SIMILAR PATTERNS OF AMINO ACIDS FOR 5LW1_H_ADNH401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  41
ALA A  54
MET A 109
MET A 112
LEU A 170
ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
ANP  A 400 (-4.6A)
None
ANP  A 400 (-4.0A)
0.62A 5lw1H-1cm8A:
35.8
5lw1H-1cm8A:
42.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE


(Escherichia
coli)
PF02374
(ArsA_ATPase)
5 GLY A  51
VAL A  50
LEU A 288
VAL A  68
LEU A  71
None
1.02A 5lw1H-1ii0A:
undetectable
5lw1H-1ii0A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB


(Amycolatopsis
orientalis)
PF03033
(Glyco_transf_28)
5 GLY A 300
VAL A 302
ASN A 294
VAL A 293
LEU A 230
None
1.05A 5lw1H-1iirA:
undetectable
5lw1H-1iirA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida)
PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII)
5 GLY A 316
VAL A 319
ALA A 336
LEU A 334
VAL A 289
None
0.89A 5lw1H-1jmzA:
undetectable
5lw1H-1jmzA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4q GLUTATHIONE
REDUCTASE


(Homo sapiens)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 157
VAL A 332
ALA A 328
LEU A 153
LEU A 298
FAD  A 499 (-3.4A)
None
None
None
None
0.95A 5lw1H-1k4qA:
undetectable
5lw1H-1k4qA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2


(Escherichia
coli)
PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N)
5 GLY A 275
VAL A 236
ALA A 234
LEU A 272
VAL A 316
None
1.06A 5lw1H-1l5jA:
undetectable
5lw1H-1l5jA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
D


(Saccharomyces
cerevisiae)
PF01466
(Skp1)
PF03931
(Skp1_POZ)
5 VAL A  18
ALA A  23
LEU A  29
VAL A  79
LEU A  87
None
0.87A 5lw1H-1nexA:
undetectable
5lw1H-1nexA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oru YUAD PROTEIN

(Bacillus
subtilis)
no annotation 5 GLY A  34
VAL A 164
ALA A 118
ASN A  94
VAL A  95
None
1.06A 5lw1H-1oruA:
undetectable
5lw1H-1oruA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  79
VAL A  86
ALA A  99
MET A 147
LEU A 201
ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 3.4A)
ATP  A 535 (-4.8A)
1.01A 5lw1H-1s9iA:
11.6
5lw1H-1s9iA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  79
VAL A  86
ALA A  99
MET A 147
MET A 150
ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 3.4A)
None
0.57A 5lw1H-1s9iA:
11.6
5lw1H-1s9iA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upi DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE


(Mycobacterium
tuberculosis)
PF00908
(dTDP_sugar_isom)
5 GLY A  96
ALA A 118
LEU A  61
VAL A 180
LEU A 186
None
None
CME  A 147 ( 4.9A)
None
None
1.07A 5lw1H-1upiA:
undetectable
5lw1H-1upiA:
19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
7 GLY A  71
ALA A  91
LEU A 148
MET A 149
ASN A 152
VAL A 196
LEU A 206
AIZ  A 501 ( 4.0A)
AIZ  A 501 (-3.4A)
AIZ  A 501 ( 4.7A)
None
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
0.91A 5lw1H-2b1pA:
43.9
5lw1H-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  78
ALA A  91
LEU A 148
MET A 149
ASN A 152
VAL A 196
LEU A 206
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
AIZ  A 501 ( 4.7A)
None
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
0.49A 5lw1H-2b1pA:
43.9
5lw1H-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  78
ALA A  91
MET A 146
LEU A 148
ASN A 152
VAL A 196
LEU A 206
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
AIZ  A 501 (-3.8A)
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
0.73A 5lw1H-2b1pA:
43.9
5lw1H-2b1pA:
93.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 GLY A  20
VAL A  27
ALA A  40
LEU A  95
MET A  96
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 ( 4.9A)
None
0.54A 5lw1H-2f9gA:
24.7
5lw1H-2f9gA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE


(Mycobacterium
tuberculosis)
PF00069
(Pkinase)
5 GLY A  23
VAL A  30
ALA A  43
MET A  93
LEU A  95
None
0.70A 5lw1H-2h34A:
19.5
5lw1H-2h34A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A 249
VAL A 256
ALA A 269
MET A 318
ASN A 322
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
None
None
0.59A 5lw1H-2hz0A:
20.6
5lw1H-2hz0A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixc DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
RMLC


(Mycobacterium
tuberculosis)
PF00908
(dTDP_sugar_isom)
5 GLY A  96
ALA A 118
LEU A  61
VAL A 180
LEU A 186
None
0.91A 5lw1H-2ixcA:
undetectable
5lw1H-2ixcA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
PF07714
(Pkinase_Tyr)
5 GLY A 429
VAL A 436
ALA A 452
MET A 499
LEU A 501
4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.3A)
0.43A 5lw1H-2j0jA:
20.5
5lw1H-2j0jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  30
VAL A  37
ALA A  50
MET A  98
LEU A 100
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.1A)
QPP  A1314 (-4.5A)
0.70A 5lw1H-2jc6A:
19.7
5lw1H-2jc6A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF07714
(Pkinase_Tyr)
5 GLY A 429
VAL A 436
ALA A 452
MET A 499
LEU A 501
BII  A1687 ( 3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-4.4A)
0.59A 5lw1H-2jkmA:
20.2
5lw1H-2jkmA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus)
PF00069
(Pkinase)
5 GLY A  26
VAL A  33
ALA A  46
LEU A 105
MET A 106
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
0.48A 5lw1H-2phkA:
23.3
5lw1H-2phkA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium)
PF07714
(Pkinase_Tyr)
5 GLY B  48
VAL B  55
ALA B  67
MET B 117
ASN B 121
None
0.40A 5lw1H-2qkwB:
20.9
5lw1H-2qkwB:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A 725
VAL A 732
ALA A 749
LEU A 798
MET A 799
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
0.61A 5lw1H-2r4bA:
19.9
5lw1H-2r4bA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  83
VAL A  90
ALA A 103
MET A 153
MET A 156
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
0.52A 5lw1H-2v55A:
22.7
5lw1H-2v55A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum)
no annotation 5 GLY A  35
VAL A  42
ALA A 171
ASN A  79
VAL A  78
None
1.03A 5lw1H-2w3yA:
undetectable
5lw1H-2w3yA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 227
VAL A 234
ALA A 247
LEU A 303
MET A 304
XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
None
0.53A 5lw1H-2xk9A:
14.9
5lw1H-2xk9A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  31
VAL A  38
ALA A  51
LEU A 109
MET A 110
B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
B49  A1294 ( 4.7A)
None
0.43A 5lw1H-2y7jA:
12.5
5lw1H-2y7jA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE


(Enterococcus
faecalis)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 GLY A  63
ALA A  81
MET A 371
VAL A 157
LEU A 159
None
1.00A 5lw1H-2yfkA:
undetectable
5lw1H-2yfkA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLY A1003
VAL A1010
ALA A1028
MET A1076
LEU A1078
MET A1079
S91  A   1 ( 3.9A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.9A)
S91  A   1 (-4.7A)
None
0.62A 5lw1H-2z8cA:
22.6
5lw1H-2z8cA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13


(Homo sapiens)
PF00069
(Pkinase)
6 GLY A  32
VAL A  39
ALA A  52
MET A 107
MET A 110
LEU A 167
None
0.78A 5lw1H-3coiA:
36.1
5lw1H-3coiA:
11.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
8 GLY A  33
VAL A  40
ALA A  53
MET A 108
LEU A 110
MET A 111
ASN A 114
VAL A 158
35F  A   1 ( 4.8A)
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
35F  A   1 ( 3.9A)
35F  A   1 (-4.5A)
None
None
None
0.73A 5lw1H-3e7oA:
43.5
5lw1H-3e7oA:
70.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
8 GLY A  33
VAL A  40
ALA A  53
MET A 108
LEU A 110
MET A 111
VAL A 158
LEU A 168
35F  A   1 ( 4.8A)
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
35F  A   1 ( 3.9A)
35F  A   1 (-4.5A)
None
None
35F  A   1 (-4.5A)
0.48A 5lw1H-3e7oA:
43.5
5lw1H-3e7oA:
70.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
6 GLY A  60
VAL A  67
ALA A  80
MET A 129
LEU A 131
MET A 132
STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
STU  A   1 (-4.6A)
None
0.52A 5lw1H-3fmeA:
20.8
5lw1H-3fmeA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 210
VAL A 217
ALA A 228
MET A 279
LEU A 340
ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
0.92A 5lw1H-3g2fA:
21.5
5lw1H-3g2fA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
6 GLY A  31
VAL A  38
ALA A  51
LEU A 108
MET A 109
LEU A 167
None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.4A)
None
NIL  A   1 (-4.0A)
0.79A 5lw1H-3gp0A:
37.5
5lw1H-3gp0A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gz7 PUTATIVE ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASE


(Bordetella
bronchiseptica)
PF03992
(ABM)
5 GLY A  21
VAL A  79
LEU A  28
VAL A  38
LEU A  52
None
None
None
None
CIT  A  97 (-4.5A)
1.04A 5lw1H-3gz7A:
undetectable
5lw1H-3gz7A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE


(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis)
PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C)
5 GLY A 283
VAL A 285
ASN A 277
VAL A 276
LEU A 213
None
None
None
U2F  A 547 (-4.0A)
None
0.97A 5lw1H-3h4iA:
undetectable
5lw1H-3h4iA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
5 GLY A  17
VAL A  24
ALA A  37
LEU A  91
VAL A 194
ANP  A 329 (-3.5A)
ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 ( 4.7A)
None
1.01A 5lw1H-3hkoA:
23.4
5lw1H-3hkoA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
5 GLY A  17
VAL A  24
ALA A  37
MET A  89
LEU A  91
ANP  A 329 (-3.5A)
ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-3.7A)
ANP  A 329 ( 4.7A)
0.32A 5lw1H-3hkoA:
23.4
5lw1H-3hkoA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2


(Homo sapiens)
PF00069
(Pkinase)
PF00498
(FHA)
5 GLY A 227
VAL A 234
ALA A 247
LEU A 303
MET A 304
None
0.75A 5lw1H-3i6uA:
21.8
5lw1H-3i6uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
5 GLY A 681
VAL A 689
ALA A 700
LEU A 747
ASN A 751
ADP  A2101 (-3.6A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
ADP  A2101 (-3.7A)
0.61A 5lw1H-3lj0A:
21.3
5lw1H-3lj0A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLY A1006
VAL A1013
ALA A1031
MET A1079
LEU A1081
MET A1082
None
None
None
CCX  A   1 ( 3.9A)
None
None
0.69A 5lw1H-3lw0A:
21.7
5lw1H-3lw0A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A 695
VAL A 702
ALA A 719
LEU A 768
LEU A 820
ITI  A   1 ( 4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
0.92A 5lw1H-3lzbA:
19.3
5lw1H-3lzbA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
5 GLY A 193
VAL A 200
ALA A 213
LEU A 265
MET A 266
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
0.39A 5lw1H-3nyoA:
24.7
5lw1H-3nyoA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0h GLUTATHIONE
REDUCTASE


(Bartonella
henselae)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 142
VAL A 306
ALA A 302
LEU A 138
LEU A 272
FAD  A 500 (-3.2A)
None
None
None
FAD  A 500 ( 4.5A)
0.99A 5lw1H-3o0hA:
undetectable
5lw1H-3o0hA:
11.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar)
PF00069
(Pkinase)
5 GLY A  32
VAL A  39
ALA A  52
LEU A 109
LEU A 168
1N1  A1000 (-3.4A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.7A)
1N1  A1000 ( 3.7A)
0.79A 5lw1H-3ohtA:
30.0
5lw1H-3ohtA:
35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar)
PF00069
(Pkinase)
5 GLY A  32
VAL A  39
ALA A  52
LEU A 109
MET A 110
1N1  A1000 (-3.4A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.7A)
None
0.58A 5lw1H-3ohtA:
30.0
5lw1H-3ohtA:
35.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A 727
VAL A 734
ALA A 751
LEU A 800
MET A 801
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
0.58A 5lw1H-3pp0A:
20.7
5lw1H-3pp0A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rez PLATELET
GLYCOPROTEIN IB BETA
CHAIN, PLATELET
GLYCOPROTEIN IX


(Homo sapiens)
PF01462
(LRRNT)
PF01463
(LRRCT)
5 GLY A  59
ALA A  56
LEU A  32
VAL A  42
LEU A  72
None
0.97A 5lw1H-3rezA:
undetectable
5lw1H-3rezA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  51
VAL A  58
ALA A  71
MET A 118
MET A 121
I85  A 350 (-3.5A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 ( 3.9A)
None
0.51A 5lw1H-3sheA:
18.3
5lw1H-3sheA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
6 GLY A  60
VAL A  67
ALA A  80
MET A 129
LEU A 131
MET A 132
ANK  A 401 (-3.4A)
ANK  A 401 (-4.3A)
ANK  A 401 (-3.0A)
ANK  A 401 (-3.7A)
None
None
0.60A 5lw1H-3vn9A:
21.1
5lw1H-3vn9A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  60
VAL A  67
ALA A  80
MET A 129
LEU A 186
ANK  A 401 (-3.4A)
ANK  A 401 (-4.3A)
ANK  A 401 (-3.0A)
ANK  A 401 (-3.7A)
ANK  A 401 ( 4.9A)
1.03A 5lw1H-3vn9A:
21.1
5lw1H-3vn9A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E


(Bombyx mori)
PF00248
(Aldo_ket_red)
5 GLY A  67
VAL A  41
ALA A  44
VAL A  77
LEU A  82
None
1.05A 5lw1H-3wczA:
undetectable
5lw1H-3wczA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  76
VAL A  83
ALA A  96
MET A 144
MET A 147
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
None
0.30A 5lw1H-3wigA:
21.4
5lw1H-3wigA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  62
VAL A  69
ALA A  82
LEU A 139
MET A 140
R4L  A1394 (-3.6A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 ( 4.9A)
None
0.42A 5lw1H-4b99A:
35.9
5lw1H-4b99A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  65
ALA A  85
LEU A 133
ASN A 137
LEU A 199
F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.4A)
F8E  A1340 ( 4.5A)
F8E  A1340 (-3.8A)
0.87A 5lw1H-4btmA:
14.0
5lw1H-4btmA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  65
ALA A  85
MET A 131
LEU A 133
ASN A 137
F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.2A)
F8E  A1340 (-4.4A)
F8E  A1340 ( 4.5A)
0.67A 5lw1H-4btmA:
14.0
5lw1H-4btmA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drr OUTER CAPSID PROTEIN
VP4


(Rotavirus sp.)
no annotation 5 GLY A  90
VAL A 106
ALA A 104
VAL A 126
LEU A 128
None
0.86A 5lw1H-4drrA:
undetectable
5lw1H-4drrA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  27
VAL A  34
ALA A  47
MET A  95
LEU A  97
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 ( 4.8A)
0.53A 5lw1H-4fg8A:
18.0
5lw1H-4fg8A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A1123
VAL A1130
ALA A1148
LEU A1198
MET A1199
0UV  A1501 ( 4.3A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
0.61A 5lw1H-4fodA:
20.2
5lw1H-4fodA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE


(Mus musculus)
PF00069
(Pkinase)
5 GLY A 409
VAL A 416
ALA A 429
MET A 471
LEU A 473
0WB  A 701 ( 4.4A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
0.60A 5lw1H-4g3fA:
16.9
5lw1H-4g3fA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE


(Mus musculus)
PF00069
(Pkinase)
5 GLY A 409
VAL A 416
ALA A 429
MET A 471
LEU A 524
0WB  A 701 ( 4.4A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
0.97A 5lw1H-4g3fA:
16.9
5lw1H-4g3fA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 407
VAL A 414
ALA A 427
MET A 469
LEU A 471
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
T28  A 701 ( 4.8A)
0.51A 5lw1H-4idtA:
16.9
5lw1H-4idtA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j57 THIOREDOXIN
REDUCTASE 2


(Plasmodium
falciparum)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 193
VAL A 358
ALA A 354
LEU A 189
LEU A 323
FAD  A 601 (-3.3A)
None
None
None
FAD  A 601 (-4.9A)
0.98A 5lw1H-4j57A:
undetectable
5lw1H-4j57A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN


(Toxoplasma
gondii)
PF14531
(Kinase-like)
5 GLY A 259
VAL A 266
ALA A 279
MET A 356
LEU A 416
ANP  A 601 (-3.4A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.3A)
ANP  A 601 ( 4.9A)
1.04A 5lw1H-4jrnA:
13.7
5lw1H-4jrnA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS)
5 GLY A 198
VAL A 205
ALA A 218
LEU A 273
MET A 274
29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
0.83A 5lw1H-4mk0A:
23.7
5lw1H-4mk0A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2


(Plasmodium
falciparum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
5 GLY A  79
VAL A  86
ALA A  99
MET A 146
LEU A 148
STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
0.53A 5lw1H-4mvfA:
19.8
5lw1H-4mvfA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  61
MET A 107
LEU A 109
ASN A 113
LEU A 175
2KC  A 401 (-2.7A)
2KC  A 401 (-4.1A)
2KC  A 401 ( 4.7A)
None
2KC  A 401 ( 3.9A)
0.89A 5lw1H-4nfnA:
19.1
5lw1H-4nfnA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  41
ALA A  61
MET A 107
LEU A 109
LEU A 175
2KC  A 401 ( 3.2A)
2KC  A 401 (-2.7A)
2KC  A 401 (-4.1A)
2KC  A 401 ( 4.7A)
2KC  A 401 ( 3.9A)
0.99A 5lw1H-4nfnA:
19.1
5lw1H-4nfnA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 228
VAL A 235
ALA A 248
LEU A 303
MET A 304
None
0.53A 5lw1H-4pwnA:
20.1
5lw1H-4pwnA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6l PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOB


(Salmonella
enterica)
PF13036
(LpoB)
5 VAL A  87
MET A 191
LEU A 193
VAL A 104
LEU A 124
None
1.06A 5lw1H-4q6lA:
undetectable
5lw1H-4q6lA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE


(Crassicarpon
hotsonii)
PF16010
(CDH-cyt)
5 GLY A 149
ALA A 144
ASN A  18
VAL A  37
LEU A  39
MG  A 407 (-3.8A)
None
None
None
None
1.01A 5lw1H-4qi3A:
undetectable
5lw1H-4qi3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE


(Leishmania
donovani)
PF00069
(Pkinase)
5 GLY A  28
VAL A  35
ALA A  49
MET A 104
MET A 107
ANP  A 402 ( 3.7A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-4.4A)
None
0.48A 5lw1H-4qnyA:
35.3
5lw1H-4qnyA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  49
VAL A  56
ALA A  69
LEU A 124
MET A 125
None
None
38Z  A 418 (-3.4A)
38Z  A 418 ( 4.8A)
None
0.41A 5lw1H-4qtbA:
37.8
5lw1H-4qtbA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14


(Mus musculus)
PF00069
(Pkinase)
5 GLY B  31
ALA B  51
LEU B 108
MET B 109
LEU B 167
None
39G  B 401 (-3.5A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
39G  B 401 (-3.6A)
0.80A 5lw1H-4tyhB:
15.5
5lw1H-4tyhB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14


(Mus musculus)
PF00069
(Pkinase)
5 GLY B  31
VAL B  38
ALA B  51
LEU B 108
MET B 109
None
None
39G  B 401 (-3.5A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
0.77A 5lw1H-4tyhB:
15.5
5lw1H-4tyhB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN


(Zobellia
galactanivorans)
no annotation 5 GLY A 283
VAL A 299
ALA A 297
LEU A 288
VAL A 279
None
1.08A 5lw1H-4u6dA:
undetectable
5lw1H-4u6dA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus)
PF00069
(Pkinase)
PF00615
(RGS)
5 GLY A 194
VAL A 201
ALA A 214
MET A 264
MET A 267
None
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
0.45A 5lw1H-4wboA:
18.3
5lw1H-4wboA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1


(Rattus
norvegicus)
PF00069
(Pkinase)
5 GLY A  30
VAL A  37
ALA A  50
LEU A 105
MET A 106
None
None
42A  A 402 (-3.2A)
42A  A 402 ( 4.9A)
None
0.58A 5lw1H-4xrlA:
37.2
5lw1H-4xrlA:
10.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK


(Drosophila
melanogaster)
PF00069
(Pkinase)
7 GLY A  31
ALA A  51
MET A 106
LEU A 108
MET A 109
VAL A 156
LEU A 166
ANP  A 401 (-3.3A)
ANP  A 401 (-3.5A)
ANP  A 401 (-3.8A)
ANP  A 401 ( 4.8A)
None
None
ANP  A 401 ( 4.5A)
0.71A 5lw1H-5awmA:
44.0
5lw1H-5awmA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK


(Drosophila
melanogaster)
PF00069
(Pkinase)
8 VAL A  38
ALA A  51
MET A 106
LEU A 108
MET A 109
ASN A 112
VAL A 156
LEU A 166
ANP  A 401 (-4.5A)
ANP  A 401 (-3.5A)
ANP  A 401 (-3.8A)
ANP  A 401 ( 4.8A)
None
ANP  A 401 (-3.9A)
None
ANP  A 401 ( 4.5A)
0.45A 5lw1H-5awmA:
44.0
5lw1H-5awmA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida)
PF13647
(Glyco_hydro_80)
5 GLY A 112
VAL A 115
ALA A 153
LEU A 154
LEU A  98
None
1.08A 5lw1H-5b4sA:
undetectable
5lw1H-5b4sA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE


(Mus musculus)
PF00069
(Pkinase)
5 GLY A  82
VAL A  89
ALA A 102
MET A 150
LEU A 152
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-4.0A)
None
0.42A 5lw1H-5dbxA:
18.8
5lw1H-5dbxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A 719
VAL A 726
ALA A 743
LEU A 792
MET A 793
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
0.66A 5lw1H-5j9zA:
20.2
5lw1H-5j9zA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 GLY A 719
VAL A 726
ALA A 743
MET A 790
LEU A 792
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.9A)
0.77A 5lw1H-5j9zA:
20.2
5lw1H-5j9zA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 397
VAL A 404
ALA A 417
MET A 465
LEU A 467
GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 ( 4.7A)
0.66A 5lw1H-5jznA:
19.6
5lw1H-5jznA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A 156
VAL A 163
ALA A 176
LEU A 230
ASN A 234
7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
None
None
0.74A 5lw1H-5lxdA:
22.3
5lw1H-5lxdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3


(Homo sapiens)
PF00069
(Pkinase)
PF12202
(OSR1_C)
5 GLY A 154
VAL A 161
ALA A 174
LEU A 229
MET A 230
None
None
GOL  A 604 ( 3.8A)
GOL  A 604 ( 4.8A)
None
0.42A 5lw1H-5o2cA:
21.2
5lw1H-5o2cA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1


(Homo sapiens)
no annotation 5 GLY A  45
VAL A  52
ALA A  65
VAL A 126
LEU A 174
None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
7LK  A 401 (-4.8A)
1.02A 5lw1H-5turA:
21.9
5lw1H-5turA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 GLY A  99
VAL A 106
ALA A 119
MET A 169
MET A 172
None
0.42A 5lw1H-5u7qA:
23.5
5lw1H-5u7qA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
5 GLY A 198
VAL A 205
ALA A 218
LEU A 273
MET A 274
QRW  A 601 ( 4.5A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
0.69A 5lw1H-5uuuA:
23.4
5lw1H-5uuuA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4


(Mus musculus)
no annotation 5 GLY A  29
VAL A  36
ALA A  49
MET A  96
MET A  99
VX6  A 402 ( 4.2A)
VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-3.7A)
None
0.55A 5lw1H-5wnmA:
21.7
5lw1H-5wnmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus)
no annotation 5 GLY B 220
VAL B 388
ALA B 384
LEU B 216
LEU B 354
FAD  B 601 (-3.1A)
None
None
None
FAD  B 601 (-4.6A)
0.97A 5lw1H-5x1yB:
undetectable
5lw1H-5x1yB:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
no annotation 5 GLY A  34
VAL A  41
ALA A  54
MET A  99
LEU A 153
ANP  A 501 ( 3.9A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.5A)
ANP  A 501 (-4.6A)
1.08A 5lw1H-6ao5A:
19.8
5lw1H-6ao5A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE


(Enterococcus
faecalis)
no annotation 5 GLY A 139
VAL A 303
ALA A 299
LEU A 135
LEU A 269
FAD  A 501 (-3.3A)
None
None
None
None
0.97A 5lw1H-6b4oA:
undetectable
5lw1H-6b4oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila)
no annotation 5 GLY A 270
VAL A 269
MET A 230
ASN A 273
VAL A 274
None
1.05A 5lw1H-6b7pA:
undetectable
5lw1H-6b7pA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1


(Homo sapiens)
no annotation 5 GLY A 882
VAL A 889
ALA A 906
MET A 956
LEU A1010
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
ADP  A1201 (-4.5A)
0.96A 5lw1H-6c7yA:
21.0
5lw1H-6c7yA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6


(Homo sapiens)
no annotation 5 GLY A 198
VAL A 205
ALA A 217
LEU A 266
MET A 267
FKY  A9001 ( 4.0A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
0.37A 5lw1H-6cz4A:
19.9
5lw1H-6cz4A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2


(Homo sapiens)
no annotation 5 GLY A 170
VAL A 177
ALA A 191
LEU A 245
LEU A 297
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.7A)
None
1.07A 5lw1H-6fylA:
17.4
5lw1H-6fylA:
undetectable