SIMILAR PATTERNS OF AMINO ACIDS FOR 5LSU_B_SAMB1304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		7 ARG A 159
GLY A 160
TRP A 161
TYR A 204
HIS A 242
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.66A 5lsuB-1pegA:
20.5		 5lsuB-1pegA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 288
PHE A  51
HIS A 317
ARG A  78
LEU A 367
 None
 1.33A 5lsuB-1rvkA:
undetectable		 5lsuB-1rvkA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		5 GLY A 250
TYR A 211
ASN A 218
THR A 223
LEU A 225
 None
 1.45A 5lsuB-1venA:
undetectable		 5lsuB-1venA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 ARG A 150
GLY A 149
HIS A 220
THR A 285
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.27A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		8 ARG A 150
GLY A 151
TRP A 152
TYR A 193
HIS A 220
THR A 285
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.61A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 HIS A 220
ASN A 299
THR A 285
CYH A 289
LEU A 298
 SAM  A 304 (-4.9A)
None
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.41A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bji PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF) 		5 PHE A 521
HIS A 554
THR A 527
CYH A 532
LEU A 536
 None
ZN  A   1 (-3.2A)
None
ZN  A   1 (-2.2A)
None
 1.24A 5lsuB-3bjiA:
undetectable		 5lsuB-3bjiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 GLY A 136
TRP A 137
TYR A 178
HIS A 210
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.63A 5lsuB-3bo5A:
21.5		 5lsuB-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 138
TYR A 178
HIS A 210
CYH A 275
LEU A 284
 None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 1.13A 5lsuB-3bo5A:
21.5		 5lsuB-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 GLY X 256
PHE X 259
HIS X 289
ASN X 285
THR X 291
 None
None
C8E  X 623 (-4.4A)
None
None
 1.38A 5lsuB-3kvnX:
undetectable		 5lsuB-3kvnX:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		10 ARG A 101
GLY A 102
TRP A 103
PHE A 145
TYR A 146
HIS A 170
ASN A 214
THR A 217
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
SAM  A 237 (-2.6A)
None
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.90A 5lsuB-3ooiA:
32.5		 5lsuB-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		5 TRP A 103
PHE A 145
TYR A 146
ASN A 214
CYH A 171
 None
None
SAM  A 237 (-4.1A)
SAM  A 237 (-2.6A)
None
 1.46A 5lsuB-3ooiA:
32.5		 5lsuB-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		5 GLY A2151
TRP A2152
TYR A2194
HIS A2218
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
ZN  A   1 (-2.7A)
 0.51A 5lsuB-3opeA:
26.0		 5lsuB-3opeA:
36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvn MANGANESE-CONTAINING
SUPEROXIDE DISMUTASE

(Candida
albicans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 133
TRP A 172
TYR A 187
ASN A 123
THR A 122
 None
 1.03A 5lsuB-3qvnA:
undetectable		 5lsuB-3qvnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		5 GLY A 230
TRP A 233
HIS A 212
PHE A 222
ASN A 221
 None
 1.50A 5lsuB-3qwtA:
undetectable		 5lsuB-3qwtA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		5 GLY A 120
PHE A 170
TYR A 171
THR A  51
LEU A  54
 None
ASP  A 451 (-3.1A)
None
ASP  A 451 ( 3.9A)
None
 1.48A 5lsuB-3tviA:
undetectable		 5lsuB-3tviA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 132
TRP A 170
TYR A 185
ASN A 122
THR A 121
 None
None
None
MLY  A 187 ( 4.3A)
None
 1.03A 5lsuB-4f6eA:
undetectable		 5lsuB-4f6eA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		7 GLY A1561
TRP A1562
HIS A1603
TYR A1605
HIS A1629
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.7A)
0UM  A1804 (-4.2A)
None
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.73A 5lsuB-4fmuA:
25.1		 5lsuB-4fmuA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  98
HIS H  95
HIS L  55
ARG L  53
LEU L  46
 None
None
SO4  L 301 (-3.8A)
None
None
 1.38A 5lsuB-4k2uH:
undetectable		 5lsuB-4k2uH:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lns ASPARAGINE
SYNTHETASE A

(Trypanosoma
brucei) 		PF03590
(AsnA) 		5 GLY A 333
PHE A 325
ASN A 262
THR A 264
LEU A 265
 None
 1.23A 5lsuB-4lnsA:
undetectable		 5lsuB-4lnsA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		6 GLY A 457
TRP A 458
TYR A 493
HIS A 552
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
ZN  A 805 ( 2.4A)
None
 0.71A 5lsuB-4qeoA:
18.2		 5lsuB-4qeoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		5 GLY A 337
HIS A  84
TYR A 173
THR A 277
CYH A 313
 None
GOL  A 504 (-4.2A)
GOL  A 504 (-4.6A)
None
None
 1.48A 5lsuB-4r33A:
undetectable		 5lsuB-4r33A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16819
(DUF5074)
PF16820
(PKD_3) 		5 ARG A 227
GLY A 225
TYR A 248
ASN A 166
LEU A 177
 None
None
7PE  A 503 (-4.6A)
7PE  A 503 (-4.3A)
None
 1.26A 5lsuB-4r5oA:
undetectable		 5lsuB-4r5oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf RNA POLYMERASE II
PRE-INITIATION
COMPLEX, TFG1
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05793
(TFIIF_alpha)
PF02270
(TFIIF_beta) 		5 HIS U 117
TYR U 393
THR V 212
ARG V  63
LEU V  59
 None
 1.48A 5lsuB-5fmfU:
undetectable		 5lsuB-5fmfU:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		11 ARG A1073
GLY A1074
TRP A1075
HIS A1116
PHE A1117
TYR A1118
HIS A1142
ASN A1186
THR A1189
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.4A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-3.6A)
SAM  A1304 ( 3.9A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.40A 5lsuB-5lsuA:
36.4		 5lsuB-5lsuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		7 GLY A1074
TRP A1075
HIS A1116
TYR A1118
HIS A1142
ARG A1192
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.4A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
None
ZN  A1301 (-2.3A)
 0.90A 5lsuB-5lsuA:
36.4		 5lsuB-5lsuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ARG A 589
GLY A 585
HIS A 798
ASN A 800
LEU A 799
 None
 1.33A 5lsuB-5t9gA:
undetectable		 5lsuB-5t9gA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1049
TRP A1050
TYR A1085
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 0.39A 5lsuB-5tuyA:
19.5		 5lsuB-5tuyA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1137
TRP A1138
TYR A1173
HIS A1201
CYH A1258
 SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
ZN  A3005 (-2.3A)
 0.43A 5lsuB-5vsdA:
19.9		 5lsuB-5vsdA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 9 ARG A1155
GLY A1156
TRP A1157
PHE A1199
TYR A1200
HIS A1224
THR A1271
CYH A1275
LEU A1284
 None
SAM  A1301 (-3.6A)
None
None
SAM  A1301 (-3.9A)
None
None
ZN  A1304 (-2.3A)
SAM  A1301 (-4.6A)
 0.78A 5lsuB-6cenA:
31.7		 5lsuB-6cenA:
77.49