SIMILAR PATTERNS OF AMINO ACIDS FOR 5LJE_A_RTLA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci7 PROTEIN (THYMIDYLATE
SYNTHASE)

(Pneumocystis
carinii) 		PF00303
(Thymidylat_synt) 		5 PHE A  49
LEU A 216
ALA A 212
PHE A 209
ILE A  63
 None
None
None
CB3  A 768 (-3.6A)
None
 1.12A 5ljeA-1ci7A:
undetectable		 5ljeA-1ci7A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 PHE A 135
LEU A 139
LEU A 182
ALA A 187
LEU A 198
 None
 0.85A 5ljeA-1ee8A:
0.0		 5ljeA-1ee8A:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 LEU A  20
ALA A  33
PRO A  38
SER A  55
PHE A  57
TYR A  60
LEU A 117
 None
 0.61A 5ljeA-1gglA:
23.2		 5ljeA-1gglA:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 LEU A  20
ALA A  33
SER A  55
PHE A  57
ARG A  58
TYR A  60
LEU A 117
 None
 0.71A 5ljeA-1gglA:
23.2		 5ljeA-1gglA:
54.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		5 LEU A1275
PRO A1316
SER A1318
TYR A1301
LEU A1312
 None
 1.11A 5ljeA-1jl5A:
undetectable		 5ljeA-1jl5A:
13.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
ALA A  33
PRO A  38
SER A  55
ARG A  58
LEU A 117
 None
 0.74A 5ljeA-1lpjA:
24.8		 5ljeA-1lpjA:
55.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 PHE A  16
LEU A  20
LEU A  29
ALA A  33
PRO A  38
ARG A  58
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.7A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
 0.88A 5ljeA-1mx8A:
19.8		 5ljeA-1mx8A:
94.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 PHE A  16
LEU A  20
LEU A  29
ALA A  33
SER A  55
ARG A  58
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.7A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
 0.79A 5ljeA-1mx8A:
19.8		 5ljeA-1mx8A:
94.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
LEU A  29
ALA A  33
PRO A  38
ARG A  58
TYR A  60
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 ( 4.6A)
RTL  A 135 (-3.5A)
 0.82A 5ljeA-1mx8A:
19.8		 5ljeA-1mx8A:
94.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
LEU A  29
ALA A  33
SER A  55
ARG A  58
TYR A  60
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 ( 4.6A)
RTL  A 135 (-3.5A)
 0.86A 5ljeA-1mx8A:
19.8		 5ljeA-1mx8A:
94.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqz COA PYROPHOSPHATASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		5 LEU A 127
LEU A 130
LEU A 188
ILE A 122
LEU A 144
 None
 1.02A 5ljeA-1nqzA:
0.0		 5ljeA-1nqzA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o8v FATTY ACID BINDING
PROTEIN HOMOLOG

(Echinococcus
granulosus) 		PF00061
(Lipocalin) 		5 PHE A  16
PRO A  38
LEU A  40
SER A  56
PHE A  58
 PLM  A1136 (-4.7A)
None
None
PLM  A1136 ( 3.8A)
PLM  A1136 ( 4.9A)
 1.09A 5ljeA-1o8vA:
19.9		 5ljeA-1o8vA:
32.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		5 LEU A 454
ALA A 505
PRO A 427
ILE A 154
LEU A 187
 None
 0.96A 5ljeA-1ohfA:
1.9		 5ljeA-1ohfA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		5 PHE B  56
LEU B  60
ALA B  88
LEU B  17
LEU B  14
 None
 1.07A 5ljeA-1ox4B:
undetectable		 5ljeA-1ox4B:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		5 PHE B  56
LEU B 102
ALA B  88
LEU B  17
LEU B  14
 None
 1.04A 5ljeA-1ox4B:
undetectable		 5ljeA-1ox4B:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 168
LEU A 194
ALA A 189
SER A 183
TYR A 180
 None
 1.14A 5ljeA-1pg5A:
undetectable		 5ljeA-1pg5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		5 LEU A 478
ALA A 461
LEU A 449
PHE A 433
ILE A 389
 None
 0.96A 5ljeA-1qxpA:
undetectable		 5ljeA-1qxpA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN
ECDYSONE RECEPTOR

(Heliothis
virescens;
Heliothis
virescens) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE D 487
LEU D 491
LEU A 419
ALA A 415
ILE D 443
 None
 0.79A 5ljeA-1r20D:
undetectable		 5ljeA-1r20D:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN
ECDYSONE RECEPTOR

(Heliothis
virescens;
Heliothis
virescens) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE D 487
LEU D 491
LEU A 419
ALA A 415
TYR D 465
 None
 0.94A 5ljeA-1r20D:
undetectable		 5ljeA-1r20D:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5c CENTROMERIC PROTEIN
E

(Homo sapiens) 		PF00225
(Kinesin) 		5 LEU A 167
LEU A 296
ARG A 208
ILE A 206
LEU A 265
 None
 1.12A 5ljeA-1t5cA:
undetectable		 5ljeA-1t5cA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965

(Mycobacterium
tuberculosis) 		PF01068
(DNA_ligase_A_M)
PF04679
(DNA_ligase_A_C) 		5 LEU A 581
LEU A 590
ALA A 558
LEU A 458
LEU A 570
 None
 1.12A 5ljeA-1vs0A:
undetectable		 5ljeA-1vs0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 168
LEU A 165
ALA A 164
LEU A 131
LEU A 117
 None
 1.14A 5ljeA-1vzoA:
undetectable		 5ljeA-1vzoA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 137
ALA A 112
LEU A 253
PHE A 109
LEU A 239
 None
 1.12A 5ljeA-1wwkA:
undetectable		 5ljeA-1wwkA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyz PUTATIVE
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A   8
LEU A  47
LEU A  77
PHE A  61
ILE A  32
 None
 1.08A 5ljeA-1wyzA:
undetectable		 5ljeA-1wyzA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 PHE A 257
LEU A 241
ALA A 204
LEU A 277
LEU A 280
 None
 1.09A 5ljeA-2e0pA:
undetectable		 5ljeA-2e0pA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 PHE A  92
LEU A 101
LEU A  66
TYR A  50
LEU A  83
 None
 1.00A 5ljeA-2enoA:
undetectable		 5ljeA-2enoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iay HYPOTHETICAL PROTEIN

(Lactobacillus
plantarum) 		PF08866
(DUF1831) 		5 LEU A  18
LEU A  66
LEU A  58
PHE A  40
ILE A 109
 None
 1.02A 5ljeA-2iayA:
undetectable		 5ljeA-2iayA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihd REGULATOR OF
G-PROTEIN SIGNALING
8

(Homo sapiens) 		PF00615
(RGS) 		5 PHE A  57
LEU A  61
LEU A  87
ARG A  71
LEU A 163
 None
 1.11A 5ljeA-2ihdA:
undetectable		 5ljeA-2ihdA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE

(Homo sapiens) 		PF00168
(C2) 		5 LEU A 122
LEU A  29
ALA A  27
LEU A  69
TYR A  42
 None
 1.05A 5ljeA-2nq3A:
undetectable		 5ljeA-2nq3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyg YOKD PROTEIN

(Bacillus
subtilis) 		PF02522
(Antibiotic_NAT) 		5 LEU A 252
LEU A 161
LEU A  56
PHE A 135
LEU A  27
 None
 1.14A 5ljeA-2nygA:
undetectable		 5ljeA-2nygA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		5 PHE A 133
LEU A 268
ALA A 137
PHE A 194
LEU A 285
 None
 0.95A 5ljeA-2qvlA:
undetectable		 5ljeA-2qvlA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r94 2-KETO-3-DEOXY-(6-PH
OSPHO-)GLUCONATE
ALDOLASE

(Thermoproteus
tenax) 		PF00701
(DHDPS) 		5 LEU A 293
ALA A 262
LEU A 224
ILE A 269
LEU A 246
 None
 1.12A 5ljeA-2r94A:
undetectable		 5ljeA-2r94A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		5 LEU A  93
LEU A 100
ALA A 124
LEU A 136
ILE A  89
 None
 1.04A 5ljeA-2rjoA:
undetectable		 5ljeA-2rjoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rnn E3 SUMO-PROTEIN
LIGASE SIZ1

(Saccharomyces
cerevisiae) 		PF02037
(SAP) 		5 LEU A 104
LEU A  37
PHE A  87
ARG A  91
LEU A  60
 None
 1.05A 5ljeA-2rnnA:
undetectable		 5ljeA-2rnnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 LEU A 263
LEU A 257
ALA A 266
TYR A 133
LEU A 285
 None
 1.10A 5ljeA-2vk9A:
undetectable		 5ljeA-2vk9A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 LEU A 446
ALA A 485
LEU A 195
ILE A 458
LEU A 521
 None
 1.07A 5ljeA-2w5fA:
undetectable		 5ljeA-2w5fA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn2 DISCOIDIN-1 SUBUNIT
A

(Dictyostelium
discoideum) 		PF00754
(F5_F8_type_C)
PF09458
(H_lectin) 		5 PHE A  71
ALA A 129
LEU A  17
ILE A  91
LEU A  10
 None
 1.08A 5ljeA-2wn2A:
undetectable		 5ljeA-2wn2A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxz ANGIOTENSINOGEN

(Rattus
norvegicus) 		PF00079
(Serpin) 		5 LEU A 372
ALA A 376
PRO A 386
LEU A 185
LEU A 177
 None
 1.13A 5ljeA-2wxzA:
undetectable		 5ljeA-2wxzA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		5 LEU A 266
LEU A 286
ALA A 259
LEU A 443
ARG A 256
 None
 1.02A 5ljeA-2z5lA:
undetectable		 5ljeA-2z5lA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byv RHOPTRY KINASE

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 PHE A 380
LEU A 384
ALA A 398
ARG A 221
ILE A 222
 None
 1.08A 5ljeA-3byvA:
undetectable		 5ljeA-3byvA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		6 PHE A 215
LEU A 148
ALA A 212
PRO A 165
PHE A 211
ILE A 141
 None
None
None
None
BEZ  A 261 (-3.6A)
None
 1.46A 5ljeA-3ccfA:
undetectable		 5ljeA-3ccfA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		5 PHE A 344
LEU A 304
LEU A 302
ILE A 294
LEU A 363
 None
 1.12A 5ljeA-3e38A:
undetectable		 5ljeA-3e38A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emu LEUCINE RICH REPEAT
AND PHOSPHATASE
DOMAIN CONTAINING
PROTEIN

(Entamoeba
histolytica) 		PF00782
(DSPc) 		5 LEU A 372
LEU A 444
ALA A 406
ILE A 376
LEU A 360
 None
 1.13A 5ljeA-3emuA:
undetectable		 5ljeA-3emuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		5 PHE A 193
LEU A 238
ALA A 189
ILE A 166
LEU A  55
 None
 1.05A 5ljeA-3fmcA:
undetectable		 5ljeA-3fmcA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grf ORNITHINE
CARBAMOYLTRANSFERASE

(Giardia
intestinalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  61
ALA A 127
PRO A 134
LEU A  15
LEU A  23
 None
 1.00A 5ljeA-3grfA:
undetectable		 5ljeA-3grfA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		5 PHE A 253
LEU A 249
LEU A  69
ALA A 252
ILE A 240
 None
 1.13A 5ljeA-3kn1A:
undetectable		 5ljeA-3kn1A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE

(Thermococcus
sibiricus) 		PF00106
(adh_short) 		5 LEU A  28
LEU A  45
ALA A  22
ARG A  19
LEU A 133
 None
 1.05A 5ljeA-3l77A:
undetectable		 5ljeA-3l77A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lke ENOYL-COA HYDRATASE

(Bacillus
halodurans) 		PF00378
(ECH_1) 		5 LEU A 251
LEU A 254
PRO A  66
LEU A 147
LEU A  87
 None
 1.10A 5ljeA-3lkeA:
undetectable		 5ljeA-3lkeA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum) 		PF01593
(Amino_oxidase) 		5 LEU A 281
ALA A 437
LEU A  71
ILE A 457
LEU A 241
 None
 1.12A 5ljeA-3lovA:
undetectable		 5ljeA-3lovA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE

(Exiguobacterium
sibiricum) 		PF01212
(Beta_elim_lyase) 		5 PHE A 289
ALA A 264
LEU A 274
ARG A 344
ILE A  15
 None
 1.08A 5ljeA-3lwsA:
undetectable		 5ljeA-3lwsA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  74
ALA A  21
PRO A  17
LEU A  14
LEU A 313
 None
 1.11A 5ljeA-3m9vA:
undetectable		 5ljeA-3m9vA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		5 LEU A 177
ALA A 155
LEU A 124
ILE A 163
LEU A 228
 None
 1.02A 5ljeA-3ndcA:
undetectable		 5ljeA-3ndcA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		5 LEU A 459
ALA A 510
PRO A 432
ILE A 157
LEU A 190
 None
 0.90A 5ljeA-3s6pA:
2.1		 5ljeA-3s6pA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc3 PUTATIVE DNA
REPLICATION
REGULATOR HDA

(Shewanella
amazonensis) 		PF00308
(Bac_DnaA) 		5 LEU A  42
ALA A  45
LEU A 128
ILE A  68
LEU A 101
 None
 1.03A 5ljeA-3sc3A:
undetectable		 5ljeA-3sc3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		5 LEU A 639
ALA A 529
PRO A 692
LEU A 696
LEU A 689
 None
 1.06A 5ljeA-3vmnA:
undetectable		 5ljeA-3vmnA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 LEU A 315
LEU A 310
ALA A 174
LEU A 185
LEU A 324
 None
 1.03A 5ljeA-3wafA:
undetectable		 5ljeA-3wafA:
16.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
ALA A  33
PRO A  38
SER A  55
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.2A)
None
 0.77A 5ljeA-3wbgA:
20.7		 5ljeA-3wbgA:
33.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amh DISKS LARGE HOMOLOG
1

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A  65
ALA A  76
LEU A 102
TYR A  85
LEU A  51
 None
 0.98A 5ljeA-4amhA:
undetectable		 5ljeA-4amhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		5 LEU A  61
ALA A  60
PRO A 406
LEU A 318
SER A 404
 None
GOL  A1436 ( 3.7A)
None
None
None
 1.05A 5ljeA-4aoaA:
undetectable		 5ljeA-4aoaA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		5 PHE A 695
LEU A 692
LEU A 688
ALA A 703
TYR A 752
 None
 0.91A 5ljeA-4cekA:
undetectable		 5ljeA-4cekA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14
RNA15

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		PF05843
(Suf)
PF14327
(CSTF2_hinge) 		5 LEU G 164
ALA G 168
LEU G 179
ILE A 627
LEU A 654
 None
 1.07A 5ljeA-4ebaG:
undetectable		 5ljeA-4ebaG:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ekc REGULATOR OF
G-PROTEIN SIGNALING
2

(Homo sapiens) 		PF00615
(RGS) 		5 PHE B  84
LEU B  88
LEU B 114
ARG B  98
LEU B 190
 None
 1.11A 5ljeA-4ekcB:
undetectable		 5ljeA-4ekcB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 129
LEU A 161
LEU A 281
TYR A 185
LEU A 277
 None
 1.14A 5ljeA-4ez5A:
undetectable		 5ljeA-4ez5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 LEU A 222
ALA A 248
LEU A 300
ILE A 260
LEU A 323
 None
 1.03A 5ljeA-4fd0A:
undetectable		 5ljeA-4fd0A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 LEU A 222
ALA A 248
LEU A 300
PHE A 227
LEU A 323
 None
 1.11A 5ljeA-4fd0A:
undetectable		 5ljeA-4fd0A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 LEU A 222
ALA A 248
LEU A 300
PHE A 227
LEU A 323
 None
 1.05A 5ljeA-4fdwA:
undetectable		 5ljeA-4fdwA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 PHE A 259
LEU A 263
ALA A 281
LEU A 291
LEU A 228
 None
 1.12A 5ljeA-4fidA:
undetectable		 5ljeA-4fidA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 LEU B 355
SER B 132
PHE B 136
TYR B  77
LEU B  80
 None
 1.13A 5ljeA-4gnkB:
undetectable		 5ljeA-4gnkB:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h32 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 PHE A 115
LEU A  75
LEU A 175
TYR A 253
LEU A 173
 None
 1.02A 5ljeA-4h32A:
undetectable		 5ljeA-4h32A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3c BILIRUBIN-INDUCIBLE
FLUORESCENT PROTEIN
UNAG

(Anguilla
japonica) 		PF00061
(Lipocalin) 		5 PHE A  17
LEU A  21
LEU A  30
PRO A  39
LEU A  41
 BLR  A 200 (-3.6A)
BLR  A 200 (-3.7A)
BLR  A 200 (-3.6A)
None
BLR  A 200 (-4.1A)
 1.05A 5ljeA-4i3cA:
19.0		 5ljeA-4i3cA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9s GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00657
(Lipase_GDSL) 		5 LEU A 253
ALA A 258
LEU A  91
SER A 230
LEU A 386
 None
 1.11A 5ljeA-4k9sA:
undetectable		 5ljeA-4k9sA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR

(Pediculus
humanus;
Pediculus
humanus) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE E 477
LEU E 481
LEU U 353
ALA U 349
ILE E 435
 None
 0.76A 5ljeA-4oztE:
undetectable		 5ljeA-4oztE:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR

(Pediculus
humanus;
Pediculus
humanus) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		5 PHE E 477
LEU E 481
LEU U 353
ALA U 349
TYR E 457
 None
 0.96A 5ljeA-4oztE:
undetectable		 5ljeA-4oztE:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Escherichia
fergusonii) 		PF03480
(DctP) 		5 LEU A 154
PRO A 109
LEU A 311
PHE A 300
ILE A 183
 None
None
IOD  A 436 ( 4.4A)
None
None
 1.09A 5ljeA-4p1eA:
undetectable		 5ljeA-4p1eA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 LEU A 175
ALA A 154
PRO A 180
LEU A 302
LEU A 306
 None
 1.09A 5ljeA-4pf1A:
undetectable		 5ljeA-4pf1A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00782
(DSPc)
PF16561
(AMPK1_CBM) 		5 LEU A 228
ALA A 209
LEU A 111
SER A 198
LEU A 120
 None
None
None
PO4  A 408 (-2.5A)
None
 1.14A 5ljeA-4pyhA:
undetectable		 5ljeA-4pyhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlq BENZOATE-COENZYME A
LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 442
ALA A 467
PRO A 465
TYR A 495
ILE A 486
 None
 1.07A 5ljeA-4rlqA:
undetectable		 5ljeA-4rlqA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 LEU D 277
LEU D 270
ALA D 269
LEU D 108
LEU D 112
 None
 1.06A 5ljeA-4s1vD:
undetectable		 5ljeA-4s1vD:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz0 NUCLEOLAR PROTEIN 3

(Homo sapiens) 		PF00619
(CARD) 		5 LEU A  19
ALA A  80
LEU A  40
ILE A  12
LEU A  48
 None
 1.12A 5ljeA-4uz0A:
undetectable		 5ljeA-4uz0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00144
(Beta-lactamase) 		5 LEU A 135
LEU A 188
ALA A 115
SER A 125
TYR A 161
 None
 1.09A 5ljeA-4x68A:
undetectable		 5ljeA-4x68A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00701
(DHDPS) 		5 LEU A  54
ALA A 277
LEU A 266
PHE A 280
LEU A  30
 None
 0.96A 5ljeA-4xkyA:
undetectable		 5ljeA-4xkyA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7m TYPE VI SECRETION
PROTEIN ICMF

(Escherichia
coli) 		PF06744
(IcmF_C) 		5 LEU C1094
LEU C 994
ARG C1049
ILE C1048
LEU C 981
 None
 1.10A 5ljeA-4y7mC:
undetectable		 5ljeA-4y7mC:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		6 LEU A 416
LEU A 393
LEU A 475
SER A 448
PHE A 424
LEU A 478
 None
 1.29A 5ljeA-4z61A:
undetectable		 5ljeA-4z61A:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		6 LEU A 406
LEU A 383
LEU A 465
SER A 438
PHE A 414
LEU A 468
 None
 1.35A 5ljeA-4z64A:
undetectable		 5ljeA-4z64A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 5 LEU A1364
LEU A1316
ARG A1262
ILE A1273
LEU A1293
 None
 1.12A 5ljeA-5b2oA:
undetectable		 5ljeA-5b2oA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		5 PHE A 311
LEU A 331
PRO A 212
LEU A 252
LEU A 225
 None
None
UNX  A 605 ( 4.3A)
None
None
 1.03A 5ljeA-5e26A:
undetectable		 5ljeA-5e26A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9c HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 PHE A 363
LEU A 311
ALA A 360
LEU A 479
LEU A 524
 None
 1.08A 5ljeA-5e9cA:
undetectable		 5ljeA-5e9cA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		5 LEU A 110
LEU A 162
ALA A  90
SER A 100
TYR A 135
 None
 1.10A 5ljeA-5evlA:
undetectable		 5ljeA-5evlA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		5 PRO A 543
SER A 126
PHE A 560
ILE A 573
LEU A 583
 None
 1.13A 5ljeA-5feiA:
undetectable		 5ljeA-5feiA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 PHE b 433
LEU b 102
ALA b 436
LEU b 135
LEU b 132
 None
 1.04A 5ljeA-5gw5b:
undetectable		 5ljeA-5gw5b:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 PHE A 486
ALA A  87
LEU A 165
ILE A  73
LEU A 210
 None
None
FAD  A 501 (-4.8A)
None
None
 1.09A 5ljeA-5l6fA:
undetectable		 5ljeA-5l6fA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 PHE A 363
LEU A 311
ALA A 360
LEU A 479
LEU A 524
 None
 1.12A 5ljeA-5la7A:
undetectable		 5ljeA-5la7A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		5 LEU A 317
LEU A 339
ALA A 323
ILE A 404
LEU A  81
 None
 1.11A 5ljeA-5mqsA:
undetectable		 5ljeA-5mqsA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 5 LEU A1207
LEU A1178
SER A1146
ILE A1115
LEU A1095
 None
 1.12A 5ljeA-5ng6A:
undetectable		 5ljeA-5ng6A:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 5 PHE A  81
SER A 182
PHE A 183
TYR A 128
ILE A 195
 None
 1.12A 5ljeA-5nnyA:
undetectable		 5ljeA-5nnyA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
RETINOIC ACID
RECEPTOR BETA

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 PHE B 367
LEU B 371
LEU A 420
ALA A 416
ILE B 325
 None
 1.01A 5ljeA-5uanB:
undetectable		 5ljeA-5uanB:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis) 		PF00291
(PALP) 		5 LEU A  24
LEU A 274
ALA A 277
LEU A 166
ILE A  19
 None
 1.13A 5ljeA-5xw3A:
undetectable		 5ljeA-5xw3A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6j NUCLEOPROTEIN

(Tomato spotted
wilt
orthotospovirus) 		PF01533
(Tospo_nucleocap) 		5 LEU A 150
ALA A 167
TYR A 215
ILE A 162
LEU A 132
 None
 1.13A 5ljeA-5y6jA:
undetectable		 5ljeA-5y6jA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 5 LEU A 843
LEU A 875
LEU A1001
TYR A 901
LEU A 997
 None
 1.10A 5ljeA-6b3eA:
undetectable		 5ljeA-6b3eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gi2 FERRIC ENTEROBACTIN
ESTERASE

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A 174
LEU A 153
LEU A 162
ILE A  86
LEU A 146
 None
 1.02A 5ljeA-6gi2A:
undetectable		 5ljeA-6gi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 LEU A 535
ILE A 409
THR A 487
TRP A 404
 None
 1.38A 5ljeA-1cb8A:
0.0		 5ljeA-1cb8A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		4 LEU B 143
ILE B 218
THR B 196
MET B 220
 None
 1.40A 5ljeA-1ep2B:
0.1		 5ljeA-1ep2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 LEU A 107
ILE A 237
THR A 254
MET A 208
 None
 1.43A 5ljeA-1fc4A:
0.0		 5ljeA-1fc4A:
15.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  36
ILE A  51
THR A  53
TRP A 106
MET A 119
 None
 0.36A 5ljeA-1lpjA:
24.8		 5ljeA-1lpjA:
55.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  57
ILE A  51
THR A  53
TRP A 106
MET A 119
 None
 1.20A 5ljeA-1lpjA:
24.8		 5ljeA-1lpjA:
55.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		4 LEU A 225
ILE A 172
THR A 171
MET A 401
 None
 1.40A 5ljeA-1lxyA:
0.0		 5ljeA-1lxyA:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 LEU A  36
ILE A  51
THR A  53
MET A  62
 RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.3A)
RTL  A 135 (-2.9A)
 0.86A 5ljeA-1mx8A:
19.8		 5ljeA-1mx8A:
94.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		4 LEU A 661
ILE A 519
MET A 517
TRP A 466
 None
 0.99A 5ljeA-1nphA:
0.0		 5ljeA-1nphA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 161
ILE A 126
THR A 128
MET A 124
 None
 1.28A 5ljeA-1ofuA:
0.0		 5ljeA-1ofuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 ILE A 256
THR A 254
MET A 196
MET A 214
 None
None
None
ADP  A1259 (-4.5A)
 1.22A 5ljeA-1oh9A:
undetectable		 5ljeA-1oh9A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 LEU A 360
ILE A 143
THR A 233
MET A 167
 None
 1.43A 5ljeA-1qonA:
undetectable		 5ljeA-1qonA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqf PROTEIN (COMPLEMENT
C3DG)

(Rattus
norvegicus) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 LEU A1088
ILE A1016
THR A1019
MET A1129
 None
 1.44A 5ljeA-1qqfA:
undetectable		 5ljeA-1qqfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r45 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
phage c-st) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A 212
ILE A 173
THR A 175
MET A 120
 None
 1.35A 5ljeA-1r45A:
undetectable		 5ljeA-1r45A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 ILE A 361
THR A 381
TRP A 305
MET A 302
 None
 1.40A 5ljeA-1s4fA:
undetectable		 5ljeA-1s4fA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 LEU A 613
ILE A 500
THR A 619
MET A 485
 None
 1.42A 5ljeA-1wkbA:
undetectable		 5ljeA-1wkbA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 LEU A 613
ILE A 500
THR A 619
MET A 485
 None
 1.40A 5ljeA-1wz2A:
undetectable		 5ljeA-1wz2A:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE

(Entamoeba
histolytica) 		PF05770
(Ins134_P3_kin) 		4 LEU X 247
ILE X 177
THR X 191
MET X 256
 None
ADP  X 871 (-4.6A)
None
None
 1.36A 5ljeA-1z2oX:
undetectable		 5ljeA-1z2oX:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		4 LEU A 279
ILE A 247
MET A 215
TRP A  59
 None
 1.09A 5ljeA-2b81A:
undetectable		 5ljeA-2b81A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 LEU A 241
ILE A 303
THR A 307
MET A 281
 None
 1.36A 5ljeA-2e28A:
undetectable		 5ljeA-2e28A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 LEU A 264
ILE A 303
THR A 307
MET A 281
 None
 1.38A 5ljeA-2e28A:
undetectable		 5ljeA-2e28A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 179
ILE A 410
THR A 412
MET A 414
 None
 1.44A 5ljeA-2iikA:
undetectable		 5ljeA-2iikA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Escherichia
coli) 		PF04381
(RdgC) 		4 LEU A   7
ILE A 280
THR A 283
MET A   1
 None
 1.24A 5ljeA-2owlA:
undetectable		 5ljeA-2owlA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU B  54
ILE B 221
THR B 197
MET B 217
 None
 1.14A 5ljeA-2po2B:
undetectable		 5ljeA-2po2B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 LEU A 370
ILE A 106
TRP A  47
MET A  44
 None
None
None
LOP  A 503 (-4.2A)
 1.28A 5ljeA-2qjpA:
undetectable		 5ljeA-2qjpA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 161
ILE A 126
THR A 128
MET A 124
 None
 1.33A 5ljeA-2vawA:
undetectable		 5ljeA-2vawA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		4 LEU A 304
ILE A 329
THR A  93
MET A 321
 None
 1.31A 5ljeA-2vgqA:
undetectable		 5ljeA-2vgqA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 1.02A 5ljeA-2w21A:
undetectable		 5ljeA-2w21A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2i 2-OXOGLUTARATE
OXYGENASE

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 LEU A 151
ILE A 157
THR A 156
TRP A 297
 None
 1.34A 5ljeA-2w2iA:
undetectable		 5ljeA-2w2iA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 228
ILE A 178
THR A 196
MET A 219
 None
None
UAG  A1498 (-4.7A)
None
 1.20A 5ljeA-2wtzA:
undetectable		 5ljeA-2wtzA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1

(Streptococcus
parasanguinis) 		no annotation 4 ILE A 377
THR A 310
MET A 379
TRP A 282
 None
 1.32A 5ljeA-2x12A:
undetectable		 5ljeA-2x12A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		4 LEU A  20
ILE A 222
THR A 114
TRP A 198
 None
 1.37A 5ljeA-2xmzA:
undetectable		 5ljeA-2xmzA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqw COMPLEMENT C3

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 LEU A  95
ILE A  23
THR A  26
MET A 136
 None
 1.37A 5ljeA-2xqwA:
undetectable		 5ljeA-2xqwA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 LEU B1066
ILE B 994
THR B 997
MET B1107
 None
 1.37A 5ljeA-2xwbB:
undetectable		 5ljeA-2xwbB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 610
ILE A 622
THR A 624
MET A 586
 None
 1.25A 5ljeA-2ycbA:
undetectable		 5ljeA-2ycbA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 LEU A 676
ILE A 620
THR A 597
MET A 655
 None
 1.39A 5ljeA-2yfsA:
undetectable		 5ljeA-2yfsA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 LEU A 865
ILE A 870
MET A 891
TRP A 560
 None
 1.37A 5ljeA-2zaiA:
undetectable		 5ljeA-2zaiA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 LEU A 625
ILE A 637
THR A 639
MET A 601
 None
 1.10A 5ljeA-3af5A:
undetectable		 5ljeA-3af5A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 3

(Schizosaccharomyces
pombe) 		PF00022
(Actin) 		4 LEU A  72
ILE A 145
MET A 146
TRP A 109
 None
 0.84A 5ljeA-3dwlA:
undetectable		 5ljeA-3dwlA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 LEU X  43
ILE X 238
THR X  61
TRP X  99
 None
 1.40A 5ljeA-3e13X:
undetectable		 5ljeA-3e13X:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 338
ILE A 310
THR A 341
MET A 315
 None
 1.27A 5ljeA-3eoeA:
undetectable		 5ljeA-3eoeA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 151
ILE A 214
THR A 218
TRP A 187
 NAD  A 500 ( 4.1A)
None
None
None
 1.38A 5ljeA-3h3jA:
undetectable		 5ljeA-3h3jA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 115
ILE A 270
THR A 110
MET A 271
 None
 1.29A 5ljeA-3i6tA:
undetectable		 5ljeA-3i6tA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF19

(Schizosaccharomyces
pombe) 		no annotation 4 LEU c 437
ILE c 470
MET c 474
TRP c 568
 None
 1.27A 5ljeA-3jb9c:
undetectable		 5ljeA-3jb9c:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khd PYRUVATE KINASE

(Plasmodium
falciparum) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 347
ILE A 319
THR A 350
MET A 324
 None
 1.27A 5ljeA-3khdA:
undetectable		 5ljeA-3khdA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Rhodopseudomonas
palustris) 		PF00551
(Formyl_trans_N) 		4 LEU A 171
ILE A 138
TRP A 109
MET A 116
 None
 1.39A 5ljeA-3obiA:
undetectable		 5ljeA-3obiA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		4 LEU A 168
ILE A 301
THR A 235
TRP A 278
 None
 1.10A 5ljeA-3qwtA:
undetectable		 5ljeA-3qwtA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 LEU A 239
ILE A 301
THR A 305
MET A 279
 None
 1.37A 5ljeA-3t05A:
undetectable		 5ljeA-3t05A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		4 ILE A 255
THR A 253
MET A 195
MET A 213
 None
 1.22A 5ljeA-3t7bA:
undetectable		 5ljeA-3t7bA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE

(Coxiella
burnetii) 		PF00155
(Aminotran_1_2) 		4 LEU A 105
ILE A 235
THR A 252
MET A 206
 None
 1.34A 5ljeA-3tqxA:
undetectable		 5ljeA-3tqxA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 LEU A 146
ILE A 200
THR A 196
TRP A 170
 NAP  A 552 (-4.2A)
None
NAP  A 552 (-3.5A)
None
 1.08A 5ljeA-3up4A:
undetectable		 5ljeA-3up4A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 257
ILE A 239
THR A 268
TRP A 341
 NAG  A 601 ( 4.4A)
None
None
None
 1.44A 5ljeA-3vlaA:
undetectable		 5ljeA-3vlaA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 257
ILE A 270
THR A 268
TRP A 341
 NAG  A 601 ( 4.4A)
None
None
None
 1.22A 5ljeA-3vlaA:
undetectable		 5ljeA-3vlaA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu1 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0242

(Pyrococcus
horikoshii) 		no annotation 4 LEU A 871
ILE A 876
MET A 897
TRP A 562
 None
 1.41A 5ljeA-3vu1A:
undetectable		 5ljeA-3vu1A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		4 LEU A 306
ILE A 150
THR A 462
MET A 198
 None
 1.31A 5ljeA-3zs6A:
undetectable		 5ljeA-3zs6A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A  36
ILE A  70
MET A  77
MET A  96
 None
 1.37A 5ljeA-4aieA:
undetectable		 5ljeA-4aieA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		4 LEU A 152
ILE A 334
MET A 330
TRP A 348
 None
 1.04A 5ljeA-4b0tA:
undetectable		 5ljeA-4b0tA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 LEU A 168
ILE A 155
THR A 159
MET A 184
 None
 1.43A 5ljeA-4evqA:
undetectable		 5ljeA-4evqA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		4 LEU A 304
ILE A 329
THR A  93
MET A 321
 None
None
None
PGE  A 502 (-4.4A)
 1.25A 5ljeA-4exkA:
undetectable		 5ljeA-4exkA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 LEU A 154
ILE A 160
THR A 159
TRP A 300
 None
 1.41A 5ljeA-4hooA:
undetectable		 5ljeA-4hooA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig7 UBIQUITIN C-TERMINAL
HYDROLASE 37

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		4 LEU A   8
ILE A  50
MET A 219
MET A  19
 None
 1.44A 5ljeA-4ig7A:
undetectable		 5ljeA-4ig7A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 LEU A 287
ILE A 219
THR A 238
MET A 193
 None
 1.12A 5ljeA-4imdA:
undetectable		 5ljeA-4imdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		4 LEU A  52
ILE A 252
THR A 286
MET A 186
 None
 1.25A 5ljeA-4pmzA:
undetectable		 5ljeA-4pmzA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 LEU B  23
ILE B 345
MET B 322
TRP B 366
 None
 1.26A 5ljeA-4pswB:
undetectable		 5ljeA-4pswB:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 LEU A 366
ILE A 223
MET A 217
MET A 248
 None
 1.30A 5ljeA-4r6hA:
undetectable		 5ljeA-4r6hA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdj CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 LEU A 484
ILE A 251
MET A 242
MET A 495
 None
 1.34A 5ljeA-4rdjA:
undetectable		 5ljeA-4rdjA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmx PHI92_GP150

(Enterobacteria
phage phi92) 		no annotation 4 LEU A 317
ILE A 251
TRP A 284
MET A 304
 None
 1.44A 5ljeA-4rmxA:
undetectable		 5ljeA-4rmxA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		4 ILE A  37
THR A 274
TRP A  45
MET A 256
 None
 1.15A 5ljeA-4ryeA:
undetectable		 5ljeA-4ryeA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryf ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Listeria
monocytogenes) 		PF00574
(CLP_protease) 		4 LEU H 126
ILE H 120
MET H 175
MET H 154
 None
None
None
MLI  H 301 ( 4.6A)
 0.91A 5ljeA-4ryfH:
undetectable		 5ljeA-4ryfH:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u65 PUTATIVE CYSTINE
PROTEASE

(Pseudomonas
fluorescens) 		PF06035
(Peptidase_C93) 		4 LEU E  65
ILE E 140
THR E 123
TRP E 233
 None
 1.41A 5ljeA-4u65E:
undetectable		 5ljeA-4u65E:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 LEU A 328
ILE A 353
THR A 117
MET A 345
 None
 1.31A 5ljeA-4wrnA:
undetectable		 5ljeA-4wrnA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		4 LEU A 156
ILE A 140
THR A 149
MET A  69
 None
 1.44A 5ljeA-4yfmA:
undetectable		 5ljeA-4yfmA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		4 LEU B 318
ILE B 307
THR B 311
MET B 290
 None
 1.25A 5ljeA-4yg8B:
undetectable		 5ljeA-4yg8B:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 LEU D 487
ILE D 340
THR D 380
TRP D 337
 None
 1.38A 5ljeA-5a6bD:
undetectable		 5ljeA-5a6bD:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 LEU A 763
ILE A 768
MET A 789
TRP A 458
 None
 1.35A 5ljeA-5azaA:
undetectable		 5ljeA-5azaA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 LEU A 107
ILE A 132
TRP A 128
MET A 187
 None
 1.41A 5ljeA-5djqA:
undetectable		 5ljeA-5djqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej2 CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 LEU A 207
ILE A 135
MET A 132
MET A 215
 None
NAD  A 300 (-3.8A)
None
NAD  A 300 (-3.6A)
 1.34A 5ljeA-5ej2A:
undetectable		 5ljeA-5ej2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvd NUCLEOCAPSID

(Human
metapneumovirus) 		PF03246
(Pneumo_ncap) 		4 LEU A 302
ILE A 176
THR A 175
TRP A 261
 None
 1.29A 5ljeA-5fvdA:
undetectable		 5ljeA-5fvdA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 LEU B 667
ILE B 845
THR B 839
TRP B 847
 None
 1.36A 5ljeA-5gjeB:
undetectable		 5ljeA-5gjeB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo sapiens) 		PF01853
(MOZ_SAS) 		4 LEU A 514
ILE A 457
THR A 477
MET A 446
 ACO  A 702 (-3.4A)
None
ACO  A 702 (-3.0A)
None
 1.23A 5ljeA-5gk9A:
undetectable		 5ljeA-5gk9A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 LEU A 305
ILE A 330
THR A  94
MET A 322
 None
 1.29A 5ljeA-5h7nA:
undetectable		 5ljeA-5h7nA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 LEU A 195
ILE A 206
THR A 202
MET A 323
 None
 1.02A 5ljeA-5hyhA:
undetectable		 5ljeA-5hyhA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		4 LEU B 143
ILE B 218
THR B 196
MET B 220
 None
 1.39A 5ljeA-5kswB:
undetectable		 5ljeA-5kswB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		4 LEU M 216
ILE M 270
THR M 272
TRP M 267
 None
 1.41A 5ljeA-5lc5M:
undetectable		 5ljeA-5lc5M:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		4 LEU B 342
ILE B 409
THR B 395
MET B 384
 None
 1.36A 5ljeA-5lxzB:
undetectable		 5ljeA-5lxzB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A1947
ILE A1901
THR A1903
MET A1932
 None
 1.11A 5ljeA-5m59A:
undetectable		 5ljeA-5m59A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A1947
ILE A1901
THR A1903
MET A1997
 None
 1.14A 5ljeA-5m59A:
undetectable		 5ljeA-5m59A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 4 LEU A 237
ILE A 253
THR A 218
MET A 198
 None
 1.41A 5ljeA-5oatA:
undetectable		 5ljeA-5oatA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 4 LEU A 218
ILE A 240
THR A 235
MET A 189
 None
 1.23A 5ljeA-5oj3A:
undetectable		 5ljeA-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 LEU A 129
ILE A  88
THR A 259
TRP A  52
 None
 1.24A 5ljeA-5t1pA:
undetectable		 5ljeA-5t1pA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 4 LEU A 341
ILE A 407
THR A 403
TRP A 287
 None
 1.44A 5ljeA-5ukhA:
undetectable		 5ljeA-5ukhA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F

(Homo sapiens) 		no annotation 4 LEU A 357
ILE A 199
MET A 195
TRP A 217
 None
 1.33A 5ljeA-5w2mA:
undetectable		 5ljeA-5w2mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xta VIRK PROTEIN

(Legionella
pneumophila) 		PF06903
(VirK) 		4 LEU A  95
ILE A  90
THR A  92
MET A 108
 None
 1.29A 5ljeA-5xtaA:
undetectable		 5ljeA-5xtaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Homo sapiens) 		PF15879
(MWFE) 		4 LEU s 103
ILE s  81
THR s 108
MET s 233
 None
 1.35A 5ljeA-5xtds:
undetectable		 5ljeA-5xtds:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 4 LEU A 384
ILE A 409
THR A 173
MET A 401
 None
 1.19A 5ljeA-6anvA:
undetectable		 5ljeA-6anvA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 4 LEU A   8
ILE A 119
THR A 121
TRP A  42
 None
 1.26A 5ljeA-6c29A:
undetectable		 5ljeA-6c29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 LEU A 232
ILE A  29
MET A  41
TRP A 183
 None
 1.35A 5ljeA-6c66A:
undetectable		 5ljeA-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfz ASK1
DAD2
HSK3

(Chaetomium
thermophilum;
Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation
no annotation 		4 LEU A  50
ILE C  73
THR C  70
MET G  59
 None
 1.15A 5ljeA-6cfzA:
undetectable		 5ljeA-6cfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 4 LEU R  65
ILE R  95
THR R  91
MET R 180
 None
None
ADN  R 400 (-3.6A)
ADN  R 400 (-4.6A)
 1.32A 5ljeA-6d9hR:
undetectable		 5ljeA-6d9hR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5

(Mus musculus) 		no annotation 4 LEU L 283
ILE L 273
THR L 276
MET L 214
 None
 1.42A 5ljeA-6g2jL:
undetectable		 5ljeA-6g2jL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Mus musculus) 		no annotation 4 LEU N 232
ILE N 297
THR N 300
MET N 175
 None
 1.43A 5ljeA-6g72N:
undetectable		 5ljeA-6g72N:
undetectable