SIMILAR PATTERNS OF AMINO ACIDS FOR 5M35_A_BEZA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2w HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Thermotoga
maritima) 		PF04204
(HTS) 		4 PHE A 152
THR A 125
MET A 128
ARG A 132
 None
 1.44A 5m35A-2h2wA:
undetectable		 5m35A-2h2wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 PHE A 575
MET A 447
GLN A 446
ARG A 443
 None
 0.93A 5m35A-2j6hA:
undetectable		 5m35A-2j6hA:
17.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2npm 14-3-3 DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		4 PHE A 225
THR A 244
MET A 247
GLN A 248
 None
 0.38A 5m35A-2npmA:
32.8		 5m35A-2npmA:
58.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynx LACA THIOREDOXIN

(synthetic
construct) 		PF00085
(Thioredoxin) 		4 PHE A  78
THR A  75
GLN A  87
ARG A 100
 None
 1.49A 5m35A-2ynxA:
undetectable		 5m35A-2ynxA:
23.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3axy 14-3-3-LIKE PROTEIN
GF14-C

(Oryza sativa) 		PF00244
(14-3-3) 		4 PHE C 200
THR C 219
MET C 222
GLN C 223
 None
 0.54A 5m35A-3axyC:
32.8		 5m35A-3axyC:
63.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhv THIOREDOXIN (TRXA-2)

(Sulfolobus
solfataricus) 		PF00085
(Thioredoxin) 		4 PHE A 107
THR A 104
GLN A 116
ARG A 129
 None
 1.40A 5m35A-3hhvA:
undetectable		 5m35A-3hhvA:
18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m51 14-3-3-LIKE PROTEIN
C

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		4 PHE A 205
THR A 224
MET A 227
GLN A 228
 None
 0.64A 5m35A-3m51A:
31.6		 5m35A-3m51A:
64.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 PHE X 289
THR X 277
GLN X 316
ARG X 293
 None
 1.33A 5m35A-3pb9X:
undetectable		 5m35A-3pb9X:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ubw 14-3-3 PROTEIN
EPSILON

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 199
THR A 218
MET A 221
ARG A 225
 None
 1.21A 5m35A-3ubwA:
33.5		 5m35A-3ubwA:
69.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dx0 14-3-3-LIKE PROTEIN
E

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		4 PHE A 203
THR A 222
MET A 225
GLN A 226
 None
 0.57A 5m35A-4dx0A:
30.8		 5m35A-4dx0A:
63.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 PHE W 751
THR W 734
MET W 737
GLN W 738
 None
 0.75A 5m35A-4f5xW:
undetectable		 5m35A-4f5xW:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN

(Arabidopsis
thaliana) 		PF00225
(Kinesin) 		4 PHE A1008
THR A1104
GLN A1103
ARG A1007
 None
 1.02A 5m35A-4frzA:
undetectable		 5m35A-4frzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 PHE A 412
THR A 388
MET A 391
GLN A 392
 None
 1.27A 5m35A-4pfwA:
undetectable		 5m35A-4pfwA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF09440
(eIF3_N) 		4 PHE E 137
THR E 101
MET E 104
GLN E 105
 None
 0.75A 5m35A-5a5tE:
5.5		 5m35A-5a5tE:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iqp 14-3-3 PROTEIN THETA

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 196
THR A 215
MET A 218
ARG A 222
 None
 1.06A 5m35A-5iqpA:
33.7		 5m35A-5iqpA:
80.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lu2 14-3-3 PROTEIN SIGMA

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.06A 5m35A-5lu2A:
33.4		 5m35A-5lu2A:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lu2 14-3-3 PROTEIN SIGMA

(Homo sapiens) 		PF00244
(14-3-3) 		4 PHE A 198
THR A 217
MET A 220
ARG A 224
 None
 0.85A 5m35A-5lu2A:
33.4		 5m35A-5lu2A:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n6n PROTEIN BMH1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 201
MET A 223
GLN A 224
ARG A 227
 None
 0.98A 5m35A-5n6nA:
33.0		 5m35A-5n6nA:
66.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n6n PROTEIN BMH1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 201
THR A 220
MET A 223
ARG A 227
 None
 0.62A 5m35A-5n6nA:
33.0		 5m35A-5n6nA:
66.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC

(Umbellularia
californica) 		no annotation 4 PHE A 201
MET A 133
GLN A 134
ARG A 199
 None
 1.15A 5m35A-5x04A:
undetectable		 5m35A-5x04A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byk 14-3-3 PROTEIN
BETA/ALPHA

(Homo sapiens) 		no annotation 4 PHE A 198
THR A 217
MET A 220
ARG A 224
 None
 1.47A 5m35A-6bykA:
33.9		 5m35A-6bykA:
undetectable