SIMILAR PATTERNS OF AMINO ACIDS FOR 5LJC_A_RTLA201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2r CYTOCHROME C2

(Rhodobacter
capsulatus) 		no annotation 5 TYR A  75
LEU A  87
ALA A  92
TYR A  53
ILE A  57
 HEM  A 120 (-4.6A)
None
None
HEM  A 120 (-4.7A)
HEM  A 120 (-4.2A)
 1.23A 5ljcA-1c2rA:
undetectable		 5ljcA-1c2rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 ALA A 145
LEU A 205
TYR A 208
ILE A 148
LEU A 260
 None
 1.00A 5ljcA-1cvrA:
undetectable		 5ljcA-1cvrA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 PHE E  27
LEU E 103
SER E  61
PHE E  64
ILE E  43
 None
 1.26A 5ljcA-1cziE:
undetectable		 5ljcA-1cziE:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 ALA A 301
LEU A 307
PHE A 305
TYR A 403
ILE A 406
 None
 1.29A 5ljcA-1d6mA:
undetectable		 5ljcA-1d6mA:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		8 TYR A  19
ALA A  33
LEU A  36
PRO A  38
SER A  55
PHE A  57
TYR A  60
LEU A 117
 None
 0.74A 5ljcA-1gglA:
23.2		 5ljcA-1gglA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		8 TYR A  19
ALA A  33
LEU A  36
SER A  55
PHE A  57
ARG A  58
TYR A  60
LEU A 117
 None
 0.82A 5ljcA-1gglA:
23.2		 5ljcA-1gglA:
54.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		5 TYR A 493
LEU A  43
ALA A 315
LEU A 318
ILE A 476
 None
 1.19A 5ljcA-1gzvA:
undetectable		 5ljcA-1gzvA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 PRO A  45
SER A  44
ARG A  51
ILE A  52
LEU A  32
 None
HEM  A1344 ( 4.5A)
HEM  A1344 (-4.4A)
None
None
 1.17A 5ljcA-1h3jA:
undetectable		 5ljcA-1h3jA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 PHE A 141
ALA A 130
LEU A 134
PHE A  60
LEU A 109
 None
 1.11A 5ljcA-1inlA:
undetectable		 5ljcA-1inlA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 PHE A  15
LEU A   8
ALA A  11
ARG A  34
LEU A  49
 None
 1.25A 5ljcA-1k6dA:
undetectable		 5ljcA-1k6dA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
ALA A  33
LEU A  36
PRO A  38
SER A  55
ARG A  58
LEU A 117
 None
 0.78A 5ljcA-1lpjA:
24.4		 5ljcA-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
SER A  55
PHE A  57
 RTL  A 135 ( 4.6A)
None
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
 1.21A 5ljcA-1mx8A:
19.7		 5ljcA-1mx8A:
95.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		9 PHE A  16
TYR A  19
LEU A  29
ALA A  33
LEU A  36
PRO A  38
ARG A  58
TYR A  60
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 ( 4.6A)
RTL  A 135 (-3.5A)
 0.89A 5ljcA-1mx8A:
19.7		 5ljcA-1mx8A:
95.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		8 PHE A  16
TYR A  19
LEU A  29
ALA A  33
LEU A  36
SER A  55
TYR A  60
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 (-3.5A)
 0.94A 5ljcA-1mx8A:
19.7		 5ljcA-1mx8A:
95.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 PHE A 106
TYR A 126
LEU A 246
ALA A 105
LEU A 109
 None
 1.16A 5ljcA-1o4sA:
undetectable		 5ljcA-1o4sA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1

(Rattus
norvegicus) 		PF13649
(Methyltransf_25) 		5 LEU A 156
SER A 154
PHE A 151
ILE A 272
LEU A  84
 None
None
None
None
SAH  A 354 (-4.2A)
 1.25A 5ljcA-1or8A:
2.1		 5ljcA-1or8A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG

(Drosophila
melanogaster) 		PF00536
(SAM_1)
PF09246
(PHAT) 		5 TYR A 622
LEU A 692
ALA A 745
SER A 740
ILE A 702
 None
 1.27A 5ljcA-1oxjA:
undetectable		 5ljcA-1oxjA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6f NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
1

(Homo sapiens) 		no annotation 5 SER A  89
PHE A   9
TYR A  75
ILE A  26
LEU A  45
 None
 1.29A 5ljcA-1p6fA:
undetectable		 5ljcA-1p6fA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		5 TYR A 149
LEU A 291
ALA A 266
LEU A 270
LEU A 413
 None
 1.19A 5ljcA-1q5dA:
undetectable		 5ljcA-1q5dA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yga HYPOTHETICAL 37.9
KDA PROTEIN IN
BIO3-HXT17
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		5 LEU A 163
ALA A 168
LEU A  77
ARG A  65
ILE A 171
 None
 1.19A 5ljcA-1ygaA:
undetectable		 5ljcA-1ygaA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		5 LEU A 232
ALA A 164
LEU A 165
PHE A 172
ILE A 185
 None
 1.00A 5ljcA-2ap1A:
undetectable		 5ljcA-2ap1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 PHE A 263
LEU A 177
ALA A 267
TYR A 191
ILE A 189
 None
 1.24A 5ljcA-2c4mA:
undetectable		 5ljcA-2c4mA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		5 TYR A 494
LEU A  44
ALA A 316
LEU A 319
ILE A 477
 None
 1.29A 5ljcA-2cxnA:
undetectable		 5ljcA-2cxnA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mh9 BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF09382
(RQC) 		5 PHE A  80
LEU A  53
ALA A  76
ILE A  64
LEU A 107
 None
 1.16A 5ljcA-2mh9A:
undetectable		 5ljcA-2mh9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 ALA A 568
LEU A 571
PRO A 979
ILE A 920
LEU A1036
 None
 1.11A 5ljcA-2po4A:
undetectable		 5ljcA-2po4A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pth PEPTIDYL-TRNA
HYDROLASE

(Escherichia
coli) 		PF01195
(Pept_tRNA_hydro) 		5 LEU A  95
PHE A 148
ARG A  19
ILE A 161
LEU A 132
 None
 1.26A 5ljcA-2pthA:
undetectable		 5ljcA-2pthA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE

(Chlorobaculum
tepidum) 		PF00800
(PDT) 		5 LEU A 262
ALA A 214
LEU A 215
PHE A 218
TYR A 243
 None
 1.14A 5ljcA-2qmxA:
undetectable		 5ljcA-2qmxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		6 PHE A 133
LEU A 268
ALA A 137
LEU A 196
PHE A 194
LEU A 285
 None
 1.19A 5ljcA-2qvlA:
undetectable		 5ljcA-2qvlA:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
ALA A  33
SER A  55
ARG A  58
LEU A 117
 None
None
None
None
SO4  A 152 (-3.1A)
None
 0.91A 5ljcA-2rcqA:
23.9		 5ljcA-2rcqA:
52.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
SER A  55
PHE A  57
ARG A  58
LEU A 117
 None
None
None
None
SO4  A 152 (-3.1A)
None
 0.89A 5ljcA-2rcqA:
23.9		 5ljcA-2rcqA:
52.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v15 DNA PROTECTION
DURING STARVATION
PROTEIN

(Streptococcus
suis) 		PF00210
(Ferritin) 		5 TYR A  65
LEU A  36
ALA A  39
LEU A 100
ILE A 155
 None
 1.17A 5ljcA-2v15A:
undetectable		 5ljcA-2v15A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA

(Mycobacterium
tuberculosis) 		PF16708
(LppA) 		5 LEU A  70
ALA A  74
LEU A 185
PHE A 175
ILE A 120
 None
 1.05A 5ljcA-2v7sA:
undetectable		 5ljcA-2v7sA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE

(Thermus
thermophilus) 		PF01081
(Aldolase) 		5 ALA A 197
LEU A 200
PRO A 166
ILE A 160
LEU A 171
 None
 1.26A 5ljcA-2yw4A:
undetectable		 5ljcA-2yw4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF01135
(PCMT) 		5 ALA A 187
LEU A 186
ARG A 149
ILE A 150
LEU A 207
 None
ACT  A1001 (-4.6A)
None
None
None
 1.20A 5ljcA-2yxeA:
undetectable		 5ljcA-2yxeA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 ALA A 173
LEU A 172
PRO A  12
TYR A   7
ILE A 300
 None
 1.26A 5ljcA-3a9sA:
undetectable		 5ljcA-3a9sA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmf PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PHE A 208
ALA A 273
SER A 267
PHE A 270
TYR A 262
 None
 1.20A 5ljcA-3hmfA:
undetectable		 5ljcA-3hmfA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE

(Yersinia pestis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 PHE A 212
LEU A 195
ALA A 214
LEU A 225
ILE A 330
 None
 1.13A 5ljcA-3kuxA:
undetectable		 5ljcA-3kuxA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		5 LEU A  70
PRO A  64
SER A  67
PHE A  69
ILE A  75
 None
 1.23A 5ljcA-3ky9A:
undetectable		 5ljcA-3ky9A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		5 PHE A 328
TYR A 164
ALA A 219
ILE A 139
LEU A 310
 None
EDO  A 347 (-4.6A)
None
None
None
 1.26A 5ljcA-3kydA:
undetectable		 5ljcA-3kydA:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
PRO A  39
SER A  56
PHE A  58
 None
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-3.7A)
None
 0.96A 5ljcA-3nr3A:
19.9		 5ljcA-3nr3A:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		5 LEU A 207
ALA A 203
LEU A 200
PRO A 195
ILE A 181
 None
 1.17A 5ljcA-3o0yA:
undetectable		 5ljcA-3o0yA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE

(Staphylococcus
aureus) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		5 PHE A 255
ALA A 234
LEU A 194
PHE A 206
ILE A 241
 None
 1.25A 5ljcA-3orqA:
undetectable		 5ljcA-3orqA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR

(Shewanella
loihica) 		PF00440
(TetR_N) 		5 PHE A 187
LEU A  81
ALA A  85
LEU A  88
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
PG4  A 216 (-3.8A)
None
 0.66A 5ljcA-3ppbA:
undetectable		 5ljcA-3ppbA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF00089
(Trypsin) 		5 LEU A 242
ALA A 209
SER A 198
ILE A 234
LEU A 180
 None
 1.28A 5ljcA-3ureA:
undetectable		 5ljcA-3ureA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2i PEPTIDYL-TRNA
HYDROLASE

(Burkholderia
thailandensis) 		PF01195
(Pept_tRNA_hydro) 		5 LEU A  95
PHE A 157
ARG A  19
ILE A 170
LEU A 131
 None
CIT  A 202 (-4.8A)
CIT  A 202 (-2.8A)
None
None
 1.22A 5ljcA-3v2iA:
undetectable		 5ljcA-3v2iA:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
ALA A  33
SER A  55
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 (-4.8A)
2AN  A 201 (-3.8A)
2AN  A 201 (-3.2A)
None
 0.75A 5ljcA-3wbgA:
20.5		 5ljcA-3wbgA:
33.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A  19
ALA A  33
PRO A  38
SER A  55
LEU A 115
 2AN  A 201 (-4.8A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.2A)
None
 0.83A 5ljcA-3wbgA:
20.5		 5ljcA-3wbgA:
33.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		5 TYR A  59
ALA A  56
PHE A 325
TYR A 331
ILE A 287
 None
 1.23A 5ljcA-3wx7A:
undetectable		 5ljcA-3wx7A:
16.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
ALA A  34
PRO A  39
SER A  56
 None
None
NA  A1132 ( 4.0A)
None
NA  A1132 (-2.9A)
 0.78A 5ljcA-4a60A:
19.4		 5ljcA-4a60A:
32.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		5 PHE A 873
LEU A 510
ALA A 514
LEU A 517
LEU A 640
 None
 1.05A 5ljcA-4ammA:
undetectable		 5ljcA-4ammA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR

(Homo sapiens) 		PF01462
(LRRNT)
PF12369
(GnHR_trans)
PF13306
(LRR_5) 		5 PHE X 214
LEU X 195
PRO X 220
ILE X 225
LEU X 261
 None
 1.18A 5ljcA-4ay9X:
undetectable		 5ljcA-4ay9X:
14.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
TYR A  22
LEU A  32
ALA A  36
SER A  58
 None
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
 0.99A 5ljcA-4azpA:
20.8		 5ljcA-4azpA:
34.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 LEU A 409
ALA A 380
LEU A 381
TYR A 373
ILE A 407
 None
 1.27A 5ljcA-4cyjA:
undetectable		 5ljcA-4cyjA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 PHE A 308
TYR A 298
ALA A 307
LEU A 311
ILE A  58
 None
 1.25A 5ljcA-4gbrA:
undetectable		 5ljcA-4gbrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 LEU B 355
SER B 132
PHE B 136
TYR B  77
LEU B  80
 None
 1.14A 5ljcA-4gnkB:
undetectable		 5ljcA-4gnkB:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)

(Schistosoma
japonicum) 		PF00248
(Aldo_ket_red) 		5 LEU A  65
ALA A  61
LEU A  58
ARG A  40
TYR A  39
 None
 1.30A 5ljcA-4hbkA:
undetectable		 5ljcA-4hbkA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF13646
(HEAT_2) 		5 LEU A 114
ALA A 117
LEU A 142
ILE A 155
LEU A 208
 None
 1.15A 5ljcA-4l7mA:
undetectable		 5ljcA-4l7mA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 209
LEU A 250
PRO A 251
SER A 249
PHE A 224
 None
 1.21A 5ljcA-4li2A:
undetectable		 5ljcA-4li2A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdv ANNEXIN

(Schistosoma
mansoni) 		PF00191
(Annexin) 		5 LEU A 339
LEU A 312
SER A 301
ILE A 294
LEU A 113
 None
 1.24A 5ljcA-4mdvA:
undetectable		 5ljcA-4mdvA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Klebsiella
pneumoniae) 		PF02826
(2-Hacid_dh_C) 		5 ALA A 284
SER A  46
TYR A  44
ILE A   4
LEU A 300
 None
 1.25A 5ljcA-4n18A:
undetectable		 5ljcA-4n18A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		5 TYR A  63
ALA A  60
PHE A 329
TYR A 335
ILE A 291
 None
 1.29A 5ljcA-4nz5A:
undetectable		 5ljcA-4nz5A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okj 3'-5'
EXORIBONUCLEASE
RV2179C/MT2234.1

(Mycobacterium
tuberculosis) 		PF16473
(DUF5051) 		5 LEU A 120
PHE A 153
ARG A   2
TYR A   3
LEU A  99
 None
 1.24A 5ljcA-4okjA:
undetectable		 5ljcA-4okjA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN

(Vibrio cholerae) 		PF00501
(AMP-binding) 		5 LEU A 409
ALA A 122
ARG A  79
ILE A 105
LEU A 141
 None
 1.24A 5ljcA-4oxiA:
undetectable		 5ljcA-4oxiA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		5 PHE A 273
LEU A 289
LEU A 324
PRO A  62
LEU A 263
 None
 1.28A 5ljcA-4p6bA:
undetectable		 5ljcA-4p6bA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 PHE A 972
ALA A 970
LEU A 981
PHE A 984
ILE A1002
 None
 1.30A 5ljcA-4ptfA:
undetectable		 5ljcA-4ptfA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sbv SOUTHERN BEAN MOSAIC
VIRUS COAT PROTEIN

(Southern bean
mosaic virus) 		PF00729
(Viral_coat) 		5 ALA A 182
ARG A 116
TYR A 117
ILE A 185
LEU A  78
 None
 1.12A 5ljcA-4sbvA:
undetectable		 5ljcA-4sbvA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sbv SOUTHERN BEAN MOSAIC
VIRUS COAT PROTEIN

(Southern bean
mosaic virus) 		PF00729
(Viral_coat) 		5 PHE A 170
ARG A 116
TYR A 117
ILE A 185
LEU A  78
 None
 1.13A 5ljcA-4sbvA:
undetectable		 5ljcA-4sbvA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN A CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		5 PHE A  41
ALA A  47
LEU A  50
ILE A 113
LEU A  68
 None
HEM  A 201 ( 3.8A)
HEM  A 201 (-4.0A)
HEM  A 201 (-3.6A)
None
 1.14A 5ljcA-4u8uA:
undetectable		 5ljcA-4u8uA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A   9
ALA A  25
LEU A  26
ILE A  46
LEU A  56
 None
 1.23A 5ljcA-4wqmA:
undetectable		 5ljcA-4wqmA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfj AMINOGLYCOSIDE
3'-N-ACETYLTRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		5 TYR A 142
LEU A 129
ALA A 133
LEU A 136
TYR A  93
 None
 1.29A 5ljcA-4yfjA:
undetectable		 5ljcA-4yfjA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 PHE A 633
ARG A 702
TYR A 701
ILE A 705
LEU A 321
 None
 1.16A 5ljcA-4zlgA:
undetectable		 5ljcA-4zlgA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 5 TYR A 583
LEU A 556
ALA A 464
PHE A 465
TYR A 458
 None
 1.21A 5ljcA-5aa6A:
undetectable		 5ljcA-5aa6A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		5 LEU A1086
ALA A1101
PRO A1067
SER A1051
ILE A1076
 None
 1.17A 5ljcA-5csaA:
undetectable		 5ljcA-5csaA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 ALA A 369
LEU A 373
SER A 352
ILE A 361
LEU A 522
 None
 1.12A 5ljcA-5df0A:
undetectable		 5ljcA-5df0A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 PHE A  34
LEU A 433
ALA A 437
PHE A 137
LEU A  39
 MPG  A 602 (-4.6A)
None
MPG  A 602 ( 3.7A)
None
None
 1.20A 5ljcA-5f15A:
undetectable		 5ljcA-5f15A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 PHE A 106
LEU A 377
LEU A 129
PHE A 127
LEU A 134
 None
 1.29A 5ljcA-5f4zA:
undetectable		 5ljcA-5f4zA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		5 LEU A 714
PHE A 818
TYR A 813
ILE A 823
LEU A 806
 None
 1.28A 5ljcA-5fdnA:
undetectable		 5ljcA-5fdnA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		5 PRO A 543
SER A 126
PHE A 560
ILE A 573
LEU A 583
 None
 1.15A 5ljcA-5feiA:
undetectable		 5ljcA-5feiA:
12.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		5 PHE A  16
TYR A  19
LEU A  36
PRO A  38
SER A  55
 None
 0.80A 5ljcA-5gkbA:
19.5		 5ljcA-5gkbA:
36.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 533
LEU A 565
PHE A 538
ILE A 573
LEU A 621
 None
 1.05A 5ljcA-5gmhA:
undetectable		 5ljcA-5gmhA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 ALA A 104
LEU A 105
PRO A  34
ARG A  67
LEU A   9
 None
 1.07A 5ljcA-5hp5A:
undetectable		 5ljcA-5hp5A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 LEU A  76
ALA A  83
LEU A  85
PHE A  74
LEU A 510
 None
 1.25A 5ljcA-5jpnA:
undetectable		 5ljcA-5jpnA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus) 		PF08534
(Redoxin) 		5 LEU A  70
ALA A  72
LEU A  97
ILE A 129
LEU A 110
 None
 1.08A 5ljcA-5k1gA:
undetectable		 5ljcA-5k1gA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llb POLYPHOSPHATE KINASE
2

(Francisella
tularensis) 		no annotation 5 PHE C  43
LEU C 115
LEU C  40
TYR C 238
ILE C 160
 None
 1.24A 5ljcA-5llbC:
undetectable		 5ljcA-5llbC:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  85
ALA A  83
LEU A  80
PHE A  77
LEU A  64
 None
 1.19A 5ljcA-5mdhA:
undetectable		 5ljcA-5mdhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 5 ALA C 147
LEU C 150
TYR C 155
ILE C 306
LEU C 169
 None
 1.25A 5ljcA-5mg5C:
undetectable		 5ljcA-5mg5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 LEU A 196
ALA A 155
SER A 147
ILE A 188
LEU A 132
 None
 1.23A 5ljcA-5mrrA:
undetectable		 5ljcA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 5 PHE A  14
TYR A 198
ALA A   5
LEU A 115
PHE A 146
 None
 1.20A 5ljcA-5nywA:
undetectable		 5ljcA-5nywA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6u UNCHARACTERIZED
PROTEIN

(Shewanella
putrefaciens) 		no annotation 5 LEU C  89
PRO C 131
SER C 130
ILE C 112
LEU C 247
 None
None
U  A  18 ( 4.6A)
None
None
 1.27A 5ljcA-5o6uC:
undetectable		 5ljcA-5o6uC:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6u UNCHARACTERIZED
PROTEIN

(Shewanella
putrefaciens) 		no annotation 6 LEU C 132
PRO C 131
SER C 130
ARG C 117
ILE C 112
LEU C 247
 None
None
U  A  18 ( 4.6A)
A  A  20 ( 3.4A)
None
None
 1.43A 5ljcA-5o6uC:
undetectable		 5ljcA-5o6uC:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 PHE T 363
TYR T 359
LEU T 367
PRO T 326
TYR T 321
 None
 1.21A 5ljcA-5ojsT:
undetectable		 5ljcA-5ojsT:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9c DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Yersinia
enterocolitica) 		PF04321
(RmlD_sub_bind) 		5 PHE A  60
LEU A 147
LEU A 196
PHE A 199
ILE A 204
 None
 1.16A 5ljcA-5u9cA:
undetectable		 5ljcA-5u9cA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 PHE A 965
TYR A 962
PRO A 997
SER A 998
LEU A 946
 None
 1.16A 5ljcA-5yimA:
undetectable		 5ljcA-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao7 ACETYLTRANSFERASE

(Elizabethkingia
anophelis) 		PF00583
(Acetyltransf_1) 		5 ALA A  24
LEU A  23
TYR A  18
ILE A  31
LEU A  42
 ACO  A 201 (-3.4A)
ACO  A 201 (-4.7A)
None
None
None
 1.28A 5ljcA-6ao7A:
undetectable		 5ljcA-6ao7A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 5 TYR A 347
LEU A 440
ARG A 387
TYR A 177
ILE A 384
 None
 1.30A 5ljcA-6bpcA:
undetectable		 5ljcA-6bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 5 PHE A 220
ALA A 178
LEU A 188
PRO A 190
ILE A 194
 None
 1.19A 5ljcA-6cauA:
undetectable		 5ljcA-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 5 TYR E 347
SER E 439
ARG E 387
TYR E 177
ILE E 384
 None
 1.17A 5ljcA-6d04E:
undetectable		 5ljcA-6d04E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 5 ALA B 320
LEU B 319
PRO B 341
ARG B 334
ILE B 325
 None
 0.96A 5ljcA-6evjB:
undetectable		 5ljcA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 5 PHE A 388
LEU A 403
ALA A 218
PRO A 221
TYR A 373
 None
 1.27A 5ljcA-6f4eA:
undetectable		 5ljcA-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 5 TYR A 325
LEU A  92
LEU A 133
PRO A 353
PHE A 136
 None
 1.24A 5ljcA-6g21A:
undetectable		 5ljcA-6g21A:
undetectable