0A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtd INVASION-ASSOCIATED
PROTEIN B

(Bartonella
henselae) 		PF06776
(IalB) 		4 GLU A 160
PRO A 161
ILE A 155
LEU A 101
 None
 1.29A 5m45J-3dtdA:
undetectable		 5m45J-3dtdA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbk REGULATOR OF
G-PROTEIN SIGNALING
3

(Homo sapiens) 		PF00168
(C2) 		4 GLU A  77
PRO A  76
ILE A  75
LEU A  74
 None
 0.86A 5m45J-3fbkA:
undetectable		 5m45J-3fbkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		4 GLU A 226
PRO A 227
ILE A 228
LEU A 229
 LLP  A 288 (-4.0A)
None
None
None
 0.85A 5m45J-3fcrA:
undetectable		 5m45J-3fcrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 GLU A 227
PRO A 228
ILE A 229
LEU A 230
 LLP  A 289 (-3.7A)
None
None
None
 0.88A 5m45J-3gjuA:
undetectable		 5m45J-3gjuA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri) 		PF00936
(BMC) 		4 GLU A 262
PRO A 252
ILE A 263
LEU A 264
 None
 1.16A 5m45J-3io0A:
undetectable		 5m45J-3io0A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1u BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE

(Clostridium
acetobutylicum) 		PF04616
(Glyco_hydro_43) 		4 GLU A 184
PRO A 183
ILE A 189
LEU A 185
 EDO  A 404 (-2.7A)
None
None
None
 1.24A 5m45J-3k1uA:
undetectable		 5m45J-3k1uA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 GLU A 171
PRO A 170
ILE A 107
LEU A 168
 None
 1.07A 5m45J-3kd8A:
undetectable		 5m45J-3kd8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsp DEST

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 GLU A 171
PRO A 170
ILE A 173
LEU A 172
 None
 1.16A 5m45J-3lspA:
undetectable		 5m45J-3lspA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 222
PRO A 224
ILE A 221
LEU A 245
 MG  A 378 (-3.1A)
None
None
None
 1.30A 5m45J-3my9A:
undetectable		 5m45J-3my9A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159

(Methanocaldococcus
jannaschii) 		PF01995
(DUF128) 		4 GLU A 442
PRO A 440
ILE A 431
LEU A 438
 None
 1.32A 5m45J-3nekA:
undetectable		 5m45J-3nekA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB

(Thermus
thermophilus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLU A 109
PRO A 107
ILE A 286
LEU A 105
 None
 1.16A 5m45J-3oa0A:
undetectable		 5m45J-3oa0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or5 THIOL:DISULFIDE
INTERCHANGE PROTEIN,
THIOREDOXIN FAMILY
PROTEIN

(Chlorobaculum
tepidum) 		PF08534
(Redoxin) 		4 GLU A 122
PRO A 121
ILE A 124
LEU A 123
 None
 1.14A 5m45J-3or5A:
undetectable		 5m45J-3or5A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLU A  15
PRO A  14
ILE A  17
LEU A  16
 None
 1.13A 5m45J-3pm9A:
undetectable		 5m45J-3pm9A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 GLU A 483
PRO A 482
ILE A 481
LEU A 480
 None
 1.19A 5m45J-3rreA:
undetectable		 5m45J-3rreA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE

(Alteromonas
macleodii) 		PF00557
(Peptidase_M24) 		4 GLU A 322
PRO A 320
ILE A 323
LEU A 318
 None
 1.23A 5m45J-3rvaA:
undetectable		 5m45J-3rvaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  53
PRO A  54
ILE A  36
LEU A  35
 None
 1.23A 5m45J-3ugvA:
undetectable		 5m45J-3ugvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 GLU A1121
PRO A1149
ILE A1148
LEU A1147
 None
 1.33A 5m45J-3ummA:
undetectable		 5m45J-3ummA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcr PUTATIVE KDPG
(2-KETO-3-DEOXY-6-PH
OSPHOGLUCONATE)
ALDOLASE

(Oleispira
antarctica) 		PF01081
(Aldolase) 		4 GLU A  96
PRO A  95
ILE A  98
LEU A  97
 None
 1.11A 5m45J-3vcrA:
undetectable		 5m45J-3vcrA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 GLU A 650
PRO A 649
ILE A 652
LEU A 651
 None
 1.01A 5m45J-3vthA:
undetectable		 5m45J-3vthA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 GLU B1019
PRO B1021
ILE B1020
LEU B1023
 None
 1.06A 5m45J-3zefB:
undetectable		 5m45J-3zefB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 GLU A 597
PRO A 596
ILE A 599
LEU A 598
 None
 1.28A 5m45J-4a2qA:
undetectable		 5m45J-4a2qA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16415
(CNOT1_CAF1_bind) 		4 GLU A 964
PRO A 995
ILE A 963
LEU A 961
 None
 1.32A 5m45J-4b8aA:
undetectable		 5m45J-4b8aA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbk FERMITIN FAMILY
HOMOLOG 1

(Mus musculus) 		PF00169
(PH) 		4 GLU A 424
PRO A 443
ILE A 442
LEU A 441
 None
 1.08A 5m45J-4bbkA:
undetectable		 5m45J-4bbkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo sapiens;
Homo sapiens) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		4 GLU C 618
PRO A2087
ILE A2090
LEU A2091
 None
 1.26A 5m45J-4c0dC:
undetectable		 5m45J-4c0dC:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di4 TATP(T) (TP0957)

(Treponema
pallidum) 		PF03480
(DctP) 		4 GLU B 288
PRO B 286
ILE B 289
LEU B 284
 None
 1.25A 5m45J-4di4B:
0.0		 5m45J-4di4B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE

(Streptococcus
mutans) 		PF01063
(Aminotran_4) 		4 GLU A 266
PRO A 238
ILE A 243
LEU A 239
 None
 1.23A 5m45J-4dqnA:
undetectable		 5m45J-4dqnA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 GLU A 279
PRO A 278
ILE A 277
LEU A 276
 None
 1.27A 5m45J-4eziA:
undetectable		 5m45J-4eziA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2e CUPA

(Streptococcus
pneumoniae) 		PF13473
(Cupredoxin_1) 		4 GLU A  52
PRO A  51
ILE A  54
LEU A  53
 None
 1.09A 5m45J-4f2eA:
undetectable		 5m45J-4f2eA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f67 UPF0176 PROTEIN
LPG2838

(Legionella
pneumophila) 		PF00581
(Rhodanese) 		4 GLU A  23
PRO A  24
ILE A  25
LEU A  26
 None
 1.00A 5m45J-4f67A:
undetectable		 5m45J-4f67A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7h FERMITIN FAMILY
HOMOLOG 2

(Homo sapiens) 		PF00169
(PH) 		4 GLU A 427
PRO A 446
ILE A 445
LEU A 444
 None
 1.03A 5m45J-4f7hA:
undetectable		 5m45J-4f7hA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01699
(Na_Ca_ex) 		4 GLU A 258
PRO A 257
ILE A 260
LEU A 259
 None
 1.02A 5m45J-4kppA:
undetectable		 5m45J-4kppA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE

(Homo sapiens) 		PF00596
(Aldolase_II) 		4 GLU A  30
PRO A  29
ILE A  28
LEU A  27
 None
 1.21A 5m45J-4m6rA:
undetectable		 5m45J-4m6rA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2i NON-LEE ENCODED TYPE
III EFFECTOR C

(Citrobacter
rodentium) 		PF13678
(Peptidase_M85) 		4 GLU A 143
PRO A 144
ILE A 145
LEU A 146
 None
 1.10A 5m45J-4o2iA:
undetectable		 5m45J-4o2iA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		4 GLU A 103
PRO A 104
ILE A 105
LEU A 106
 None
 1.29A 5m45J-4p98A:
undetectable		 5m45J-4p98A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN

(Entamoeba
histolytica) 		PF13499
(EF-hand_7) 		4 GLU A 138
PRO A 136
ILE A 139
LEU A 134
 NA  A 301 ( 4.9A)
None
None
None
 1.25A 5m45J-4q04A:
undetectable		 5m45J-4q04A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 GLU A 536
PRO A 535
ILE A 534
LEU A 533
 None
 1.21A 5m45J-4rbnA:
undetectable		 5m45J-4rbnA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rug SLIT-ROBO RHO
GTPASE-ACTIVATING
PROTEIN 2

(Homo sapiens) 		PF00018
(SH3_1) 		4 GLU A 746
PRO A 778
ILE A 777
LEU A 776
 None
 1.14A 5m45J-4rugA:
undetectable		 5m45J-4rugA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx1 ESTERASE

(Sinorhizobium
meliloti) 		PF13472
(Lipase_GDSL_2) 		4 GLU A 128
PRO A 127
ILE A  83
LEU A  82
 None
 1.30A 5m45J-4tx1A:
undetectable		 5m45J-4tx1A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 GLU A1591
PRO A1325
ILE A1592
LEU A1594
 None
 1.24A 5m45J-4wxxA:
undetectable		 5m45J-4wxxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		4 GLU A  90
PRO A  94
ILE A  92
LEU A  89
 None
 1.15A 5m45J-4y9sA:
undetectable		 5m45J-4y9sA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7z UNCHARACTERIZED
PROTEIN TM_0416

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		4 GLU A 149
PRO A 150
ILE A 148
LEU A 180
 NI  A 305 (-2.4A)
None
None
None
 1.30A 5m45J-5b7zA:
undetectable		 5m45J-5b7zA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 GLU A 372
PRO A 371
ILE A 370
LEU A 369
 None
 1.15A 5m45J-5bzaA:
undetectable		 5m45J-5bzaA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		4 GLU A 310
PRO A 307
ILE A 305
LEU A 309
 None
 1.17A 5m45J-5d1pA:
undetectable		 5m45J-5d1pA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dud YBGJ

(Escherichia
coli) 		PF02682
(CT_C_D) 		4 GLU B 198
PRO B 199
ILE B 200
LEU B 201
 None
 1.06A 5m45J-5dudB:
undetectable		 5m45J-5dudB:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e86 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 GLU A 533
PRO A 531
ILE A 534
LEU A 529
 None
 1.20A 5m45J-5e86A:
undetectable		 5m45J-5e86A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		4 GLU A1498
PRO A1497
ILE A1496
LEU A1482
 None
 1.07A 5m45J-5ffjA:
undetectable		 5m45J-5ffjA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 GLU A 478
PRO A 464
ILE A 463
LEU A 462
 None
 1.08A 5m45J-5fkuA:
undetectable		 5m45J-5fkuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE DELTA
CHAIN, MITOCHONDRIAL

(Yarrowia
lipolytica) 		PF02823
(ATP-synt_DE_N) 		4 GLU H  36
PRO H  31
ILE H  30
LEU H  37
 None
 1.17A 5m45J-5fl7H:
undetectable		 5m45J-5fl7H:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE

(Escherichia
coli) 		PF01814
(Hemerythrin)
PF04405
(ScdA_N) 		4 GLU A  93
PRO A  92
ILE A  95
LEU A  94
 None
 1.16A 5m45J-5fnpA:
0.6		 5m45J-5fnpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus) 		PF01248
(Ribosomal_L7Ae) 		4 GLU C 106
PRO C 107
ILE C 104
LEU C 105
 None
 1.31A 5m45J-5ginC:
undetectable		 5m45J-5ginC:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 GLU A 179
PRO A 280
ILE A 277
LEU A 278
 GCS  A 801 (-2.3A)
None
None
None
 1.23A 5m45J-5gsmA:
0.0		 5m45J-5gsmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 GLU A1593
PRO A1328
ILE A1594
LEU A1596
 None
 1.27A 5m45J-5gutA:
undetectable		 5m45J-5gutA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 GLU A  29
PRO A  30
ILE A  31
LEU A  27
 None
 1.21A 5m45J-5iclA:
undetectable		 5m45J-5iclA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
ES10
RIBOSOMAL PROTEIN
ES29

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		PF03501
(S10_plectin)
PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 GLU d   4
PRO K   4
ILE K   3
LEU K   2
 U  21231 ( 4.5A)
None
U  21256 ( 4.6A)
U  21231 ( 4.1A)
 1.13A 5m45J-5it9d:
undetectable		 5m45J-5it9d:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgh ARS-BINDING FACTOR
2, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00505
(HMG_box) 		4 GLU A  72
PRO A  70
ILE A  73
LEU A  68
 None
 1.33A 5m45J-5jghA:
undetectable		 5m45J-5jghA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 GLU A 297
PRO A 320
ILE A 295
LEU A 296
 None
 1.03A 5m45J-5kjzA:
undetectable		 5m45J-5kjzA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 GLU B 939
PRO B 938
ILE B 941
LEU B 940
 None
 1.13A 5m45J-5kyuB:
undetectable		 5m45J-5kyuB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myb ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		4 GLU A 643
PRO A 642
ILE A 661
LEU A 662
 None
 0.94A 5m45J-5mybA:
undetectable		 5m45J-5mybA:
15.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 GLU A  53
PRO A  54
ILE A  55
LEU A  56
 None
 0.38A 5m45J-5svcA:
59.4		 5m45J-5svcA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF07034
(ORC3_N) 		4 GLU A  99
PRO A 101
ILE A 100
LEU A 270
 None
 1.15A 5m45J-5uj8A:
0.0		 5m45J-5uj8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsf UNCHARACTERIZED
PROTEIN TM1459

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		4 GLU A  59
PRO A 109
ILE A 108
LEU A 107
 None
 1.01A 5m45J-5wsfA:
undetectable		 5m45J-5wsfA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z43 AMBP1

(Fischerella
ambigua) 		no annotation 4 GLU A  95
PRO A  94
ILE A  93
LEU A  92
 None
 1.22A 5m45J-5z43A:
undetectable		 5m45J-5z43A:
undetectable