SIMILAR PATTERNS OF AMINO ACIDS FOR 5LSU_A_SAMA1304_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lia R-PHYCOERYTHRIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		5 ASN B  63
CYH B  75
ARG B  80
CYH B  84
LEU B  66
 None
CYC  B 175 (-3.5A)
CYC  B 175 (-3.9A)
CYC  B 175 (-1.8A)
CYC  B 175 ( 4.8A)
 1.42A 5lsuA-1liaB:
undetectable		 5lsuA-1liaB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lia R-PHYCOERYTHRIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		5 GLY B 123
ASN B  63
CYH B  75
CYH B  84
LEU B  66
 None
None
CYC  B 175 (-3.5A)
CYC  B 175 (-1.8A)
CYC  B 175 ( 4.8A)
 1.27A 5lsuA-1liaB:
undetectable		 5lsuA-1liaB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		8 ARG A 159
GLY A 160
TRP A 161
TYR A 204
HIS A 242
CYH A 306
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-4.3A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.58A 5lsuA-1pegA:
20.5		 5lsuA-1pegA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptq PROTEIN KINASE C
DELTA TYPE

(Mus musculus) 		PF00130
(C1_1) 		5 GLY A 265
HIS A 269
THR A 242
CYH A 244
LEU A 251
 None
ZN  A   2 (-3.4A)
None
ZN  A   2 (-2.4A)
None
 1.35A 5lsuA-1ptqA:
undetectable		 5lsuA-1ptqA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		5 TYR A 372
THR A 447
CYH A 444
CYH A 470
LEU A 451
 None
 1.31A 5lsuA-1sxjA:
undetectable		 5lsuA-1sxjA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg0 B-PHYCOERYTHRIN BETA
CHAIN

(Rhodomonas sp.
CS24) 		PF00502
(Phycobilisome) 		5 GLY C 121
ASN C  63
CYH C  73
CYH C  82
LEU C  66
 MEN  C  72 ( 4.5A)
None
PEB  C 282 (-3.5A)
PEB  C 282 (-1.8A)
PEB  C 282 ( 4.8A)
 1.36A 5lsuA-1xg0C:
undetectable		 5lsuA-1xg0C:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8f UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1) 		5 HIS A 605
THR A 578
CYH A 580
CYH A 608
LEU A 587
 ZN  A 702 (-3.3A)
None
ZN  A 702 (-2.3A)
ZN  A 702 (-2.3A)
None
 1.18A 5lsuA-1y8fA:
undetectable		 5lsuA-1y8fA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 ARG X 388
GLY X 319
TYR X 329
ARG X 389
LEU X 386
 SO4  X 736 (-4.0A)
None
None
None
None
 1.46A 5lsuA-1z3iX:
undetectable		 5lsuA-1z3iX:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2enz PROTEIN KINASE C
THETA TYPE

(Homo sapiens) 		PF00130
(C1_1) 		5 HIS A 270
THR A 243
CYH A 245
CYH A 273
LEU A 252
 ZN  A 400 (-3.1A)
None
ZN  A 400 (-2.3A)
ZN  A 400 ( 2.2A)
None
 1.18A 5lsuA-2enzA:
undetectable		 5lsuA-2enzA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 ARG A 150
GLY A 149
HIS A 220
THR A 285
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.08A 5lsuA-2r3aA:
20.4		 5lsuA-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		9 ARG A 150
GLY A 151
TRP A 152
TYR A 193
HIS A 220
THR A 285
CYH A 287
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-4.9A)
None
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.53A 5lsuA-2r3aA:
20.4		 5lsuA-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 HIS A 220
ASN A 299
THR A 285
CYH A 287
CYH A 289
LEU A 298
 SAM  A 304 (-4.9A)
None
None
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.34A 5lsuA-2r3aA:
20.4		 5lsuA-2r3aA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE

(Paraburkholderia
xenovorans) 		PF12697
(Abhydrolase_6) 		5 GLY A 138
HIS A 244
ASN A 251
THR A 219
LEU A 222
 None
 1.30A 5lsuA-2ri6A:
undetectable		 5lsuA-2ri6A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjh PHYCOERYTHRIN BETA
SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		5 ASN B  63
CYH B  73
ARG B  78
CYH B  82
LEU B  66
 None
PEB  B1082 (-3.5A)
PEB  B1082 (-4.5A)
PEB  B1082 (-1.6A)
PEB  B1082 ( 4.7A)
 1.35A 5lsuA-2vjhB:
undetectable		 5lsuA-2vjhB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjh PHYCOERYTHRIN BETA
SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		5 GLY B 121
ASN B  63
CYH B  73
CYH B  82
LEU B  66
 MEN  B  72 ( 4.5A)
None
PEB  B1082 (-3.5A)
PEB  B1082 (-1.6A)
PEB  B1082 ( 4.7A)
 1.36A 5lsuA-2vjhB:
undetectable		 5lsuA-2vjhB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
HIS A3907
CYH A3957
CYH A3959
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-4.7A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.54A 5lsuA-2w5zA:
14.5		 5lsuA-2w5zA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bji PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF) 		5 TYR A 541
HIS A 554
CYH A 529
CYH A 557
LEU A 536
 None
ZN  A   1 (-3.2A)
ZN  A   1 (-2.1A)
ZN  A   1 (-2.1A)
None
 1.18A 5lsuA-3bjiA:
undetectable		 5lsuA-3bjiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 136
TRP A 137
TYR A 178
HIS A 210
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
 1.44A 5lsuA-3bo5A:
22.0		 5lsuA-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		7 GLY A 136
TRP A 137
TYR A 178
HIS A 210
CYH A 273
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.52A 5lsuA-3bo5A:
22.0		 5lsuA-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 138
TYR A 178
HIS A 210
CYH A 273
CYH A 275
 None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 1.27A 5lsuA-3bo5A:
22.0		 5lsuA-3bo5A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		10 ARG A 101
GLY A 102
TRP A 103
TYR A 146
HIS A 170
ASN A 214
THR A 217
CYH A 219
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-4.1A)
SAM  A 237 (-4.7A)
SAM  A 237 (-2.6A)
None
ZN  A 232 ( 2.3A)
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.72A 5lsuA-3ooiA:
33.7		 5lsuA-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		5 TRP A 103
TYR A 146
ASN A 214
CYH A 171
LEU A 230
 None
SAM  A 237 (-4.1A)
SAM  A 237 (-2.6A)
None
SAM  A 237 (-4.8A)
 1.43A 5lsuA-3ooiA:
33.7		 5lsuA-3ooiA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		6 GLY A2151
TRP A2152
TYR A2194
HIS A2218
CYH A2268
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 0.45A 5lsuA-3opeA:
26.6		 5lsuA-3opeA:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		5 GLY A2153
TYR A2194
HIS A2218
CYH A2268
CYH A2270
 None
SAM  A   7 (-3.4A)
None
ZN  A   1 ( 2.5A)
ZN  A   1 (-2.7A)
 1.44A 5lsuA-3opeA:
26.6		 5lsuA-3opeA:
36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		5 HIS A 107
HIS A 140
THR A 113
CYH A 115
LEU A 122
 None
ZN  A 751 (-3.1A)
None
ZN  A 751 (-2.7A)
None
 1.10A 5lsuA-3pfqA:
undetectable		 5lsuA-3pfqA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvn MANGANESE-CONTAINING
SUPEROXIDE DISMUTASE

(Candida
albicans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 133
TRP A 172
TYR A 187
ASN A 123
THR A 122
 None
 1.07A 5lsuA-3qvnA:
undetectable		 5lsuA-3qvnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uff PROTEIN KINASE C
DELTA TYPE

(Mus musculus) 		PF00130
(C1_1) 		5 GLY A 265
HIS A 269
THR A 242
CYH A 244
LEU A 251
 None
ZN  A   2 (-3.2A)
None
ZN  A   2 (-2.3A)
None
 1.33A 5lsuA-3uffA:
undetectable		 5lsuA-3uffA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN BETA
SUBUNIT

(Porphyridium
purpureum) 		PF00502
(Phycobilisome) 		5 GLY B 121
ASN B  63
CYH B  73
CYH B  82
LEU B  66
 MEN  B  72 ( 4.5A)
None
PEB  B 203 (-3.4A)
PEB  B 203 (-1.8A)
PEB  B 203 ( 4.6A)
 1.41A 5lsuA-3v57B:
undetectable		 5lsuA-3v57B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 132
TRP A 170
TYR A 185
ASN A 122
THR A 121
 None
None
None
MLY  A 187 ( 4.3A)
None
 1.06A 5lsuA-4f6eA:
undetectable		 5lsuA-4f6eA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		8 GLY A1561
TRP A1562
HIS A1603
TYR A1605
HIS A1629
CYH A1678
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.7A)
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.66A 5lsuA-4fmuA:
25.9		 5lsuA-4fmuA:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		5 GLY A1563
TYR A1605
HIS A1629
CYH A1678
CYH A1680
 None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
 1.48A 5lsuA-4fmuA:
25.9		 5lsuA-4fmuA:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lms CRYPTOPHYTE
PHYCOCYANIN (BETA
CHAIN)

(Chroomonas sp.) 		PF00502
(Phycobilisome) 		5 ASN B  63
CYH B  73
ARG B  78
CYH B  82
LEU B  66
 None
CYC  B 203 (-3.6A)
None
CYC  B 203 (-1.8A)
CYC  B 203 ( 4.8A)
 1.34A 5lsuA-4lmsB:
undetectable		 5lsuA-4lmsB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lms CRYPTOPHYTE
PHYCOCYANIN (BETA
CHAIN)

(Chroomonas sp.) 		PF00502
(Phycobilisome) 		5 GLY B 121
ASN B  63
CYH B  73
CYH B  82
LEU B  66
 MEN  B  72 ( 4.6A)
None
CYC  B 203 (-3.6A)
CYC  B 203 (-1.8A)
CYC  B 203 ( 4.8A)
 1.34A 5lsuA-4lmsB:
undetectable		 5lsuA-4lmsB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		7 GLY A 457
TRP A 458
TYR A 493
HIS A 552
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.66A 5lsuA-4qeoA:
18.3		 5lsuA-4qeoA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5o QUINONPROTEIN
ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16819
(DUF5074)
PF16820
(PKD_3) 		5 ARG A 227
GLY A 225
TYR A 248
ASN A 166
LEU A 177
 None
None
7PE  A 503 (-4.6A)
7PE  A 503 (-4.3A)
None
 1.36A 5lsuA-4r5oA:
undetectable		 5lsuA-4r5oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		5 GLY A5408
TYR A5451
HIS A5475
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.42A 5lsuA-4z4pA:
16.5		 5lsuA-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		5 GLY A4782
TYR A4825
HIS A4849
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.65A 5lsuA-5f59A:
16.1		 5lsuA-5f59A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
HIS A3907
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.46A 5lsuA-5f6lA:
16.0		 5lsuA-5f6lA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
TYR A3883
HIS A3907
CYH A3957
CYH A3959
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
 0.65A 5lsuA-5f6lA:
16.0		 5lsuA-5f6lA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		5 HIS A3907
ASN A3969
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-4.9A)
None
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 1.48A 5lsuA-5f6lA:
16.0		 5lsuA-5f6lA:
25.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		12 ARG A1073
GLY A1074
TRP A1075
HIS A1116
TYR A1118
HIS A1142
ASN A1186
THR A1189
CYH A1191
ARG A1192
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.4A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-3.6A)
SAM  A1304 ( 3.9A)
ZN  A1301 ( 2.3A)
None
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.04A 5lsuA-5lsuA:
39.6		 5lsuA-5lsuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nb3 PHYCOERYTHRIN BETA
SUBUNIT,PHYCOERYTHRI
N BETA SUBUNIT

(Phormidium
rubidum) 		PF00502
(Phycobilisome) 		5 GLY M 119
ASN M  61
CYH M  71
CYH M  80
LEU M  64
 MEN  M  70 ( 4.6A)
None
PEB  M 186 (-3.5A)
PEB  M 186 (-2.0A)
PEB  M 186 ( 4.5A)
 1.34A 5lsuA-5nb3M:
undetectable		 5lsuA-5nb3M:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 GLY A1049
TRP A1050
TYR A1085
HIS A1113
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.38A 5lsuA-5tuyA:
19.8		 5lsuA-5tuyA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		5 GLY A 594
HIS A 605
HIS A 567
CYH A 597
LEU A 612
 None
ZN  A1701 (-3.1A)
ZN  A1702 (-3.0A)
ZN  A1702 (-2.3A)
None
 1.27A 5lsuA-5ue8A:
undetectable		 5lsuA-5ue8A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 GLY A1137
TRP A1138
TYR A1173
HIS A1201
CYH A1256
CYH A1258
 SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
 0.41A 5lsuA-5vsdA:
20.2		 5lsuA-5vsdA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 9 ARG A1155
GLY A1156
TRP A1157
TYR A1200
HIS A1224
THR A1271
CYH A1273
CYH A1275
LEU A1284
 None
SAM  A1301 (-3.6A)
None
SAM  A1301 (-3.9A)
None
None
ZN  A1304 ( 2.3A)
ZN  A1304 (-2.3A)
SAM  A1301 (-4.6A)
 0.58A 5lsuA-6cenA:
32.5		 5lsuA-6cenA:
77.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 5 GLY A 588
TYR A 616
HIS A 592
THR A 623
LEU A 624
 None
 1.43A 5lsuA-6f8zA:
undetectable		 5lsuA-6f8zA:
undetectable