SIMILAR PATTERNS OF AMINO ACIDS FOR 5LJC_A_RTLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 300
ILE A 340
THR A 339
MET A 215
 None
 1.40A 5ljcA-1ewkA:
0.0		 5ljcA-1ewkA:
14.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  20
LYS A  40
THR A  53
TRP A 106
 None
 0.34A 5ljcA-1gglA:
23.2		 5ljcA-1gglA:
54.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfo MIGRATION INHIBITORY
FACTOR

(Trichinella
spiralis) 		PF01187
(MIF) 		4 LEU A  19
ILE A  89
THR A   7
MET A  94
 None
 1.38A 5ljcA-1hfoA:
undetectable		 5ljcA-1hfoA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llc L-LACTATE
DEHYDROGENASE

(Lactobacillus
casei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 285
ILE A 191
THR A 165
MET A 315
 None
 1.47A 5ljcA-1llcA:
0.0		 5ljcA-1llcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo9 4-HYDROXYBENZOYL-COA
THIOESTERASE

(Pseudomonas sp.
CBS3) 		no annotation 4 LEU A  44
ILE A  80
THR A  82
MET A   7
 None
 0.87A 5ljcA-1lo9A:
1.0		 5ljcA-1lo9A:
17.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LYS A  40
ILE A  51
THR A  53
TRP A 106
MET A 119
 None
 0.69A 5ljcA-1lpjA:
24.4		 5ljcA-1lpjA:
56.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 LEU A 272
ILE A 365
THR A 254
MET A 400
 None
 1.22A 5ljcA-1mlzA:
0.0		 5ljcA-1mlzA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzy 4-CHLOROBENZOYL
COENZYME A
DEHALOGENASE

(Pseudomonas sp.
CBS3) 		PF00378
(ECH_1) 		4 LEU B  66
ILE B  93
THR B 146
MET B  92
 BCA  B 272 (-3.8A)
None
BCA  B 272 (-4.3A)
None
 1.39A 5ljcA-1nzyB:
0.0		 5ljcA-1nzyB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 ILE A 256
THR A 254
MET A 196
MET A 214
 None
None
None
ADP  A1259 (-4.5A)
 1.21A 5ljcA-1oh9A:
undetectable		 5ljcA-1oh9A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		4 LEU A 240
ILE A 280
MET A 277
TRP A 251
 None
 1.09A 5ljcA-1qguA:
undetectable		 5ljcA-1qguA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 292
ILE A 172
THR A 174
MET A 249
 None
 1.00A 5ljcA-1r0lA:
undetectable		 5ljcA-1r0lA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 LEU A 373
ILE A 344
MET A 365
MET A 389
 None
 1.42A 5ljcA-1rf5A:
undetectable		 5ljcA-1rf5A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1saw HYPOTHETICAL PROTEIN
FLJ36880

(Homo sapiens) 		PF01557
(FAA_hydrolase) 		4 LEU A 148
ILE A 173
MET A  91
MET A 165
 None
 1.29A 5ljcA-1sawA:
undetectable		 5ljcA-1sawA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LEU A 218
ILE A 315
THR A 297
MET A 312
 None
 1.47A 5ljcA-1u5qA:
undetectable		 5ljcA-1u5qA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 LEU A 116
ILE A  74
TRP A 378
MET A  46
 None
 1.17A 5ljcA-1uz4A:
undetectable		 5ljcA-1uz4A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 149
ILE A 358
MET A 349
MET A 250
 None
 0.68A 5ljcA-1x55A:
undetectable		 5ljcA-1x55A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydm HYPOTHETICAL PROTEIN
YQGN

(Bacillus
subtilis) 		PF01812
(5-FTHF_cyc-lig) 		4 LEU A 144
ILE A  72
THR A  47
MET A  82
 None
 1.22A 5ljcA-1ydmA:
undetectable		 5ljcA-1ydmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbe COAT PROTEIN VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 LEU 1 183
ILE 1  42
THR 1  56
MET 1 178
 None
 1.21A 5ljcA-1zbe1:
undetectable		 5ljcA-1zbe1:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1x PHYTANOYL-COA
DIOXYGENASE

(Homo sapiens) 		PF05721
(PhyH) 		4 LEU A 174
ILE A 199
MET A 250
TRP A 193
 None
None
None
AKG  A 451 (-3.9A)
 1.28A 5ljcA-2a1xA:
undetectable		 5ljcA-2a1xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1x PHYTANOYL-COA
DIOXYGENASE

(Homo sapiens) 		PF05721
(PhyH) 		4 LEU A 209
ILE A 199
MET A 250
TRP A 193
 None
None
None
AKG  A 451 (-3.9A)
 1.27A 5ljcA-2a1xA:
undetectable		 5ljcA-2a1xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 125
ILE A 106
THR A 107
MET A 101
 None
 1.19A 5ljcA-2a8xA:
undetectable		 5ljcA-2a8xA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN

(Streptococcus
pneumoniae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 214
ILE A 167
MET A 159
MET A 209
 None
 1.09A 5ljcA-2am2A:
undetectable		 5ljcA-2am2A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LEU A 428
ILE A 199
MET A 334
TRP A 326
 None
 1.06A 5ljcA-2b24A:
1.0		 5ljcA-2b24A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		4 LEU A 295
ILE A 247
MET A 215
TRP A  59
 None
 1.39A 5ljcA-2b81A:
undetectable		 5ljcA-2b81A:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		4 LEU A  19
ILE A  63
THR A  61
TRP A 109
 None
 1.00A 5ljcA-2cbrA:
20.2		 5ljcA-2cbrA:
41.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 LEU A 405
ILE A 389
THR A 358
MET A 430
 None
 1.18A 5ljcA-2d3lA:
undetectable		 5ljcA-2d3lA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 LEU A 306
ILE A 288
TRP A 314
MET A 233
 None
 1.37A 5ljcA-2dkhA:
undetectable		 5ljcA-2dkhA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 LEU A 259
ILE A 120
THR A 119
TRP A 129
 None
 1.16A 5ljcA-2dsjA:
undetectable		 5ljcA-2dsjA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 963
THR A 950
TRP A 961
MET A 955
 None
 1.43A 5ljcA-2np0A:
undetectable		 5ljcA-2np0A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 115
ILE A   3
THR A  38
MET A  36
 None
 1.28A 5ljcA-2p88A:
undetectable		 5ljcA-2p88A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 322
ILE A 351
THR A 350
MET A 354
 None
 1.38A 5ljcA-2rjtA:
undetectable		 5ljcA-2rjtA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 LEU A 412
LYS A 185
ILE A 181
MET A 178
 None
 1.11A 5ljcA-2vk9A:
undetectable		 5ljcA-2vk9A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x12 FIMBRIAE-ASSOCIATED
PROTEIN FAP1

(Streptococcus
parasanguinis) 		no annotation 4 ILE A 377
THR A 310
MET A 379
TRP A 282
 None
 1.34A 5ljcA-2x12A:
undetectable		 5ljcA-2x12A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 LEU A 561
ILE A 451
THR A 453
MET A 501
 None
 1.46A 5ljcA-2xdfA:
undetectable		 5ljcA-2xdfA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
sporotrichioides) 		PF02458
(Transferase) 		4 LEU A 273
THR A 281
MET A 442
MET A 420
 None
 1.46A 5ljcA-2zbaA:
undetectable		 5ljcA-2zbaA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zet RAS-RELATED PROTEIN
RAB-27B

(Mus musculus) 		PF00071
(Ras) 		4 LEU A  97
ILE A  44
THR A  85
TRP A  73
 None
 1.45A 5ljcA-2zetA:
undetectable		 5ljcA-2zetA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		4 LEU A 236
ILE A 307
MET A 303
TRP A 289
 None
 1.43A 5ljcA-3aivA:
undetectable		 5ljcA-3aivA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 LEU A 207
LYS A 177
ILE A 180
THR A 175
 None
 1.38A 5ljcA-3b3dA:
undetectable		 5ljcA-3b3dA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5n SYNAPTOBREVIN
HOMOLOG 1
PROTEIN SSO1
PROTEIN TRANSPORT
PROTEIN SEC9

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00957
(Synaptobrevin)
PF00804
(Syntaxin)
PF05739
(SNARE)
no annotation 		4 LEU C 462
ILE A  36
THR A  39
MET B 207
 None
 1.08A 5ljcA-3b5nC:
undetectable		 5ljcA-3b5nC:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3but UNCHARACTERIZED
PROTEIN AF_0446

(Archaeoglobus
fulgidus) 		PF03168
(LEA_2) 		4 LEU A 124
ILE A  94
THR A  92
MET A  43
 None
 1.41A 5ljcA-3butA:
undetectable		 5ljcA-3butA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deu TRANSCRIPTIONAL
REGULATOR SLYA

(Salmonella
enterica) 		PF01047
(MarR) 		4 LEU A  68
ILE A 108
MET A 104
TRP A  35
 None
 1.43A 5ljcA-3deuA:
undetectable		 5ljcA-3deuA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		4 LEU A 387
ILE A 468
MET A 305
TRP A 433
 None
 1.28A 5ljcA-3drkA:
undetectable		 5ljcA-3drkA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN

(Agrobacterium
fabrum) 		PF03466
(LysR_substrate) 		4 LEU A 315
ILE A 145
THR A 119
MET A 307
 None
 1.15A 5ljcA-3fd3A:
undetectable		 5ljcA-3fd3A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 LEU A 236
ILE A 139
MET A  22
TRP A  44
 None
 1.37A 5ljcA-3fiiA:
undetectable		 5ljcA-3fiiA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb4 DDMC

(Stenotrophomonas
maltophilia) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LEU A 158
ILE A 331
TRP A 222
MET A 228
 D3M  A 601 ( 4.0A)
None
None
None
 1.43A 5ljcA-3gb4A:
1.9		 5ljcA-3gb4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 LEU A 127
THR A 143
TRP A 159
MET A 162
 None
GLU  A 264 (-3.6A)
None
None
 1.42A 5ljcA-3h6tA:
undetectable		 5ljcA-3h6tA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		4 LEU A  99
ILE A 125
MET A 121
TRP A  74
 None
GOL  A   5 (-4.5A)
None
None
 1.39A 5ljcA-3hbcA:
undetectable		 5ljcA-3hbcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io1 AMINOBENZOYL-GLUTAMA
TE UTILIZATION
PROTEIN

(Klebsiella
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 158
ILE A  57
MET A 192
MET A 117
 None
 1.24A 5ljcA-3io1A:
undetectable		 5ljcA-3io1A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 LEU A 218
ILE A 319
MET A 373
MET A 244
 None
 1.31A 5ljcA-3is5A:
undetectable		 5ljcA-3is5A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 LEU A 283
ILE A 653
THR A 655
MET A 269
 None
 0.68A 5ljcA-3k0sA:
undetectable		 5ljcA-3k0sA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu NON-DISCRIMINATING
AND ARCHAEAL-TYPE
ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 139
ILE A 346
THR A 347
MET A 241
 None
 1.43A 5ljcA-3kfuA:
undetectable		 5ljcA-3kfuA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 LEU B 106
ILE B  42
THR B  45
MET B 178
 None
 1.03A 5ljcA-3m2rB:
undetectable		 5ljcA-3m2rB:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		4 LEU A 396
THR A 479
MET A 476
TRP A 406
 BOG  A 705 ( 4.1A)
None
None
None
 1.34A 5ljcA-3mpnA:
undetectable		 5ljcA-3mpnA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqp PUTATIVE
ISOCHORISMATASE

(Paraburkholderia
xenovorans) 		PF00857
(Isochorismatase) 		4 LEU A  99
ILE A  36
THR A 114
MET A  40
 None
 1.19A 5ljcA-3oqpA:
undetectable		 5ljcA-3oqpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 135
ILE A 109
THR A 353
MET A  92
 None
 1.47A 5ljcA-3qtpA:
undetectable		 5ljcA-3qtpA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		4 ILE A 255
THR A 253
MET A 195
MET A 213
 None
 1.19A 5ljcA-3t7bA:
undetectable		 5ljcA-3t7bA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc3 UV DAMAGE
ENDONUCLEASE

(Sulfolobus
acidocaldarius) 		PF03851
(UvdE) 		4 LEU A  45
ILE A  63
THR A  62
MET A 132
 None
 1.08A 5ljcA-3tc3A:
undetectable		 5ljcA-3tc3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpf ORNITHINE
CARBAMOYLTRANSFERASE

(Campylobacter
jejuni) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 261
ILE A 135
THR A 134
TRP A 161
 None
 1.26A 5ljcA-3tpfA:
undetectable		 5ljcA-3tpfA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu9 CHROMOSOME
SEGREGATION IN
MEIOSIS PROTEIN 2

(Saccharomyces
cerevisiae) 		PF16834
(CSM2) 		4 LEU B 139
ILE B 159
THR B 161
MET B 149
 None
 1.13A 5ljcA-3vu9B:
undetectable		 5ljcA-3vu9B:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		4 LEU A 245
ILE A 321
THR A 322
MET A 371
 None
 1.41A 5ljcA-3x3yA:
1.6		 5ljcA-3x3yA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 LEU A 102
ILE A  57
THR A 134
TRP A 138
 None
 1.19A 5ljcA-4a0hA:
undetectable		 5ljcA-4a0hA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0w T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Bos taurus) 		PF00118
(Cpn60_TCP1) 		4 LEU A 128
ILE A 480
THR A 481
MET A 475
 None
 1.43A 5ljcA-4a0wA:
undetectable		 5ljcA-4a0wA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 LEU A  91
ILE A 141
TRP A 132
MET A 159
 None
 1.45A 5ljcA-4ag4A:
undetectable		 5ljcA-4ag4A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euk HISTIDINE KINASE 5
HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN 1

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00072
(Response_reg)
PF01627
(Hpt) 		4 LEU B  30
ILE A 904
MET A 883
MET A 796
 None
 0.98A 5ljcA-4eukB:
undetectable		 5ljcA-4eukB:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 LEU A 184
ILE A  42
THR A  56
MET A 179
 None
 1.15A 5ljcA-4gh4A:
undetectable		 5ljcA-4gh4A:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  19
ILE A  63
TRP A 109
MET A 123
 None
RET  A 201 ( 4.7A)
RET  A 201 (-3.7A)
RET  A 201 (-4.6A)
 1.02A 5ljcA-4i9rA:
19.6		 5ljcA-4i9rA:
43.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  22
ILE A  63
TRP A 109
MET A 123
 None
RET  A 201 ( 4.7A)
RET  A 201 (-3.7A)
RET  A 201 (-4.6A)
 1.45A 5ljcA-4i9rA:
19.6		 5ljcA-4i9rA:
43.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		4 LEU A 274
ILE A 211
THR A 210
MET A 214
 None
 1.44A 5ljcA-4nnbA:
undetectable		 5ljcA-4nnbA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		4 LEU A   3
ILE A 253
TRP A  58
MET A  77
 None
 1.23A 5ljcA-4rgyA:
undetectable		 5ljcA-4rgyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		4 LEU A  62
ILE A 335
THR A 334
MET A 240
 None
 1.42A 5ljcA-4rp8A:
undetectable		 5ljcA-4rp8A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvc ABC TRANSPORTER
ATP-BINDING PROTEIN

(Geobacillus
kaustophilus) 		PF00005
(ABC_tran) 		4 LEU A 174
ILE A  35
THR A 191
MET A  31
 None
 1.35A 5ljcA-4rvcA:
undetectable		 5ljcA-4rvcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		4 ILE A  37
THR A 274
TRP A  45
MET A 256
 None
 1.17A 5ljcA-4ryeA:
undetectable		 5ljcA-4ryeA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 LEU A 242
ILE A 282
MET A 279
TRP A 253
 None
 1.06A 5ljcA-4wzbA:
undetectable		 5ljcA-4wzbA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Streptococcus
mutans) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 298
ILE A 196
THR A 237
MET A 193
 None
 0.96A 5ljcA-4xb3A:
undetectable		 5ljcA-4xb3A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 LEU A1102
ILE A1084
THR A1141
MET A1068
 None
 1.29A 5ljcA-4xqkA:
undetectable		 5ljcA-4xqkA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		4 LEU A 257
ILE A  58
MET A 365
TRP A 227
 None
 1.04A 5ljcA-4xuvA:
undetectable		 5ljcA-4xuvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoq TORSO

(Bombyx mori) 		no annotation 4 LEU A  18
ILE A  47
TRP A 113
MET A  80
 None
 1.47A 5ljcA-5aoqA:
undetectable		 5ljcA-5aoqA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2
CAPSID PROTEIN VP3
CAPSID PROTEIN VP4

(Enterovirus D;
Enterovirus D;
Enterovirus D) 		PF00073
(Rhv)
PF00073
(Rhv)
PF02226
(Pico_P1A) 		4 LEU D  60
THR C 116
MET C 118
TRP B 177
 None
 1.25A 5ljcA-5bnnD:
undetectable		 5ljcA-5bnnD:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 236
ILE A 260
MET A 314
MET A 255
 None
 1.28A 5ljcA-5brqA:
undetectable		 5ljcA-5brqA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 LEU A 232
ILE A 156
THR A 204
MET A 110
 None
 1.46A 5ljcA-5bzaA:
undetectable		 5ljcA-5bzaA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		4 ILE A 134
THR A 135
MET A 129
MET A 442
 None
 1.46A 5ljcA-5cg0A:
undetectable		 5ljcA-5cg0A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 LEU A 113
ILE A 132
TRP A 128
MET A 187
 None
 1.17A 5ljcA-5djqA:
undetectable		 5ljcA-5djqA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		4 LEU A 120
LYS A 315
ILE A  66
THR A 316
 None
SO4  A 403 (-3.2A)
None
SO4  A 403 (-4.0A)
 1.41A 5ljcA-5evlA:
1.0		 5ljcA-5evlA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI

(Ruegeria
pomeroyi) 		PF00107
(ADH_zinc_N) 		4 LEU A 141
ILE A 204
THR A 156
MET A 236
 None
 1.21A 5ljcA-5gxfA:
undetectable		 5ljcA-5gxfA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ict GLUTAMATE RECEPTOR 1

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		4 LEU A 133
THR A 149
TRP A 165
MET A 168
 None
GLU  A 301 (-3.4A)
None
None
 1.43A 5ljcA-5ictA:
undetectable		 5ljcA-5ictA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzg CAPSID PROTEIN VP0

(Rhinovirus C) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		4 LEU C 148
ILE C 311
THR C 176
TRP C 144
 None
 1.22A 5ljcA-5jzgC:
undetectable		 5ljcA-5jzgC:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP2

(Rhinovirus C) 		PF00073
(Rhv) 		4 LEU C  82
ILE C 245
THR C 110
TRP C  78
 None
 1.24A 5ljcA-5k0uC:
undetectable		 5ljcA-5k0uC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		4 LEU A 258
ILE A 298
MET A 295
TRP A 269
 None
 1.06A 5ljcA-5kojA:
undetectable		 5ljcA-5kojA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 LEU A 639
THR A 655
TRP A 671
MET A 674
 None
 1.36A 5ljcA-5l1bA:
0.0		 5ljcA-5l1bA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		4 LEU A 290
ILE A 384
THR A 383
TRP A 319
 None
 1.22A 5ljcA-5ladA:
undetectable		 5ljcA-5ladA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		4 LEU A 328
ILE A 384
THR A 383
TRP A 319
 None
 1.20A 5ljcA-5ladA:
undetectable		 5ljcA-5ladA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 4 LEU A 691
ILE A 649
MET A 722
MET A 698
 None
 1.38A 5ljcA-5m41A:
undetectable		 5ljcA-5m41A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LEU A 203
ILE A 164
THR A 165
MET A 223
 None
None
ATP  A 601 (-2.7A)
GDP  A 602 (-4.7A)
 1.43A 5ljcA-5tc3A:
undetectable		 5ljcA-5tc3A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trv DENOVO NTF2

(synthetic
construct) 		PF12680
(SnoaL_2) 		4 LEU A  28
ILE A 106
MET A  88
MET A  50
 None
None
None
PEG  A 201 (-3.5A)
 0.89A 5ljcA-5trvA:
undetectable		 5ljcA-5trvA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 LEU A 632
ILE A 162
MET A 203
TRP A 213
 None
 1.45A 5ljcA-5wugA:
undetectable		 5ljcA-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 LEU A 279
ILE A 646
THR A 648
MET A 265
 None
 0.85A 5ljcA-5x9wA:
undetectable		 5ljcA-5x9wA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LEU A  76
ILE A 430
THR A 427
MET A  70
 None
 0.99A 5ljcA-5xapA:
undetectable		 5ljcA-5xapA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Homo sapiens) 		PF15879
(MWFE) 		4 LEU s 162
ILE s  81
THR s 108
MET s 233
 None
 1.17A 5ljcA-5xtds:
undetectable		 5ljcA-5xtds:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emz INT PROTEIN

(Enterococcus
faecalis) 		no annotation 4 LEU A 200
ILE A 244
THR A 222
MET A 274
 None
 1.12A 5ljcA-6emzA:
undetectable		 5ljcA-6emzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 LEU L 216
MET M 383
TRP L 196
MET L 137
 None
 1.46A 5ljcA-6g2jL:
undetectable		 5ljcA-6g2jL:
undetectable