SIMILAR PATTERNS OF AMINO ACIDS FOR 5M0O_A_EPAA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 LEU S 776
ILE S 784
PHE S 835
PRO S 781
VAL S 874
 None
 1.34A 5m0oA-1bkdS:
0.0		 5m0oA-1bkdS:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 LEU A 308
PRO A 232
ALA A 207
PHE A 123
VAL A 300
 None
 1.34A 5m0oA-1c2oA:
undetectable		 5m0oA-1c2oA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coj PROTEIN (SUPEROXIDE
DISMUTASE)

(Aquifex
pyrophilus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 PRO A  13
ILE A 181
PHE A 184
ALA A 122
VAL A 161
 None
 1.37A 5m0oA-1cojA:
0.0		 5m0oA-1cojA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		5 LEU A 188
ILE A 131
ALA A 118
PHE A 161
PRO A 238
 None
 1.22A 5m0oA-1cvmA:
0.0		 5m0oA-1cvmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnl PYRIDOXINE
5'-PHOSPHATE OXIDASE

(Escherichia
coli) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		5 PRO A  28
LEU A  32
PHE A  35
PHE A 103
VAL A 112
 None
 1.41A 5m0oA-1dnlA:
0.0		 5m0oA-1dnlA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR 2

(Homo sapiens) 		PF00167
(FGF) 		5 PRO A 141
LEU A  53
ILE A  34
ALA A  84
VAL A 116
 None
 1.32A 5m0oA-1fq9A:
undetectable		 5m0oA-1fq9A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		5 LEU A 394
ILE A 434
ALA A 372
VAL A 366
PRO A 358
 None
None
None
UDP  A 900 (-3.9A)
None
 1.31A 5m0oA-1gz5A:
0.0		 5m0oA-1gz5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 PRO A 384
LEU A 379
PRO A 357
ALA A 513
PRO A 349
 None
 1.42A 5m0oA-1itzA:
0.0		 5m0oA-1itzA:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU A  78
ARG A 242
PRO A 243
ALA A 246
PHE A 289
 PAM  A 601 ( 4.7A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
HEM  A 501 ( 4.0A)
 0.30A 5m0oA-1izoA:
57.6		 5m0oA-1izoA:
42.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU A  78
PHE A 173
ARG A 242
PRO A 243
ALA A 246
 PAM  A 601 ( 4.7A)
PAM  A 601 ( 4.2A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
 0.65A 5m0oA-1izoA:
57.6		 5m0oA-1izoA:
42.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		5 PRO A1130
LEU A1149
ILE A1178
ALA A1180
VAL A1138
 None
 1.37A 5m0oA-1jl5A:
undetectable		 5m0oA-1jl5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 PRO A  18
ILE A  89
PRO A 112
ALA A 119
VAL A  67
 None
 1.38A 5m0oA-1lamA:
undetectable		 5m0oA-1lamA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		5 PRO A  18
LEU A 229
PHE A 263
VAL A 264
PRO A  51
 None
 1.39A 5m0oA-1o60A:
undetectable		 5m0oA-1o60A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o77 TOLL-LIKE RECEPTOR 2

(Homo sapiens) 		PF01582
(TIR) 		5 PRO A 765
LEU A 778
ILE A 782
ALA A 643
VAL A 702
 None
 1.42A 5m0oA-1o77A:
undetectable		 5m0oA-1o77A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		5 PRO A  14
ALA A 197
PHE A 195
VAL A 191
PRO A 141
 None
 1.39A 5m0oA-1pp0A:
undetectable		 5m0oA-1pp0A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 PRO A  46
PRO A  67
ALA A  69
PHE A  21
VAL A  17
 FAD  A 749 (-3.6A)
None
None
None
None
 1.02A 5m0oA-1q1rA:
undetectable		 5m0oA-1q1rA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A  32
ILE A 135
ALA A 138
VAL A 124
PRO A 148
 None
 1.34A 5m0oA-1q8iA:
undetectable		 5m0oA-1q8iA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qav NEURONAL NITRIC
OXIDE SYNTHASE
(RESIDUES 1-130)

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 PRO B1039
LEU B1097
ILE B1058
ALA B1052
VAL B1032
 None
 1.31A 5m0oA-1qavB:
undetectable		 5m0oA-1qavB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		5 PRO A 269
LEU A 279
PRO A 244
ALA A 245
VAL A 285
 None
 1.37A 5m0oA-1vf8A:
undetectable		 5m0oA-1vf8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		5 LEU A 776
ILE A 784
PHE A 835
PRO A 781
VAL A 874
 None
 1.34A 5m0oA-1xdvA:
undetectable		 5m0oA-1xdvA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuw GLUTAMATE RACEMASE 1

(Bacillus
subtilis) 		PF01177
(Asp_Glu_race) 		5 PRO A   5
LEU A  70
ILE A  72
ALA A  77
VAL A  34
 None
 1.34A 5m0oA-1zuwA:
undetectable		 5m0oA-1zuwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		5 LEU A 625
ILE A 615
PRO A 575
ALA A 576
PHE A 613
 None
 1.34A 5m0oA-2cgeA:
undetectable		 5m0oA-2cgeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 438
ILE A 434
PHE A 450
ALA A  21
VAL A 453
 None
 1.23A 5m0oA-2cgjA:
undetectable		 5m0oA-2cgjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ck2 HUMAN FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		5 PRO A  87
LEU A  34
ILE A  59
ALA A  18
PHE A  92
 None
 1.36A 5m0oA-2ck2A:
undetectable		 5m0oA-2ck2A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2doc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3) 		5 PRO A  18
ILE A  66
ARG A  68
VAL A  91
PRO A  41
 None
 1.34A 5m0oA-2docA:
undetectable		 5m0oA-2docA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 535
ILE A 544
ARG A 399
PHE A 373
VAL A 375
 None
 1.29A 5m0oA-2gksA:
undetectable		 5m0oA-2gksA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 5 LEU A 384
ILE A 380
PHE A  22
VAL A  21
PRO A 117
 None
 1.28A 5m0oA-2hihA:
undetectable		 5m0oA-2hihA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6e HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02621
(VitK2_biosynth) 		5 PRO A  89
ALA A 191
PHE A 204
VAL A  84
PRO A  29
 None
 1.39A 5m0oA-2i6eA:
undetectable		 5m0oA-2i6eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		5 LEU A  72
ILE A 112
ALA A 160
PHE A 188
VAL A 192
 None
 1.35A 5m0oA-2iluA:
undetectable		 5m0oA-2iluA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		5 PRO A 261
LEU A  61
ALA A 110
VAL A  50
PRO A  79
 None
 1.25A 5m0oA-2iy9A:
undetectable		 5m0oA-2iy9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		5 PRO A   9
LEU A  73
ILE A  75
ALA A  80
VAL A  38
 None
 1.16A 5m0oA-2jfwA:
undetectable		 5m0oA-2jfwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		5 LEU A  34
PHE A 106
ARG A  86
ALA A  87
PRO A 112
 None
 1.29A 5m0oA-2npnA:
undetectable		 5m0oA-2npnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvo RO SIXTY-RELATED
PROTEIN, RSR

(Deinococcus
radiodurans) 		PF05731
(TROVE) 		5 PRO A 401
LEU A 397
ILE A 417
ALA A 426
PRO A 357
 None
 1.23A 5m0oA-2nvoA:
undetectable		 5m0oA-2nvoA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		5 PRO A 139
LEU A 129
ILE A 114
ALA A 121
VAL A 202
 None
 1.31A 5m0oA-2o78A:
undetectable		 5m0oA-2o78A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF03466
(LysR_substrate) 		5 PRO A 225
LEU A 197
PRO A 184
ALA A 186
VAL A 241
 None
 1.27A 5m0oA-2ql3A:
undetectable		 5m0oA-2ql3A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsi 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF01128
(IspD) 		5 LEU A   7
ARG A  85
ALA A 196
PHE A 173
VAL A 108
 CDF  A1234 (-3.8A)
CDF  A1234 (-3.5A)
None
None
None
 1.35A 5m0oA-2vsiA:
undetectable		 5m0oA-2vsiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 PRO A 363
LEU A 309
ILE A 313
ALA A 381
VAL A 335
 None
 1.27A 5m0oA-2w5fA:
undetectable		 5m0oA-2w5fA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		5 PRO A 227
PHE A 263
ALA A 285
PHE A 313
VAL A 317
 None
 1.27A 5m0oA-2y2wA:
undetectable		 5m0oA-2y2wA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE

(Burkholderia
cenocepacia) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 LEU A 313
ILE A 264
ARG A 322
PHE A 292
VAL A 291
 None
 1.27A 5m0oA-2y4oA:
undetectable		 5m0oA-2y4oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 LEU A 165
ARG A 122
ALA A 124
PHE A  95
VAL A 133
 None
 1.24A 5m0oA-3ab4A:
undetectable		 5m0oA-3ab4A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		5 LEU A 206
ARG A 167
PRO A 173
ALA A 166
PHE A 161
 None
 1.30A 5m0oA-3aytA:
undetectable		 5m0oA-3aytA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvq NOTI RESTRICTION
ENDONUCLEASE

(Nocardia
otitidiscaviarum) 		PF12183
(NotI) 		5 PRO A  43
ILE A 183
ALA A 260
PHE A  90
PRO A 313
 None
 1.32A 5m0oA-3bvqA:
undetectable		 5m0oA-3bvqA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 PRO A  44
ALA A  46
PHE A   5
VAL A   7
PRO A  58
 None
 1.34A 5m0oA-3c3wA:
undetectable		 5m0oA-3c3wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5n TUBBY-RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		5 PRO A 383
LEU A 243
ILE A 314
VAL A 328
PRO A 373
 None
 1.38A 5m0oA-3c5nA:
undetectable		 5m0oA-3c5nA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 PRO A 623
LEU A 656
ILE A 653
VAL A 574
PRO A 568
 None
 1.25A 5m0oA-3dduA:
undetectable		 5m0oA-3dduA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 LEU A 302
ALA A 349
PHE A 356
VAL A 253
PRO A 275
 None
 1.41A 5m0oA-3dqqA:
undetectable		 5m0oA-3dqqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geh TRNA MODIFICATION
GTPASE MNME

(Nostoc sp. PCC
7120) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 LEU A  38
ILE A  34
PHE A  88
ALA A 109
VAL A  24
 None
 1.36A 5m0oA-3gehA:
undetectable		 5m0oA-3gehA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE

(Aquifex
aeolicus) 		PF07992
(Pyr_redox_2) 		5 LEU A 390
ILE A  58
PHE A  39
ALA A  44
VAL A  12
 None
None
None
None
FAD  A 441 (-4.1A)
 1.37A 5m0oA-3hyvA:
undetectable		 5m0oA-3hyvA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k49 MRNA-BINDING PROTEIN
PUF3

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 592
PHE A 596
ALA A 579
PHE A 611
VAL A 608
 None
 1.29A 5m0oA-3k49A:
undetectable		 5m0oA-3k49A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 PRO A 920
LEU A 914
ILE A 775
PHE A 910
PHE A 980
 None
 1.37A 5m0oA-3lj0A:
undetectable		 5m0oA-3lj0A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lms CARBOXYPEPTIDASE B2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 LEU A 183
ILE A 189
PHE A 182
ALA A  61
VAL A  49
 None
 1.38A 5m0oA-3lmsA:
undetectable		 5m0oA-3lmsA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7o LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		5 PRO A 107
LEU A  81
PHE A 111
ALA A 153
PHE A  70
 None
None
None
L9R  A 301 (-3.6A)
L9R  A 301 ( 4.3A)
 0.89A 5m0oA-3m7oA:
undetectable		 5m0oA-3m7oA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkm CAS6 PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		5 PRO A 128
PRO A  94
ALA A  97
PHE A   9
VAL A 124
 None
 1.41A 5m0oA-3pkmA:
undetectable		 5m0oA-3pkmA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pn1 DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		5 LEU A 281
ILE A 274
PRO A 115
PHE A 316
PRO A 200
 None
 1.34A 5m0oA-3pn1A:
undetectable		 5m0oA-3pn1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		5 LEU A  50
ILE A  62
ALA A  42
PHE A 172
PRO A 304
 None
 1.38A 5m0oA-3pshA:
undetectable		 5m0oA-3pshA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 LEU A 236
PHE A 249
PRO A 216
ALA A 212
VAL A 264
 None
 1.33A 5m0oA-3q60A:
undetectable		 5m0oA-3q60A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		5 PHE A 195
ARG A 220
PRO A 173
ALA A 174
VAL A 229
 None
 0.91A 5m0oA-3t58A:
undetectable		 5m0oA-3t58A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		5 PRO A 257
PRO A 328
ALA A 180
VAL A 271
PRO A 264
 None
 1.23A 5m0oA-3w53A:
undetectable		 5m0oA-3w53A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		5 PRO A  43
LEU A  66
ILE A  74
ALA A 130
VAL A  81
 None
 1.29A 5m0oA-3wxbA:
undetectable		 5m0oA-3wxbA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc4 SSO1398

(Sulfolobus
solfataricus) 		no annotation 5 PRO A 132
LEU A  50
ILE A  46
PHE A 140
PRO A  36
 None
 1.34A 5m0oA-3zc4A:
undetectable		 5m0oA-3zc4A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 PRO A 655
ILE A 675
ARG A 736
PRO A 733
VAL A 612
 None
 1.11A 5m0oA-3zzwA:
undetectable		 5m0oA-3zzwA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aib ORNITHINE
DECARBOXYLASE

(Entamoeba
histolytica) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A 200
ILE A 222
PHE A 196
ALA A 256
PHE A 226
 None
 1.32A 5m0oA-4aibA:
undetectable		 5m0oA-4aibA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE

(Bacteroides
plebeius) 		PF04616
(Glyco_hydro_43) 		5 PRO A  91
LEU A 351
PRO A 308
ALA A 314
VAL A 304
 None
 1.29A 5m0oA-4ak5A:
undetectable		 5m0oA-4ak5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 PRO A 177
LEU A 304
ILE A 308
ALA A 697
PHE A  15
 None
 1.30A 5m0oA-4bejA:
undetectable		 5m0oA-4bejA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN

(Streptococcus
mutans) 		PF00497
(SBP_bac_3) 		5 LEU A 214
ALA A  38
PHE A 206
VAL A 207
PRO A  85
 None
 1.41A 5m0oA-4c0rA:
undetectable		 5m0oA-4c0rA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 PRO A 142
LEU A 152
ARG A 254
PRO A 253
VAL A 167
 HEM  A1374 ( 4.8A)
None
None
None
None
 1.41A 5m0oA-4czpA:
undetectable		 5m0oA-4czpA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 LEU A  18
ILE A  36
PHE A  22
ALA A   9
VAL A 308
 None
 1.22A 5m0oA-4hy3A:
undetectable		 5m0oA-4hy3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij3 SULFHYDRYL OXIDASE 1

(Homo sapiens) 		PF00085
(Thioredoxin) 		5 PHE A 192
ARG A 217
PRO A 170
ALA A 171
VAL A 226
 None
 1.00A 5m0oA-4ij3A:
undetectable		 5m0oA-4ij3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilt INTRADIOL
RING-CLEAVAGE
DIOXYGENASE

(Streptomyces
sp. SirexAA-E) 		PF00775
(Dioxygenase_C) 		5 PRO A 164
LEU A  98
PHE A 129
ARG A  95
PRO A  93
 None
 1.07A 5m0oA-4iltA:
undetectable		 5m0oA-4iltA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6e MRNA-DECAPPING
ENZYME SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00293
(NUDIX) 		5 LEU A 181
PHE A 111
PRO A 230
PHE A 207
PRO A 132
 None
 1.18A 5m0oA-4k6eA:
undetectable		 5m0oA-4k6eA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF16010
(CDH-cyt) 		5 LEU A  55
ILE A  80
PHE A  35
PHE A  51
VAL A  37
 None
 1.43A 5m0oA-4qi3A:
undetectable		 5m0oA-4qi3A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A3217
PHE A3215
PRO A3219
ALA A3222
PHE A3210
 None
 1.22A 5m0oA-4tktA:
undetectable		 5m0oA-4tktA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74

(Saccharomyces
cerevisiae) 		PF05719
(GPP34) 		5 LEU A 106
ILE A 250
ARG A 251
PHE A 335
VAL A 334
 None
 1.25A 5m0oA-4tu3A:
undetectable		 5m0oA-4tu3A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk1 PHOSPHOSERINE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		5 PRO A 240
LEU A 204
ILE A 199
PHE A  72
PHE A 252
 None
 1.20A 5m0oA-4xk1A:
undetectable		 5m0oA-4xk1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A 632
PHE A 630
PRO A 634
ALA A 637
PHE A 625
 None
EPE  A1201 (-4.8A)
None
None
None
 1.24A 5m0oA-4zdnA:
undetectable		 5m0oA-4zdnA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoc ESTERASE

(Thermogutta
terrifontis) 		PF07859
(Abhydrolase_3) 		5 PRO A  60
ILE A 158
PHE A  49
ALA A 268
PHE A  70
 None
 1.24A 5m0oA-5aocA:
undetectable		 5m0oA-5aocA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8i SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin) 		5 PHE A 195
ARG A 220
PRO A 173
ALA A 174
VAL A 229
 None
 1.11A 5m0oA-5d8iA:
undetectable		 5m0oA-5d8iA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG

(Homo sapiens) 		PF02724
(CDC45) 		5 LEU A 565
PHE A 445
ALA A 529
VAL A 492
PRO A 511
 None
 1.37A 5m0oA-5dgoA:
undetectable		 5m0oA-5dgoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 LEU A 612
ILE A 607
PRO A 634
ALA A 569
VAL A 596
 None
 1.12A 5m0oA-5ehkA:
undetectable		 5m0oA-5ehkA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 PRO A2052
LEU A2164
PHE A2045
ALA A2154
PHE A2081
 None
 1.43A 5m0oA-5fbyA:
undetectable		 5m0oA-5fbyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		5 LEU A 185
PHE A 182
PRO A 151
ALA A 117
PRO A 535
 None
 1.39A 5m0oA-5fifA:
undetectable		 5m0oA-5fifA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 PRO A 177
LEU A 153
ILE A 157
ALA A 189
VAL A 193
 None
 1.29A 5m0oA-5ft6A:
undetectable		 5m0oA-5ft6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwt 4-HYDROXYISOLECUINE
DEHYDROGENASE

(Bacillus
thuringiensis) 		no annotation 5 LEU A  67
ILE A  64
PHE A  68
ALA A 111
VAL A 119
 None
 1.36A 5m0oA-5gwtA:
undetectable		 5m0oA-5gwtA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis) 		PF01177
(Asp_Glu_race) 		5 PRO A   7
LEU A  71
ILE A  73
ALA A  78
VAL A  36
 None
 1.24A 5m0oA-5hj7A:
undetectable		 5m0oA-5hj7A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		5 LEU A 854
PRO A 906
ALA A 908
VAL A 889
PRO A 896
 None
 1.28A 5m0oA-5i6eA:
undetectable		 5m0oA-5i6eA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijw GLUTAMATE RACEMASE

(Mycolicibacterium
smegmatis) 		PF01177
(Asp_Glu_race) 		5 PRO A   7
LEU A  71
ILE A  73
ALA A  78
VAL A  36
 None
 1.25A 5m0oA-5ijwA:
undetectable		 5m0oA-5ijwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isu LMO0135 PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		5 PRO A 160
PHE A 157
ALA A 115
VAL A 122
PRO A 144
 None
 1.40A 5m0oA-5isuA:
undetectable		 5m0oA-5isuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kss 5'-NUCLEOTIDASE SURE

(Xylella
fastidiosa) 		PF01975
(SurE) 		5 PRO A 156
ILE A 146
ALA A  22
VAL A   3
PRO A 119
 None
 1.30A 5m0oA-5kssA:
undetectable		 5m0oA-5kssA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfb GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 LEU A 122
ILE A 231
ALA A 156
PHE A 209
VAL A 202
 None
 0.95A 5m0oA-5nfbA:
undetectable		 5m0oA-5nfbA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 PRO A 793
LEU A 411
ILE A 180
PRO A 182
PHE A  78
 None
 1.43A 5m0oA-5o0sA:
undetectable		 5m0oA-5o0sA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofu FBP PROTEIN

(Leishmania
major) 		PF00316
(FBPase) 		5 LEU A 307
ILE A 306
PRO A 287
ALA A 285
PHE A 322
 None
 1.38A 5m0oA-5ofuA:
undetectable		 5m0oA-5ofuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uai METHIONYL-TRNA
FORMYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 PRO A 245
LEU A 241
ALA A 266
PHE A 295
PRO A 288
 None
 1.37A 5m0oA-5uaiA:
undetectable		 5m0oA-5uaiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PRO A  44
LEU A  41
ILE A 524
ALA A 527
PHE A 607
 None
 1.39A 5m0oA-5vniA:
undetectable		 5m0oA-5vniA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 PRO A 163
LEU A 222
PRO A 319
ALA A 322
PHE A 328
 None
 1.25A 5m0oA-5xvuA:
undetectable		 5m0oA-5xvuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhj CYTOCHROME P450

(Exiguobacterium
sp. AT1b) 		no annotation 6 PRO A  71
LEU A  78
ARG A 239
PRO A 240
ALA A 243
PHE A 285
 None
None
MYR  A 502 (-4.2A)
MYR  A 502 ( 3.7A)
MYR  A 502 (-3.7A)
HEM  A 501 ( 3.9A)
 0.66A 5m0oA-5yhjA:
55.8		 5m0oA-5yhjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 5 ILE A 351
PHE A 308
ALA A 376
PHE A 327
VAL A 329
 None
 1.16A 5m0oA-6bk7A:
undetectable		 5m0oA-6bk7A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))

(Escherichia
coli) 		no annotation 5 PRO A 275
PRO A 221
ALA A 200
PHE A 174
VAL A 255
 None
 1.37A 5m0oA-6dkhA:
undetectable		 5m0oA-6dkhA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 5 LEU D  30
ILE D  86
ARG D  53
ALA D  52
VAL D  58
 None
 1.29A 5m0oA-6fmlD:
undetectable		 5m0oA-6fmlD:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB

(Thermotoga
maritima) 		no annotation 5 LEU A 156
ILE A 154
PRO A 102
ALA A 103
VAL A 122
 None
 1.38A 5m0oA-6fpeA:
undetectable		 5m0oA-6fpeA:
11.00