SIMILAR PATTERNS OF AMINO ACIDS FOR 5LJE_A_RTLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LEU A 535
ILE A 409
THR A 487
TRP A 404
 None
 1.38A 5ljeA-1cb8A:
0.0		 5ljeA-1cb8A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		4 LEU B 143
ILE B 218
THR B 196
MET B 220
 None
 1.40A 5ljeA-1ep2B:
0.1		 5ljeA-1ep2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 LEU A 107
ILE A 237
THR A 254
MET A 208
 None
 1.43A 5ljeA-1fc4A:
0.0		 5ljeA-1fc4A:
15.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  36
ILE A  51
THR A  53
TRP A 106
MET A 119
 None
 0.36A 5ljeA-1lpjA:
24.8		 5ljeA-1lpjA:
55.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  57
ILE A  51
THR A  53
TRP A 106
MET A 119
 None
 1.20A 5ljeA-1lpjA:
24.8		 5ljeA-1lpjA:
55.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		4 LEU A 225
ILE A 172
THR A 171
MET A 401
 None
 1.40A 5ljeA-1lxyA:
0.0		 5ljeA-1lxyA:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 LEU A  36
ILE A  51
THR A  53
MET A  62
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.3A)
RTL  A 135 (-2.9A)
 0.86A 5ljeA-1mx8A:
19.8		 5ljeA-1mx8A:
94.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		4 LEU A 661
ILE A 519
MET A 517
TRP A 466
 None
 0.99A 5ljeA-1nphA:
0.0		 5ljeA-1nphA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 161
ILE A 126
THR A 128
MET A 124
 None
 1.28A 5ljeA-1ofuA:
0.0		 5ljeA-1ofuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 ILE A 256
THR A 254
MET A 196
MET A 214
 None
None
None
ADP  A1259 (-4.5A)
 1.22A 5ljeA-1oh9A:
undetectable		 5ljeA-1oh9A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 LEU A 360
ILE A 143
THR A 233
MET A 167
 None
 1.43A 5ljeA-1qonA:
undetectable		 5ljeA-1qonA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqf PROTEIN (COMPLEMENT
C3DG)

(Rattus
norvegicus) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 LEU A1088
ILE A1016
THR A1019
MET A1129
 None
 1.44A 5ljeA-1qqfA:
undetectable		 5ljeA-1qqfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r45 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
phage c-st) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A 212
ILE A 173
THR A 175
MET A 120
 None
 1.35A 5ljeA-1r45A:
undetectable		 5ljeA-1r45A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 ILE A 361
THR A 381
TRP A 305
MET A 302
 None
 1.40A 5ljeA-1s4fA:
undetectable		 5ljeA-1s4fA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 LEU A 613
ILE A 500
THR A 619
MET A 485
 None
 1.42A 5ljeA-1wkbA:
undetectable		 5ljeA-1wkbA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 LEU A 613
ILE A 500
THR A 619
MET A 485
 None
 1.40A 5ljeA-1wz2A:
undetectable		 5ljeA-1wz2A:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE

(Entamoeba
histolytica) 		PF05770
(Ins134_P3_kin) 		4 LEU X 247
ILE X 177
THR X 191
MET X 256
 None
ADP  X 871 (-4.6A)
None
None
 1.36A 5ljeA-1z2oX:
undetectable		 5ljeA-1z2oX:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		4 LEU A 279
ILE A 247
MET A 215
TRP A  59
 None
 1.09A 5ljeA-2b81A:
undetectable		 5ljeA-2b81A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 LEU A 241
ILE A 303
THR A 307
MET A 281
 None
 1.36A 5ljeA-2e28A:
undetectable		 5ljeA-2e28A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 LEU A 264
ILE A 303
THR A 307
MET A 281
 None
 1.38A 5ljeA-2e28A:
undetectable		 5ljeA-2e28A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 179
ILE A 410
THR A 412
MET A 414
 None
 1.44A 5ljeA-2iikA:
undetectable		 5ljeA-2iikA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Escherichia
coli) 		PF04381
(RdgC) 		4 LEU A   7
ILE A 280
THR A 283
MET A   1
 None
 1.24A 5ljeA-2owlA:
undetectable		 5ljeA-2owlA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU B  54
ILE B 221
THR B 197
MET B 217
 None
 1.14A 5ljeA-2po2B:
undetectable		 5ljeA-2po2B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 LEU A 370
ILE A 106
TRP A  47
MET A  44
 None
None
None
LOP  A 503 (-4.2A)
 1.28A 5ljeA-2qjpA:
undetectable		 5ljeA-2qjpA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 161
ILE A 126
THR A 128
MET A 124
 None
 1.33A 5ljeA-2vawA:
undetectable		 5ljeA-2vawA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 LEU A 304
ILE A 329
THR A  93
MET A 321
 None
 1.31A 5ljeA-2vgqA:
undetectable		 5ljeA-2vgqA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 1.02A 5ljeA-2w21A:
undetectable		 5ljeA-2w21A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2i 2-OXOGLUTARATE
OXYGENASE

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 LEU A 151
ILE A 157
THR A 156
TRP A 297
 None
 1.34A 5ljeA-2w2iA:
undetectable		 5ljeA-2w2iA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 228
ILE A 178
THR A 196
MET A 219
 None
None
UAG  A1498 (-4.7A)
None
 1.20A 5ljeA-2wtzA:
undetectable		 5ljeA-2wtzA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1

(Streptococcus
parasanguinis) 		no annotation 4 ILE A 377
THR A 310
MET A 379
TRP A 282
 None
 1.32A 5ljeA-2x12A:
undetectable		 5ljeA-2x12A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 LEU A  20
ILE A 222
THR A 114
TRP A 198
 None
 1.37A 5ljeA-2xmzA:
undetectable		 5ljeA-2xmzA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqw COMPLEMENT C3

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 LEU A  95
ILE A  23
THR A  26
MET A 136
 None
 1.37A 5ljeA-2xqwA:
undetectable		 5ljeA-2xqwA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 LEU B1066
ILE B 994
THR B 997
MET B1107
 None
 1.37A 5ljeA-2xwbB:
undetectable		 5ljeA-2xwbB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 610
ILE A 622
THR A 624
MET A 586
 None
 1.25A 5ljeA-2ycbA:
undetectable		 5ljeA-2ycbA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 LEU A 676
ILE A 620
THR A 597
MET A 655
 None
 1.39A 5ljeA-2yfsA:
undetectable		 5ljeA-2yfsA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 LEU A 865
ILE A 870
MET A 891
TRP A 560
 None
 1.37A 5ljeA-2zaiA:
undetectable		 5ljeA-2zaiA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 625
ILE A 637
THR A 639
MET A 601
 None
 1.10A 5ljeA-3af5A:
undetectable		 5ljeA-3af5A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 3

(Schizosaccharomyces
pombe) 		PF00022
(Actin) 		4 LEU A  72
ILE A 145
MET A 146
TRP A 109
 None
 0.84A 5ljeA-3dwlA:
undetectable		 5ljeA-3dwlA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 LEU X  43
ILE X 238
THR X  61
TRP X  99
 None
 1.40A 5ljeA-3e13X:
undetectable		 5ljeA-3e13X:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 338
ILE A 310
THR A 341
MET A 315
 None
 1.27A 5ljeA-3eoeA:
undetectable		 5ljeA-3eoeA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 151
ILE A 214
THR A 218
TRP A 187
 NAD  A 500 ( 4.1A)
None
None
None
 1.38A 5ljeA-3h3jA:
undetectable		 5ljeA-3h3jA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 115
ILE A 270
THR A 110
MET A 271
 None
 1.29A 5ljeA-3i6tA:
undetectable		 5ljeA-3i6tA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF19

(Schizosaccharomyces
pombe) 		no annotation 4 LEU c 437
ILE c 470
MET c 474
TRP c 568
 None
 1.27A 5ljeA-3jb9c:
undetectable		 5ljeA-3jb9c:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khd PYRUVATE KINASE

(Plasmodium
falciparum) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 347
ILE A 319
THR A 350
MET A 324
 None
 1.27A 5ljeA-3khdA:
undetectable		 5ljeA-3khdA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Rhodopseudomonas
palustris) 		PF00551
(Formyl_trans_N) 		4 LEU A 171
ILE A 138
TRP A 109
MET A 116
 None
 1.39A 5ljeA-3obiA:
undetectable		 5ljeA-3obiA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		4 LEU A 168
ILE A 301
THR A 235
TRP A 278
 None
 1.10A 5ljeA-3qwtA:
undetectable		 5ljeA-3qwtA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 LEU A 239
ILE A 301
THR A 305
MET A 279
 None
 1.37A 5ljeA-3t05A:
undetectable		 5ljeA-3t05A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		4 ILE A 255
THR A 253
MET A 195
MET A 213
 None
 1.22A 5ljeA-3t7bA:
undetectable		 5ljeA-3t7bA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE

(Coxiella
burnetii) 		PF00155
(Aminotran_1_2) 		4 LEU A 105
ILE A 235
THR A 252
MET A 206
 None
 1.34A 5ljeA-3tqxA:
undetectable		 5ljeA-3tqxA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 LEU A 146
ILE A 200
THR A 196
TRP A 170
 NAP  A 552 (-4.2A)
None
NAP  A 552 (-3.5A)
None
 1.08A 5ljeA-3up4A:
undetectable		 5ljeA-3up4A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 257
ILE A 239
THR A 268
TRP A 341
 NAG  A 601 ( 4.4A)
None
None
None
 1.44A 5ljeA-3vlaA:
undetectable		 5ljeA-3vlaA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 257
ILE A 270
THR A 268
TRP A 341
 NAG  A 601 ( 4.4A)
None
None
None
 1.22A 5ljeA-3vlaA:
undetectable		 5ljeA-3vlaA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu1 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0242

(Pyrococcus
horikoshii) 		no annotation 4 LEU A 871
ILE A 876
MET A 897
TRP A 562
 None
 1.41A 5ljeA-3vu1A:
undetectable		 5ljeA-3vu1A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		4 LEU A 306
ILE A 150
THR A 462
MET A 198
 None
 1.31A 5ljeA-3zs6A:
undetectable		 5ljeA-3zs6A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A  36
ILE A  70
MET A  77
MET A  96
 None
 1.37A 5ljeA-4aieA:
undetectable		 5ljeA-4aieA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		4 LEU A 152
ILE A 334
MET A 330
TRP A 348
 None
 1.04A 5ljeA-4b0tA:
undetectable		 5ljeA-4b0tA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 LEU A 168
ILE A 155
THR A 159
MET A 184
 None
 1.43A 5ljeA-4evqA:
undetectable		 5ljeA-4evqA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		4 LEU A 304
ILE A 329
THR A  93
MET A 321
 None
None
None
PGE  A 502 (-4.4A)
 1.25A 5ljeA-4exkA:
undetectable		 5ljeA-4exkA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 LEU A 154
ILE A 160
THR A 159
TRP A 300
 None
 1.41A 5ljeA-4hooA:
undetectable		 5ljeA-4hooA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig7 UBIQUITIN C-TERMINAL
HYDROLASE 37

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		4 LEU A   8
ILE A  50
MET A 219
MET A  19
 None
 1.44A 5ljeA-4ig7A:
undetectable		 5ljeA-4ig7A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 LEU A 287
ILE A 219
THR A 238
MET A 193
 None
 1.12A 5ljeA-4imdA:
undetectable		 5ljeA-4imdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		4 LEU A  52
ILE A 252
THR A 286
MET A 186
 None
 1.25A 5ljeA-4pmzA:
undetectable		 5ljeA-4pmzA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 LEU B  23
ILE B 345
MET B 322
TRP B 366
 None
 1.26A 5ljeA-4pswB:
undetectable		 5ljeA-4pswB:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 LEU A 366
ILE A 223
MET A 217
MET A 248
 None
 1.30A 5ljeA-4r6hA:
undetectable		 5ljeA-4r6hA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdj CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 LEU A 484
ILE A 251
MET A 242
MET A 495
 None
 1.34A 5ljeA-4rdjA:
undetectable		 5ljeA-4rdjA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmx PHI92_GP150

(Enterobacteria
phage phi92) 		no annotation 4 LEU A 317
ILE A 251
TRP A 284
MET A 304
 None
 1.44A 5ljeA-4rmxA:
undetectable		 5ljeA-4rmxA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		4 ILE A  37
THR A 274
TRP A  45
MET A 256
 None
 1.15A 5ljeA-4ryeA:
undetectable		 5ljeA-4ryeA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Listeria
monocytogenes) 		PF00574
(CLP_protease) 		4 LEU H 126
ILE H 120
MET H 175
MET H 154
 None
None
None
MLI  H 301 ( 4.6A)
 0.91A 5ljeA-4ryfH:
undetectable		 5ljeA-4ryfH:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u65 PUTATIVE CYSTINE
PROTEASE

(Pseudomonas
fluorescens) 		PF06035
(Peptidase_C93) 		4 LEU E  65
ILE E 140
THR E 123
TRP E 233
 None
 1.41A 5ljeA-4u65E:
undetectable		 5ljeA-4u65E:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 LEU A 328
ILE A 353
THR A 117
MET A 345
 None
 1.31A 5ljeA-4wrnA:
undetectable		 5ljeA-4wrnA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		4 LEU A 156
ILE A 140
THR A 149
MET A  69
 None
 1.44A 5ljeA-4yfmA:
undetectable		 5ljeA-4yfmA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		4 LEU B 318
ILE B 307
THR B 311
MET B 290
 None
 1.25A 5ljeA-4yg8B:
undetectable		 5ljeA-4yg8B:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 LEU D 487
ILE D 340
THR D 380
TRP D 337
 None
 1.38A 5ljeA-5a6bD:
undetectable		 5ljeA-5a6bD:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 LEU A 763
ILE A 768
MET A 789
TRP A 458
 None
 1.35A 5ljeA-5azaA:
undetectable		 5ljeA-5azaA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 LEU A 107
ILE A 132
TRP A 128
MET A 187
 None
 1.41A 5ljeA-5djqA:
undetectable		 5ljeA-5djqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej2 CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 LEU A 207
ILE A 135
MET A 132
MET A 215
 None
NAD  A 300 (-3.8A)
None
NAD  A 300 (-3.6A)
 1.34A 5ljeA-5ej2A:
undetectable		 5ljeA-5ej2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvd NUCLEOCAPSID

(Human
metapneumovirus) 		PF03246
(Pneumo_ncap) 		4 LEU A 302
ILE A 176
THR A 175
TRP A 261
 None
 1.29A 5ljeA-5fvdA:
undetectable		 5ljeA-5fvdA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 LEU B 667
ILE B 845
THR B 839
TRP B 847
 None
 1.36A 5ljeA-5gjeB:
undetectable		 5ljeA-5gjeB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo sapiens) 		PF01853
(MOZ_SAS) 		4 LEU A 514
ILE A 457
THR A 477
MET A 446
 ACO  A 702 (-3.4A)
None
ACO  A 702 (-3.0A)
None
 1.23A 5ljeA-5gk9A:
undetectable		 5ljeA-5gk9A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 LEU A 305
ILE A 330
THR A  94
MET A 322
 None
 1.29A 5ljeA-5h7nA:
undetectable		 5ljeA-5h7nA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 LEU A 195
ILE A 206
THR A 202
MET A 323
 None
 1.02A 5ljeA-5hyhA:
undetectable		 5ljeA-5hyhA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		4 LEU B 143
ILE B 218
THR B 196
MET B 220
 None
 1.39A 5ljeA-5kswB:
undetectable		 5ljeA-5kswB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		4 LEU M 216
ILE M 270
THR M 272
TRP M 267
 None
 1.41A 5ljeA-5lc5M:
undetectable		 5ljeA-5lc5M:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		4 LEU B 342
ILE B 409
THR B 395
MET B 384
 None
 1.36A 5ljeA-5lxzB:
undetectable		 5ljeA-5lxzB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A1947
ILE A1901
THR A1903
MET A1932
 None
 1.11A 5ljeA-5m59A:
undetectable		 5ljeA-5m59A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A1947
ILE A1901
THR A1903
MET A1997
 None
 1.14A 5ljeA-5m59A:
undetectable		 5ljeA-5m59A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 4 LEU A 237
ILE A 253
THR A 218
MET A 198
 None
 1.41A 5ljeA-5oatA:
undetectable		 5ljeA-5oatA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 4 LEU A 218
ILE A 240
THR A 235
MET A 189
 None
 1.23A 5ljeA-5oj3A:
undetectable		 5ljeA-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 LEU A 129
ILE A  88
THR A 259
TRP A  52
 None
 1.24A 5ljeA-5t1pA:
undetectable		 5ljeA-5t1pA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 4 LEU A 341
ILE A 407
THR A 403
TRP A 287
 None
 1.44A 5ljeA-5ukhA:
undetectable		 5ljeA-5ukhA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F

(Homo sapiens) 		no annotation 4 LEU A 357
ILE A 199
MET A 195
TRP A 217
 None
 1.33A 5ljeA-5w2mA:
undetectable		 5ljeA-5w2mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xta VIRK PROTEIN

(Legionella
pneumophila) 		PF06903
(VirK) 		4 LEU A  95
ILE A  90
THR A  92
MET A 108
 None
 1.29A 5ljeA-5xtaA:
undetectable		 5ljeA-5xtaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Homo sapiens) 		PF15879
(MWFE) 		4 LEU s 103
ILE s  81
THR s 108
MET s 233
 None
 1.35A 5ljeA-5xtds:
undetectable		 5ljeA-5xtds:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 4 LEU A 384
ILE A 409
THR A 173
MET A 401
 None
 1.19A 5ljeA-6anvA:
undetectable		 5ljeA-6anvA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 4 LEU A   8
ILE A 119
THR A 121
TRP A  42
 None
 1.26A 5ljeA-6c29A:
undetectable		 5ljeA-6c29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 LEU A 232
ILE A  29
MET A  41
TRP A 183
 None
 1.35A 5ljeA-6c66A:
undetectable		 5ljeA-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfz ASK1
DAD2
HSK3

(Chaetomium
thermophilum;
Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation
no annotation 		4 LEU A  50
ILE C  73
THR C  70
MET G  59
 None
 1.15A 5ljeA-6cfzA:
undetectable		 5ljeA-6cfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 4 LEU R  65
ILE R  95
THR R  91
MET R 180
 None
None
ADN  R 400 (-3.6A)
ADN  R 400 (-4.6A)
 1.32A 5ljeA-6d9hR:
undetectable		 5ljeA-6d9hR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 4 LEU L 283
ILE L 273
THR L 276
MET L 214
 None
 1.42A 5ljeA-6g2jL:
undetectable		 5ljeA-6g2jL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Mus musculus) 		no annotation 4 LEU N 232
ILE N 297
THR N 300
MET N 175
 None
 1.43A 5ljeA-6g72N:
undetectable		 5ljeA-6g72N:
undetectable