SIMILAR PATTERNS OF AMINO ACIDS FOR 5M24_A_9CRA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens)
PF00561
(Abhydrolase_1)
5 ALA A 115
LEU A 117
ILE A 118
LEU A  76
ILE A 104
None
1.05A 5m24A-1a8sA:
undetectable
5m24A-1a8sA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2


(Homo sapiens)
PF00104
(Hormone_recep)
12 TRP A 227
PHE A 230
ALA A 234
LEU A 271
MET A 272
ILE A 275
ARG A 278
SER A 289
PHE A 304
GLY A 393
LEU A 400
ILE A 412
None
961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-3.1A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 ( 4.0A)
None
961  A 450 ( 4.1A)
0.50A 5m24A-1exxA:
41.0
5m24A-1exxA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00579
(tRNA-synt_1b)
5 ALA A 299
ILE A 115
ARG A  63
GLY A 242
LEU A 254
None
1.12A 5m24A-1h3eA:
undetectable
5m24A-1h3eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE


(Thermus
thermophilus)
PF00764
(Arginosuc_synth)
5 PHE A 220
ALA A 337
SER A 287
GLY A 274
LEU A 238
None
0.85A 5m24A-1kh2A:
0.0
5m24A-1kh2A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE


(Thermus
thermophilus)
PF00764
(Arginosuc_synth)
5 PHE A 220
ALA A 337
SER A 287
GLY A 275
LEU A 238
None
0.94A 5m24A-1kh2A:
0.0
5m24A-1kh2A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus)
PF00962
(A_deaminase)
5 PHE A 331
ALA A 176
GLY A 234
LEU A  11
ILE A 148
None
0.99A 5m24A-1krmA:
undetectable
5m24A-1krmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 ALA A   6
LEU A   8
ILE A  49
GLY A  29
ILE A   2
None
0.91A 5m24A-1kyaA:
undetectable
5m24A-1kyaA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Tritrichomonas
suis)
PF00478
(IMPDH)
5 PHE A  12
ALA A 370
ILE A 336
GLY A 312
ILE A 378
None
1.00A 5m24A-1lrtA:
undetectable
5m24A-1lrtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE


(Plasmodium
falciparum)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 PHE A 405
ALA A 442
LEU A 446
ARG A  33
PHE A 401
None
0.78A 5m24A-1v8bA:
0.0
5m24A-1v8bA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x94 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE


(Vibrio cholerae)
PF13580
(SIS_2)
5 ALA A  33
ILE A 186
PHE A  62
LEU A 118
ILE A 160
None
1.00A 5m24A-1x94A:
0.1
5m24A-1x94A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA


(Homo sapiens)
PF00104
(Hormone_recep)
11 TRP A 218
PHE A 221
ALA A 225
LEU A 262
ILE A 266
ARG A 269
SER A 280
PHE A 295
GLY A 384
LEU A 391
ILE A 403
None
TTB  A   1 (-4.7A)
TTB  A   1 (-4.0A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
TTB  A   1 ( 4.0A)
None
TTB  A   1 ( 4.8A)
0.74A 5m24A-1xapA:
38.4
5m24A-1xapA:
86.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xdk RETINOIC ACID
RECEPTOR, BETA


(Mus musculus)
PF00104
(Hormone_recep)
11 TRP B 218
PHE B 221
ALA B 225
LEU B 262
ILE B 266
ARG B 269
SER B 280
PHE B 295
GLY B 384
LEU B 391
ILE B 403
None
9CR  B 600 ( 4.7A)
9CR  B 600 (-3.8A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 3.8A)
9CR  B 600 (-3.8A)
9CR  B 600 (-3.0A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 4.6A)
None
9CR  B 600 ( 4.4A)
0.49A 5m24A-1xdkB:
37.5
5m24A-1xdkB:
79.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
5 PHE A  80
ALA A  55
PHE A  96
GLY A  92
ILE A  87
None
0.94A 5m24A-1xeuA:
undetectable
5m24A-1xeuA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y80 PREDICTED COBALAMIN
BINDING PROTEIN


(Moorella
thermoacetica)
PF02310
(B12-binding)
5 MET A 156
ILE A 160
GLY A 177
LEU A 204
ILE A 142
None
None
B1M  A 301 (-3.5A)
None
None
1.10A 5m24A-1y80A:
undetectable
5m24A-1y80A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN


(Homo sapiens)
PF00102
(Y_phosphatase)
5 ALA A1156
LEU A1179
GLY A1147
LEU A1036
ILE A1153
None
1.09A 5m24A-1yguA:
undetectable
5m24A-1yguA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 PHE A 127
ALA A 111
SER A 365
GLY A  61
ILE A  43
None
1.12A 5m24A-1ysjA:
undetectable
5m24A-1ysjA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum)
PF00117
(GATase)
5 PHE A 154
ALA A  83
ILE A 161
PHE A 140
GLY A  91
None
1.05A 5m24A-2a9vA:
undetectable
5m24A-2a9vA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fxv XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE


(Bacillus
subtilis)
PF00156
(Pribosyltran)
5 ALA A 176
ILE A 152
SER A 157
GLY A  39
LEU A  34
None
1.11A 5m24A-2fxvA:
undetectable
5m24A-2fxvA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnw NON-SYMBIOTIC
HEMOGLOBIN 1


(Oryza sativa)
PF00042
(Globin)
5 TRP A  40
PHE A  39
ALA A 124
ILE A 129
PHE A  78
None
1.07A 5m24A-2gnwA:
undetectable
5m24A-2gnwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 ALA A   6
LEU A   8
ILE A  49
GLY A  29
ILE A   2
None
0.91A 5m24A-2hzhA:
undetectable
5m24A-2hzhA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5j HASR PROTEIN

(Serratia
marcescens)
PF07660
(STN)
5 ALA A  26
MET A  48
GLY A  68
LEU A  63
ILE A  18
None
1.08A 5m24A-2m5jA:
undetectable
5m24A-2m5jA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Arabidopsis
thaliana)
PF02542
(YgbB)
5 ALA A  83
LEU A  52
ILE A  60
GLY A   7
LEU A  97
None
None
C5P  A 700 (-4.9A)
None
None
1.06A 5m24A-2pmpA:
undetectable
5m24A-2pmpA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14


(Homo sapiens)
PF00566
(RabGAP-TBC)
5 ALA A 514
LEU A 506
ILE A 503
LEU A 575
ILE A 400
None
UNX  A 201 ( 4.0A)
None
None
None
0.99A 5m24A-2qq8A:
undetectable
5m24A-2qq8A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ


(Aquifex
aeolicus)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 PHE 1 132
ALA 1 178
ILE 1 165
SER 1 169
GLY 1  18
ILE 1 175
None
None
None
None
GDP  1 339 (-3.4A)
None
1.33A 5m24A-2r6r1:
undetectable
5m24A-2r6r1:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc2 INTEGRIN ALPHA-IIB

(Homo sapiens)
PF01839
(FG-GAP)
PF13517
(VCBS)
5 LEU A 306
SER A 344
PHE A 289
GLY A 256
ILE A 360
None
1.08A 5m24A-2vc2A:
undetectable
5m24A-2vc2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri)
PF01979
(Amidohydro_1)
5 ALA A  36
LEU A  42
MET A  43
LEU A 333
ILE A  37
None
1.12A 5m24A-2vunA:
undetectable
5m24A-2vunA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE


(Rhodospirillum
rubrum)
PF03747
(ADP_ribosyl_GH)
5 ALA A 129
LEU A 250
SER A  65
LEU A 193
ILE A 213
None
1.10A 5m24A-2wocA:
undetectable
5m24A-2wocA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE


(Xanthomonas
campestris)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
5 ALA A 484
ILE A 373
PHE A 575
GLY A 357
LEU A 477
None
1.04A 5m24A-2wpgA:
undetectable
5m24A-2wpgA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 ALA A   6
LEU A   8
ILE A  49
GLY A  29
ILE A   2
None
0.94A 5m24A-2xybA:
undetectable
5m24A-2xybA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a68 FERRITIN-4,
CHLOROPLASTIC


(Glycine max)
PF00210
(Ferritin)
5 PHE A  84
ALA A 132
ILE A 181
SER A 138
PHE A  83
None
1.02A 5m24A-3a68A:
undetectable
5m24A-3a68A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350


(Thermus
thermophilus)
PF00582
(Usp)
5 ALA A   6
LEU A   4
ILE A   3
LEU A 137
ILE A 103
ALA  A   6 ( 0.0A)
LEU  A   4 ( 0.6A)
ILE  A   3 ( 0.7A)
LEU  A 137 ( 0.6A)
ILE  A 103 ( 0.7A)
1.05A 5m24A-3ab7A:
undetectable
5m24A-3ab7A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj5 PROTEIN
DISULFIDE-ISOMERASE


(Homo sapiens)
PF13848
(Thioredoxin_6)
5 ALA A 272
ILE A 301
PHE A 232
GLY A 234
ILE A 221
None
1.05A 5m24A-3bj5A:
undetectable
5m24A-3bj5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE EPSILON SUBUNIT


(Methanosarcina
barkeri)
PF02552
(CO_dh)
5 ALA G  66
LEU G  38
ILE G 112
SER G  58
ILE G  85
None
1.08A 5m24A-3cf4G:
undetectable
5m24A-3cf4G:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkt MARITIMACIN

(Thermotoga
maritima)
PF04454
(Linocin_M18)
5 ALA A 154
LEU A 266
PHE A 183
LEU A 193
ILE A 155
None
1.09A 5m24A-3dktA:
undetectable
5m24A-3dktA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE


(Methanococcus
maripaludis)
PF08241
(Methyltransf_11)
5 ALA A  59
ILE A  35
SER A  64
GLY A 148
LEU A 154
None
1.06A 5m24A-3dlcA:
undetectable
5m24A-3dlcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae)
PF01048
(PNP_UDP_1)
5 ALA A  55
MET A   9
ILE A  50
GLY A  75
ILE A 179
None
BIG  A 301 ( 4.1A)
BIG  A 301 (-3.8A)
None
None
1.10A 5m24A-3dp9A:
undetectable
5m24A-3dp9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG


(Sulfolobus
solfataricus)
PF01890
(CbiG_C)
PF11760
(CbiG_N)
5 ALA A 330
LEU A 316
ILE A 317
SER A 217
GLY A  16
None
1.08A 5m24A-3eeqA:
undetectable
5m24A-3eeqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens)
PF00266
(Aminotran_5)
5 LEU C 195
MET C 194
ILE C 193
SER C 210
GLY C 201
None
1.05A 5m24A-3gzdC:
undetectable
5m24A-3gzdC:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA


(Moorella
thermoacetica)
PF03598
(CdhC)
5 PHE M 251
ALA M 305
ILE M 311
PHE M 181
ILE M 301
None
1.01A 5m24A-3i04M:
undetectable
5m24A-3i04M:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw3 ALANINE RACEMASE

(Bartonella
henselae)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 ALA A 252
ILE A 339
GLY A 299
LEU A 308
ILE A 283
None
1.05A 5m24A-3kw3A:
undetectable
5m24A-3kw3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli)
PF01048
(PNP_UDP_1)
5 ALA A  55
MET A   9
ILE A  50
GLY A  75
ILE A 178
None
4CT  A 233 ( 3.8A)
4CT  A 233 (-3.7A)
None
None
1.12A 5m24A-3o4vA:
undetectable
5m24A-3o4vA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olm E3 UBIQUITIN-PROTEIN
LIGASE RSP5


(Saccharomyces
cerevisiae)
PF00397
(WW)
PF00632
(HECT)
5 ALA A 468
LEU A 507
GLY A 555
LEU A 480
ILE A 457
None
1.07A 5m24A-3olmA:
undetectable
5m24A-3olmA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbp NUCLEOPORIN
NUP116/NSP116


(Saccharomyces
cerevisiae)
PF04096
(Nucleoporin2)
5 PHE B1005
ALA B1109
GLY B 996
LEU B1019
ILE B1033
None
1.03A 5m24A-3pbpB:
undetectable
5m24A-3pbpB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5


(Mycobacterium
marinum)
PF00378
(ECH_1)
5 TRP A 114
PHE A  39
ALA A  51
GLY A  55
LEU A 111
None
1.13A 5m24A-3qkaA:
undetectable
5m24A-3qkaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0z D-SERINE DEHYDRATASE

(Salmonella
enterica)
PF00291
(PALP)
5 PHE A  65
ILE A 175
SER A 112
GLY A 181
LEU A 148
None
1.09A 5m24A-3r0zA:
undetectable
5m24A-3r0zA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3c 4-HYDROXYBENZOYL-COA
THIOESTERASE


(Arthrobacter
sp.)
PF03061
(4HBT)
5 ALA A 111
LEU A  75
MET A  74
SER A 140
GLY A  13
None
None
4CO  A 152 (-4.2A)
None
None
1.10A 5m24A-3r3cA:
undetectable
5m24A-3r3cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6h ENOYL-COA HYDRATASE,
ECHA3


(Mycobacterium
marinum)
PF00378
(ECH_1)
5 PHE A 174
ALA A 109
MET A 142
SER A 114
GLY A 159
None
0.85A 5m24A-3r6hA:
undetectable
5m24A-3r6hA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9q ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacteroides
abscessus)
PF00378
(ECH_1)
5 TRP A 118
PHE A  43
ALA A  55
GLY A  59
LEU A 115
None
1.09A 5m24A-3r9qA:
undetectable
5m24A-3r9qA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8i PROTEIN DDI1 HOMOLOG
1


(Homo sapiens)
PF09668
(Asp_protease)
5 PHE A 318
ALA A 305
LEU A 281
MET A 279
LEU A 255
None
1.05A 5m24A-3s8iA:
undetectable
5m24A-3s8iA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0p DNA POLYMERASE III,
BETA SUBUNIT


([Eubacterium]
rectale)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 ILE A  16
SER A  18
PHE A 227
GLY A 208
LEU A 134
None
1.06A 5m24A-3t0pA:
undetectable
5m24A-3t0pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2h S-LAYER PROTEIN
MA0829


(Methanosarcina
acetivorans)
PF07752
(S-layer)
5 LEU A 525
ILE A 527
SER A 508
PHE A 376
ILE A 391
None
1.07A 5m24A-3u2hA:
undetectable
5m24A-3u2hA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida)
PF00743
(FMO-like)
5 TRP A 170
PHE A 183
ALA A 204
LEU A 211
ILE A 200
None
1.10A 5m24A-3up4A:
undetectable
5m24A-3up4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE


(Bacteroides
ovatus)
PF03414
(Glyco_transf_6)
5 PHE A  28
ILE A 226
SER A 102
PHE A  94
GLY A 160
None
1.07A 5m24A-4ayjA:
undetectable
5m24A-4ayjA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0z 26S PROTEASOME
REGULATORY SUBUNIT
RPN12


(Schizosaccharomyces
pombe)
PF10075
(CSN8_PSD8_EIF3K)
5 ALA A  74
ILE A  62
SER A  69
GLY A  92
ILE A  78
None
SGM  A1226 (-4.7A)
None
None
None
1.12A 5m24A-4b0zA:
undetectable
5m24A-4b0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
5 LEU A 306
SER A 344
PHE A 289
GLY A 256
ILE A 360
None
1.10A 5m24A-4cakA:
undetectable
5m24A-4cakA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A


(Parabacteroides
distasonis)
PF09375
(Peptidase_M75)
5 ALA A 115
PHE A  61
GLY A 323
LEU A 337
ILE A 317
None
1.00A 5m24A-4ecgA:
undetectable
5m24A-4ecgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A


(Parabacteroides
distasonis)
PF09375
(Peptidase_M75)
5 ALA A 115
PHE A  61
GLY A 324
LEU A 337
ILE A 317
None
1.06A 5m24A-4ecgA:
undetectable
5m24A-4ecgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH


(Campylobacter
jejuni)
PF01808
(AICARFT_IMPCHas)
PF02142
(MGS)
5 PHE A 231
LEU A 350
ILE A 351
PHE A 226
ILE A 246
None
1.13A 5m24A-4ehiA:
undetectable
5m24A-4ehiA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewc PUTATIVE
NUCLEOPROTEIN


(Salmon isavirus)
no annotation 5 LEU A 390
ILE A 394
GLY A 170
LEU A 177
ILE A 257
None
0.92A 5m24A-4ewcA:
undetectable
5m24A-4ewcA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3p GLUTAMINE-BINDING
PERIPLASMIC PROTEIN


(Burkholderia
pseudomallei)
PF00497
(SBP_bac_3)
5 TRP A  64
ILE A  68
GLY A 211
LEU A 218
ILE A  58
None
1.11A 5m24A-4f3pA:
undetectable
5m24A-4f3pA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME


(unidentified)
PF12146
(Hydrolase_4)
5 ALA A 219
MET A 122
GLY A 128
LEU A 153
ILE A 221
None
0.98A 5m24A-4fblA:
undetectable
5m24A-4fblA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi4 AEROTAXIS TRANSDUCER
AER2


(Pseudomonas
aeruginosa)
PF13188
(PAS_8)
5 PHE A 233
LEU A 206
ILE A 213
GLY A 223
ILE A 195
HEM  A 301 (-2.8A)
None
None
None
HEM  A 301 (-4.5A)
1.13A 5m24A-4hi4A:
undetectable
5m24A-4hi4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1


(Homo sapiens)
PF13181
(TPR_8)
PF13424
(TPR_12)
5 TRP A 147
ALA A 182
LEU A 206
GLY A 217
ILE A 183
None
1.09A 5m24A-4houA:
undetectable
5m24A-4houA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE


(Rhizobium etli)
PF02826
(2-Hacid_dh_C)
5 ALA A  12
ILE A  36
ARG A  27
LEU A  75
ILE A  44
None
1.12A 5m24A-4hy3A:
undetectable
5m24A-4hy3A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip3 ORF169B

(Shigella
flexneri)
no annotation 6 ALA A 143
MET A 137
ILE A 190
SER A 104
PHE A  94
GLY A  64
None
1.36A 5m24A-4ip3A:
undetectable
5m24A-4ip3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgj CARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 15


(Mus musculus)
PF07686
(V-set)
5 ALA A  74
LEU A  85
GLY A  91
LEU A 103
ILE A  95
None
1.05A 5m24A-4jgjA:
undetectable
5m24A-4jgjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens)
PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2)
5 ALA A 688
LEU A 648
ILE A 649
GLY A 614
ILE A 685
None
1.07A 5m24A-4krfA:
undetectable
5m24A-4krfA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR


(Escherichia
coli)
PF04198
(Sugar-bind)
5 LEU A 132
ILE A 160
GLY A 125
LEU A 245
ILE A 207
None
1.11A 5m24A-4l5iA:
undetectable
5m24A-4l5iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2z GH62
ARABINOFURANOSIDASE


(Podospora
anserina)
PF03664
(Glyco_hydro_62)
5 PHE A  76
ALA A  63
ILE A  52
PHE A  78
ILE A  47
None
1.11A 5m24A-4n2zA:
undetectable
5m24A-4n2zA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns1 PURINE NUCLEOSIDE
PHOSPHORYLASE


(Porphyromonas
gingivalis)
PF01048
(PNP_UDP_1)
5 ALA A  93
LEU A  44
ILE A  43
GLY A 278
ILE A  55
None
1.07A 5m24A-4ns1A:
undetectable
5m24A-4ns1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2w PUTATIVE
ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE


(Streptococcus
pneumoniae)
PF01832
(Glucosaminidase)
5 PHE A 206
ALA A 232
ILE A 178
GLY A 166
LEU A 162
None
1.12A 5m24A-4q2wA:
undetectable
5m24A-4q2wA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis)
PF00378
(ECH_1)
5 PHE A  39
ALA A  51
ILE A   7
GLY A  55
LEU A 111
None
0.99A 5m24A-4qfeA:
undetectable
5m24A-4qfeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis)
PF00378
(ECH_1)
5 TRP A 114
PHE A  39
ALA A  51
ILE A   7
GLY A  55
EDO  A 303 (-3.6A)
None
None
None
None
1.08A 5m24A-4qfeA:
undetectable
5m24A-4qfeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE


(Crassicarpon
hotsonii)
PF16010
(CDH-cyt)
5 ALA A 109
LEU A  78
ILE A  80
SER A  92
PHE A  51
None
1.06A 5m24A-4qi3A:
undetectable
5m24A-4qi3A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1


(Mus musculus)
PF00307
(CH)
PF01494
(FAD_binding_3)
5 ALA A 363
LEU A 330
ARG A 358
GLY A 307
ILE A 238
None
1.12A 5m24A-4txkA:
undetectable
5m24A-4txkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y68 PUTATIVE
NISIN-RESISTANCE
PROTEIN


(Streptococcus
agalactiae)
no annotation 5 LEU C  48
ILE C  47
SER C  83
GLY C  55
ILE C  66
None
1.08A 5m24A-4y68C:
undetectable
5m24A-4y68C:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5s ACETIC ACID

(Talaromyces
cellulolyticus)
PF13472
(Lipase_GDSL_2)
5 ALA A 163
ILE A 130
GLY A   8
LEU A   6
ILE A 125
None
1.05A 5m24A-5b5sA:
undetectable
5m24A-5b5sA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c78 ATP-DRIVEN FLIPPASE
PGLK


(Campylobacter
jejuni)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
5 ALA A 461
ILE A 443
GLY A 426
LEU A 508
ILE A 530
None
1.01A 5m24A-5c78A:
undetectable
5m24A-5c78A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT


(Azospira oryzae)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 ALA A 669
LEU A 590
SER A 148
GLY A  30
ILE A 684
None
1.11A 5m24A-5chcA:
undetectable
5m24A-5chcA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis)
PF05147
(LANC_like)
PF13575
(DUF4135)
5 PHE A 286
ILE A 492
PHE A 343
GLY A 338
ILE A 298
None
1.10A 5m24A-5dztA:
undetectable
5m24A-5dztA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE


(Plasmodium
falciparum)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
5 ALA C 192
ILE C  33
GLY C  75
LEU C 147
ILE C  44
None
1.09A 5m24A-5fmgC:
undetectable
5m24A-5fmgC:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3


(Saccharomyces
cerevisiae)
PF13513
(HEAT_EZ)
5 LEU A 728
ILE A 727
SER A 773
LEU A 628
ILE A 704
None
1.12A 5m24A-5h2vA:
undetectable
5m24A-5h2vA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192


(Chaetomium
thermophilum)
PF11894
(Nup192)
5 ALA B1342
LEU B1321
SER B1212
PHE B1330
LEU B1375
None
1.13A 5m24A-5hb4B:
undetectable
5m24A-5hb4B:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpl RSP5

(Saccharomyces
cerevisiae)
PF00632
(HECT)
5 ALA A 468
LEU A 507
GLY A 555
LEU A 480
ILE A 457
None
1.09A 5m24A-5hplA:
undetectable
5m24A-5hplA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
9 TRP A 225
PHE A 228
LEU A 269
ILE A 273
ARG A 276
SER A 287
PHE A 302
GLY A 391
LEU A 398
None
6Q7  A 501 (-3.9A)
6Q7  A 501 (-3.7A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 4.1A)
None
0.72A 5m24A-5k13A:
36.8
5m24A-5k13A:
81.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE


(Schistosoma
mansoni)
PF01048
(PNP_UDP_1)
5 ILE A  19
PHE A  58
GLY A  68
LEU A  87
ILE A  32
None
1.08A 5m24A-5ko5A:
undetectable
5m24A-5ko5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkq DNA REPAIR PROTEIN
RADA


(Streptococcus
pneumoniae)
PF13541
(ChlI)
5 ALA A 412
ILE A 293
SER A 277
GLY A 391
ILE A 409
None
1.01A 5m24A-5lkqA:
undetectable
5m24A-5lkqA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum)
PF12708
(Pectate_lyase_3)
5 PHE A 229
ALA A 236
ILE A 184
SER A 182
ILE A 257
None
0.98A 5m24A-5m60A:
undetectable
5m24A-5m60A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster)
no annotation 5 MET A 646
ILE A 770
SER A 761
PHE A 852
LEU A 888
None
1.04A 5m24A-5n94A:
undetectable
5m24A-5n94A:
14.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR BETA


(Homo sapiens)
no annotation 11 TRP B 218
PHE B 221
ALA B 225
LEU B 262
ILE B 266
ARG B 269
SER B 280
PHE B 295
GLY B 384
LEU B 391
ILE B 403
None
REA  B 503 ( 4.8A)
REA  B 503 (-3.8A)
REA  B 503 (-3.9A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
REA  B 503 ( 4.4A)
None
REA  B 503 ( 4.7A)
0.55A 5m24A-5uanB:
37.8
5m24A-5uanB:
62.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN


(Agrobacterium
tumefaciens)
PF01408
(GFO_IDH_MocA)
5 PHE A  63
ALA A  59
ILE A  73
SER A  79
GLY A   8
None
NAD  A 401 ( 4.6A)
None
NAD  A 401 (-2.8A)
None
1.08A 5m24A-5uibA:
undetectable
5m24A-5uibA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli)
PF00118
(Cpn60_TCP1)
5 ALA A 223
LEU A 221
ILE A 220
LEU A 200
ILE A 227
None
1.00A 5m24A-5w0sA:
undetectable
5m24A-5w0sA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens)
no annotation 5 ALA A 690
LEU A 650
ILE A 651
GLY A 616
ILE A 687
None
IPH  A 901 (-4.7A)
IPH  A 901 ( 4.7A)
None
None
1.10A 5m24A-5weaA:
undetectable
5m24A-5weaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16


(Schizosaccharomyces
pombe)
no annotation 5 ALA A  92
LEU A  77
ILE A  76
GLY A 399
ILE A 122
None
1.12A 5m24A-5wjcA:
undetectable
5m24A-5wjcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqn PROBABLE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00106
(adh_short)
5 ALA A 117
LEU A  80
ILE A  81
GLY A 128
LEU A 172
None
1.04A 5m24A-5wqnA:
undetectable
5m24A-5wqnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus)
no annotation 5 ALA A  76
LEU A 283
SER A 332
PHE A 217
GLY A 215
None
1.00A 5m24A-5xgvA:
undetectable
5m24A-5xgvA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE


(Plasmodium
vivax)
no annotation 5 ALA A 397
LEU A 342
ILE A 337
PHE A 415
ILE A 349
None
1.07A 5m24A-5xmrA:
undetectable
5m24A-5xmrA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft1 FLAVODOXIN

(Bacillus cereus)
no annotation 5 ALA A  44
ILE A  36
GLY A  52
LEU A 110
ILE A  79
None
1.11A 5m24A-6ft1A:
undetectable
5m24A-6ft1A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA


(Homo sapiens)
no annotation 11 TRP A 227
PHE A 230
ALA A 234
LEU A 271
ILE A 275
ARG A 278
SER A 289
PHE A 304
GLY A 393
LEU A 400
ILE A 412
None
E9T  A 501 (-4.3A)
E9T  A 501 (-3.7A)
E9T  A 501 (-3.6A)
E9T  A 501 (-3.8A)
E9T  A 501 (-3.1A)
E9T  A 501 (-2.6A)
E9T  A 501 (-4.2A)
E9T  A 501 (-3.7A)
None
E9T  A 501 ( 4.8A)
0.54A 5m24A-6fx0A:
40.5
5m24A-6fx0A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA


(Homo sapiens)
no annotation 10 TRP A 227
PHE A 230
ALA A 234
LEU A 271
MET A 272
ILE A 275
ARG A 278
SER A 289
PHE A 304
ILE A 412
None
E9T  A 501 (-4.3A)
E9T  A 501 (-3.7A)
E9T  A 501 (-3.6A)
None
E9T  A 501 (-3.8A)
E9T  A 501 (-3.1A)
E9T  A 501 (-2.6A)
E9T  A 501 (-4.2A)
E9T  A 501 ( 4.8A)
0.69A 5m24A-6fx0A:
40.5
5m24A-6fx0A:
17.80