SIMILAR PATTERNS OF AMINO ACIDS FOR 5LRB_B_ACRB1003

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c72 PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Gallus gallus) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 GLU A  29
THR A  25
TYR A  27
GLY A   5
TYR A   6
 None
 1.43A 5lrbB-1c72A:
0.1		 5lrbB-1c72A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejn SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		5 GLU A 329
PHE A 368
TYR A 371
TYR A 421
PHE A 322
 None
 1.39A 5lrbB-3ejnA:
0.2		 5lrbB-3ejnA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtu GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 GLU B  33
THR B  29
TYR B  31
GLY B   9
TYR B  10
 None
 1.46A 5lrbB-3gtuB:
0.0		 5lrbB-3gtuB:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 GLU A 224
GLU A 247
TYR A 509
GLY A 243
TYR A 214
 None
 1.44A 5lrbB-3ps5A:
0.6		 5lrbB-3ps5A:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		6 GLU A 576
THR A 619
TYR A 620
GLY A 774
TYR A 778
PHE A 779
 None
 0.47A 5lrbB-4bqiA:
60.1		 5lrbB-4bqiA:
55.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idt GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Burkholderia
vietnamiensis) 		PF00483
(NTP_transferase) 		5 PHE A 178
THR A 134
TYR A 177
GLY A 147
TYR A 146
 None
 1.45A 5lrbB-5idtA:
0.0		 5lrbB-5idtA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 5 GLU A 320
PHE A 257
THR A 256
TYR A 313
GLY A 319
 None
None
LLP  A 255 ( 4.4A)
None
BR  A 501 ( 4.2A)
 1.49A 5lrbB-5vehA:
0.0		 5lrbB-5vehA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Homo sapiens) 		no annotation 5 THR A 714
TYR A 711
GLY A 651
TYR A 656
PHE A 668
 None
 1.39A 5lrbB-5yx9A:
0.0		 5lrbB-5yx9A:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp7 ATP SYNTHASE SUBUNIT
A
ATP SYNTHASE SUBUNIT
F, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 5 PHE X  29
THR X  33
TYR X  32
TYR U  83
PHE U  84
 None
 1.35A 5lrbB-6cp7X:
1.4		 5lrbB-6cp7X:
6.98