SIMILAR PATTERNS OF AMINO ACIDS FOR 5M10_A_NCAA603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 LEU A 110
ARG A 163
PHE A 169
TRP A 161
 None
 1.28A 5m10A-1e4oA:
0.3		 5m10A-1e4oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 LEU A 110
PHE A 169
LEU A 217
TRP A 161
 None
 1.23A 5m10A-1e4oA:
0.3		 5m10A-1e4oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcm PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
ALPHA

(Mus musculus) 		PF02121
(IP_trans) 		4 LEU A 182
ARG A 171
PHE A 230
LEU A  11
 None
 1.23A 5m10A-1kcmA:
undetectable		 5m10A-1kcmA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 147
PHE A 103
LEU A 281
TRP A 145
 None
 1.30A 5m10A-1m7sA:
undetectable		 5m10A-1m7sA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 211
ARG A 202
PHE A 186
LEU A 238
 None
 1.32A 5m10A-1mdfA:
undetectable		 5m10A-1mdfA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Klebsiella
pneumoniae) 		PF01636
(APH) 		4 LEU A 126
ARG A 122
PHE A 206
LEU A  70
 None
 1.19A 5m10A-1nd4A:
undetectable		 5m10A-1nd4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 LEU A 490
PHE A 217
LEU A 506
TRP A 204
 None
 1.37A 5m10A-1sy7A:
3.4		 5m10A-1sy7A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unf IRON SUPEROXIDE
DISMUTASE

(Vigna
unguiculata) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU X 114
PHE X 128
LEU X 171
TRP X 223
 None
 1.29A 5m10A-1unfX:
undetectable		 5m10A-1unfX:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		4 LEU A 225
PHE A 203
LEU A 232
TRP A 221
 None
 1.40A 5m10A-1venA:
undetectable		 5m10A-1venA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		4 LEU A 133
ARG A  17
PHE A  15
LEU A 110
 None
 1.29A 5m10A-2cunA:
3.2		 5m10A-2cunA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpa PROTEIN (ACID
PHOSPHATASE)

(Homo sapiens) 		PF00328
(His_Phos_2) 		4 LEU A1159
PHE A1021
LEU A1165
TRP A1194
 None
 1.44A 5m10A-2hpaA:
undetectable		 5m10A-2hpaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		4 LEU A 261
ARG A 350
PHE A 339
LEU A 342
 None
 1.48A 5m10A-2jh9A:
undetectable		 5m10A-2jh9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kiv ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00536
(SAM_1) 		4 LEU A 132
PHE A  94
LEU A 113
TRP A  81
 None
 1.45A 5m10A-2kivA:
undetectable		 5m10A-2kivA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjm PROTEIN NLRC5

(Mus musculus) 		no annotation 4 LEU A  84
PHE A  76
LEU A  22
TRP A  32
 None
 1.14A 5m10A-2mjmA:
undetectable		 5m10A-2mjmA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn5 HYPOTHETICAL PROTEIN
EF_2215

(Enterococcus
faecalis) 		PF08327
(AHSA1) 		4 LEU A  37
PHE A  88
LEU A 128
TRP A  55
 None
 1.46A 5m10A-2nn5A:
undetectable		 5m10A-2nn5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0x POSSIBLE FLAVIN
REDUCTASE

(Histophilus
somni) 		PF01613
(Flavin_Reduct) 		4 LEU A 108
PHE A  83
LEU A  72
TRP A  98
 None
 1.35A 5m10A-2r0xA:
undetectable		 5m10A-2r0xA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgq DOMAIN OF UNKNOWN
FUNCTION WITH A
CYSTATIN-LIKE FOLD

(Nostoc
punctiforme) 		PF13577
(SnoaL_4) 		4 LEU A  40
PHE A  64
LEU A  22
TRP A  44
 None
 1.36A 5m10A-2rgqA:
undetectable		 5m10A-2rgqA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		4 LEU A 269
PHE A 262
LEU A 278
TRP A 223
 None
 0.91A 5m10A-2vouA:
7.6		 5m10A-2vouA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x77 ADP-RIBOSYLATION
FACTOR

(Leishmania
major) 		PF00025
(Arf) 		4 LEU A  26
ARG A  78
LEU A 119
TRP A  69
 None
 1.15A 5m10A-2x77A:
2.4		 5m10A-2x77A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 LEU A 157
ARG A 253
LEU A 143
TRP A 256
 None
 1.02A 5m10A-2xu0A:
undetectable		 5m10A-2xu0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 LEU A 157
ARG A 253
LEU A 143
TRP A 256
 None
 1.01A 5m10A-2yk0A:
undetectable		 5m10A-2yk0A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywa HYPOTHETICAL PROTEIN
TTHA0048

(Thermus
thermophilus) 		PF08780
(NTase_sub_bind) 		4 LEU A  42
PHE A 108
LEU A   4
TRP A  75
 None
 1.46A 5m10A-2ywaA:
undetectable		 5m10A-2ywaA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 LEU A 133
ARG A 261
PHE A 263
LEU A 193
 None
SO4  A 702 (-3.8A)
None
None
 1.30A 5m10A-2yylA:
undetectable		 5m10A-2yylA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb0 4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE

(Brucella
melitensis) 		PF01613
(Flavin_Reduct) 		4 LEU A 122
PHE A  95
LEU A  84
TRP A 112
 None
 1.34A 5m10A-3cb0A:
undetectable		 5m10A-3cb0A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF15

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF01423
(LSM) 		4 LEU A1132
PHE A1122
LEU A1174
TRP h 225
 None
 1.49A 5m10A-3jb9A:
undetectable		 5m10A-3jb9A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js4 SUPEROXIDE DISMUTASE

(Anaplasma
phagocytophilum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU A  99
PHE A 113
LEU A 141
TRP A 193
 None
 1.31A 5m10A-3js4A:
undetectable		 5m10A-3js4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kky SUPEROXIDE DISMUTASE
[MN]

(Deinococcus
radiodurans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU A 103
PHE A 117
LEU A 143
TRP A 199
 None
 1.31A 5m10A-3kkyA:
undetectable		 5m10A-3kkyA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqz UNCHARACTERIZED
CONSERVED PROTEIN
DUF1054

(Leptospirillum
rubarum) 		PF06335
(DUF1054) 		4 LEU A 179
PHE A 133
LEU A 204
TRP A 162
 None
 1.21A 5m10A-3mqzA:
undetectable		 5m10A-3mqzA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7t MACROPHAGE BINDING
PROTEIN

(Coccidioides
immitis) 		PF01965
(DJ-1_PfpI) 		4 LEU A  28
PHE A  83
LEU A  10
TRP A  58
 None
 1.26A 5m10A-3n7tA:
3.6		 5m10A-3n7tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 LEU A 257
PHE A   9
LEU A 285
TRP A  14
 None
 1.17A 5m10A-3pieA:
undetectable		 5m10A-3pieA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 LEU A 128
PHE A 299
LEU A 288
TRP A 315
 None
 1.50A 5m10A-3rblA:
undetectable		 5m10A-3rblA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrc DUFFY RECEPTOR

(Plasmodium
vivax) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		4 LEU A 272
ARG A 346
LEU A 250
TRP A 349
 None
EDO  A   3 ( 4.9A)
None
None
 1.05A 5m10A-3rrcA:
1.2		 5m10A-3rrcA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 183
PHE A 191
LEU A 337
TRP A 212
 None
 1.34A 5m10A-3vnsA:
undetectable		 5m10A-3vnsA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 4 LEU A 219
PHE A 262
LEU A 223
TRP A 183
 None
 1.11A 5m10A-3wlaA:
undetectable		 5m10A-3wlaA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		4 LEU A 129
PHE A 122
LEU A 149
TRP A 191
 None
 0.74A 5m10A-4b6zA:
undetectable		 5m10A-4b6zA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 LEU A 310
PHE A 318
LEU A 346
TRP A  97
 None
 1.42A 5m10A-4dshA:
9.9		 5m10A-4dshA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Escherichia
coli) 		PF04452
(Methyltrans_RNA) 		4 LEU A 110
PHE A 212
LEU A 199
TRP A 159
 None
 1.07A 5m10A-4e8bA:
undetectable		 5m10A-4e8bA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2n SUPEROXIDE DISMUTASE

(Leishmania
major) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU A 126
PHE A 140
LEU A 168
TRP A 218
 None
 1.34A 5m10A-4f2nA:
undetectable		 5m10A-4f2nA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 LEU A 139
PHE A  40
LEU A 224
TRP A 278
 None
 1.34A 5m10A-4j7mA:
undetectable		 5m10A-4j7mA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjn HISTONE H2A.2
HISTONE H2B.2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C)
PF00125
(Histone) 		4 LEU D 105
ARG D  75
PHE D  68
LEU C  94
 None
 1.47A 5m10A-4jjnD:
undetectable		 5m10A-4jjnD:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Pectobacterium
atrosepticum) 		PF13416
(SBP_bac_8) 		4 LEU A 347
ARG A  91
PHE A 318
LEU A 338
 None
 1.47A 5m10A-4ry1A:
undetectable		 5m10A-4ry1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uac CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-)

([Eubacterium]
rectale) 		PF13416
(SBP_bac_8) 		4 LEU A 286
PHE A 187
LEU A 176
TRP A 159
 None
 1.21A 5m10A-4uacA:
undetectable		 5m10A-4uacA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwd ESTERASE

(Pelagibacterium
halotolerans) 		PF02230
(Abhydrolase_2) 		4 LEU A 215
PHE A 141
LEU A 162
TRP A  43
 None
 1.35A 5m10A-5dwdA:
1.6		 5m10A-5dwdA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 LEU A 685
PHE A 624
LEU A 612
TRP A 665
 None
 1.23A 5m10A-5f56A:
undetectable		 5m10A-5f56A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2a KLLA0C04147P

(Kluyveromyces
lactis) 		PF00023
(Ank) 		4 LEU A  34
PHE A  54
LEU A  22
TRP A  77
 None
 1.27A 5m10A-5h2aA:
undetectable		 5m10A-5h2aA:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		5 LEU A 146
ARG A 329
PHE A 434
LEU A 437
TRP A 492
 NAP  A 602 ( 4.0A)
NAP  A 602 (-3.0A)
NCA  A 603 ( 3.7A)
FAD  A 601 ( 4.0A)
NAP  A 602 (-4.0A)
 0.00A 5m10A-5m10A:
65.7		 5m10A-5m10A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 LEU A 146
PHE A 507
LEU A 437
TRP A 492
 NAP  A 602 ( 4.0A)
None
FAD  A 601 ( 4.0A)
NAP  A 602 (-4.0A)
 1.40A 5m10A-5m10A:
65.7		 5m10A-5m10A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 LEU A 337
PHE A 406
LEU A 376
TRP A 468
 None
 1.17A 5m10A-5m8tA:
undetectable		 5m10A-5m8tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 187
PHE A 195
LEU A 341
TRP A 216
 None
 1.47A 5m10A-5n9xA:
2.7		 5m10A-5n9xA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 4 LEU A  85
PHE A 171
LEU A  91
TRP A 275
 None
 1.39A 5m10A-5nijA:
undetectable		 5m10A-5nijA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 4 LEU A  85
PHE A 171
LEU A  91
TRP A 275
 None
 1.34A 5m10A-5obtA:
1.7		 5m10A-5obtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vey HISTONE H2B TYPE
1-J,HISTONE H2A TYPE
1-B/E

(Homo sapiens) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		4 LEU A  78
ARG A  48
PHE A  41
LEU A 182
 None
 1.33A 5m10A-5veyA:
undetectable		 5m10A-5veyA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6n DUFFY BINDING
PROTEIN

(Plasmodium
knowlesi) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		4 LEU A  71
ARG A 145
LEU A  49
TRP A 148
 None
 1.05A 5m10A-5x6nA:
undetectable		 5m10A-5x6nA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xey PHLORETIN HYDROLASE

(Mycobacteroides
abscessus) 		no annotation 4 LEU A  72
ARG A 231
LEU A 218
TRP A 233
 None
 1.46A 5m10A-5xeyA:
undetectable		 5m10A-5xeyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 4 LEU A 195
PHE A 222
LEU A 187
TRP A 232
 None
 1.44A 5m10A-6bk5A:
undetectable		 5m10A-6bk5A:
undetectable