SIMILAR PATTERNS OF AMINO ACIDS FOR 5LJD_A_RTLA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  20
LEU A  36
THR A  53
TRP A 106
LEU A 117
 None
 0.54A 5ljdA-1gglA:
23.2		 5ljdA-1gglA:
54.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 196
LEU A 203
THR A 206
ILE A 184
GLN A 354
 None
 1.43A 5ljdA-1i41A:
0.0		 5ljdA-1i41A:
14.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  23
ILE A  51
THR A  53
LEU A 117
MET A 119
 None
 1.43A 5ljdA-1lpjA:
24.7		 5ljdA-1lpjA:
55.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  36
ILE A  51
THR A  53
TRP A 106
LEU A 117
MET A 119
 None
 0.49A 5ljdA-1lpjA:
24.7		 5ljdA-1lpjA:
55.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  57
ILE A  51
THR A  53
TRP A 106
MET A 119
 None
 1.20A 5ljdA-1lpjA:
24.7		 5ljdA-1lpjA:
55.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s04 HYPOTHETICAL PROTEIN
PF0455

(Pyrococcus
furiosus) 		PF04266
(ASCH) 		5 LEU A  26
ILE A  15
ILE A  34
LEU A   7
MET A   5
 None
 1.22A 5ljdA-1s04A:
0.0		 5ljdA-1s04A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Arabidopsis
thaliana) 		PF00903
(Glyoxalase) 		5 LEU A 116
ILE A 374
THR A 361
ILE A 370
LEU A  47
 None
 1.09A 5ljdA-1tg5A:
0.0		 5ljdA-1tg5A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 LEU A 103
LEU A 108
ILE A 152
THR A 128
LEU A 117
 None
 1.46A 5ljdA-1z7eA:
0.0		 5ljdA-1z7eA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq0 ACYL CARRIER PROTEIN

(Plasmodium
falciparum) 		PF00550
(PP-binding) 		5 LEU A  40
ILE A  70
THR A   4
ILE A  23
GLN A  67
 None
 1.41A 5ljdA-2fq0A:
undetectable		 5ljdA-2fq0A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i52 HYPOTHETICAL PROTEIN

(Picrophilus
torridus) 		PF04038
(DHNA) 		5 LEU A  86
LEU A  25
ILE A  55
THR A  53
ILE A  64
 None
 1.20A 5ljdA-2i52A:
0.3		 5ljdA-2i52A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  36
LEU A 303
ILE A  45
ILE A  61
LEU A  91
 None
 1.17A 5ljdA-2i6uA:
0.0		 5ljdA-2i6uA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 LEU A 227
ILE A 133
TRP A 122
LEU A  40
MET A  44
 None
 1.44A 5ljdA-2okcA:
undetectable		 5ljdA-2okcA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		5 LEU A 331
LEU A 423
ILE A 445
GLN A 454
LEU A 383
 None
 1.50A 5ljdA-2oudA:
undetectable		 5ljdA-2oudA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phl PHASEOLIN

(Phaseolus
vulgaris) 		PF00190
(Cupin_1) 		5 LEU A  87
LEU A  99
ILE A  33
ILE A 112
LEU A  65
 None
 1.37A 5ljdA-2phlA:
undetectable		 5ljdA-2phlA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emu LEUCINE RICH REPEAT
AND PHOSPHATASE
DOMAIN CONTAINING
PROTEIN

(Entamoeba
histolytica) 		PF00782
(DSPc) 		5 LEU A 322
LEU A 412
ILE A 434
GLN A 443
LEU A 372
 None
 1.44A 5ljdA-3emuA:
undetectable		 5ljdA-3emuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN

(Agrobacterium
fabrum) 		PF03466
(LysR_substrate) 		5 LEU A 265
LEU A 184
ILE A 145
THR A 119
LEU A 129
 None
 1.41A 5ljdA-3fd3A:
undetectable		 5ljdA-3fd3A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		5 LEU A 114
LEU A 107
ILE A 104
LEU A 160
MET A 158
 None
 1.39A 5ljdA-3fssA:
undetectable		 5ljdA-3fssA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo sapiens) 		PF09817
(Zwilch) 		5 LEU A 167
LEU A 155
ILE A  63
ILE A 110
LEU A  51
 None
 1.17A 5ljdA-3if8A:
undetectable		 5ljdA-3if8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 LEU B 860
ILE B 757
ILE B 857
LEU B 806
MET B 499
 None
 1.32A 5ljdA-3k70B:
undetectable		 5ljdA-3k70B:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Listeria
innocua) 		PF02082
(Rrf2) 		5 LEU A  37
ILE A  54
THR A  14
ILE A  31
LEU A  83
 None
 1.22A 5ljdA-3lwfA:
undetectable		 5ljdA-3lwfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		5 LEU A 279
LEU A 109
ILE A 326
ILE A 310
GLN A  84
 None
 1.39A 5ljdA-3mwtA:
undetectable		 5ljdA-3mwtA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj3 PERIOD CIRCADIAN
PROTEIN HOMOLOG 3

(Mus musculus) 		PF08447
(PAS_3) 		5 LEU A 307
LEU A 291
ILE A 367
THR A 272
ILE A 303
 None
 1.47A 5ljdA-4dj3A:
undetectable		 5ljdA-4dj3A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 386
LEU A 379
THR A 375
LEU A 354
MET A 357
 None
 1.14A 5ljdA-4k17A:
undetectable		 5ljdA-4k17A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		5 LEU A 577
LEU A 466
ILE A 475
GLN A 550
MET A 546
 None
 1.46A 5ljdA-4ka8A:
undetectable		 5ljdA-4ka8A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8i ARNA

(Sulfolobus
acidocaldarius) 		PF00498
(FHA) 		5 LEU A 120
LEU A 204
ILE A 181
LEU A 195
MET A 130
 None
 1.49A 5ljdA-5a8iA:
undetectable		 5ljdA-5a8iA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpv POLYMERASE COFACTOR
VP35

(Zaire
ebolavirus) 		PF02097
(Filo_VP35) 		5 LEU A 242
LEU A 249
ILE A 219
ILE A 280
MET A 228
 None
 1.43A 5ljdA-5bpvA:
undetectable		 5ljdA-5bpvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU B 667
ILE B 820
THR B 823
ILE B 726
LEU B 671
 None
 1.12A 5ljdA-5eduB:
undetectable		 5ljdA-5eduB:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exx TRANSCRIPTIONAL
REGULATOR FLEQ

(Pseudomonas
aeruginosa) 		PF00158
(Sigma54_activat) 		5 LEU A 303
LEU A 252
ILE A 206
ILE A 247
LEU A 215
 None
 1.07A 5ljdA-5exxA:
undetectable		 5ljdA-5exxA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezd KUNITZ-TYPE PROTEASE
INHIBITOR 1

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		5 LEU A 222
LEU A 219
ILE A 169
GLN A 176
LEU A 179
 None
 1.10A 5ljdA-5ezdA:
undetectable		 5ljdA-5ezdA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7v KUNITZ-TYPE PROTEASE
INHIBITOR 1

(Homo sapiens) 		PF00014
(Kunitz_BPTI)
PF00057
(Ldl_recept_a)
PF07502
(MANEC) 		5 LEU A 222
LEU A 219
ILE A 169
GLN A 176
LEU A 179
 None
 1.14A 5ljdA-5h7vA:
undetectable		 5ljdA-5h7vA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 LEU A 195
LEU A 161
ILE A 265
ILE A 185
LEU A 203
 None
 1.34A 5ljdA-5hdtA:
undetectable		 5ljdA-5hdtA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 LEU A 195
ILE A 206
THR A 202
LEU A 320
MET A 323
 None
 1.31A 5ljdA-5hyhA:
undetectable		 5ljdA-5hyhA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr5 MATA PROTEIN

(Dictyostelium
discoideum) 		no annotation 5 LEU A  52
ILE A  66
ILE A  55
GLN A  39
LEU A  35
 None
 1.41A 5ljdA-5nr5A:
undetectable		 5ljdA-5nr5A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0n LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		PF03466
(LysR_substrate) 		5 LEU A 267
THR A  97
ILE A 264
LEU A 110
MET A 109
 None
 1.41A 5ljdA-5x0nA:
undetectable		 5ljdA-5x0nA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Homo sapiens) 		PF15879
(MWFE) 		5 LEU s 162
LEU s 103
ILE s  81
THR s 108
MET s 233
 None
 1.27A 5ljdA-5xtds:
undetectable		 5ljdA-5xtds:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax8 METHIONINE-TRNA
LIGASE

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 388
LEU A 494
ILE A 463
LEU A 418
MET A 417
 None
 1.37A 5ljdA-6ax8A:
undetectable		 5ljdA-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2

(Danio rerio) 		no annotation 5 LEU A 233
ILE A 207
ILE A 229
GLN A 200
LEU A 197
 None
 1.16A 5ljdA-6d21A:
undetectable		 5ljdA-6d21A:
undetectable