SIMILAR PATTERNS OF AMINO ACIDS FOR 5LW1_B_ADNB401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  41
ALA A  54
ILE A  87
MET A 109
MET A 112
LEU A 170
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
ANP  A 400 (-4.9A)
ANP  A 400 (-4.6A)
None
ANP  A 400 (-4.0A)
 0.69A 5lw1B-1cm8A:
35.8		 5lw1B-1cm8A:
42.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  79
VAL A  86
ALA A  99
MET A 147
MET A 150
 ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 3.4A)
None
 0.72A 5lw1B-1s9iA:
20.8		 5lw1B-1s9iA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  35
VAL A  42
ALA A  55
ILE A  89
MET A 105
 None
 0.30A 5lw1B-1u5qA:
22.6		 5lw1B-1u5qA:
11.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  70
GLY A  71
ALA A  91
MET A 149
ASN A 152
LEU A 206
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.0A)
AIZ  A 501 (-3.4A)
None
AIZ  A 501 (-3.6A)
AIZ  A 501 (-4.0A)
 0.91A 5lw1B-2b1pA:
43.9		 5lw1B-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  70
VAL A  78
ALA A  91
MET A 146
ASN A 152
LEU A 206
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
AIZ  A 501 (-3.8A)
AIZ  A 501 (-3.6A)
AIZ  A 501 (-4.0A)
 0.81A 5lw1B-2b1pA:
43.9		 5lw1B-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  70
VAL A  78
ALA A  91
MET A 149
ASN A 152
LEU A 206
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
None
AIZ  A 501 (-3.6A)
AIZ  A 501 (-4.0A)
 0.57A 5lw1B-2b1pA:
43.9		 5lw1B-2b1pA:
93.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
ILE A  72
MET A  96
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
None
 0.63A 5lw1B-2f9gA:
21.7		 5lw1B-2f9gA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  35
VAL A  42
ALA A  55
ILE A  89
MET A 105
 STU  A 400 (-4.2A)
STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 ( 3.7A)
 0.39A 5lw1B-2gcdA:
23.3		 5lw1B-2gcdA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A  59
GLY A  60
VAL A  67
ALA A  80
MET A 129
 None
 0.51A 5lw1B-2hakA:
21.0		 5lw1B-2hakA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 635
GLY A 636
VAL A 643
ALA A 659
ILE A 691
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.7A)
 1.30A 5lw1B-2henA:
14.7		 5lw1B-2henA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 635
GLY A 636
VAL A 643
ALA A 659
ILE A 691
MET A 710
 ADP  A 400 (-4.9A)
ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
 0.62A 5lw1B-2henA:
14.7		 5lw1B-2henA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 249
VAL A 256
ALA A 269
MET A 318
ASN A 322
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
None
None
 0.72A 5lw1B-2hz0A:
20.8		 5lw1B-2hz0A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 ILE A 428
GLY A 429
VAL A 436
ALA A 452
MET A 499
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
 0.44A 5lw1B-2j0jA:
20.5		 5lw1B-2j0jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 GLY A  26
VAL A  33
ALA A  46
ILE A  87
MET A 106
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
 0.43A 5lw1B-2phkA:
23.0		 5lw1B-2phkA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 488
VAL A 495
ALA A 515
ILE A 548
ASN A 571
 None
 0.75A 5lw1B-2psqA:
21.0		 5lw1B-2psqA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
GLY B  48
VAL B  55
ALA B  67
MET B 117
ASN B 121
 None
 0.52A 5lw1B-2qkwB:
14.2		 5lw1B-2qkwB:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		5 ILE A 428
GLY A 429
ALA A 449
ILE A 477
MET A 496
 None
 0.62A 5lw1B-2qr7A:
19.2		 5lw1B-2qr7A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  83
VAL A  90
ALA A 103
MET A 153
MET A 156
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
 0.64A 5lw1B-2v55A:
22.6		 5lw1B-2v55A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  82
GLY A  83
VAL A  90
ALA A 103
MET A 156
 None
ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
None
 0.67A 5lw1B-2v55A:
22.6		 5lw1B-2v55A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		5 ILE A 490
GLY A 491
VAL A 498
ALA A 509
ILE A 557
 None
5ID  A1800 (-3.5A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
5ID  A1800 ( 4.5A)
 0.41A 5lw1B-2vuwA:
9.5		 5lw1B-2vuwA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 424
GLY A 425
ALA A 445
ILE A 473
MET A 492
 None
 0.63A 5lw1B-2wntA:
19.7		 5lw1B-2wntA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 113
VAL A 120
ALA A 133
ILE A 164
MET A 180
 16X  A1374 (-3.4A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
None
16X  A1374 (-4.2A)
 0.53A 5lw1B-2x4fA:
18.4		 5lw1B-2x4fA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 227
VAL A 234
ALA A 247
ILE A 286
MET A 304
 XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
None
 0.61A 5lw1B-2xk9A:
20.8		 5lw1B-2xk9A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 627
GLY A 628
VAL A 635
ALA A 651
ILE A 683
MET A 702
 None
None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.9A)
None
 0.86A 5lw1B-2xyuA:
20.2		 5lw1B-2xyuA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  30
GLY A  31
VAL A  38
ALA A  51
ILE A  91
MET A 110
 B49  A1294 (-3.9A)
B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
B49  A1294 ( 4.6A)
None
 0.46A 5lw1B-2y7jA:
23.8		 5lw1B-2y7jA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A1003
VAL A1010
ALA A1028
MET A1076
MET A1079
 S91  A   1 ( 3.9A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.9A)
None
 0.74A 5lw1B-2z8cA:
22.5		 5lw1B-2z8cA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  18
GLY A  19
VAL A  26
ALA A  39
MET A  94
 3AM  A 338 (-4.5A)
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
 0.59A 5lw1B-3c0iA:
23.2		 5lw1B-3c0iA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A1084
GLY A1085
VAL A1092
ALA A1108
MET A1160
 CKK  A1500 ( 4.4A)
None
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
None
 0.52A 5lw1B-3c1xA:
19.3		 5lw1B-3c1xA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  32
VAL A  39
ALA A  52
ILE A  85
MET A 107
MET A 110
 None
 0.67A 5lw1B-3coiA:
36.0		 5lw1B-3coiA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  39
ALA A  52
ILE A  85
MET A 107
MET A 110
LEU A 167
 None
 0.82A 5lw1B-3coiA:
36.0		 5lw1B-3coiA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 151
VAL A 158
ALA A 169
ILE A 204
MET A 220
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.7A)
 0.58A 5lw1B-3dtcA:
20.4		 5lw1B-3dtcA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 150
GLY A 151
VAL A 158
ALA A 169
ILE A 204
LEU A 275
 VIN  A6331 (-4.0A)
VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-4.5A)
 1.34A 5lw1B-3dtcA:
20.4		 5lw1B-3dtcA:
13.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  32
GLY A  33
VAL A  40
ALA A  53
ILE A  86
MET A 108
MET A 111
ASN A 114
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.8A)
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
None
35F  A   1 ( 3.9A)
None
None
 0.80A 5lw1B-3e7oA:
43.2		 5lw1B-3e7oA:
70.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  32
GLY A  33
VAL A  40
ALA A  53
ILE A  86
MET A 108
MET A 111
LEU A 168
 35F  A   1 ( 4.4A)
35F  A   1 ( 4.8A)
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
None
35F  A   1 ( 3.9A)
None
35F  A   1 (-4.5A)
 0.57A 5lw1B-3e7oA:
43.2		 5lw1B-3e7oA:
70.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 GLY A  35
VAL A  42
ALA A  55
ILE A  86
MET A 102
 DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-3.6A)
 0.64A 5lw1B-3f3zA:
23.1		 5lw1B-3f3zA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ILE A  34
GLY A  35
VAL A  42
ALA A  55
ILE A  86
 DRK  A   1 (-4.2A)
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
 0.47A 5lw1B-3f3zA:
23.1		 5lw1B-3f3zA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdi UNCHARACTERIZED
PROTEIN

(Eubacterium
ventriosum) 		PF13189
(Cytidylate_kin2) 		5 ILE A 177
GLY A 178
VAL A 180
ALA A 185
MET A 188
 None
 0.74A 5lw1B-3fdiA:
undetectable		 5lw1B-3fdiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ILE A  62
GLY A  63
VAL A  70
ALA A  83
MET A 132
 None
 0.56A 5lw1B-3fe3A:
22.5		 5lw1B-3fe3A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  60
VAL A  67
ALA A  80
MET A 129
MET A 132
 STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
None
 0.48A 5lw1B-3fmeA:
20.8		 5lw1B-3fmeA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 209
GLY A 210
VAL A 217
ALA A 228
MET A 279
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.99A 5lw1B-3g2fA:
21.4		 5lw1B-3g2fA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  31
VAL A  38
ALA A  51
ILE A  84
MET A 109
LEU A 167
 None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
None
NIL  A   1 (-4.0A)
 0.89A 5lw1B-3gp0A:
37.6		 5lw1B-3gp0A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ILE A  16
GLY A  17
VAL A  24
ALA A  37
MET A  89
 ANP  A 329 ( 4.2A)
ANP  A 329 (-3.5A)
ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-3.7A)
 0.45A 5lw1B-3hkoA:
16.4		 5lw1B-3hkoA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 GLY A 681
VAL A 689
ALA A 700
ILE A 729
ASN A 751
 ADP  A2101 (-3.6A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
ADP  A2101 (-3.7A)
 0.41A 5lw1B-3lj0A:
21.3		 5lw1B-3lj0A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  35
VAL A  42
ALA A  55
ILE A  88
LEU A 161
 GOL  A 434 ( 4.5A)
None
None
GOL  A 434 ( 4.1A)
None
GOL  A 434 (-4.2A)
 1.38A 5lw1B-3n9xA:
23.8		 5lw1B-3n9xA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ILE A  36
GLY A  37
VAL A  44
ALA A  57
ILE A  90
LEU A 163
 ANP  A 430 (-4.4A)
ANP  A 430 (-3.5A)
ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 ( 4.5A)
ANP  A 430 (-4.4A)
 1.28A 5lw1B-3nieA:
35.8		 5lw1B-3nieA:
16.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		5 GLY A  32
VAL A  39
ALA A  52
ILE A  85
MET A 110
 1N1  A1000 (-3.4A)
1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 ( 4.1A)
None
 0.67A 5lw1B-3ohtA:
29.9		 5lw1B-3ohtA:
35.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A1088
GLY A1089
VAL A1096
ALA A1112
MET A1164
 ANP  A1358 (-4.3A)
ANP  A1358 ( 3.7A)
ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
None
 0.76A 5lw1B-3plsA:
14.7		 5lw1B-3plsA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		6 GLY A 119
VAL A  63
ALA A  69
ILE A   9
MET A  72
LEU A  86
 None
 1.43A 5lw1B-3qivA:
undetectable		 5lw1B-3qivA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  51
VAL A  58
ALA A  71
MET A 118
MET A 121
 I85  A 350 (-3.5A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 ( 3.9A)
None
 0.60A 5lw1B-3sheA:
11.1		 5lw1B-3sheA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  60
VAL A  67
ALA A  80
MET A 129
MET A 132
 ANK  A 401 (-3.4A)
ANK  A 401 (-4.3A)
ANK  A 401 (-3.0A)
ANK  A 401 (-3.7A)
None
 0.49A 5lw1B-3vn9A:
21.2		 5lw1B-3vn9A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  76
VAL A  83
ALA A  96
MET A 144
MET A 147
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
None
 0.41A 5lw1B-3wigA:
21.4		 5lw1B-3wigA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		6 ILE B 466
GLY B 467
VAL B  42
ALA B  45
ILE B 483
LEU B 482
 None
 1.12A 5lw1B-3ze7B:
undetectable		 5lw1B-3ze7B:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 625
GLY A 626
VAL A 633
ALA A 649
ILE A 681
LEU A 751
 None
 1.48A 5lw1B-3zfxA:
20.9		 5lw1B-3zfxA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 625
GLY A 626
VAL A 633
ALA A 649
ILE A 681
MET A 700
 None
 0.74A 5lw1B-3zfxA:
20.9		 5lw1B-3zfxA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ILE A  83
GLY A  84
VAL A  91
ALA A 104
MET A 154
 None
None
None
EDO  A1420 (-3.4A)
None
 0.63A 5lw1B-4aw2A:
22.8		 5lw1B-4aw2A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A  97
GLY A  98
VAL A 105
ALA A 121
ILE A 153
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-4.5A)
 1.41A 5lw1B-4aw5A:
20.8		 5lw1B-4aw5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A  97
GLY A  98
VAL A 105
ALA A 121
ILE A 153
MET A 172
 30K  A1365 (-4.5A)
30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
 0.65A 5lw1B-4aw5A:
20.8		 5lw1B-4aw5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  61
GLY A  62
VAL A  69
ALA A  82
ILE A 115
MET A 140
 R4L  A1394 (-4.0A)
R4L  A1394 (-3.6A)
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-4.9A)
None
 0.81A 5lw1B-4b99A:
35.7		 5lw1B-4b99A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  64
GLY A  65
VAL A  72
ALA A  88
MET A 134
 None
ADP  A 601 ( 3.8A)
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 ( 3.9A)
 0.50A 5lw1B-4f99A:
8.4		 5lw1B-4f99A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		5 ILE A 327
GLY A 328
VAL A 335
ALA A 348
MET A 395
 None
ANP  A1001 (-4.4A)
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-4.8A)
 0.67A 5lw1B-4fieA:
23.4		 5lw1B-4fieA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 479
VAL A 486
ALA A 506
ILE A 539
ASN A 562
 ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 (-3.8A)
 0.36A 5lw1B-4k33A:
14.7		 5lw1B-4k33A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		5 ILE A 197
GLY A 198
VAL A 205
ALA A 218
MET A 274
 29X  A 702 (-4.7A)
29X  A 702 ( 4.1A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
 0.67A 5lw1B-4mk0A:
23.7		 5lw1B-4mk0A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 619
GLY A 620
VAL A 627
ALA A 644
ILE A 676
LEU A 746
 None
 1.33A 5lw1B-4p2kA:
21.0		 5lw1B-4p2kA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ILE A 619
GLY A 620
VAL A 627
ALA A 644
ILE A 676
MET A 695
 None
 0.71A 5lw1B-4p2kA:
21.0		 5lw1B-4p2kA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 227
GLY A 228
VAL A 235
ALA A 248
MET A 304
 None
 0.72A 5lw1B-4pwnA:
20.0		 5lw1B-4pwnA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		6 ILE A 372
GLY A 373
VAL A 174
ILE A 416
ASN A 397
LEU A 412
 None
 1.37A 5lw1B-4qbuA:
undetectable		 5lw1B-4qbuA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 ILE A  27
GLY A  28
VAL A  35
ALA A  49
ILE A  83
LEU A 156
 ANP  A 402 (-4.6A)
ANP  A 402 ( 3.7A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-4.8A)
ANP  A 402 (-4.6A)
 1.43A 5lw1B-4qnyA:
35.2		 5lw1B-4qnyA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		7 ILE A  27
GLY A  28
VAL A  35
ALA A  49
ILE A  83
MET A 104
MET A 107
 ANP  A 402 (-4.6A)
ANP  A 402 ( 3.7A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-4.8A)
ANP  A 402 (-4.4A)
None
 0.46A 5lw1B-4qnyA:
35.2		 5lw1B-4qnyA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  48
GLY A  49
VAL A  56
ALA A  69
ILE A 101
MET A 125
 38Z  A 418 ( 4.4A)
None
None
38Z  A 418 (-3.4A)
38Z  A 418 ( 4.9A)
None
 0.62A 5lw1B-4qtbA:
26.0		 5lw1B-4qtbA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  25
VAL A  32
ALA A  45
ILE A  79
MET A  95
 None
 0.60A 5lw1B-4redA:
19.2		 5lw1B-4redA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 GLY A  25
VAL A  32
ALA A  45
ILE A  79
MET A  95
 STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.3A)
 0.62A 5lw1B-4rewA:
24.7		 5lw1B-4rewA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 150
GLY A 151
VAL A 158
ALA A 169
ILE A 204
 None
 0.37A 5lw1B-4uy9A:
14.3		 5lw1B-4uy9A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 GLY A 194
VAL A 201
ALA A 214
MET A 264
MET A 267
 None
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
 0.59A 5lw1B-4wboA:
16.6		 5lw1B-4wboA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		5 ILE A 327
GLY A 328
VAL A 335
ALA A 348
MET A 395
 None
ATP  A 601 ( 4.1A)
ATP  A 601 (-4.4A)
ATP  A 601 ( 3.7A)
ATP  A 601 (-4.3A)
 0.61A 5lw1B-4xbrA:
16.1		 5lw1B-4xbrA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  29
GLY A  30
VAL A  37
ALA A  50
MET A 106
 42A  A 402 ( 4.7A)
None
None
42A  A 402 (-3.2A)
None
 0.73A 5lw1B-4xrlA:
36.9		 5lw1B-4xrlA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  29
VAL A  37
ALA A  50
ILE A  82
MET A 106
 42A  A 402 ( 4.7A)
None
42A  A 402 (-3.2A)
None
None
 0.69A 5lw1B-4xrlA:
36.9		 5lw1B-4xrlA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 469
GLY A 470
VAL A 477
ALA A 488
ILE A 522
 4CV  A 801 (-4.3A)
4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 ( 4.2A)
 0.38A 5lw1B-4yffA:
18.9		 5lw1B-4yffA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		6 ILE A  46
GLY A  47
VAL A  48
ALA A 279
ILE A 220
ASN A 243
 None
 1.11A 5lw1B-4yfmA:
undetectable		 5lw1B-4yfmA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  61
GLY A  62
VAL A  69
ALA A  82
ILE A 115
LEU A 189
 None
 1.46A 5lw1B-4zslA:
33.8		 5lw1B-4zslA:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 ILE A  30
GLY A  31
ALA A  51
ILE A  84
MET A 106
MET A 109
LEU A 166
 ANP  A 401 (-4.9A)
ANP  A 401 (-3.3A)
ANP  A 401 (-3.5A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 ( 4.5A)
 0.69A 5lw1B-5awmA:
43.8		 5lw1B-5awmA:
64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 ILE A  30
VAL A  38
ALA A  51
ILE A  84
MET A 106
MET A 109
ASN A 112
LEU A 166
 ANP  A 401 (-4.9A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.5A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-3.9A)
ANP  A 401 ( 4.5A)
 0.56A 5lw1B-5awmA:
43.8		 5lw1B-5awmA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  22
GLY A  23
VAL A  30
ALA A  44
MET A  92
 51W  A 401 (-3.9A)
51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 (-3.9A)
 0.61A 5lw1B-5ci7A:
23.0		 5lw1B-5ci7A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 ILE A  81
GLY A  82
VAL A  89
ALA A 102
MET A 150
 ANP  A 401 ( 4.1A)
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-4.0A)
 0.56A 5lw1B-5dbxA:
18.8		 5lw1B-5dbxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		5 ILE A 540
GLY A 541
VAL A 548
ALA A 561
ILE A 595
 4ZS  A 901 (-4.2A)
4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
 0.27A 5lw1B-5ezrA:
21.9		 5lw1B-5ezrA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 904
VAL A 911
ALA A 928
ILE A 960
MET A 978
 5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.6A)
5U3  A1200 ( 4.0A)
 0.26A 5lw1B-5f1zA:
21.0		 5lw1B-5f1zA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 GLY A  23
VAL A  30
ALA A  43
ILE A  77
MET A  93
 STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 ( 3.9A)
 0.64A 5lw1B-5isoA:
25.1		 5lw1B-5isoA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  22
GLY A  23
VAL A  30
ALA A  43
MET A  90
 6G2  A 901 (-3.8A)
None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-3.5A)
 0.26A 5lw1B-5j5tA:
20.9		 5lw1B-5j5tA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 155
GLY A 156
VAL A 163
ALA A 176
ILE A 212
ASN A 234
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
None
 0.81A 5lw1B-5lxdA:
20.4		 5lw1B-5lxdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 358
GLY A 359
VAL A 366
ALA A 379
MET A 429
 ANP  A 801 (-4.2A)
ANP  A 801 ( 4.1A)
ANP  A 801 (-4.7A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.5A)
 0.64A 5lw1B-5nclA:
21.1		 5lw1B-5nclA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  98
GLY A  99
VAL A 106
ALA A 119
MET A 169
MET A 172
 None
 0.59A 5lw1B-5u7qA:
23.3		 5lw1B-5u7qA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ILE A 197
GLY A 198
VAL A 205
ALA A 218
MET A 274
 QRW  A 601 (-4.7A)
QRW  A 601 ( 4.5A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
MES  A 604 (-3.9A)
 0.60A 5lw1B-5uuuA:
23.5		 5lw1B-5uuuA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 5 ILE A 327
GLY A 328
VAL A 335
ALA A 348
MET A 395
 M77  A 601 ( 4.8A)
M77  A 601 (-3.4A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 2.9A)
 0.55A 5lw1B-5vefA:
23.9		 5lw1B-5vefA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 GLY A  29
VAL A  36
ALA A  49
MET A  96
MET A  99
 VX6  A 402 ( 4.2A)
VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-3.7A)
None
 0.63A 5lw1B-5wnmA:
21.6		 5lw1B-5wnmA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5x1t PPKA-294

(Serratia sp.
FS14) 		no annotation 5 ILE A  29
GLY A  30
VAL A  37
ALA A  50
LEU A 182
 None
ADP  A 401 (-3.4A)
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
ADP  A 401 ( 4.2A)
 0.56A 5lw1B-5x1tA:
21.1		 5lw1B-5x1tA:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ILE A  49
GLY A  50
VAL A  57
ALA A  70
ILE A  99
 ATP  A 403 (-4.9A)
ATP  A 403 (-3.4A)
ATP  A 403 (-3.9A)
ATP  A 403 (-3.4A)
ATP  A 403 (-4.9A)
 0.39A 5lw1B-5xvuA:
11.6		 5lw1B-5xvuA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 ILE A 215
GLY A 216
VAL A 223
ALA A 236
ILE A 272
 None
None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 ( 4.8A)
 0.43A 5lw1B-5y86A:
26.4		 5lw1B-5y86A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 5 ILE A 733
GLY A 734
VAL A 741
ALA A 754
MET A 816
 CJM  A1102 (-3.4A)
CJM  A1102 (-3.4A)
None
CJM  A1102 (-3.1A)
None
 0.67A 5lw1B-6b3eA:
28.2		 5lw1B-6b3eA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 6 ILE A 531
GLY A 532
VAL A 539
ALA A 551
ILE A 586
MET A 602
 CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.0A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
CQ7  A 801 (-3.4A)
 0.55A 5lw1B-6b4wA:
23.3		 5lw1B-6b4wA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 5 GLY A  23
VAL A  30
ALA A  43
ILE A  77
MET A  93
 EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
EDJ  A 301 ( 4.2A)
 0.72A 5lw1B-6bx6A:
14.3		 5lw1B-6bx6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 ILE A  66
GLY A  67
VAL A  74
ALA A  87
MET A 136
 None
 0.38A 5lw1B-6c9dA:
24.1		 5lw1B-6c9dA:
28.72