SIMILAR PATTERNS OF AMINO ACIDS FOR 5LUR_A_STRA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		5 MET A 232
TYR A 274
VAL A 197
PHE A 260
THR A 304
 None
 1.49A 5lurA-1smrA:
0.0		 5lurA-1smrA:
18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wbi AVIDIN-RELATED
PROTEIN 2

(Gallus gallus) 		PF01382
(Avidin) 		6 TYR A  33
TRP A  68
PHE A  70
PHE A  77
TRP A  95
ASN A 116
 BTN  A1001 (-4.6A)
BTN  A1001 (-3.5A)
BTN  A1001 (-4.5A)
BTN  A1001 ( 4.9A)
BTN  A1001 (-3.2A)
BTN  A1001 (-3.4A)
 0.37A 5lurA-1wbiA:
18.7		 5lurA-1wbiA:
63.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a8g AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		7 TYR A  33
TRP A  70
PHE A  72
THR A  77
PHE A  79
TRP A  97
ASN A 118
 None
 0.29A 5lurA-2a8gA:
21.8		 5lurA-2a8gA:
92.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a8g AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		6 TYR A  33
VAL A  37
THR A  77
PHE A  79
TRP A  97
ASN A 118
 None
 0.74A 5lurA-2a8gA:
21.8		 5lurA-2a8gA:
92.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c1q BIOTIN BINDING
PROTEIN A

(Gallus gallus) 		PF01382
(Avidin) 		7 TYR A  33
TRP A  71
PHE A  73
THR A  78
PHE A  80
TRP A  98
ASN A 119
 BTN  A1126 (-4.5A)
BTN  A1126 (-3.6A)
BTN  A1126 ( 4.9A)
BTN  A1126 (-3.4A)
BTN  A1126 ( 4.8A)
BTN  A1126 (-3.3A)
BTN  A1126 (-3.2A)
 0.40A 5lurA-2c1qA:
18.2		 5lurA-2c1qA:
53.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4i AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		7 TYR A 112
TRP A  15
PHE A  17
THR A  22
PHE A  24
TRP A  42
ASN A  63
 BTN  A1274 (-4.5A)
BTN  A1274 (-3.6A)
BTN  A1274 (-4.6A)
BTN  A1274 (-3.3A)
None
BTN  A1274 (-3.3A)
BTN  A1274 (-3.2A)
 0.36A 5lurA-2c4iA:
0.0		 5lurA-2c4iA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c4i AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		6 TYR A 233
TRP A 270
THR A 143
PHE A 145
TRP A 163
ASN A 184
 BTN  A1275 (-4.6A)
BTN  A1275 (-3.6A)
BTN  A1275 (-3.3A)
None
BTN  A1275 (-3.3A)
BTN  A1275 (-3.2A)
 0.38A 5lurA-2c4iA:
0.0		 5lurA-2c4iA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fhl AVIDIN-RELATED
PROTEIN 4/5

(Gallus gallus) 		PF01382
(Avidin) 		7 TYR A  33
TRP A  68
PHE A  70
THR A  75
PHE A  77
TRP A  95
ASN A 116
 BNI  A 501 (-4.6A)
BNI  A 501 (-3.6A)
BNI  A 501 ( 4.8A)
BNI  A 501 (-3.3A)
None
BNI  A 501 (-3.2A)
BNI  A 501 (-3.3A)
 0.34A 5lurA-2fhlA:
19.7		 5lurA-2fhlA:
75.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgs CIRCULAR PERMUTANT
OF AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		6 TYR A 125
TRP A  28
PHE A  30
THR A  35
PHE A  37
TRP A  55
 BTN  A1001 (-4.5A)
BTN  A1001 (-3.6A)
BTN  A1001 ( 4.8A)
BTN  A1001 (-3.5A)
None
BTN  A1001 (-3.3A)
 0.20A 5lurA-2jgsA:
8.7		 5lurA-2jgsA:
50.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uz2 XENAVIDIN

(Xenopus
tropicalis) 		PF01382
(Avidin) 		5 TYR A  35
TRP A  69
THR A  76
TRP A  96
ASN A 117
 ACT  A1123 (-4.5A)
None
None
ACT  A1123 ( 4.7A)
ACT  A1123 ( 4.8A)
 0.65A 5lurA-2uz2A:
20.0		 5lurA-2uz2A:
50.75