SIMILAR PATTERNS OF AMINO ACIDS FOR 5LVN_A_ADNA402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
VAL A 675
TYR A 693
LEU A 818
 None
 0.47A 5lvnA-1rjbA:
21.9		 5lvnA-1rjbA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
GLY A 596
VAL A 603
ALA A 621
VAL A 654
TYR A 672
LEU A 799
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
 0.70A 5lvnA-1t46A:
22.9		 5lvnA-1t46A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
VAL A 352
ALA A 367
VAL A 399
ALA A 417
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.7A)
STU  A 100 (-4.5A)
 0.39A 5lvnA-1u59A:
26.5		 5lvnA-1u59A:
24.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
LEU A  84
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.32A 5lvnA-1zltA:
21.2		 5lvnA-1zltA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
VAL A  68
LEU A  84
TYR A  86
GLU A  91
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.7A)
HYM  A 400 ( 4.7A)
HYM  A 400 (-4.5A)
 0.42A 5lvnA-1zltA:
21.2		 5lvnA-1zltA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  93
GLU A 143
 None
None
None
GOL  A3001 (-3.5A)
GOL  A3001 ( 4.5A)
None
 0.38A 5lvnA-2a2aA:
29.7		 5lvnA-2a2aA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
GLY X  18
VAL X  25
ALA X  37
VAL X  67
TYR X  84
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
 0.45A 5lvnA-2dq7X:
27.5		 5lvnA-2dq7X:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
GLY A 249
VAL A 256
ALA A 269
VAL A 299
LEU A 370
 GIN  A 600 ( 4.6A)
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
 0.55A 5lvnA-2hz0A:
24.7		 5lvnA-2hz0A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
GLY A 589
VAL A 596
ALA A 614
VAL A 647
TYR A 665
LEU A 785
 None
 0.48A 5lvnA-2ogvA:
15.1		 5lvnA-2ogvA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
VAL A 352
ALA A 367
VAL A 399
ALA A 417
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
ANP  A 615 (-3.9A)
ANP  A 615 (-4.7A)
 0.59A 5lvnA-2ozoA:
21.4		 5lvnA-2ozoA:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
GLY A  26
VAL A  33
ALA A  46
GLU A 110
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.3A)
ATP  A 381 ( 4.8A)
 0.50A 5lvnA-2phkA:
32.0		 5lvnA-2phkA:
33.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
 None
 0.44A 5lvnA-2psqA:
26.8		 5lvnA-2psqA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  83
VAL A  90
ALA A 103
VAL A 137
TYR A 155
LEU A 205
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
 0.54A 5lvnA-2v55A:
31.7		 5lvnA-2v55A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  93
GLU A 143
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.1A)
None
 0.29A 5lvnA-2w4kA:
29.8		 5lvnA-2w4kA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
GLY A  53
VAL A  60
ALA A  73
LEU A 118
GLU A 125
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 ( 4.7A)
None
DKI  A1338 (-4.9A)
 0.51A 5lvnA-2w4oA:
13.2		 5lvnA-2w4oA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU C  55
GLY C  56
VAL C  63
ALA C  76
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.56A 5lvnA-2wtkC:
31.9		 5lvnA-2wtkC:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  93
GLU A 143
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 ( 3.6A)
None
 0.37A 5lvnA-2yabA:
23.7		 5lvnA-2yabA:
28.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
GLY A  69
VAL A  76
ALA A  92
VAL A 125
LEU A 141
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 ( 4.6A)
STU  A   1 (-4.6A)
 0.53A 5lvnA-2z7rA:
31.6		 5lvnA-2z7rA:
32.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
GLY A  98
VAL A 105
ALA A 121
LEU A 172
TYR A 174
GLU A 179
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.1A)
STU  A 400 (-4.7A)
STU  A 400 (-3.6A)
 0.60A 5lvnA-3a62A:
31.7		 5lvnA-3a62A:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
GLY A  98
VAL A 105
ALA A 121
VAL A 156
LEU A 172
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
STU  A 400 ( 4.1A)
STU  A 400 (-4.7A)
 0.51A 5lvnA-3a62A:
31.7		 5lvnA-3a62A:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 488
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.61A 5lvnA-3b2tA:
22.5		 5lvnA-3b2tA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  93
GLU A 100
 4RB  A 401 ( 3.9A)
4RB  A 401 (-3.6A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 4.1A)
4RB  A 401 (-3.8A)
 0.47A 5lvnA-3bqrA:
27.8		 5lvnA-3bqrA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
 0.45A 5lvnA-3c4fA:
23.1		 5lvnA-3c4fA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
ALA A  83
VAL A 116
TYR A 134
ALA A 135
GLU A 182
 None
 0.60A 5lvnA-3fe3A:
17.8		 5lvnA-3fe3A:
32.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
GLY A  60
VAL A  67
ALA A  80
VAL A 113
LEU A 186
 STU  A   1 (-3.8A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
None
STU  A   1 (-4.4A)
 0.37A 5lvnA-3fmeA:
22.9		 5lvnA-3fmeA:
25.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 105
VAL A 112
ALA A 125
LEU A 176
TYR A 178
GLU A 183
LEU A 229
 None
None
GMG  A   1 (-3.4A)
GMG  A   1 (-4.5A)
GMG  A   1 ( 4.9A)
None
GMG  A   1 ( 4.9A)
 0.63A 5lvnA-3hdnA:
28.4		 5lvnA-3hdnA:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 105
VAL A 112
ALA A 125
VAL A 160
LEU A 176
TYR A 178
GLU A 183
 None
None
GMG  A   1 (-3.4A)
None
GMG  A   1 (-4.5A)
GMG  A   1 ( 4.9A)
None
 0.75A 5lvnA-3hdnA:
28.4		 5lvnA-3hdnA:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
GLY A 834
VAL A 841
ALA A 859
VAL A 892
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
 0.42A 5lvnA-3hngA:
23.1		 5lvnA-3hngA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  82
GLY A  83
VAL A  90
ALA A 103
GLU A 203
LEU A 206
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A 542 (-4.3A)
GOL  A 542 ( 4.6A)
 0.60A 5lvnA-3hztA:
22.0		 5lvnA-3hztA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 GLY A  60
VAL A  67
ALA A  80
VAL A 113
TYR A 131
ALA A 132
GLU A 136
LEU A 182
 None
 0.51A 5lvnA-3iecA:
30.9		 5lvnA-3iecA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 680
GLY A 681
VAL A 689
ALA A 700
LEU A 745
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-3.6A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 ( 4.4A)
ADP  A2101 (-4.4A)
 0.52A 5lvnA-3lj0A:
25.9		 5lvnA-3lj0A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LEU A 110
TYR A 112
ALA A 113
GLU A 117
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
None
 0.44A 5lvnA-3lm5A:
29.3		 5lvnA-3lm5A:
25.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LEU A  40
GLY A  41
VAL A  48
ALA A  61
GLU A 161
LEU A 164
 DXR  A 299 ( 4.3A)
DXR  A 299 ( 4.2A)
DXR  A 299 (-4.3A)
DXR  A 299 ( 3.9A)
None
None
 0.59A 5lvnA-3ma6A:
17.8		 5lvnA-3ma6A:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 171
GLY A 172
VAL A 179
ALA A 192
VAL A 224
TYR A 242
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.62A 5lvnA-3mtlA:
24.9		 5lvnA-3mtlA:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  49
GLY A  50
VAL A  57
ALA A  70
VAL A 104
TYR A 122
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
 0.42A 5lvnA-3mvjA:
35.3		 5lvnA-3mvjA:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
LEU A 109
ALA A 112
LEU A 161
 None
None
GOL  A 434 ( 4.1A)
GOL  A 433 (-4.3A)
GOL  A 434 (-3.9A)
GOL  A 434 (-4.2A)
 0.60A 5lvnA-3n9xA:
24.2		 5lvnA-3n9xA:
25.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  88
GLY A  89
VAL A  96
ALA A 109
LEU A 159
TYR A 161
ALA A 162
GLU A 166
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
JOZ  A 361 (-4.0A)
None
JOZ  A 361 (-3.8A)
None
None
 0.34A 5lvnA-3nuuA:
43.5		 5lvnA-3nuuA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 193
VAL A 200
ALA A 213
VAL A 247
LEU A 263
LEU A 318
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 ( 4.7A)
AMP  A 577 (-4.8A)
 0.58A 5lvnA-3nyoA:
34.5		 5lvnA-3nyoA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LEU A 263
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 ( 4.7A)
AMP  A 577 (-4.8A)
 0.58A 5lvnA-3nyoA:
34.5		 5lvnA-3nyoA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  63
GLY A  64
VAL A  71
ALA A  84
GLU A 151
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.1A)
ANP  A1634 (-4.4A)
 0.42A 5lvnA-3q5iA:
28.1		 5lvnA-3q5iA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  50
GLY A  51
VAL A  58
ALA A  71
VAL A  98
GLU A 125
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-3.5A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
None
None
None
 0.62A 5lvnA-3sheA:
21.5		 5lvnA-3sheA:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  50
GLY A  51
VAL A  58
ALA A  71
VAL A  98
GLU A 170
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-3.5A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
None
None
None
 0.64A 5lvnA-3sheA:
21.5		 5lvnA-3sheA:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  57
GLY A  58
VAL A  65
ALA A  78
GLU A 135
GLU A 178
LEU A 181
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
None
None
None
 0.50A 5lvnA-3sxfA:
24.6		 5lvnA-3sxfA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 423
GLY A 424
VAL A 431
ALA A 443
VAL A 473
TYR A 491
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.52A 5lvnA-3sxsA:
18.9		 5lvnA-3sxsA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.4A)
 0.45A 5lvnA-3tt0A:
23.2		 5lvnA-3tt0A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc3 SERINE/THREONINE-PRO
TEIN KINASE SRK2I

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 GLY A  34
ALA A  49
VAL A  79
TYR A  97
ALA A  98
LEU A 148
 None
 0.63A 5lvnA-3uc3A:
26.0		 5lvnA-3uc3A:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
GLY A 841
VAL A 848
ALA A 866
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.8A)
 0.39A 5lvnA-3vidA:
22.3		 5lvnA-3vidA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 139
GLY A 140
VAL A 147
ALA A 160
LEU A 210
TYR A 212
ALA A 213
LEU A 263
 N13  A 501 (-3.7A)
None
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 ( 4.8A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-4.5A)
 0.48A 5lvnA-3w18A:
21.3		 5lvnA-3w18A:
32.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  75
GLY A  76
VAL A  83
ALA A  96
VAL A 128
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
ANP  A 401 (-4.8A)
 0.62A 5lvnA-3wigA:
24.2		 5lvnA-3wigA:
26.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
GLY A  84
VAL A  91
ALA A 104
TYR A 156
ALA A 157
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-4.6A)
 0.58A 5lvnA-4af3A:
25.6		 5lvnA-4af3A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
VAL A  91
ALA A 104
LEU A 154
TYR A 156
ALA A 157
GLU A 161
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
None
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 ( 4.6A)
 0.70A 5lvnA-4af3A:
25.6		 5lvnA-4af3A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
VAL A  91
ALA A 104
LEU A 154
TYR A 156
ALA A 157
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
None
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-4.6A)
 0.49A 5lvnA-4af3A:
25.6		 5lvnA-4af3A:
33.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
GLY A 841
VAL A 848
ALA A 866
VAL A 899
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
 0.47A 5lvnA-4agdA:
22.2		 5lvnA-4agdA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		9 LEU A 246
GLY A 247
VAL A 254
ALA A 267
LEU A 318
TYR A 320
ALA A 321
GLU A 325
LEU A 371
 None
 0.50A 5lvnA-4c0tA:
35.3		 5lvnA-4c0tA:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 663
VAL A 671
ALA A 684
VAL A 721
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.30A 5lvnA-4crsA:
27.1		 5lvnA-4crsA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  26
GLY A  27
VAL A  34
ALA A  47
VAL A  79
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-4.7A)
ATP  A 401 (-4.6A)
 0.47A 5lvnA-4fg8A:
24.6		 5lvnA-4fg8A:
32.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 377
GLY A 378
VAL A 385
ALA A 400
VAL A 433
ALA A 451
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
 0.53A 5lvnA-4fl3A:
22.5		 5lvnA-4fl3A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
GLY A 856
VAL A 863
ALA A 880
TYR A 931
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
None
IZA  A2001 ( 4.7A)
 0.49A 5lvnA-4gl9A:
26.2		 5lvnA-4gl9A:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
GLY A 157
VAL A 164
ALA A 177
TYR A 229
ALA A 230
GLU A 234
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
GOL  A 505 ( 2.9A)
 0.35A 5lvnA-4gv1A:
36.2		 5lvnA-4gv1A:
31.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
GLY A 829
VAL A 836
ALA A 853
VAL A 884
TYR A 904
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
 0.53A 5lvnA-4hviA:
13.9		 5lvnA-4hviA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 132
GLY A 133
VAL A 140
ALA A 156
ALA A 208
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.8A)
1G0  A 401 (-4.6A)
 0.41A 5lvnA-4id7A:
26.9		 5lvnA-4id7A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 406
GLY A 407
VAL A 414
ALA A 427
VAL A 453
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 (-3.9A)
 0.59A 5lvnA-4idtA:
25.3		 5lvnA-4idtA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
 0.63A 5lvnA-4k11A:
22.9		 5lvnA-4k11A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
GLY A 479
VAL A 486
ALA A 506
TYR A 557
ALA A 558
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 (-3.7A)
ACP  A 801 (-4.4A)
 0.46A 5lvnA-4k33A:
20.9		 5lvnA-4k33A:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  43
VAL A  50
ALA A  61
TYR A 106
ALA A 107
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.3A)
 0.48A 5lvnA-4l52A:
17.5		 5lvnA-4l52A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
 0.45A 5lvnA-4oliA:
26.0		 5lvnA-4oliA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 627
GLY A 628
VAL A 635
ALA A 648
VAL A 685
TYR A 703
LEU A 753
 None
 0.38A 5lvnA-4otdA:
27.6		 5lvnA-4otdA:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 386
GLY A 387
VAL A 394
ALA A 407
TYR A 460
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
 0.50A 5lvnA-4q9zA:
28.7		 5lvnA-4q9zA:
34.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.44A 5lvnA-4rt7A:
22.9		 5lvnA-4rt7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 193
VAL A 200
ALA A 213
VAL A 247
LEU A 263
LEU A 318
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.5A)
SGV  A 601 (-4.9A)
 0.50A 5lvnA-4tnbA:
27.5		 5lvnA-4tnbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LEU A 263
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
SGV  A 601 (-4.9A)
 0.39A 5lvnA-4tnbA:
27.5		 5lvnA-4tnbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 131
VAL A 138
ALA A 149
LEU A 200
ALA A 203
LEU A 270
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
AGS  A1438 (-3.6A)
AGS  A1438 (-3.7A)
AGS  A1438 (-4.7A)
 0.40A 5lvnA-4uyaA:
22.7		 5lvnA-4uyaA:
26.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
GLY A 105
VAL A 112
ALA A 125
VAL A 159
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-4.5A)
 0.49A 5lvnA-4wb7A:
35.6		 5lvnA-4wb7A:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
VAL A 112
ALA A 125
VAL A 159
TYR A 177
GLU A 182
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-3.5A)
ATP  A 501 (-4.5A)
 0.67A 5lvnA-4wb7A:
35.6		 5lvnA-4wb7A:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
VAL A 201
ALA A 214
VAL A 248
GLU A 318
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-4.9A)
 0.64A 5lvnA-4wboA:
29.2		 5lvnA-4wboA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
VAL A 201
ALA A 214
VAL A 248
LEU A 264
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
AN2  A 601 ( 4.8A)
None
 0.43A 5lvnA-4yhjA:
32.3		 5lvnA-4yhjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A  27
VAL A  34
ALA A  47
LEU A  96
GLU A 146
LEU A 149
 None
 0.52A 5lvnA-4ynzA:
25.8		 5lvnA-4ynzA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LEU A  96
GLU A 146
 None
 0.55A 5lvnA-4ynzA:
25.8		 5lvnA-4ynzA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
GLY A  35
VAL A  42
ALA A  55
GLU A 112
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.7A)
 0.48A 5lvnA-4ysjA:
31.5		 5lvnA-4ysjA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
 0.43A 5lvnA-5a46A:
23.3		 5lvnA-5a46A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  23
VAL A  30
ALA A  44
VAL A  76
TYR A  94
LEU A 145
 51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
 0.41A 5lvnA-5ci7A:
29.1		 5lvnA-5ci7A:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 GLY A  63
VAL A  70
ALA A  83
VAL A 116
ALA A 135
GLU A 139
GLU A 182
LEU A 185
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-3.7A)
None
5RC  A4000 (-4.0A)
None
 0.60A 5lvnA-5es1A:
29.6		 5lvnA-5es1A:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 GLY A  63
VAL A  70
ALA A  83
VAL A 116
TYR A 134
ALA A 135
GLU A 139
LEU A 185
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
None
None
 0.50A 5lvnA-5es1A:
29.6		 5lvnA-5es1A:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		8 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LEU A 170
ALA A 173
GLU A 177
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.8A)
5U5  A 401 (-3.9A)
5U5  A 401 (-3.3A)
5U5  A 401 (-4.7A)
 0.44A 5lvnA-5eykA:
27.5		 5lvnA-5eykA:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
 0.40A 5lvnA-5f1zA:
26.1		 5lvnA-5f1zA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
GLY A 731
VAL A 738
ALA A 756
TYR A 806
ALA A 807
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 (-4.6A)
 0.59A 5lvnA-5fm2A:
26.9		 5lvnA-5fm2A:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
GLY A 600
VAL A 607
ALA A 625
VAL A 658
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.63A 5lvnA-5grnA:
23.2		 5lvnA-5grnA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  74
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
 0.50A 5lvnA-5hu3A:
32.3		 5lvnA-5hu3A:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  57
VAL A  65
ALA A  77
VAL A 109
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.63A 5lvnA-5i3oA:
25.9		 5lvnA-5i3oA:
28.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		6 GLY A  25
VAL A  32
ALA A  45
VAL A  78
TYR A  96
LEU A 147
 None
None
None
None
PO4  A 401 (-4.8A)
None
 0.47A 5lvnA-5ig1A:
24.5		 5lvnA-5ig1A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
GLU A 100
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.5A)
 0.51A 5lvnA-5isoA:
31.7		 5lvnA-5isoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2

(Homo sapiens) 		no annotation 6 LEU A 468
GLY A 469
VAL A 476
ALA A 489
LEU A 544
TYR A 546
 AGS  A 801 (-4.1A)
AGS  A 801 ( 4.0A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 ( 4.0A)
AGS  A 801 ( 4.8A)
 0.37A 5lvnA-5o0yA:
27.5		 5lvnA-5o0yA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 7 GLY A  18
VAL A  25
ALA A  38
LEU A  86
TYR A  88
GLU A  93
LEU A 139
 7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 ( 4.2A)
7LV  A 401 (-4.6A)
7LV  A 401 ( 4.7A)
7LV  A 401 (-4.9A)
 0.30A 5lvnA-5tvtA:
30.4		 5lvnA-5tvtA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  99
VAL A 106
ALA A 119
VAL A 153
TYR A 171
LEU A 221
 None
 0.43A 5lvnA-5u7qA:
26.9		 5lvnA-5u7qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 LEU A  17
GLY A  18
VAL A  25
ALA A  38
VAL A  72
TYR A  94
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
None
 0.36A 5lvnA-5u94A:
21.4		 5lvnA-5u94A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 LEU A 686
GLY A 687
VAL A 694
ALA A 707
VAL A 738
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-4.5A)
 0.49A 5lvnA-5vilA:
24.0		 5lvnA-5vilA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 6 VAL A  83
ALA A  95
VAL A 125
TYR A 143
ALA A 144
LEU A 206
 ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
None
ANP  A1000 (-4.3A)
ANP  A1000 (-3.5A)
ANP  A1000 (-4.5A)
 0.59A 5lvnA-5xd6A:
19.0		 5lvnA-5xd6A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
GLY A 882
VAL A 889
ALA A 906
VAL A 938
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 (-4.5A)
 0.51A 5lvnA-6c7yA:
25.8		 5lvnA-6c7yA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 GLY A  67
VAL A  74
ALA A  87
VAL A 120
TYR A 138
ALA A 139
LEU A 189
 None
 0.40A 5lvnA-6c9dA:
26.4		 5lvnA-6c9dA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 7 LEU A 730
GLY A 731
VAL A 738
ALA A 756
TYR A 806
ALA A 807
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-4.3A)
 0.52A 5lvnA-6fekA:
27.8		 5lvnA-6fekA:
13.28