SIMILAR PATTERNS OF AMINO ACIDS FOR 5M36_B_BEZB302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lr0 TOLA PROTEIN

(Pseudomonas
aeruginosa) 		PF13103
(TonB_2) 		4 PHE A 105
MET A  97
GLN A  98
ARG A 102
 None
 1.33A 5m36B-1lr0A:
undetectable		 5m36B-1lr0A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.91A 5m36B-2j6hA:
0.0		 5m36B-2j6hA:
17.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lu2 14-3-3 PROTEIN SIGMA

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.11A 5m36B-5lu2A:
33.2		 5m36B-5lu2A:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n6n PROTEIN BMH1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 201
MET A 223
GLN A 224
ARG A 227
 None
 1.06A 5m36B-5n6nA:
32.4		 5m36B-5n6nA:
66.11