SIMILAR PATTERNS OF AMINO ACIDS FOR 5LJB_A_RTLA201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ALA A 426
SER A 314
ARG A 186
ILE A 449
LEU A 238
 None
PTE  A 609 ( 4.1A)
None
PTE  A 609 (-3.7A)
None
 1.32A 5ljbA-1aorA:
undetectable		 5ljbA-1aorA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2r CYTOCHROME C2

(Rhodobacter
capsulatus) 		no annotation 5 TYR A  75
LEU A  87
ALA A  92
TYR A  53
ILE A  57
 HEM  A 120 (-4.6A)
None
None
HEM  A 120 (-4.7A)
HEM  A 120 (-4.2A)
 1.23A 5ljbA-1c2rA:
undetectable		 5ljbA-1c2rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 PHE E  27
LEU E 103
SER E  61
PHE E  64
ILE E  43
 None
 1.29A 5ljbA-1cziE:
undetectable		 5ljbA-1cziE:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 PHE A  56
LEU A 104
ALA A  66
TYR A  94
LEU A  16
 None
 1.40A 5ljbA-1ee8A:
undetectable		 5ljbA-1ee8A:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 TYR A  19
ALA A  33
PRO A  38
SER A  55
PHE A  57
TYR A  60
LEU A 117
 None
 0.80A 5ljbA-1gglA:
23.1		 5ljbA-1gglA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 TYR A  19
ALA A  33
SER A  55
PHE A  57
ARG A  58
TYR A  60
LEU A 117
 None
 0.84A 5ljbA-1gglA:
23.1		 5ljbA-1gglA:
54.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		5 LEU C 398
ALA C 394
TYR C 372
MET C 371
LEU C 336
 None
 1.38A 5ljbA-1h2tC:
undetectable		 5ljbA-1h2tC:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ALA A 388
PRO A 397
PHE A 393
MET A 405
ILE A 368
 None
 1.35A 5ljbA-1jx2A:
undetectable		 5ljbA-1jx2A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 PHE A  15
LEU A   8
ALA A  11
ARG A  34
LEU A  49
 None
 1.26A 5ljbA-1k6dA:
undetectable		 5ljbA-1k6dA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
ALA A  33
PRO A  38
SER A  55
ARG A  58
LEU A 117
 None
 0.81A 5ljbA-1lpjA:
24.4		 5ljbA-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
LEU A  29
ALA A  33
PRO A  38
ARG A  58
TYR A  60
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 ( 4.6A)
RTL  A 135 (-3.5A)
 0.88A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
LEU A  29
ALA A  33
PRO A  38
TYR A  60
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.88A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
LEU A  29
ALA A  33
SER A  55
TYR A  60
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.94A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
ALA A  33
SER A  55
PHE A  57
MET A  62
 RTL  A 135 ( 4.6A)
None
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 (-2.9A)
 1.23A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
LEU A  29
ALA A  33
PRO A  38
ARG A  58
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 (-3.5A)
 0.83A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
LEU A  29
ALA A  33
PRO A  38
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.94A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
LEU A  29
ALA A  33
SER A  55
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.95A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG

(Drosophila
melanogaster) 		PF00536
(SAM_1)
PF09246
(PHAT) 		5 TYR A 622
LEU A 692
ALA A 745
SER A 740
ILE A 702
 None
 1.27A 5ljbA-1oxjA:
undetectable		 5ljbA-1oxjA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyj GLUTATHIONE
S-TRANSFERASE

(Oryza sativa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 SER A  15
PHE A  17
ARG A  20
MET A  25
ILE A  72
 GSH  A 799 (-3.3A)
GSH  A 799 (-4.0A)
None
None
None
 1.29A 5ljbA-1oyjA:
undetectable		 5ljbA-1oyjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6f NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
1

(Homo sapiens) 		no annotation 5 SER A  89
PHE A   9
TYR A  75
ILE A  26
LEU A  45
 None
 1.30A 5ljbA-1p6fA:
undetectable		 5ljbA-1p6fA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq4 GLYOXYLATE-INDUCED
PROTEIN

(Pseudomonas
aeruginosa) 		PF07883
(Cupin_2) 		5 ALA A 118
PHE A 119
TYR A 263
ILE A 141
LEU A 219
 None
 1.31A 5ljbA-1sq4A:
undetectable		 5ljbA-1sq4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		5 PHE A  11
SER A 216
PHE A 438
TYR A 180
ILE A 176
 None
 1.36A 5ljbA-1tdkA:
undetectable		 5ljbA-1tdkA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to9 THI-4 PROTEIN

(Bacillus
subtilis) 		PF03070
(TENA_THI-4) 		5 ALA B 212
SER B 106
TYR B 112
MET B 116
LEU B  48
 None
None
None
None
HMH  B 302 ( 4.9A)
 1.09A 5ljbA-1to9B:
undetectable		 5ljbA-1to9B:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 PHE A 128
TYR A  36
LEU A 120
ALA A 127
LEU A   8
 None
 1.40A 5ljbA-1ufaA:
undetectable		 5ljbA-1ufaA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 PHE A 263
LEU A 177
ALA A 267
TYR A 191
ILE A 189
 None
 1.22A 5ljbA-2c4mA:
undetectable		 5ljbA-2c4mA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7l PHYCOERYTHROCYANIN
BETA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		5 LEU B  59
ALA B  55
MET B 105
ILE B 131
LEU B 160
 None
 1.30A 5ljbA-2c7lB:
undetectable		 5ljbA-2c7lB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwb METHICILLIN
RESISTANCE MECR1
PROTEIN

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		5 LEU A 432
PHE A 402
TYR A 396
ILE A 395
LEU A 482
 None
 1.29A 5ljbA-2iwbA:
undetectable		 5ljbA-2iwbA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mh9 BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF09382
(RQC) 		5 PHE A  80
LEU A  53
ALA A  76
ILE A  64
LEU A 107
 None
 1.17A 5ljbA-2mh9A:
undetectable		 5ljbA-2mh9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		5 PHE A 133
LEU A 268
ALA A 137
PHE A 194
LEU A 285
 None
 0.97A 5ljbA-2qvlA:
undetectable		 5ljbA-2qvlA:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
ALA A  33
SER A  55
ARG A  58
LEU A 117
 None
None
None
None
SO4  A 152 (-3.1A)
None
 0.91A 5ljbA-2rcqA:
23.9		 5ljbA-2rcqA:
53.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
SER A  55
PHE A  57
ARG A  58
LEU A 117
 None
None
None
None
SO4  A 152 (-3.1A)
None
 0.93A 5ljbA-2rcqA:
23.9		 5ljbA-2rcqA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		5 LEU A  78
PHE A  67
TYR A 155
MET A 156
ILE A  58
 GOL  A1345 (-4.3A)
GOL  A1345 (-4.2A)
GOL  A1343 (-4.5A)
GOL  A1343 (-3.8A)
None
 1.26A 5ljbA-2wabA:
undetectable		 5ljbA-2wabA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A 414
ALA A 423
PHE A 407
TYR A 495
LEU A 435
 None
 1.41A 5ljbA-2xpzA:
undetectable		 5ljbA-2xpzA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7b ACTIN-BINDING
PROTEIN ANILLIN

(Homo sapiens) 		PF00169
(PH) 		5 PHE A1056
ALA A1089
TYR A1016
ILE A 992
LEU A1034
 None
 1.19A 5ljbA-2y7bA:
undetectable		 5ljbA-2y7bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 PHE A 471
LEU A 466
PRO A 138
PHE A 478
LEU A 134
 None
 1.31A 5ljbA-2ycbA:
undetectable		 5ljbA-2ycbA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		5 PHE A 411
PRO A 381
SER A 398
TYR A 385
ILE A 392
 None
 1.37A 5ljbA-3a3cA:
undetectable		 5ljbA-3a3cA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 PHE A 166
PRO A 167
MET A 116
ILE A 137
LEU A 148
 None
 1.39A 5ljbA-3b2dA:
undetectable		 5ljbA-3b2dA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		5 TYR A 101
LEU A 129
ALA A 385
PHE A 384
ILE A 392
 None
 1.40A 5ljbA-3ez6A:
undetectable		 5ljbA-3ez6A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmp ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU B 168
PRO B 163
TYR B 196
ILE B 215
LEU B 192
 None
 1.41A 5ljbA-3fmpB:
undetectable		 5ljbA-3fmpB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 PHE A  97
LEU A1415
ALA A1419
PHE A  21
LEU A 245
 None
 1.41A 5ljbA-3h0gA:
undetectable		 5ljbA-3h0gA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		5 LEU A 322
ALA A 366
PRO A 358
PHE A 362
ILE A 306
 None
 1.40A 5ljbA-3h6eA:
undetectable		 5ljbA-3h6eA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmf PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PHE A 208
ALA A 273
SER A 267
PHE A 270
TYR A 262
 None
 1.21A 5ljbA-3hmfA:
undetectable		 5ljbA-3hmfA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks2 CHAPERONE PROTEIN
IPGC

(Shigella
flexneri) 		PF07720
(TPR_3) 		5 PHE A 127
ALA A 123
TYR A  93
MET A  74
LEU A 139
 None
 1.39A 5ljbA-3ks2A:
undetectable		 5ljbA-3ks2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		5 PHE A 328
TYR A 164
ALA A 219
ILE A 139
LEU A 310
 None
EDO  A 347 (-4.6A)
None
None
None
 1.22A 5ljbA-3kydA:
undetectable		 5ljbA-3kydA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 PHE A 260
LEU A 304
TYR A 233
ILE A 266
LEU A 168
 None
 1.33A 5ljbA-3m07A:
undetectable		 5ljbA-3m07A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		5 ALA A 145
SER A 202
PHE A 205
TYR A 134
LEU A  52
 None
 1.36A 5ljbA-3nfvA:
undetectable		 5ljbA-3nfvA:
17.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
PRO A  39
SER A  56
PHE A  58
 None
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-3.7A)
None
 0.97A 5ljbA-3nr3A:
19.8		 5ljbA-3nr3A:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A 108
PHE A 105
ARG A 290
TYR A 288
LEU A 374
 None
 1.32A 5ljbA-3nzgA:
undetectable		 5ljbA-3nzgA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		5 TYR A 494
LEU A 243
ALA A 246
ILE A 276
LEU A 259
 None
 1.31A 5ljbA-3nztA:
undetectable		 5ljbA-3nztA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR

(Shewanella
loihica) 		PF00440
(TetR_N) 		5 PHE A 187
LEU A  81
ALA A  85
MET A 124
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
None
None
 1.13A 5ljbA-3ppbA:
undetectable		 5ljbA-3ppbA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 PHE A 150
TYR A 153
LEU A 129
ALA A 245
LEU A 156
 None
 1.36A 5ljbA-3tqoA:
undetectable		 5ljbA-3tqoA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		5 PHE A 919
LEU A 507
ALA A 508
SER A 926
PHE A 511
 None
 1.33A 5ljbA-3u6nA:
undetectable		 5ljbA-3u6nA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF00089
(Trypsin) 		5 LEU A 242
ALA A 209
SER A 198
ILE A 234
LEU A 180
 None
 1.24A 5ljbA-3ureA:
undetectable		 5ljbA-3ureA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		5 TYR A  10
ALA A  38
PRO A 201
PHE A  37
ILE A 297
 None
 1.37A 5ljbA-3vywA:
undetectable		 5ljbA-3vywA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Bacteroides
fragilis) 		PF04041
(Glyco_hydro_130) 		5 LEU A 357
PRO A 259
PHE A 307
TYR A 339
LEU A 134
 None
 1.33A 5ljbA-3wauA:
undetectable		 5ljbA-3wauA:
15.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
ALA A  33
PRO A  38
SER A  55
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 (-4.8A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.2A)
None
 0.93A 5ljbA-3wbgA:
20.3		 5ljbA-3wbgA:
32.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 PHE A 902
LEU A 793
PHE A 777
ILE A 759
LEU A 906
 None
 1.28A 5ljbA-3welA:
2.2		 5ljbA-3welA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		5 TYR A  59
ALA A  56
PHE A 325
TYR A 331
ILE A 287
 None
 1.23A 5ljbA-3wx7A:
undetectable		 5ljbA-3wx7A:
16.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
ALA A  34
PRO A  39
SER A  56
 None
None
NA  A1132 ( 4.0A)
None
NA  A1132 (-2.9A)
 0.79A 5ljbA-4a60A:
19.3		 5ljbA-4a60A:
32.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE

(Pyrococcus
furiosus) 		PF00697
(PRAI) 		5 LEU A 149
ALA A 115
PRO A 105
SER A 108
ARG A 145
 None
 1.31A 5ljbA-4aajA:
undetectable		 5ljbA-4aajA:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
TYR A  22
LEU A  32
ALA A  36
SER A  58
 None
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
 0.98A 5ljbA-4azpA:
20.6		 5ljbA-4azpA:
34.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04153
(NOT2_3_5) 		5 PHE B 170
TYR B 168
ALA B 145
ILE B 190
LEU B 184
 None
 1.39A 5ljbA-4by6B:
undetectable		 5ljbA-4by6B:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqb SPERMIDINE/PUTRESCIN
E ABC SUPERFAMILY
ATP BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		5 LEU A  37
ALA A 277
PHE A 280
TYR A  40
LEU A 102
 None
 1.36A 5ljbA-4eqbA:
undetectable		 5ljbA-4eqbA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct) 		PF00977
(His_biosynth) 		5 LEU A 112
ALA A 116
MET A  62
ILE A  83
LEU A  77
 None
 1.33A 5ljbA-4evzA:
undetectable		 5ljbA-4evzA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 5 PHE A 129
LEU A 699
PRO A  63
SER A  55
PHE A 188
 None
 1.34A 5ljbA-4fyeA:
undetectable		 5ljbA-4fyeA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g19 GLUTATHIONE
TRANSFERASE GTE1

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		5 LEU A 118
ALA A  89
PRO A  74
TYR A  30
ILE A 207
 None
None
GSH  A 302 (-4.4A)
None
None
 1.36A 5ljbA-4g19A:
undetectable		 5ljbA-4g19A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 LEU A  37
ALA A 278
PHE A 281
TYR A  40
LEU A 102
 None
 1.35A 5ljbA-4gl0A:
undetectable		 5ljbA-4gl0A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 LEU B 355
SER B 132
PHE B 136
TYR B  77
LEU B  80
 None
 1.13A 5ljbA-4gnkB:
undetectable		 5ljbA-4gnkB:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		5 PHE A 346
LEU A 277
ALA A 279
PRO A 282
ARG A 318
 None
 1.16A 5ljbA-4hh1A:
undetectable		 5ljbA-4hh1A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis) 		PF07155
(ECF-ribofla_trS)
PF02361
(CbiQ) 		5 LEU T 161
ALA S  62
SER S  80
PHE S  65
LEU S  39
 None
 1.35A 5ljbA-4hzuT:
undetectable		 5ljbA-4hzuT:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld6 PWWP
DOMAIN-CONTAINING
PROTEIN 2B

(Homo sapiens) 		PF00855
(PWWP) 		5 PHE A 547
LEU A 585
ALA A 571
PRO A 505
ARG A 564
 None
 1.30A 5ljbA-4ld6A:
undetectable		 5ljbA-4ld6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Klebsiella
pneumoniae) 		PF02826
(2-Hacid_dh_C) 		5 ALA A 284
SER A  46
TYR A  44
ILE A   4
LEU A 300
 None
 1.25A 5ljbA-4n18A:
undetectable		 5ljbA-4n18A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		5 TYR A  63
ALA A  60
PHE A 329
TYR A 335
ILE A 291
 None
 1.28A 5ljbA-4nz5A:
undetectable		 5ljbA-4nz5A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF02940
(mRNA_triPase) 		5 ALA A 147
SER A 138
PHE A 135
ILE A 239
LEU A 290
 None
 1.34A 5ljbA-4pn0A:
undetectable		 5ljbA-4pn0A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sbv SOUTHERN BEAN MOSAIC
VIRUS COAT PROTEIN

(Southern bean
mosaic virus) 		PF00729
(Viral_coat) 		5 ALA A 182
ARG A 116
TYR A 117
ILE A 185
LEU A  78
 None
 1.13A 5ljbA-4sbvA:
undetectable		 5ljbA-4sbvA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 PHE A 330
LEU A 337
ALA A 334
TYR A 235
ILE A 266
 None
 1.42A 5ljbA-4u33A:
undetectable		 5ljbA-4u33A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		5 LEU A  79
ALA A  52
PHE A  55
ILE A  64
LEU A 179
 None
None
GOL  A 305 ( 4.8A)
None
None
 1.22A 5ljbA-4wrwA:
undetectable		 5ljbA-4wrwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		5 PHE A 377
LEU A 357
ALA A 356
SER A 339
ILE A 215
 None
 1.37A 5ljbA-4z43A:
undetectable		 5ljbA-4z43A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 PHE A 633
ARG A 702
TYR A 701
ILE A 705
LEU A 321
 None
 1.17A 5ljbA-4zlgA:
2.6		 5ljbA-4zlgA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PHE A  58
ALA A 103
PRO A  54
SER A 222
ILE A  93
 None
 1.38A 5ljbA-4zyjA:
undetectable		 5ljbA-4zyjA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 5 TYR A 583
LEU A 556
ALA A 464
PHE A 465
TYR A 458
 None
 1.21A 5ljbA-5aa6A:
undetectable		 5ljbA-5aa6A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		5 LEU A1086
ALA A1101
PRO A1067
SER A1051
ILE A1076
 None
 1.17A 5ljbA-5csaA:
undetectable		 5ljbA-5csaA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 PHE A  34
LEU A 433
ALA A 437
PHE A 137
LEU A  39
 MPG  A 602 (-4.6A)
None
MPG  A 602 ( 3.7A)
None
None
 1.22A 5ljbA-5f15A:
undetectable		 5ljbA-5f15A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		5 PRO A 543
SER A 126
PHE A 560
ILE A 573
LEU A 583
 None
 1.15A 5ljbA-5feiA:
undetectable		 5ljbA-5feiA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 PHE A 113
PRO A 410
PHE A 463
MET A 509
LEU A 407
 HEM  A 601 (-4.7A)
None
HEM  A 601 (-4.4A)
VOR  A 602 ( 4.2A)
None
 1.28A 5ljbA-5hs1A:
undetectable		 5ljbA-5hs1A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		5 LEU A1086
ALA A1101
PRO A1067
SER A1051
ILE A1076
 None
 1.20A 5ljbA-5i6eA:
undetectable		 5ljbA-5i6eA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 669
ALA A 681
PHE A 684
ILE A 785
LEU A 900
 None
 1.35A 5ljbA-5im3A:
undetectable		 5ljbA-5im3A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PHE A  76
LEU A 118
ALA A 295
ILE A 332
LEU A   5
 None
 1.38A 5ljbA-5kufA:
undetectable		 5ljbA-5kufA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		5 PHE S 309
ALA S 270
SER S 277
PHE S 273
ILE S 297
 None
 1.35A 5ljbA-5mpdS:
undetectable		 5ljbA-5mpdS:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 LEU A 196
ALA A 155
SER A 147
ILE A 188
LEU A 132
 None
 1.19A 5ljbA-5mrrA:
undetectable		 5ljbA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6u UNCHARACTERIZED
PROTEIN

(Shewanella
putrefaciens) 		no annotation 5 LEU C  89
PRO C 131
SER C 130
ILE C 112
LEU C 247
 None
None
U  A  18 ( 4.6A)
None
None
 1.28A 5ljbA-5o6uC:
undetectable		 5ljbA-5o6uC:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6u UNCHARACTERIZED
PROTEIN

(Shewanella
putrefaciens) 		no annotation 5 PRO C 131
SER C 130
ARG C 117
ILE C 112
LEU C 247
 None
U  A  18 ( 4.6A)
A  A  20 ( 3.4A)
None
None
 1.26A 5ljbA-5o6uC:
undetectable		 5ljbA-5o6uC:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 5 PHE A 559
LEU A 405
ALA A 558
TYR A 507
LEU A 222
 None
None
79M  A 711 ( 4.3A)
None
None
 1.37A 5ljbA-5oc9A:
undetectable		 5ljbA-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 PHE A 965
TYR A 962
PRO A 997
SER A 998
LEU A 946
 None
 1.19A 5ljbA-5yimA:
undetectable		 5ljbA-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 LEU A 665
SER A 661
PHE A 572
MET A 702
LEU A 706
 None
 1.30A 5ljbA-6byiA:
undetectable		 5ljbA-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 5 TYR E 347
SER E 439
ARG E 387
TYR E 177
ILE E 384
 None
 1.16A 5ljbA-6d04E:
undetectable		 5ljbA-6d04E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 5 PHE A 188
ALA A 285
PHE A 272
TYR A 288
ILE A 394
 None
 1.41A 5ljbA-6eo5A:
undetectable		 5ljbA-6eo5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 5 PHE A 388
LEU A 403
ALA A 218
PRO A 221
TYR A 191
 None
 1.36A 5ljbA-6f4eA:
undetectable		 5ljbA-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 5 PHE A 388
LEU A 403
ALA A 218
PRO A 221
TYR A 373
 None
 1.27A 5ljbA-6f4eA:
undetectable		 5ljbA-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 5 PHE A 169
LEU A 123
ALA A 165
ILE A 119
LEU A 176
 None
 1.40A 5ljbA-6fwhA:
undetectable		 5ljbA-6fwhA:
undetectable