SIMILAR PATTERNS OF AMINO ACIDS FOR 5LW1_E_ADNE401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  41
ALA A  54
ILE A  87
MET A 109
MET A 112
LEU A 170
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
ANP  A 400 (-4.9A)
ANP  A 400 (-4.6A)
None
ANP  A 400 (-4.0A)
 0.66A 5lw1E-1cm8A:
26.2		 5lw1E-1cm8A:
42.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nex CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
D

(Saccharomyces
cerevisiae) 		PF01466
(Skp1)
PF03931
(Skp1_POZ) 		5 VAL A  18
ALA A  23
LEU A  29
VAL A  79
LEU A  87
 None
 0.86A 5lw1E-1nexA:
undetectable		 5lw1E-1nexA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  79
VAL A  86
ALA A  99
MET A 147
MET A 150
 ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 3.4A)
None
 0.72A 5lw1E-1s9iA:
20.7		 5lw1E-1s9iA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
ILE A  89
MET A 105
LEU A 158
 None
 1.46A 5lw1E-1u5qA:
22.3		 5lw1E-1u5qA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
ILE A  77
LEU A  95
 None
 0.43A 5lw1E-1zwsA:
22.8		 5lw1E-1zwsA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
ILE A  77
LEU A  95
 None
None
GOL  A3001 (-3.5A)
GOL  A3001 (-4.8A)
None
 0.45A 5lw1E-2a2aA:
22.8		 5lw1E-2a2aA:
13.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  91
MET A 146
LEU A 148
ASN A 152
VAL A 196
LEU A 206
 AIZ  A 501 (-3.4A)
AIZ  A 501 (-3.8A)
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
 0.85A 5lw1E-2b1pA:
43.5		 5lw1E-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  71
ALA A  91
LEU A 148
MET A 149
ASN A 152
VAL A 196
LEU A 206
 AIZ  A 501 ( 4.0A)
AIZ  A 501 (-3.4A)
AIZ  A 501 ( 4.7A)
None
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
 0.91A 5lw1E-2b1pA:
43.5		 5lw1E-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  78
ALA A  91
LEU A 148
MET A 149
ASN A 152
VAL A 196
LEU A 206
 AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
AIZ  A 501 ( 4.7A)
None
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
 0.59A 5lw1E-2b1pA:
43.5		 5lw1E-2b1pA:
93.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLY A  20
VAL A  27
ALA A  40
ILE A  72
LEU A  95
MET A  96
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 ( 4.9A)
None
 0.68A 5lw1E-2f9gA:
24.1		 5lw1E-2f9gA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 GLY A  35
VAL A  42
ALA A  55
ILE A  89
MET A 105
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 ( 3.7A)
 0.51A 5lw1E-2gcdA:
17.4		 5lw1E-2gcdA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 GLY A  23
VAL A  30
ALA A  43
MET A  93
LEU A  95
VAL A 156
 None
 1.21A 5lw1E-2h34A:
19.3		 5lw1E-2h34A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 249
VAL A 256
ALA A 269
MET A 318
ASN A 322
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
None
None
 0.71A 5lw1E-2hz0A:
20.4		 5lw1E-2hz0A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 GLY A 429
VAL A 436
ALA A 452
MET A 499
LEU A 501
 4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.3A)
 0.45A 5lw1E-2j0jA:
20.2		 5lw1E-2j0jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  30
VAL A  37
ALA A  50
MET A  98
LEU A 100
 QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.1A)
QPP  A1314 (-4.5A)
 0.67A 5lw1E-2jc6A:
19.3		 5lw1E-2jc6A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 GLY A 429
VAL A 436
ALA A 452
MET A 499
LEU A 501
 BII  A1687 ( 3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.1A)
BII  A1687 (-4.4A)
 0.67A 5lw1E-2jkmA:
20.0		 5lw1E-2jkmA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 GLY A  26
VAL A  33
ALA A  46
ILE A  87
LEU A 105
MET A 106
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
 0.55A 5lw1E-2phkA:
22.8		 5lw1E-2phkA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 488
VAL A 495
ALA A 515
ILE A 548
ASN A 571
 None
 0.86A 5lw1E-2psqA:
20.5		 5lw1E-2psqA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		5 GLY B  48
VAL B  55
ALA B  67
MET B 117
ASN B 121
 None
 0.46A 5lw1E-2qkwB:
15.2		 5lw1E-2qkwB:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A 429
ALA A 449
ILE A 477
LEU A 495
MET A 496
 None
 0.64A 5lw1E-2qr7A:
18.9		 5lw1E-2qr7A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 725
VAL A 732
ALA A 749
LEU A 798
MET A 799
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
None
 0.71A 5lw1E-2r4bA:
16.3		 5lw1E-2r4bA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  83
VAL A  90
ALA A 103
MET A 153
MET A 156
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
 0.65A 5lw1E-2v55A:
22.6		 5lw1E-2v55A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
ILE A  77
LEU A  95
 ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.2A)
None
 0.47A 5lw1E-2w4kA:
22.6		 5lw1E-2w4kA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  53
VAL A  60
ALA A  73
ILE A 102
LEU A 120
 DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 ( 4.4A)
DKI  A1338 (-4.2A)
 0.56A 5lw1E-2w4oA:
20.1		 5lw1E-2w4oA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 425
ALA A 445
ILE A 473
LEU A 491
MET A 492
 None
 0.67A 5lw1E-2wntA:
19.4		 5lw1E-2wntA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 113
VAL A 120
ALA A 133
ILE A 164
MET A 180
 16X  A1374 (-3.4A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
None
16X  A1374 (-4.2A)
 0.62A 5lw1E-2x4fA:
22.4		 5lw1E-2x4fA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 227
VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
 XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.1A)
None
 0.70A 5lw1E-2xk9A:
20.5		 5lw1E-2xk9A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  31
VAL A  38
ALA A  51
ILE A  91
LEU A 109
MET A 110
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
B49  A1294 ( 4.6A)
B49  A1294 ( 4.7A)
None
 0.54A 5lw1E-2y7jA:
23.4		 5lw1E-2y7jA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
ILE A  77
LEU A  95
 AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 ( 3.8A)
AMP  A1302 ( 4.9A)
 0.43A 5lw1E-2yabA:
22.9		 5lw1E-2yabA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A1003
VAL A1010
ALA A1028
MET A1076
LEU A1078
MET A1079
 S91  A   1 ( 3.9A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.9A)
S91  A   1 (-4.7A)
None
 0.69A 5lw1E-2z8cA:
22.3		 5lw1E-2z8cA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 532
VAL A 539
ALA A 551
ILE A 586
MET A 602
 None
None
None
None
7PE  A   1 ( 4.3A)
 0.82A 5lw1E-2zmcA:
23.0		 5lw1E-2zmcA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
ILE A  77
LEU A  95
 4RB  A 401 (-3.6A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 4.3A)
4RB  A 401 (-4.4A)
 0.65A 5lw1E-3bqrA:
20.6		 5lw1E-3bqrA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  32
VAL A  39
ALA A  52
ILE A  85
MET A 107
MET A 110
 None
 0.66A 5lw1E-3coiA:
35.9		 5lw1E-3coiA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  39
ALA A  52
ILE A  85
MET A 107
MET A 110
LEU A 167
 None
 0.80A 5lw1E-3coiA:
35.9		 5lw1E-3coiA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 151
VAL A 158
ALA A 169
ILE A 204
MET A 220
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.7A)
 0.64A 5lw1E-3dtcA:
20.1		 5lw1E-3dtcA:
13.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY A  33
VAL A  40
ALA A  53
ILE A  86
MET A 108
LEU A 110
MET A 111
VAL A 158
LEU A 168
 35F  A   1 ( 4.8A)
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
None
35F  A   1 ( 3.9A)
35F  A   1 (-4.5A)
None
None
35F  A   1 (-4.5A)
 0.54A 5lw1E-3e7oA:
42.9		 5lw1E-3e7oA:
70.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  33
VAL A  40
ALA A  53
MET A 108
LEU A 110
MET A 111
ASN A 114
VAL A 158
 35F  A   1 ( 4.8A)
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
35F  A   1 ( 3.9A)
35F  A   1 (-4.5A)
None
None
None
 0.78A 5lw1E-3e7oA:
42.9		 5lw1E-3e7oA:
70.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 GLY A  35
VAL A  42
ALA A  55
ILE A  86
LEU A 104
 DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-4.4A)
 0.38A 5lw1E-3f3zA:
22.8		 5lw1E-3f3zA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 GLY A  35
VAL A  42
ALA A  55
ILE A  86
MET A 102
 DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-3.6A)
 0.69A 5lw1E-3f3zA:
22.8		 5lw1E-3f3zA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  60
VAL A  67
ALA A  80
MET A 129
LEU A 131
MET A 132
 STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
STU  A   1 (-4.6A)
None
 0.49A 5lw1E-3fmeA:
20.5		 5lw1E-3fmeA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  31
VAL A  38
ALA A  51
ILE A  84
LEU A 108
MET A 109
LEU A 167
 None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 ( 4.4A)
None
NIL  A   1 (-4.0A)
 0.83A 5lw1E-3gp0A:
37.2		 5lw1E-3gp0A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 GLY A  17
VAL A  24
ALA A  37
MET A  89
LEU A  91
 ANP  A 329 (-3.5A)
ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-3.7A)
ANP  A 329 ( 4.7A)
 0.35A 5lw1E-3hkoA:
8.5		 5lw1E-3hkoA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		5 GLY A 227
VAL A 234
ALA A 247
ILE A 286
LEU A 303
 None
 0.77A 5lw1E-3i6uA:
21.5		 5lw1E-3i6uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		5 VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
 None
 0.77A 5lw1E-3i6uA:
21.5		 5lw1E-3i6uA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 GLY A 681
VAL A 689
ALA A 700
ILE A 729
LEU A 747
ASN A 751
 ADP  A2101 (-3.6A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
ADP  A2101 (-3.7A)
 0.59A 5lw1E-3lj0A:
21.0		 5lw1E-3lj0A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A1006
VAL A1013
ALA A1031
MET A1079
LEU A1081
MET A1082
 None
None
None
CCX  A   1 ( 3.9A)
None
None
 0.73A 5lw1E-3lw0A:
21.5		 5lw1E-3lw0A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		6 GLY A 577
VAL A 578
ILE A 633
LEU A 585
VAL A 655
LEU A 637
 None
 1.25A 5lw1E-3nowA:
undetectable		 5lw1E-3nowA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 GLY A 193
VAL A 200
ALA A 213
LEU A 265
MET A 266
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.9A)
None
 0.43A 5lw1E-3nyoA:
24.4		 5lw1E-3nyoA:
9.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		6 GLY A  32
VAL A  39
ALA A  52
ILE A  85
LEU A 109
LEU A 168
 1N1  A1000 (-3.4A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-4.7A)
1N1  A1000 ( 3.7A)
 1.01A 5lw1E-3ohtA:
17.1		 5lw1E-3ohtA:
35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		6 GLY A  32
VAL A  39
ALA A  52
ILE A  85
LEU A 109
MET A 110
 1N1  A1000 (-3.4A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-4.7A)
None
 0.76A 5lw1E-3ohtA:
17.1		 5lw1E-3ohtA:
35.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojc PUTATIVE
ASPARTATE/GLUTAMATE
RACEMASE

(Yersinia pestis) 		PF01177
(Asp_Glu_race) 		5 GLY A 133
ALA A 106
ILE A 195
VAL A 147
LEU A 123
 None
 0.85A 5lw1E-3ojcA:
undetectable		 5lw1E-3ojcA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 727
VAL A 734
ALA A 751
LEU A 800
MET A 801
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.6A)
None
 0.68A 5lw1E-3pp0A:
20.4		 5lw1E-3pp0A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		6 GLY A 119
VAL A  63
ALA A  69
ILE A   9
MET A  72
LEU A  86
 None
 1.39A 5lw1E-3qivA:
undetectable		 5lw1E-3qivA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  51
VAL A  58
ALA A  71
MET A 118
MET A 121
 I85  A 350 (-3.5A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 ( 3.9A)
None
 0.65A 5lw1E-3sheA:
18.0		 5lw1E-3sheA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  60
VAL A  67
ALA A  80
MET A 129
LEU A 131
MET A 132
 ANK  A 401 (-3.4A)
ANK  A 401 (-4.3A)
ANK  A 401 (-3.0A)
ANK  A 401 (-3.7A)
None
None
 0.58A 5lw1E-3vn9A:
20.8		 5lw1E-3vn9A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  76
VAL A  83
ALA A  96
MET A 144
MET A 147
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
None
 0.42A 5lw1E-3wigA:
21.3		 5lw1E-3wigA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 626
VAL A 633
ALA A 649
ILE A 681
MET A 700
 None
 0.82A 5lw1E-3zfxA:
20.6		 5lw1E-3zfxA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A  98
VAL A 105
ALA A 121
ILE A 153
MET A 172
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
 0.65A 5lw1E-4aw5A:
20.6		 5lw1E-4aw5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  62
VAL A  69
ALA A  82
ILE A 115
LEU A 139
MET A 140
 R4L  A1394 (-3.6A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
None
 0.55A 5lw1E-4b99A:
26.9		 5lw1E-4b99A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  65
ALA A  85
MET A 131
LEU A 133
ASN A 137
 F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.2A)
F8E  A1340 (-4.4A)
F8E  A1340 ( 4.5A)
 0.77A 5lw1E-4btmA:
14.2		 5lw1E-4btmA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		6 GLY B 293
VAL A 325
ALA A 323
ILE B 351
LEU B 246
ASN B 303
 None
 1.22A 5lw1E-4cakB:
undetectable		 5lw1E-4cakB:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqx PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		6 GLY A 135
VAL A  82
ALA A  88
ILE A  31
MET A  91
LEU A 105
 None
 1.46A 5lw1E-4dqxA:
undetectable		 5lw1E-4dqxA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  27
VAL A  34
ALA A  47
MET A  95
LEU A  97
 ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 ( 4.8A)
 0.47A 5lw1E-4fg8A:
21.4		 5lw1E-4fg8A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A1123
VAL A1130
ALA A1148
LEU A1198
MET A1199
 0UV  A1501 ( 4.3A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 ( 4.8A)
None
 0.67A 5lw1E-4fodA:
20.0		 5lw1E-4fodA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A 409
VAL A 416
ALA A 429
MET A 471
LEU A 473
 0WB  A 701 ( 4.4A)
0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.9A)
0WB  A 701 (-4.3A)
 0.60A 5lw1E-4g3fA:
19.6		 5lw1E-4g3fA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxh PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Xenorhabdus
bovienii) 		PF01470
(Peptidase_C15) 		5 GLY A 163
VAL A  65
ILE A  42
VAL A 146
LEU A  53
 None
 0.78A 5lw1E-4gxhA:
undetectable		 5lw1E-4gxhA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 133
VAL A 140
ALA A 156
ILE A 190
LEU A 207
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 4.9A)
 0.64A 5lw1E-4id7A:
20.8		 5lw1E-4id7A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 407
VAL A 414
ALA A 427
MET A 469
LEU A 471
 T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 (-2.6A)
T28  A 701 ( 4.8A)
 0.43A 5lw1E-4idtA:
20.0		 5lw1E-4idtA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 479
VAL A 486
ALA A 506
ILE A 539
ASN A 562
 ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 (-3.8A)
 0.47A 5lw1E-4k33A:
15.4		 5lw1E-4k33A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		5 GLY A 198
VAL A 205
ALA A 218
LEU A 273
MET A 274
 29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.6A)
None
 0.78A 5lw1E-4mk0A:
23.4		 5lw1E-4mk0A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 GLY A  79
VAL A  86
ALA A  99
MET A 146
LEU A 148
 STU  A 601 (-3.6A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
 0.55A 5lw1E-4mvfA:
19.4		 5lw1E-4mvfA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 904
VAL A 911
ALA A 928
ILE A 960
MET A 978
LEU A1030
 2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.4A)
 1.50A 5lw1E-4oliA:
19.9		 5lw1E-4oliA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 228
VAL A 235
ALA A 248
LEU A 303
MET A 304
 None
 0.60A 5lw1E-4pwnA:
19.9		 5lw1E-4pwnA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 GLY A  28
VAL A  35
ALA A  49
ILE A  83
MET A 104
LEU A 156
 ANP  A 402 ( 3.7A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-4.8A)
ANP  A 402 (-4.4A)
ANP  A 402 (-4.6A)
 1.37A 5lw1E-4qnyA:
34.9		 5lw1E-4qnyA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 GLY A  28
VAL A  35
ALA A  49
ILE A  83
MET A 104
MET A 107
 ANP  A 402 ( 3.7A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-4.8A)
ANP  A 402 (-4.4A)
None
 0.50A 5lw1E-4qnyA:
34.9		 5lw1E-4qnyA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  49
VAL A  56
ALA A  69
ILE A 101
LEU A 124
MET A 125
 None
None
38Z  A 418 (-3.4A)
38Z  A 418 ( 4.9A)
38Z  A 418 ( 4.8A)
None
 0.54A 5lw1E-4qtbA:
24.6		 5lw1E-4qtbA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  25
VAL A  32
ALA A  45
ILE A  79
MET A  95
 None
 0.65A 5lw1E-4redA:
19.1		 5lw1E-4redA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 GLY A  25
VAL A  32
ALA A  45
ILE A  79
MET A  95
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.3A)
 0.74A 5lw1E-4rewA:
24.6		 5lw1E-4rewA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY B  31
VAL B  38
ALA B  51
LEU B 108
MET B 109
 None
None
39G  B 401 (-3.5A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
 0.77A 5lw1E-4tyhB:
36.8		 5lw1E-4tyhB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 GLY A 194
VAL A 201
ALA A 214
MET A 264
MET A 267
 None
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
 0.62A 5lw1E-4wboA:
17.8		 5lw1E-4wboA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 GLY A  30
VAL A  37
ALA A  50
LEU A 105
MET A 106
 None
None
42A  A 402 (-3.2A)
42A  A 402 ( 4.9A)
None
 0.67A 5lw1E-4xrlA:
36.4		 5lw1E-4xrlA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 VAL A  37
ALA A  50
ILE A  82
LEU A 105
MET A 106
 None
42A  A 402 (-3.2A)
None
42A  A 402 ( 4.9A)
None
 0.64A 5lw1E-4xrlA:
36.4		 5lw1E-4xrlA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 GLY A 578
VAL A 586
ALA A 597
ILE A 626
LEU A 644
 None
 0.53A 5lw1E-4z7gA:
18.3		 5lw1E-4z7gA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  62
VAL A  69
ALA A  82
ILE A 115
LEU A 139
 None
 0.79A 5lw1E-4zslA:
33.4		 5lw1E-4zslA:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		9 GLY A  31
VAL A  38
ALA A  51
ILE A  84
MET A 106
LEU A 108
MET A 109
VAL A 156
LEU A 166
 ANP  A 401 (-3.3A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.5A)
None
ANP  A 401 (-3.8A)
ANP  A 401 ( 4.8A)
None
None
ANP  A 401 ( 4.5A)
 0.82A 5lw1E-5awmA:
43.6		 5lw1E-5awmA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		9 VAL A  38
ALA A  51
ILE A  84
MET A 106
LEU A 108
MET A 109
ASN A 112
VAL A 156
LEU A 166
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.5A)
None
ANP  A 401 (-3.8A)
ANP  A 401 ( 4.8A)
None
ANP  A 401 (-3.9A)
None
ANP  A 401 ( 4.5A)
 0.61A 5lw1E-5awmA:
43.6		 5lw1E-5awmA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A  82
VAL A  89
ALA A 102
MET A 150
LEU A 152
 ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-4.0A)
None
 0.42A 5lw1E-5dbxA:
18.4		 5lw1E-5dbxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		5 GLY A 541
VAL A 548
ALA A 561
ILE A 595
LEU A 613
 4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-4.7A)
 0.42A 5lw1E-5ezrA:
21.8		 5lw1E-5ezrA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 904
VAL A 911
ALA A 928
ILE A 960
MET A 978
LEU A1030
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.6A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.4A)
 1.46A 5lw1E-5f1zA:
20.8		 5lw1E-5f1zA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 GLY A  23
VAL A  30
ALA A  43
ILE A  77
MET A  93
 STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 ( 3.9A)
 0.75A 5lw1E-5isoA:
25.0		 5lw1E-5isoA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 719
VAL A 726
ALA A 743
LEU A 792
MET A 793
 6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.9A)
None
 0.75A 5lw1E-5j9zA:
15.5		 5lw1E-5j9zA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 156
VAL A 163
ALA A 176
ILE A 212
LEU A 230
ASN A 234
 7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
None
None
 0.68A 5lw1E-5lxdA:
22.0		 5lw1E-5lxdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		5 GLY A 154
VAL A 161
ALA A 174
LEU A 229
MET A 230
 None
None
GOL  A 604 ( 3.8A)
GOL  A 604 ( 4.8A)
None
 0.53A 5lw1E-5o2cA:
21.0		 5lw1E-5o2cA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  99
VAL A 106
ALA A 119
MET A 169
MET A 172
 None
 0.55A 5lw1E-5u7qA:
23.2		 5lw1E-5u7qA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 GLY A 198
VAL A 205
ALA A 218
LEU A 273
MET A 274
 QRW  A 601 ( 4.5A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
 0.64A 5lw1E-5uuuA:
16.3		 5lw1E-5uuuA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 GLY A  29
VAL A  36
ALA A  49
MET A  96
MET A  99
 VX6  A 402 ( 4.2A)
VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-3.7A)
None
 0.64A 5lw1E-5wnmA:
21.3		 5lw1E-5wnmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 GLY A 216
VAL A 223
ALA A 236
ILE A 272
LEU A 290
 None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 ( 4.8A)
HRM  A 601 (-4.6A)
 0.46A 5lw1E-5y86A:
26.1		 5lw1E-5y86A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 5 GLY A 532
VAL A 539
ALA A 551
ILE A 586
MET A 602
 CQ7  A 801 ( 4.0A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
CQ7  A 801 (-3.4A)
 0.59A 5lw1E-6b4wA:
23.1		 5lw1E-6b4wA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 5 GLY A  23
VAL A  30
ALA A  43
ILE A  77
MET A  93
 EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
EDJ  A 301 ( 4.2A)
 0.77A 5lw1E-6bx6A:
16.4		 5lw1E-6bx6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 GLY A 198
VAL A 205
ALA A 217
LEU A 266
MET A 267
 FKY  A9001 ( 4.0A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
 0.34A 5lw1E-6cz4A:
19.6		 5lw1E-6cz4A:
24.49