SIMILAR PATTERNS OF AMINO ACIDS FOR 5M36_A_BEZA303_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA

(Helicobacter
pylori;
Helicobacter
pylori) 		PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 MET B 104
GLN B 105
ARG A 165
 None
 1.07A 5m36A-1e9yB:
undetectable		 5m36A-1e9yB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN

(Thermococcus
litoralis) 		PF01547
(SBP_bac_1) 		3 MET A 245
GLN A 248
ARG A 243
 PT  A 415 (-3.2A)
None
None
 1.03A 5m36A-1eu8A:
undetectable		 5m36A-1eu8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		3 MET A 330
GLN A 548
ARG A 329
 None
 0.81A 5m36A-1gxnA:
4.7		 5m36A-1gxnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		3 MET A  40
GLN A  48
ARG A 379
 None
 0.96A 5m36A-1h14A:
3.7		 5m36A-1h14A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlb HEMOGLOBIN (DEOXY)

(Molpadia
arenicola) 		PF00042
(Globin) 		3 MET A  70
GLN A  69
ARG A  68
 None
 1.11A 5m36A-1hlbA:
undetectable		 5m36A-1hlbA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ki9 ADENYLATE KINASE

(Methanothermococcus
thermolithotrophicus) 		PF13207
(AAA_17) 		3 MET A  59
GLN A  58
ARG A  60
 None
 1.02A 5m36A-1ki9A:
0.2		 5m36A-1ki9A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76

(Thermotoga
maritima) 		PF03641
(Lysine_decarbox) 		3 MET A  88
GLN A  87
ARG A  89
 None
 1.01A 5m36A-1rcuA:
undetectable		 5m36A-1rcuA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 MET A 210
GLN A 209
ARG A 208
 None
 1.01A 5m36A-1s5jA:
2.6		 5m36A-1s5jA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		3 MET A  27
GLN A  23
ARG A  24
 None
PO4  A 304 (-3.9A)
None
 0.84A 5m36A-1to3A:
undetectable		 5m36A-1to3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		3 MET A 141
GLN A 137
ARG A 138
 None
 0.99A 5m36A-1to3A:
undetectable		 5m36A-1to3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		3 MET A 139
GLN A  12
ARG A 137
 None
 1.13A 5m36A-1u70A:
undetectable		 5m36A-1u70A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xgy K42-41L FAB LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 MET L   4
GLN L   6
ARG L  24
 None
 1.06A 5m36A-1xgyL:
undetectable		 5m36A-1xgyL:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yio RESPONSE REGULATORY
PROTEIN

(Pseudomonas
fluorescens) 		PF00072
(Response_reg)
PF00196
(GerE) 		3 MET A 182
GLN A 183
ARG A 188
 None
 1.09A 5m36A-1yioA:
undetectable		 5m36A-1yioA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		3 MET A 551
GLN A 554
ARG A 209
 None
 0.70A 5m36A-2gw1A:
8.4		 5m36A-2gw1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwf RING FINGER PROTEIN
41

(Homo sapiens) 		PF08941
(USP8_interact) 		3 MET B 267
GLN B 266
ARG B 265
 None
 0.95A 5m36A-2gwfB:
undetectable		 5m36A-2gwfB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7v PROTEIN KINASE YPKA

(Yersinia
pseudotuberculosis) 		PF09632
(Rac1) 		3 MET C 664
GLN C 663
ARG C 662
 None
 1.10A 5m36A-2h7vC:
4.8		 5m36A-2h7vC:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE

(Aedes aegypti) 		PF00266
(Aminotran_5) 		3 MET A 190
GLN A  66
ARG A 194
 None
 0.89A 5m36A-2hufA:
undetectable		 5m36A-2hufA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		3 MET A 447
GLN A 446
ARG A 443
 None
 0.92A 5m36A-2j6hA:
undetectable		 5m36A-2j6hA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lck MITOCHONDRIAL
UNCOUPLING PROTEIN 2

(Mus musculus) 		PF00153
(Mito_carr) 		3 MET A  90
GLN A  89
ARG A  88
 None
 1.11A 5m36A-2lckA:
2.3		 5m36A-2lckA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldi ZINC-TRANSPORTING
ATPASE

(Synechocystis
sp. PCC 6803) 		PF00403
(HMA) 		3 MET A  12
GLN A  11
ARG A  47
 None
 0.86A 5m36A-2ldiA:
undetectable		 5m36A-2ldiA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7a UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		no annotation 3 MET A  21
GLN A  22
ARG A  32
 None
 0.97A 5m36A-2m7aA:
undetectable		 5m36A-2m7aA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm6 GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		3 MET B 505
GLN B 506
ARG B 513
 None
 1.06A 5m36A-2qm6B:
undetectable		 5m36A-2qm6B:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		3 MET A 279
GLN A 281
ARG A 280
 None
None
ACT  A1395 (-4.1A)
 0.94A 5m36A-2vqaA:
undetectable		 5m36A-2vqaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3z PUTATIVE DEACETYLASE

(Streptococcus
mutans) 		PF01522
(Polysacc_deac_1) 		3 MET A  96
GLN A  95
ARG A  94
 None
 0.96A 5m36A-2w3zA:
undetectable		 5m36A-2w3zA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn7 OUTER SURFACE
PROTEIN

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		3 MET A 396
GLN A 397
ARG A 400
 None
 0.80A 5m36A-2yn7A:
3.7		 5m36A-2yn7A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 MET A 170
GLN A 174
ARG A 173
 None
 1.06A 5m36A-2yv2A:
undetectable		 5m36A-2yv2A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0z FLAGELLAR
BIOSYNTHETIC PROTEIN
FLHB

(Salmonella
enterica) 		PF01312
(Bac_export_2) 		3 MET A 247
GLN A 246
ARG A 245
 None
 0.85A 5m36A-3b0zA:
undetectable		 5m36A-3b0zA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo6 HYDROPHILIC PROTEIN,
VIRA PROTEIN

(Chromobacterium
violaceum) 		PF03536
(VRP3) 		3 MET A  47
GLN A  46
ARG A  45
 None
 1.06A 5m36A-3bo6A:
undetectable		 5m36A-3bo6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt5 UNCHARACTERIZED
PROTEIN DUF305

(Deinococcus
radiodurans) 		PF03713
(DUF305) 		3 MET A  81
GLN A  80
ARG A  79
 None
None
CL  A 200 (-4.4A)
 1.02A 5m36A-3bt5A:
3.4		 5m36A-3bt5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8x THIOREDOXIN
REDUCTASE 1

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		3 MET A  71
GLN A  74
ARG A  70
 None
 1.09A 5m36A-3d8xA:
undetectable		 5m36A-3d8xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY

(Bacillus
anthracis) 		PF02567
(PhzC-PhzF) 		3 MET A 121
GLN A 123
ARG A 122
 None
 1.11A 5m36A-3ednA:
undetectable		 5m36A-3ednA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0d CTSR

(Geobacillus
stearothermophilus) 		PF05848
(CtsR) 		3 MET A 123
GLN A  95
ARG A 135
 None
None
PO4  A 157 (-3.9A)
 1.04A 5m36A-3h0dA:
2.3		 5m36A-3h0dA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itf PERIPLASMIC ADAPTOR
PROTEIN CPXP

(Escherichia
coli) 		PF07813
(LTXXQ) 		3 MET A 120
GLN A 119
ARG A 122
 None
 1.01A 5m36A-3itfA:
2.0		 5m36A-3itfA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-PROCESSING
PROTEIN 45

(Schizosaccharomyces
pombe) 		PF02731
(SKIP_SNW) 		3 MET M 312
GLN M 314
ARG M 313
 None
 1.01A 5m36A-3jb9M:
undetectable		 5m36A-3jb9M:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcx FAB E LIGHT CHAIN

(Rattus
norvegicus) 		PF07686
(V-set) 		3 MET L  76
GLN L  77
ARG L  59
 None
 0.96A 5m36A-3jcxL:
undetectable		 5m36A-3jcxL:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		3 MET D 462
GLN D 463
ARG D 466
 None
 0.79A 5m36A-3k70D:
undetectable		 5m36A-3k70D:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 MET A1247
GLN A1250
ARG A1246
 None
 1.11A 5m36A-3lw0A:
undetectable		 5m36A-3lw0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 MET A 330
GLN A 329
ARG A 328
 None
 1.08A 5m36A-3m4pA:
undetectable		 5m36A-3m4pA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		3 MET A 320
GLN A 319
ARG A 318
 None
 1.13A 5m36A-3mzvA:
3.6		 5m36A-3mzvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ni7 BACTERIAL REGULATORY
PROTEINS, TETR
FAMILY

(Nitrosomonas
europaea) 		PF00440
(TetR_N)
PF08511
(COQ9) 		3 MET A 105
GLN A 104
ARG A 103
 None
 1.05A 5m36A-3ni7A:
2.3		 5m36A-3ni7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		3 MET A 479
GLN A 483
ARG A 482
 None
 1.00A 5m36A-3odwA:
2.6		 5m36A-3odwA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		3 MET A 479
GLN A 483
ARG A 482
 None
 0.94A 5m36A-3odxA:
2.6		 5m36A-3odxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 MET A1320
GLN A1321
ARG A1305
 None
 1.12A 5m36A-3plsA:
undetectable		 5m36A-3plsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		3 MET A 482
GLN A 481
ARG A 484
 None
 1.05A 5m36A-3q4tA:
undetectable		 5m36A-3q4tA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk FUSION OF UREASE
BETA AND GAMMA
SUBUNITS
UREASE SUBUNIT BETA
2

(Helicobacter
mustelae;
Helicobacter
mustelae) 		PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 MET C 103
GLN C 104
ARG A 165
 None
 0.99A 5m36A-3qgkC:
undetectable		 5m36A-3qgkC:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0y NEPR

(Caulobacter
vibrioides) 		no annotation 3 MET B  41
GLN B  40
ARG B  39
 None
 1.12A 5m36A-3t0yB:
undetectable		 5m36A-3t0yB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgv HEME-BINDING PROTEIN
HUTZ

(Vibrio cholerae) 		PF01243
(Putative_PNPOx) 		3 MET A  76
GLN A  29
ARG A  25
 None
 1.07A 5m36A-3tgvA:
undetectable		 5m36A-3tgvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		3 MET A 177
GLN A 176
ARG A 203
 None
 0.80A 5m36A-3ue1A:
undetectable		 5m36A-3ue1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 MET A2766
GLN A2765
ARG A2764
 None
None
MG  A   1 ( 4.9A)
 1.05A 5m36A-3vkgA:
undetectable		 5m36A-3vkgA:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 MET A 507
GLN A 505
ARG A 571
 None
None
MPD  A1207 ( 4.1A)
 1.05A 5m36A-3w5nA:
6.3		 5m36A-3w5nA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		3 MET A 143
GLN A 144
ARG A 147
 None
 1.12A 5m36A-3wczA:
undetectable		 5m36A-3wczA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		3 MET A  66
GLN A  67
ARG A  72
 None
 1.05A 5m36A-3zjkA:
undetectable		 5m36A-3zjkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis) 		PF16754
(Pesticin) 		3 MET A 234
GLN A 210
ARG A 211
 None
 1.04A 5m36A-4arpA:
undetectable		 5m36A-4arpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 MET R 212
GLN R 211
ARG R 214
 None
 1.04A 5m36A-4bv4R:
undetectable		 5m36A-4bv4R:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		3 MET B 661
GLN B 660
ARG B 659
 None
 0.80A 5m36A-4ci6B:
4.4		 5m36A-4ci6B:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 MET A 619
GLN A 618
ARG A 617
 None
 0.93A 5m36A-4cyjA:
undetectable		 5m36A-4cyjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
subtilis) 		PF02350
(Epimerase_2) 		3 MET A 140
GLN A 139
ARG A 138
 None
 1.07A 5m36A-4fkzA:
undetectable		 5m36A-4fkzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gps KLLA0E02245P

(Kluyveromyces
lactis) 		no annotation 3 MET A 294
GLN A 297
ARG A 293
 None
CIT  A 501 (-3.6A)
CIT  A 501 (-3.0A)
 1.07A 5m36A-4gpsA:
undetectable		 5m36A-4gpsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 MET A 311
GLN A 310
ARG A 309
 None
 1.13A 5m36A-4iv5A:
undetectable		 5m36A-4iv5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpp MINOR SPIKE PROTEIN
H

(Escherichia
virus phiX174) 		PF04687
(Microvir_H) 		3 MET A 232
GLN A 231
ARG A 230
 None
 0.90A 5m36A-4jppA:
undetectable		 5m36A-4jppA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 MET A  48
GLN A  47
ARG A  46
 None
 0.88A 5m36A-4lglA:
undetectable		 5m36A-4lglA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		3 MET A 277
GLN A 280
ARG A 255
 None
 1.12A 5m36A-4mdpA:
undetectable		 5m36A-4mdpA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE

(Aquifex
aeolicus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		3 MET A 245
GLN A 242
ARG A 246
 None
None
ADP  A1001 (-2.6A)
 0.96A 5m36A-4nmnA:
2.6		 5m36A-4nmnA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		3 MET A 103
GLN A 131
ARG A 102
 None
 1.08A 5m36A-4ozyA:
undetectable		 5m36A-4ozyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 MET A 964
GLN A 967
ARG A 781
 None
 1.12A 5m36A-4q0wA:
undetectable		 5m36A-4q0wA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd9 AMYLOID-LIKE PROTEIN
1

(Homo sapiens) 		PF12925
(APP_E2) 		3 MET A 445
GLN A 444
ARG A 446
 None
 1.06A 5m36A-4rd9A:
7.0		 5m36A-4rd9A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpd CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		3 MET A 303
GLN A 304
ARG A 289
 None
 1.05A 5m36A-4rpdA:
undetectable		 5m36A-4rpdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz2 SITE-DETERMINING
PROTEIN

(Geobacillus
thermodenitrificans) 		PF10609
(ParA) 		3 MET A 258
GLN A 257
ARG A 256
 None
 1.07A 5m36A-4rz2A:
undetectable		 5m36A-4rz2A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7i SPARTIN

(Homo sapiens) 		PF04212
(MIT) 		3 MET A  77
GLN A  76
ARG A  75
 None
 1.12A 5m36A-4u7iA:
6.6		 5m36A-4u7iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		3 MET A 618
GLN A 617
ARG A 723
 None
 0.91A 5m36A-4xpdA:
undetectable		 5m36A-4xpdA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynh SPINDLE ASSEMBLY
ABNORMAL PROTEIN 5

(Caenorhabditis
elegans) 		no annotation 3 MET A 242
GLN A 245
ARG A 244
 None
 1.06A 5m36A-4ynhA:
undetectable		 5m36A-4ynhA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpk GAMMA-GLUTAMYLTRANSP
EPTIDASE (GGT)

(Helicobacter
pylori) 		PF01019
(G_glu_transpept) 		3 MET C 505
GLN C 506
ARG C 513
 None
 1.03A 5m36A-5bpkC:
undetectable		 5m36A-5bpkC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds0 PEPTIDASE M42

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF05343
(Peptidase_M42) 		3 MET A 195
GLN A 198
ARG A 193
 None
 1.08A 5m36A-5ds0A:
undetectable		 5m36A-5ds0A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 MET A 405
GLN A 403
ARG A 407
 None
 0.79A 5m36A-5e6sA:
undetectable		 5m36A-5e6sA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 MET A 244
GLN A 247
ARG A 392
 None
U  B   2 ( 2.9A)
None
 0.99A 5m36A-5elxA:
undetectable		 5m36A-5elxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		3 MET D 341
GLN D 339
ARG D 185
 None
 0.90A 5m36A-5exrD:
undetectable		 5m36A-5exrD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		3 MET A 230
GLN A 287
ARG A 313
 FAD  A 401 (-3.6A)
None
None
 0.99A 5m36A-5ez7A:
undetectable		 5m36A-5ez7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 MET A 307
GLN A 306
ARG A 305
 None
 0.79A 5m36A-5fl7A:
undetectable		 5m36A-5fl7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq1 GENOME POLYPROTEIN

(Enterovirus A) 		PF00910
(RNA_helicase) 		3 MET A 193
GLN A 192
ARG A 241
 None
 0.86A 5m36A-5gq1A:
undetectable		 5m36A-5gq1A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome) 		PF00150
(Cellulase) 		3 MET A 201
GLN A 181
ARG A 215
 None
 1.04A 5m36A-5i2uA:
undetectable		 5m36A-5i2uA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imt INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 MET A 206
GLN A 207
ARG A 205
 SO4  A 602 (-4.9A)
None
None
 1.09A 5m36A-5imtA:
undetectable		 5m36A-5imtA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izt OUTER SURFACE
PROTEIN

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		3 MET A 396
GLN A 397
ARG A 400
 None
 0.91A 5m36A-5iztA:
3.7		 5m36A-5iztA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 3 MET B 481
GLN B 485
ARG B 516
 None
 0.77A 5m36A-5ltmB:
3.4		 5m36A-5ltmB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdq CHITOPORIN

(Vibrio harveyi) 		no annotation 3 MET A  48
GLN A  49
ARG A  32
 None
 0.95A 5m36A-5mdqA:
undetectable		 5m36A-5mdqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		3 MET A1411
GLN A1414
ARG A1409
 None
 1.10A 5m36A-5me3A:
4.4		 5m36A-5me3A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mps SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1

(Saccharomyces
cerevisiae) 		PF02847
(MA3) 		3 MET h  36
GLN h  35
ARG h  88
 U  5 173 ( 4.6A)
U  5 172 ( 3.8A)
U  5 171 ( 2.9A)
 1.12A 5m36A-5mpsh:
undetectable		 5m36A-5mpsh:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n6n PROTEIN BMH1

(Saccharomyces
cerevisiae) 		no annotation 3 MET A 223
GLN A 224
ARG A 227
 None
 0.94A 5m36A-5n6nA:
32.5		 5m36A-5n6nA:
66.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 MET A2237
GLN A2236
ARG A2235
 None
 1.08A 5m36A-5nnnA:
undetectable		 5m36A-5nnnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL

(Homo sapiens) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		3 MET d  57
GLN d  58
ARG d  61
 None
 1.04A 5m36A-5oold:
undetectable		 5m36A-5oold:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB

(Escherichia
coli) 		no annotation 3 MET B 126
GLN B 125
ARG B 124
 None
 1.11A 5m36A-5sv0B:
3.5		 5m36A-5sv0B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		3 MET C 577
GLN C 576
ARG C 575
 None
 1.06A 5m36A-5tw1C:
undetectable		 5m36A-5tw1C:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umu FACT COMPLEX SUBUNIT
SPT16

(Homo sapiens) 		no annotation 3 MET A 676
GLN A 677
ARG A 675
 None
None
FMT  A1009 ( 4.6A)
 1.06A 5m36A-5umuA:
undetectable		 5m36A-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 MET A  19
GLN A  22
ARG A  18
 None
 1.00A 5m36A-5ur2A:
2.8		 5m36A-5ur2A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 3 MET A 240
GLN A 237
ARG A 274
 None
 0.97A 5m36A-5utiA:
undetectable		 5m36A-5utiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC

(Umbellularia
californica) 		no annotation 3 MET A 133
GLN A 134
ARG A 199
 None
 0.94A 5m36A-5x04A:
undetectable		 5m36A-5x04A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 3 MET A 413
GLN A 414
ARG A 423
 None
 0.79A 5m36A-6c0tA:
undetectable		 5m36A-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cws C-C MOTIF CHEMOKINE
28

(Homo sapiens) 		no annotation 3 MET A  66
GLN A  69
ARG A  21
 None
 1.08A 5m36A-6cwsA:
undetectable		 5m36A-6cwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 3 MET A 715
GLN A 714
ARG A 713
 None
 1.04A 5m36A-6fa5A:
undetectable		 5m36A-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		3 MET A  56
GLN A  54
ARG A  64
 3TL  A 201 (-4.7A)
3TL  A 201 ( 4.1A)
None
 0.97A 5m36A-6fivA:
undetectable		 5m36A-6fivA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Mus musculus) 		no annotation 3 MET N 175
GLN N 174
ARG N 176
 None
 0.89A 5m36A-6g72N:
undetectable		 5m36A-6g72N:
undetectable