SIMILAR PATTERNS OF AMINO ACIDS FOR 5LSU_B_SAMB1304

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		7 ARG A 159
GLY A 160
TRP A 161
TYR A 204
HIS A 242
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.66A 5lsuB-1pegA:
20.5		 5lsuB-1pegA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 288
PHE A  51
HIS A 317
ARG A  78
LEU A 367
 None
 1.33A 5lsuB-1rvkA:
undetectable		 5lsuB-1rvkA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		5 GLY A 250
TYR A 211
ASN A 218
THR A 223
LEU A 225
 None
 1.45A 5lsuB-1venA:
undetectable		 5lsuB-1venA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 ARG A 150
GLY A 149
HIS A 220
THR A 285
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.27A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		8 ARG A 150
GLY A 151
TRP A 152
TYR A 193
HIS A 220
THR A 285
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.61A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 HIS A 220
ASN A 299
THR A 285
CYH A 289
LEU A 298
 SAM  A 304 (-4.9A)
None
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.41A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bji PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF) 		5 PHE A 521
HIS A 554
THR A 527
CYH A 532
LEU A 536
 None
ZN  A   1 (-3.2A)
None
ZN  A   1 (-2.2A)
None
 1.24A 5lsuB-3bjiA:
undetectable		 5lsuB-3bjiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 GLY A 136
TRP A 137
TYR A 178
HIS A 210
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.63A 5lsuB-3bo5A:
21.5		 5lsuB-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 138
TYR A 178
HIS A 210
CYH A 275
LEU A 284
 None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 1.13A 5lsuB-3bo5A:
21.5		 5lsuB-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 GLY X 256
PHE X 259
HIS X 289
ASN X 285
THR X 291
 None
None
C8E  X 623 (-4.4A)
None
None
 1.38A 5lsuB-3kvnX:
undetectable		 5lsuB-3kvnX:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		10 ARG A 101
GLY A 102
TRP A 103
PHE A 145
TYR A 146
HIS A 170
ASN A 214
THR A 217
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
SAM  A 237 (-2.6A)
None
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.90A 5lsuB-3ooiA:
32.5		 5lsuB-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		5 TRP A 103
PHE A 145
TYR A 146
ASN A 214
CYH A 171
 None
None
SAM  A 237 (-4.1A)
SAM  A 237 (-2.6A)
None
 1.46A 5lsuB-3ooiA:
32.5		 5lsuB-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		5 GLY A2151
TRP A2152
TYR A2194
HIS A2218
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
ZN  A   1 (-2.7A)
 0.51A 5lsuB-3opeA:
26.0		 5lsuB-3opeA:
36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvn MANGANESE-CONTAINING
SUPEROXIDE DISMUTASE

(Candida
albicans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 133
TRP A 172
TYR A 187
ASN A 123
THR A 122
 None
 1.03A 5lsuB-3qvnA:
undetectable		 5lsuB-3qvnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		5 GLY A 230
TRP A 233
HIS A 212
PHE A 222
ASN A 221
 None
 1.50A 5lsuB-3qwtA:
undetectable		 5lsuB-3qwtA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		5 GLY A 120
PHE A 170
TYR A 171
THR A  51
LEU A  54
 None
ASP  A 451 (-3.1A)
None
ASP  A 451 ( 3.9A)
None
 1.48A 5lsuB-3tviA:
undetectable		 5lsuB-3tviA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 132
TRP A 170
TYR A 185
ASN A 122
THR A 121
 None
None
None
MLY  A 187 ( 4.3A)
None
 1.03A 5lsuB-4f6eA:
undetectable		 5lsuB-4f6eA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		7 GLY A1561
TRP A1562
HIS A1603
TYR A1605
HIS A1629
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.7A)
0UM  A1804 (-4.2A)
None
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.73A 5lsuB-4fmuA:
25.1		 5lsuB-4fmuA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  98
HIS H  95
HIS L  55
ARG L  53
LEU L  46
 None
None
SO4  L 301 (-3.8A)
None
None
 1.38A 5lsuB-4k2uH:
undetectable		 5lsuB-4k2uH:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lns ASPARAGINE
SYNTHETASE A

(Trypanosoma
brucei) 		PF03590
(AsnA) 		5 GLY A 333
PHE A 325
ASN A 262
THR A 264
LEU A 265
 None
 1.23A 5lsuB-4lnsA:
undetectable		 5lsuB-4lnsA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		6 GLY A 457
TRP A 458
TYR A 493
HIS A 552
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
ZN  A 805 ( 2.4A)
None
 0.71A 5lsuB-4qeoA:
18.2		 5lsuB-4qeoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		5 GLY A 337
HIS A  84
TYR A 173
THR A 277
CYH A 313
 None
GOL  A 504 (-4.2A)
GOL  A 504 (-4.6A)
None
None
 1.48A 5lsuB-4r33A:
undetectable		 5lsuB-4r33A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16819
(DUF5074)
PF16820
(PKD_3) 		5 ARG A 227
GLY A 225
TYR A 248
ASN A 166
LEU A 177
 None
None
7PE  A 503 (-4.6A)
7PE  A 503 (-4.3A)
None
 1.26A 5lsuB-4r5oA:
undetectable		 5lsuB-4r5oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf RNA POLYMERASE II
PRE-INITIATION
COMPLEX, TFG1
TRANSCRIPTION
INITIATION FACTOR
IIF SUBUNIT BETA,
TFG2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05793
(TFIIF_alpha)
PF02270
(TFIIF_beta) 		5 HIS U 117
TYR U 393
THR V 212
ARG V  63
LEU V  59
 None
 1.48A 5lsuB-5fmfU:
undetectable		 5lsuB-5fmfU:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		11 ARG A1073
GLY A1074
TRP A1075
HIS A1116
PHE A1117
TYR A1118
HIS A1142
ASN A1186
THR A1189
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.4A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-3.6A)
SAM  A1304 ( 3.9A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.40A 5lsuB-5lsuA:
36.4		 5lsuB-5lsuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		7 GLY A1074
TRP A1075
HIS A1116
TYR A1118
HIS A1142
ARG A1192
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.4A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
None
ZN  A1301 (-2.3A)
 0.90A 5lsuB-5lsuA:
36.4		 5lsuB-5lsuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ARG A 589
GLY A 585
HIS A 798
ASN A 800
LEU A 799
 None
 1.33A 5lsuB-5t9gA:
undetectable		 5lsuB-5t9gA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1049
TRP A1050
TYR A1085
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 0.39A 5lsuB-5tuyA:
19.5		 5lsuB-5tuyA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1137
TRP A1138
TYR A1173
HIS A1201
CYH A1258
 SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
ZN  A3005 (-2.3A)
 0.43A 5lsuB-5vsdA:
19.9		 5lsuB-5vsdA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 9 ARG A1155
GLY A1156
TRP A1157
PHE A1199
TYR A1200
HIS A1224
THR A1271
CYH A1275
LEU A1284
 None
SAM  A1301 (-3.6A)
None
None
SAM  A1301 (-3.9A)
None
None
ZN  A1304 (-2.3A)
SAM  A1301 (-4.6A)
 0.78A 5lsuB-6cenA:
31.7		 5lsuB-6cenA:
77.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2a PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		3 ASN A  34
TYR A  28
CYH A 126
 None
 1.02A 5lsuB-1a2aA:
undetectable		 5lsuB-1a2aA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASN A 383
TYR A 358
CYH A 478
 None
 0.86A 5lsuB-1dlcA:
undetectable		 5lsuB-1dlcA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		3 ASN A  28
TYR A  19
CYH A 157
 None
 0.65A 5lsuB-1fi4A:
undetectable		 5lsuB-1fi4A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		3 ASN A  58
TYR A 126
CYH A  65
 None
None
HEC  A 601 (-1.8A)
 1.10A 5lsuB-1gq1A:
undetectable		 5lsuB-1gq1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Escherichia
coli) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		3 ASN A 213
TYR A 219
CYH A 208
 None
None
SF4  A 300 (-2.3A)
 0.90A 5lsuB-1kqjA:
undetectable		 5lsuB-1kqjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ASN A 241
TYR A 283
CYH A 306
 SAH  A 319 (-3.6A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
 0.31A 5lsuB-1pegA:
20.6		 5lsuB-1pegA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00378
(ECH_1) 		3 ASN A 105
TYR A 130
CYH A 108
 None
 1.09A 5lsuB-1sg4A:
undetectable		 5lsuB-1sg4A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3b UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110

(Homo sapiens) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13414
(TPR_11)
PF13424
(TPR_12) 		3 ASN A 291
TYR A 272
CYH A 305
 None
 0.94A 5lsuB-1w3bA:
undetectable		 5lsuB-1w3bA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 ASN A 194
TYR A 225
CYH A 357
 MAE  A 901 ( 3.4A)
PLP  A 905 (-4.2A)
None
 1.01A 5lsuB-1yaaA:
undetectable		 5lsuB-1yaaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASN A 366
TYR A 356
CYH A 404
 None
 0.80A 5lsuB-2b9eA:
undetectable		 5lsuB-2b9eA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		3 ASN A 407
TYR A  67
CYH A 412
 FAD  A 500 (-4.2A)
FAD  A 500 ( 4.8A)
None
 1.02A 5lsuB-2bacA:
undetectable		 5lsuB-2bacA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ASN A  10
TYR A  62
CYH A  44
 FAD  A 601 (-3.5A)
None
FAD  A 601 (-3.5A)
 1.10A 5lsuB-2bc0A:
undetectable		 5lsuB-2bc0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio
parahaemolyticus) 		PF04952
(AstE_AspA) 		3 ASN A 197
TYR A 341
CYH A 328
 None
 1.06A 5lsuB-2bcoA:
undetectable		 5lsuB-2bcoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 ASN B 722
TYR B 775
CYH B 728
 None
 1.01A 5lsuB-2bkuB:
undetectable		 5lsuB-2bkuB:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASN A 112
TYR A 143
CYH A 102
 None
None
ZN  A1001 (-2.3A)
 1.00A 5lsuB-2dphA:
undetectable		 5lsuB-2dphA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 ASN A 632
TYR A 479
CYH A 639
 None
 0.92A 5lsuB-2h4tA:
undetectable		 5lsuB-2h4tA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		3 ASN A 122
TYR A  17
CYH A  73
 GYS  A  68 ( 3.7A)
None
None
 0.72A 5lsuB-2hpwA:
undetectable		 5lsuB-2hpwA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrj TALIN-1

(Gallus gallus) 		PF00373
(FERM_M) 		3 ASN A  97
TYR A  53
CYH A  48
 None
 0.99A 5lsuB-2hrjA:
undetectable		 5lsuB-2hrjA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijr HYPOTHETICAL PROTEIN
API92

(Yersinia
pseudotuberculosis) 		PF06924
(DUF1281) 		3 ASN A 258
TYR A 231
CYH A   5
 None
 0.72A 5lsuB-2ijrA:
undetectable		 5lsuB-2ijrA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		3 ASN A 177
TYR A 489
CYH A 188
 None
 0.93A 5lsuB-2j6lA:
undetectable		 5lsuB-2j6lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		3 ASN A 175
TYR A 487
CYH A 186
 None
 0.95A 5lsuB-2jg7A:
undetectable		 5lsuB-2jg7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv NUCLEAR PROTEIN SNF4

(Saccharomyces
cerevisiae) 		PF00571
(CBS) 		3 ASN C 286
TYR C 272
CYH C 274
 None
 0.93A 5lsuB-2qlvC:
undetectable		 5lsuB-2qlvC:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz9 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ASN A 234
TYR A 211
CYH A 237
 None
 0.82A 5lsuB-2qz9A:
undetectable		 5lsuB-2qz9A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ASN A 219
TYR A 261
CYH A 287
 SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 0.16A 5lsuB-2r3aA:
20.3		 5lsuB-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		3 ASN A3906
TYR A3944
CYH A3957
 SAH  A4971 (-3.1A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 0.12A 5lsuB-2w5zA:
14.3		 5lsuB-2w5zA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		3 ASN A  15
TYR A 310
CYH A  17
 None
 0.81A 5lsuB-2za1A:
undetectable		 5lsuB-2za1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ASN A 209
TYR A 248
CYH A 273
 SAH  A 305 (-3.4A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.17A 5lsuB-3bo5A:
21.5		 5lsuB-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhn PROTEIN TRANSPORT
PROTEIN TIP20

(Saccharomyces
cerevisiae) 		PF04437
(RINT1_TIP1) 		3 ASN A 247
TYR A 275
CYH A 283
 None
 1.06A 5lsuB-3fhnA:
undetectable		 5lsuB-3fhnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0n UNCHARACTERIZED
PROTEIN DUF1470

(Jannaschia sp.
CCS1) 		PF07336
(ABATE)
PF11706
(zf-CGNR) 		3 ASN A 148
TYR A 156
CYH A 152
 None
None
ZN  A 201 ( 2.3A)
 0.95A 5lsuB-3h0nA:
undetectable		 5lsuB-3h0nA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqf RESTRICTION
ENDONUCLEASE

(Escherichia
coli) 		PF09217
(EcoRII-N) 		3 ASN A 135
TYR A  18
CYH A 131
 None
 1.02A 5lsuB-3hqfA:
undetectable		 5lsuB-3hqfA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		3 ASN A 283
TYR A 413
CYH A 274
 None
 0.99A 5lsuB-3i44A:
undetectable		 5lsuB-3i44A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		3 ASN A 145
TYR A 224
CYH A 129
 None
 0.88A 5lsuB-3i7aA:
undetectable		 5lsuB-3i7aA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 ASN A  40
TYR A  42
CYH A  52
 None
 1.07A 5lsuB-3jtmA:
undetectable		 5lsuB-3jtmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krn PROTEIN C14A4.5,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF01138
(RNase_PH) 		3 ASN A 110
TYR A 201
CYH A  10
 None
 0.92A 5lsuB-3krnA:
undetectable		 5lsuB-3krnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqk DIPICOLINATE
SYNTHASE SUBUNIT B

(Bacillus
halodurans) 		PF02441
(Flavoprotein) 		3 ASN A 149
TYR A 151
CYH A  87
 None
 1.01A 5lsuB-3lqkA:
undetectable		 5lsuB-3lqkA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcu DIPICOLINATE
SYNTHASE, B CHAIN

(Bacillus cereus) 		PF02441
(Flavoprotein) 		3 ASN A 149
TYR A 151
CYH A  87
 None
 1.02A 5lsuB-3mcuA:
undetectable		 5lsuB-3mcuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpi GLUTARYL-COA
DEHYDROGENASE

(Desulfococcus
multivorans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ASN A 336
TYR A 357
CYH A 260
 None
 1.06A 5lsuB-3mpiA:
undetectable		 5lsuB-3mpiA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwy CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF00385
(Chromo) 		3 ASN W 206
TYR W 211
CYH W 246
 None
 1.02A 5lsuB-3mwyW:
undetectable		 5lsuB-3mwyW:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		3 ASN A 205
TYR A 252
CYH A 274
 SFG  A 491 (-3.3A)
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.28A 5lsuB-3n71A:
5.7		 5lsuB-3n71A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5s BETA-GLUCANASE

(Bacillus
subtilis) 		PF00722
(Glyco_hydro_16) 		3 ASN A 228
TYR A 224
CYH A  89
 None
 1.08A 5lsuB-3o5sA:
undetectable		 5lsuB-3o5sA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		3 ASN A  87
TYR A  92
CYH A  49
 None
 1.01A 5lsuB-3o82A:
undetectable		 5lsuB-3o82A:
17.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		3 ASN A 169
TYR A 207
CYH A 219
 SAM  A 237 (-3.3A)
None
ZN  A 232 ( 2.3A)
 0.10A 5lsuB-3ooiA:
32.5		 5lsuB-3ooiA:
72.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		3 ASN A 197
TYR A  71
CYH A  59
 None
 1.01A 5lsuB-3oosA:
undetectable		 5lsuB-3oosA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		3 ASN A2217
TYR A2255
CYH A2268
 SAM  A   7 (-3.9A)
None
ZN  A   1 ( 2.5A)
 0.28A 5lsuB-3opeA:
26.0		 5lsuB-3opeA:
36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		3 ASN X 150
TYR X 169
CYH X 167
 None
 1.00A 5lsuB-3pb9X:
undetectable		 5lsuB-3pb9X:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmr AVIRULENCE PROTEIN

(Hyaloperonospora
parasitica) 		no annotation 3 ASN A 216
TYR A 230
CYH A 258
 None
 0.81A 5lsuB-3rmrA:
undetectable		 5lsuB-3rmrA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		3 ASN A 113
TYR A  25
CYH A  29
 None
 0.98A 5lsuB-3s1sA:
undetectable		 5lsuB-3s1sA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		3 ASN A 294
TYR A 298
CYH A 349
 None
 0.95A 5lsuB-3s29A:
undetectable		 5lsuB-3s29A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4t TPR
REPEAT-CONTAINING
PROTEIN

(Cytophaga
hutchinsonii) 		PF07719
(TPR_2) 		3 ASN A 399
TYR A 404
CYH A 434
 None
 0.83A 5lsuB-3u4tA:
undetectable		 5lsuB-3u4tA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ASN A 336
TYR A 251
CYH A 499
 None
 1.03A 5lsuB-3uggA:
undetectable		 5lsuB-3uggA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1s PARTNER OF
INSCUTEABLE

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		3 ASN A  89
TYR A  93
CYH A  54
 None
 1.01A 5lsuB-4a1sA:
undetectable		 5lsuB-4a1sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		3 ASN A 182
TYR A 217
CYH A 229
 SAH  A1247 (-3.1A)
None
ZN  A1248 ( 2.3A)
 0.33A 5lsuB-4au7A:
8.0		 5lsuB-4au7A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bk1 PROBABLE SALICYLATE
MONOOXYGENASE

(Rhodococcus
jostii) 		PF01494
(FAD_binding_3) 		3 ASN A 259
TYR A 207
CYH A 256
 None
 1.07A 5lsuB-4bk1A:
undetectable		 5lsuB-4bk1A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 ASN A 407
TYR A 512
CYH A 445
 None
 1.08A 5lsuB-4byfA:
undetectable		 5lsuB-4byfA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f88 PLYCA

(Streptococcus
virus C1) 		PF05257
(CHAP) 		3 ASN 1 366
TYR 1 334
CYH 1 404
 None
 0.80A 5lsuB-4f881:
undetectable		 5lsuB-4f881:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		3 ASN A 380
TYR A 477
CYH A 373
 None
 0.77A 5lsuB-4g25A:
undetectable		 5lsuB-4g25A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4goj PROTEIN UNC-119
HOMOLOG A

(Homo sapiens) 		PF05351
(GMP_PDE_delta) 		3 ASN C 157
TYR C  84
CYH C 182
 None
 1.09A 5lsuB-4gojC:
undetectable		 5lsuB-4gojC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he4 YELLOW FLUORESCENT
PROTEIN

(Phialidium sp.
SL-2003) 		PF01353
(GFP) 		3 ASN A 119
TYR A  14
CYH A  70
 CRO  A  65 ( 4.0A)
None
None
 0.77A 5lsuB-4he4A:
undetectable		 5lsuB-4he4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1l TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27) 		3 ASN A 138
TYR A  33
CYH A  27
 None
 1.04A 5lsuB-4j1lA:
undetectable		 5lsuB-4j1lA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9c F-BOX ONLY PROTEIN 7

(Homo sapiens) 		PF11566
(PI31_Prot_N) 		3 ASN A 196
TYR A 234
CYH A 192
 None
 0.99A 5lsuB-4l9cA:
undetectable		 5lsuB-4l9cA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN

(Bacteroides
uniformis) 		PF16255
(Lipase_GDSL_lke) 		3 ASN A 125
TYR A 100
CYH A  91
 ACT  A 301 (-2.8A)
None
None
 0.97A 5lsuB-4m8kA:
undetectable		 5lsuB-4m8kA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrd UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF16255
(Lipase_GDSL_lke) 		3 ASN A 124
TYR A  99
CYH A  90
 None
 1.03A 5lsuB-4nrdA:
undetectable		 5lsuB-4nrdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		3 ASN A 551
TYR A 593
CYH A 612
 SAH  A 801 (-3.2A)
None
ZN  A 805 ( 2.4A)
 0.20A 5lsuB-4qeoA:
18.2		 5lsuB-4qeoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		3 ASN A5474
TYR A5512
CYH A5525
 SAH  A5602 (-3.1A)
None
ZN  A5601 ( 2.2A)
 0.12A 5lsuB-4z4pA:
16.5		 5lsuB-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Sulfolobus
solfataricus) 		PF00288
(GHMP_kinases_N) 		3 ASN A  28
TYR A  18
CYH A 143
 None
 0.53A 5lsuB-4z7yA:
undetectable		 5lsuB-4z7yA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpq MCG133388, ISOFORM
CRA_F

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		3 ASN A 236
TYR A 250
CYH A 305
 NAG  A 407 (-1.9A)
None
None
 0.93A 5lsuB-4zpqA:
undetectable		 5lsuB-4zpqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		3 ASN A 432
TYR A 413
CYH A 446
 None
 0.89A 5lsuB-5a01A:
undetectable		 5lsuB-5a01A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		3 ASN A1627
TYR A1698
CYH A1630
 None
 1.03A 5lsuB-5a31A:
undetectable		 5lsuB-5a31A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co1 PROTOCADHERIN-19
ISOFORM 1

(Danio rerio) 		PF00028
(Cadherin) 		3 ASN A 238
TYR A 252
CYH A 307
 CA  A1004 ( 4.5A)
None
None
 1.06A 5lsuB-5co1A:
undetectable		 5lsuB-5co1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpr HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1

(Homo sapiens) 		PF00856
(SET) 		3 ASN B 272
TYR B 307
CYH B 319
 SAM  B 402 (-3.1A)
539  B 403 ( 3.9A)
ZN  B 401 ( 2.3A)
 0.43A 5lsuB-5cprB:
7.3		 5lsuB-5cprB:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzv PROTEIN PCDHA7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		3 ASN A 236
TYR A 250
CYH A 305
 NAG  A 615 (-1.9A)
None
None
 1.10A 5lsuB-5dzvA:
undetectable		 5lsuB-5dzvA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzw PROTOCADHERIN
ALPHA-4

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		3 ASN A 236
TYR A 250
CYH A 305
 NAG  A 504 (-1.8A)
None
None
 1.04A 5lsuB-5dzwA:
undetectable		 5lsuB-5dzwA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		3 ASN A4848
TYR A4886
CYH A4899
 SAH  A5002 (-2.7A)
None
ZN  A5001 ( 2.0A)
 0.19A 5lsuB-5f59A:
16.2		 5lsuB-5f59A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		3 ASN A3906
TYR A3944
CYH A3957
 SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
 0.26A 5lsuB-5f6lA:
16.0		 5lsuB-5f6lA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fol LEUCYL-TRNA
SYNTHETASE

(Cryptosporidium
muris) 		no annotation 3 ASN A 355
TYR A 539
CYH A 348
 None
 1.04A 5lsuB-5folA:
undetectable		 5lsuB-5folA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51)
PF14520
(HHH_5) 		3 ASN A 188
TYR A 216
CYH A 144
 None
 1.10A 5lsuB-5h1cA:
undetectable		 5lsuB-5h1cA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikk HISTONE DEACETYLASE
CLR3

(Schizosaccharomyces
pombe) 		PF00850
(Hist_deacetyl)
PF09757
(Arb2) 		3 ASN A 602
TYR A 624
CYH A 599
 None
 0.84A 5lsuB-5ikkA:
undetectable		 5lsuB-5ikkA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7u MAJOR CAPSID PROTEIN

(Faustovirus) 		PF04451
(Capsid_NCLDV) 		3 ASN A 429
TYR A 595
CYH A 606
 None
 0.84A 5lsuB-5j7uA:
undetectable		 5lsuB-5j7uA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ASN A 636
TYR A 250
CYH A 644
 None
 1.11A 5lsuB-5k6oA:
undetectable		 5lsuB-5k6oA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		3 ASN A 206
TYR A 240
CYH A 262
 SAM  A 501 (-3.2A)
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.19A 5lsuB-5kjmA:
6.1		 5lsuB-5kjmA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		3 ASN A1141
TYR A1179
CYH A1191
 SAM  A1304 (-2.9A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.08A 5lsuB-5lsuA:
36.4		 5lsuB-5lsuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3h POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		3 ASN A 115
TYR A 110
CYH A  95
 None
 1.05A 5lsuB-5m3hA:
undetectable		 5lsuB-5m3hA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 ASN A 138
TYR A  33
CYH A  27
 None
 1.03A 5lsuB-5n0cA:
undetectable		 5lsuB-5n0cA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		3 ASN A 177
TYR A 200
CYH A 172
 None
 0.90A 5lsuB-5ncsA:
undetectable		 5lsuB-5ncsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nl6 CALPONIN DOMAIN
FAMILY PROTEIN

(Entamoeba
histolytica) 		no annotation 3 ASN A 438
TYR A 285
CYH A 434
 None
None
BME  A 501 (-2.3A)
 1.11A 5lsuB-5nl6A:
undetectable		 5lsuB-5nl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 3 ASN A 393
TYR A 374
CYH A 407
 None
 0.87A 5lsuB-5nprA:
undetectable		 5lsuB-5nprA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 ASN W 452
TYR W 469
CYH W 455
 None
 1.05A 5lsuB-5o9gW:
undetectable		 5lsuB-5o9gW:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5the UNCHARACTERIZED
PROTEIN

(Vanderwaltozyma
polyspora) 		no annotation 3 ASN A1163
TYR A1169
CYH A1158
 None
 1.08A 5lsuB-5theA:
undetectable		 5lsuB-5theA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ASN A1112
TYR A1154
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.21A 5lsuB-5tuyA:
19.5		 5lsuB-5tuyA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35

(Homo sapiens) 		no annotation 3 ASN A 585
TYR A 780
CYH A 785
 None
None
ZN  A1006 (-2.3A)
 1.03A 5lsuB-5txkA:
undetectable		 5lsuB-5txkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		3 ASN A 848
TYR A 763
CYH A 829
 None
 0.96A 5lsuB-5uj7A:
undetectable		 5lsuB-5uj7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		3 ASN A 848
TYR A 763
CYH A 829
 None
 0.96A 5lsuB-5ujmA:
undetectable		 5lsuB-5ujmA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 3 ASN A  80
TYR A 154
CYH A  49
 WO4  A 403 ( 2.3A)
WO4  A 404 ( 4.0A)
None
 0.94A 5lsuB-5vjwA:
undetectable		 5lsuB-5vjwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ASN A1200
TYR A1242
CYH A1256
 SAM  A3001 (-3.4A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
 0.12A 5lsuB-5vsdA:
19.9		 5lsuB-5vsdA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 3 ASN A 205
TYR A 239
CYH A 261
 SAM  A 502 (-3.1A)
8HR  A 501 ( 4.0A)
ZN  A 503 (-2.2A)
 0.56A 5lsuB-5xxgA:
5.9		 5lsuB-5xxgA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 3 ASN A1223
TYR A1261
CYH A1273
 SAM  A1301 (-3.2A)
SAM  A1301 (-4.9A)
ZN  A1304 ( 2.3A)
 0.24A 5lsuB-6cenA:
31.7		 5lsuB-6cenA:
77.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cer PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
ALPHA, SOMATIC FORM,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 ASN A 130
TYR A 132
CYH A 152
 None
 1.12A 5lsuB-6cerA:
undetectable		 5lsuB-6cerA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 3 ASN A 141
TYR A 114
CYH A 138
 None
 1.00A 5lsuB-6f5zA:
undetectable		 5lsuB-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 3 ASN A 890
TYR A 819
CYH A 823
 None
None
CD  A1101 (-2.6A)
 1.02A 5lsuB-6fj4A:
undetectable		 5lsuB-6fj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25 -

(-) 		no annotation 3 ASN D 135
TYR D 224
CYH D  33
 None
 0.94A 5lsuB-6h25D:
undetectable		 5lsuB-6h25D:
undetectable