SIMILAR PATTERNS OF AMINO ACIDS FOR 5LUR_B_STRB201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wbi AVIDIN-RELATED
PROTEIN 2

(Gallus gallus) 		PF01382
(Avidin) 		6 TYR A  33
TRP A  68
PHE A  70
PHE A  77
TRP A  95
ASN A 116
 BTN  A1001 (-4.6A)
BTN  A1001 (-3.5A)
BTN  A1001 (-4.5A)
BTN  A1001 ( 4.9A)
BTN  A1001 (-3.2A)
BTN  A1001 (-3.4A)
 0.35A 5lurB-1wbiA:
18.7		 5lurB-1wbiA:
63.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a8g AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		5 TYR A  33
VAL A  37
TRP A  70
PHE A  72
ASN A  12
 None
 1.24A 5lurB-2a8gA:
21.4		 5lurB-2a8gA:
92.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a8g AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		8 TYR A  33
VAL A  37
TRP A  70
PHE A  72
THR A  77
PHE A  79
TRP A  97
ASN A 118
 None
 0.48A 5lurB-2a8gA:
21.4		 5lurB-2a8gA:
92.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c1q BIOTIN BINDING
PROTEIN A

(Gallus gallus) 		PF01382
(Avidin) 		7 TYR A  33
TRP A  71
PHE A  73
THR A  78
PHE A  80
TRP A  98
ASN A 119
 BTN  A1126 (-4.5A)
BTN  A1126 (-3.6A)
BTN  A1126 ( 4.9A)
BTN  A1126 (-3.4A)
BTN  A1126 ( 4.8A)
BTN  A1126 (-3.3A)
BTN  A1126 (-3.2A)
 0.37A 5lurB-2c1qA:
17.9		 5lurB-2c1qA:
53.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4i AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		7 TYR A 112
TRP A  15
PHE A  17
THR A  22
PHE A  24
TRP A  42
ASN A  63
 BTN  A1274 (-4.5A)
BTN  A1274 (-3.6A)
BTN  A1274 (-4.6A)
BTN  A1274 (-3.3A)
None
BTN  A1274 (-3.3A)
BTN  A1274 (-3.2A)
 0.32A 5lurB-2c4iA:
4.4		 5lurB-2c4iA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4i AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		6 TYR A 233
TRP A 270
THR A 143
PHE A 145
TRP A 163
ASN A 184
 BTN  A1275 (-4.6A)
BTN  A1275 (-3.6A)
BTN  A1275 (-3.3A)
None
BTN  A1275 (-3.3A)
BTN  A1275 (-3.2A)
 0.31A 5lurB-2c4iA:
4.4		 5lurB-2c4iA:
42.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 HIS A 661
TYR A 643
VAL A 471
PHE A 467
PHE A 619
 None
 1.48A 5lurB-2e8yA:
3.1		 5lurB-2e8yA:
12.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fhl AVIDIN-RELATED
PROTEIN 4/5

(Gallus gallus) 		PF01382
(Avidin) 		7 TYR A  33
TRP A  68
PHE A  70
THR A  75
PHE A  77
TRP A  95
ASN A 116
 BNI  A 501 (-4.6A)
BNI  A 501 (-3.6A)
BNI  A 501 ( 4.8A)
BNI  A 501 (-3.3A)
None
BNI  A 501 (-3.2A)
BNI  A 501 (-3.3A)
 0.30A 5lurB-2fhlA:
19.6		 5lurB-2fhlA:
75.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgs CIRCULAR PERMUTANT
OF AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		6 TYR A 125
TRP A  28
PHE A  30
THR A  35
PHE A  37
TRP A  55
 BTN  A1001 (-4.5A)
BTN  A1001 (-3.6A)
BTN  A1001 ( 4.8A)
BTN  A1001 (-3.5A)
None
BTN  A1001 (-3.3A)
 0.22A 5lurB-2jgsA:
7.7		 5lurB-2jgsA:
50.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		5 HIS A 234
ALA A 233
VAL A 132
PHE A  91
THR A  97
 None
 1.42A 5lurB-3vscA:
0.0		 5lurB-3vscA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx7 STREPTAVIDIN

(Streptomyces
avidinii) 		PF01382
(Avidin) 		5 TYR A  43
ALA A  45
TRP A  79
THR A  90
TRP A 108
 MPD  A1134 (-4.7A)
None
MPD  A1134 (-4.4A)
MPD  A1134 (-3.1A)
MPD  A1134 (-3.8A)
 0.49A 5lurB-4bx7A:
15.9		 5lurB-4bx7A:
29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 VAL A 443
TRP A 378
PHE A 424
THR A 377
ASN A 162
 None
 1.42A 5lurB-4jkmA:
0.8		 5lurB-4jkmA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		5 TYR A  79
ALA A  82
VAL A  86
THR A  97
PHE A 101
 None
 1.35A 5lurB-5im2A:
undetectable		 5lurB-5im2A:
14.65