SIMILAR PATTERNS OF AMINO ACIDS FOR 5LUH_B_SRYB303

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aka DYNAMIN-1

(Rattus
norvegicus) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 ASP B 194
ASP B  30
HIS B 288
ILE B 289
THR B 292
 None
 1.17A 5luhB-2akaB:
0.0		 5luhB-2akaB:
16.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 GLN A 108
ASP A 130
TRP A 173
HIS A 185
ILE A 186
THR A 189
 None
 1.31A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 GLN A 108
ASP A 130
TRP A 173
HIS A 185
ILE A 186
THR A 189
 None
 1.39A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 GLN A 108
TRP A 112
ASP A 130
HIS A 185
ILE A 186
THR A 189
 None
 1.39A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 GLN A 108
TRP A 112
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 1.46A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 GLN A 108
TRP A 173
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 0.99A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 GLN A 108
TRP A 173
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 1.39A 5luhB-4cs6A:
37.1		 5luhB-4cs6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE

(Pectobacterium
atrosepticum) 		PF02275
(CBAH) 		5 ASP A  74
ASP A 282
HIS A 283
ILE A  16
THR A  17
 None
 1.48A 5luhB-4wl2A:
0.0		 5luhB-4wl2A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3q DYNAMIN-1,DYNAMIN-1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 ASP A 194
ASP A  30
HIS A 288
ILE A 289
THR A 292
 None
 0.97A 5luhB-5d3qA:
0.0		 5luhB-5d3qA:
13.66