SIMILAR PATTERNS OF AMINO ACIDS FOR 5M45_A_ACTA802_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhw | XYLOSE ISOMERASE (Actinoplanesmissouriensis) |
PF01261(AP_endonuc_2) | 4 | HIS A 243ASP A 245HIS A 290MET A 88 | None | 1.44A | 5m45A-1bhwA:0.1 | 5m45A-1bhwA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxc | XYLOSE ISOMERASE (Thermuscaldophilus) |
PF01261(AP_endonuc_2) | 4 | HIS A 242ASP A 244HIS A 284MET A 87 | None | 1.37A | 5m45A-1bxcA:0.0 | 5m45A-1bxcA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eyw | PHOSPHOTRIESTERASE (Brevundimonasdiminuta) |
PF02126(PTE) | 4 | HIS A 55ASP A 301HIS A 57TRP A 131 | ZN A 401 (-3.2A) ZN A 401 ( 2.6A) ZN A 401 (-3.3A)TEN A 403 (-4.4A) | 1.24A | 5m45A-1eywA:0.0 | 5m45A-1eywA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hww | ALPHA-MANNOSIDASE II (Drosophilamelanogaster) |
PF01074(Glyco_hydro_38)PF07748(Glyco_hydro_38C)PF09261(Alpha-mann_mid) | 4 | HIS A 471ASP A 204HIS A 90TRP A 95 | ZN A1102 ( 3.3A)SWA A1103 ( 3.0A) ZN A1102 ( 3.3A)SWA A1103 (-3.6A) | 1.40A | 5m45A-1hwwA:0.7 | 5m45A-1hwwA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pth | PEPTIDYL-TRNAHYDROLASE (Escherichiacoli) |
PF01195(Pept_tRNA_hydro) | 4 | HIS A 20ASP A 93HIS A 113MET A 67 | None | 1.49A | 5m45A-2pthA:0.0 | 5m45A-2pthA:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qsd | UNCHARACTERIZEDCONSERVED PROTEIN (Idiomarinaloihiensis) |
PF07566(DUF1543) | 4 | HIS A 54ASP A 56HIS A 25TRP A 46 | None | 1.33A | 5m45A-2qsdA:0.2 | 5m45A-2qsdA:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wyh | ALPHA-MANNOSIDASE (Streptococcuspyogenes) |
PF01074(Glyco_hydro_38)PF07748(Glyco_hydro_38C)PF09261(Alpha-mann_mid) | 4 | HIS A 351ASP A 125HIS A 13TRP A 18 | ZN A 902 (-3.4A) ZN A 902 (-3.5A) ZN A 902 (-3.4A)None | 1.43A | 5m45A-2wyhA:0.0 | 5m45A-2wyhA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9t | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNALPROTEIN (Methylobacillusflagellatus) |
PF03069(FmdA_AmdA) | 4 | HIS A 160ASP A 341HIS A 110TRP A 207 | EDO A 494 ( 3.9A) MG A 484 (-2.0A)EDO A 494 (-4.0A)EDO A 490 (-3.5A) | 1.43A | 5m45A-3b9tA:0.0 | 5m45A-3b9tA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i70 | AGRIN (Gallus gallus) |
PF03146(NtA) | 4 | HIS A 99ASP A 29HIS A 32MET A 95 | None | 1.22A | 5m45A-3i70A:undetectable | 5m45A-3i70A:11.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nea | PEPTIDYL-TRNAHYDROLASE (Francisellatularensis) |
PF01195(Pept_tRNA_hydro) | 4 | HIS A 22ASP A 95HIS A 115MET A 69 | EDO A 511 (-4.6A)NoneEDO A 511 ( 4.5A)None | 1.45A | 5m45A-3neaA:undetectable | 5m45A-3neaA:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tb2 | 1-CYS PEROXIREDOXIN (Plasmodiumyoelii) |
PF00578(AhpC-TSA)PF10417(1-cysPrx_C) | 4 | HIS A 79ASP A 42HIS A 39TRP A 95 | None | 1.33A | 5m45A-3tb2A:undetectable | 5m45A-3tb2A:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v2i | PEPTIDYL-TRNAHYDROLASE (Burkholderiathailandensis) |
PF01195(Pept_tRNA_hydro) | 4 | HIS A 20ASP A 93HIS A 113MET A 67 | None | 1.48A | 5m45A-3v2iA:0.0 | 5m45A-3v2iA:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cz1 | KYNURENINEFORMAMIDASE (Bacillusanthracis) |
PF04199(Cyclase) | 4 | HIS A 60ASP A 56HIS A 161TRP A 20 | VNJ A 501 (-4.2A) ZN A 401 ( 2.5A) ZN A 401 (-3.4A)VNJ A 501 (-3.6A) | 1.29A | 5m45A-4cz1A:undetectable | 5m45A-4cz1A:14.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fno | PEPTIDYL-TRNAHYDROLASE (Pseudomonasaeruginosa) |
PF01195(Pept_tRNA_hydro) | 4 | HIS A 22ASP A 95HIS A 115MET A 69 | None | 1.48A | 5m45A-4fnoA:undetectable | 5m45A-4fnoA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yly | PEPTIDYL-TRNAHYDROLASE (Staphylococcusaureus) |
PF01195(Pept_tRNA_hydro) | 4 | HIS A 19ASP A 91HIS A 111MET A 65 | None | 1.44A | 5m45A-4ylyA:undetectable | 5m45A-4ylyA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9w | ACETOPHENONECARBOXYLASE DELTASUBUNIT (Aromatoleumaromaticum) |
PF02538(Hydantoinase_B) | 4 | HIS A 123ASP A 126HIS A 148MET A 160 | HG A 701 (-3.3A) HG A 701 (-2.0A) HG A 701 (-3.5A)None | 0.78A | 5m45A-5l9wA:39.0 | 5m45A-5l9wA:25.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5svc | ACETONE CARBOXYLASEALPHA SUBUNIT (Xanthobacterautotrophicus) |
PF02538(Hydantoinase_B) | 6 | HIS A 150ASP A 153HIS A 175MET A 187TRP A 401TRP A 479 | MN A 801 (-2.9A) MN A 801 (-2.0A) MN A 801 (-3.1A)NoneNoneNone | 0.37A | 5m45A-5svcA:59.4 | 5m45A-5svcA:99.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w3w | ARYLDIALKYLPHOSPHATASE (Sulfolobussolfataricus) |
no annotation | 4 | HIS A 22ASP A 256HIS A 24TRP A 97 | FE A 401 (-3.3A) FE A 401 (-2.4A) FE A 401 (-3.2A)None | 1.49A | 5m45A-5w3wA:0.0 | 5m45A-5w3wA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y4j | XYLOSE ISOMERASE (Streptomycesrubiginosus) |
PF01261(AP_endonuc_2) | 4 | HIS A 243ASP A 245HIS A 285MET A 88 | None MG A 401 ( 3.0A)NoneNone | 1.38A | 5m45A-5y4jA:0.0 | 5m45A-5y4jA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6a31 | PEPTIDYL-TRNAHYDROLASE (Acinetobacterbaumannii) |
no annotation | 4 | HIS A 22ASP A 95HIS A 115MET A 69 | None | 1.46A | 5m45A-6a31A:undetectable | 5m45A-6a31A:undetectable |