SIMILAR PATTERNS OF AMINO ACIDS FOR 5LJB_A_RTLA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ALA A 426
SER A 314
ARG A 186
ILE A 449
LEU A 238
 None
PTE  A 609 ( 4.1A)
None
PTE  A 609 (-3.7A)
None
 1.32A 5ljbA-1aorA:
undetectable		 5ljbA-1aorA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2r CYTOCHROME C2

(Rhodobacter
capsulatus) 		no annotation 5 TYR A  75
LEU A  87
ALA A  92
TYR A  53
ILE A  57
 HEM  A 120 (-4.6A)
None
None
HEM  A 120 (-4.7A)
HEM  A 120 (-4.2A)
 1.23A 5ljbA-1c2rA:
undetectable		 5ljbA-1c2rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 PHE E  27
LEU E 103
SER E  61
PHE E  64
ILE E  43
 None
 1.29A 5ljbA-1cziE:
undetectable		 5ljbA-1cziE:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		5 PHE A  56
LEU A 104
ALA A  66
TYR A  94
LEU A  16
 None
 1.40A 5ljbA-1ee8A:
undetectable		 5ljbA-1ee8A:
17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 TYR A  19
ALA A  33
PRO A  38
SER A  55
PHE A  57
TYR A  60
LEU A 117
 None
 0.80A 5ljbA-1gglA:
23.1		 5ljbA-1gglA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 TYR A  19
ALA A  33
SER A  55
PHE A  57
ARG A  58
TYR A  60
LEU A 117
 None
 0.84A 5ljbA-1gglA:
23.1		 5ljbA-1gglA:
54.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		5 LEU C 398
ALA C 394
TYR C 372
MET C 371
LEU C 336
 None
 1.38A 5ljbA-1h2tC:
undetectable		 5ljbA-1h2tC:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ALA A 388
PRO A 397
PHE A 393
MET A 405
ILE A 368
 None
 1.35A 5ljbA-1jx2A:
undetectable		 5ljbA-1jx2A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 PHE A  15
LEU A   8
ALA A  11
ARG A  34
LEU A  49
 None
 1.26A 5ljbA-1k6dA:
undetectable		 5ljbA-1k6dA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
ALA A  33
PRO A  38
SER A  55
ARG A  58
LEU A 117
 None
 0.81A 5ljbA-1lpjA:
24.4		 5ljbA-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
LEU A  29
ALA A  33
PRO A  38
ARG A  58
TYR A  60
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 ( 4.6A)
RTL  A 135 (-3.5A)
 0.88A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
LEU A  29
ALA A  33
PRO A  38
TYR A  60
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.88A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
LEU A  29
ALA A  33
SER A  55
TYR A  60
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.94A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
ALA A  33
SER A  55
PHE A  57
MET A  62
 RTL  A 135 ( 4.6A)
None
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 (-2.9A)
 1.23A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
LEU A  29
ALA A  33
PRO A  38
ARG A  58
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
None
RTL  A 135 (-3.5A)
 0.83A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
LEU A  29
ALA A  33
PRO A  38
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.94A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		7 PHE A  16
TYR A  19
LEU A  29
ALA A  33
SER A  55
MET A  62
ILE A  77
 RTL  A 135 ( 4.6A)
None
RTL  A 135 (-3.8A)
RTL  A 135 ( 3.9A)
RTL  A 135 ( 4.4A)
RTL  A 135 (-2.9A)
RTL  A 135 (-3.5A)
 0.95A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG

(Drosophila
melanogaster) 		PF00536
(SAM_1)
PF09246
(PHAT) 		5 TYR A 622
LEU A 692
ALA A 745
SER A 740
ILE A 702
 None
 1.27A 5ljbA-1oxjA:
undetectable		 5ljbA-1oxjA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyj GLUTATHIONE
S-TRANSFERASE

(Oryza sativa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 SER A  15
PHE A  17
ARG A  20
MET A  25
ILE A  72
 GSH  A 799 (-3.3A)
GSH  A 799 (-4.0A)
None
None
None
 1.29A 5ljbA-1oyjA:
undetectable		 5ljbA-1oyjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6f NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
1

(Homo sapiens) 		no annotation 5 SER A  89
PHE A   9
TYR A  75
ILE A  26
LEU A  45
 None
 1.30A 5ljbA-1p6fA:
undetectable		 5ljbA-1p6fA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq4 GLYOXYLATE-INDUCED
PROTEIN

(Pseudomonas
aeruginosa) 		PF07883
(Cupin_2) 		5 ALA A 118
PHE A 119
TYR A 263
ILE A 141
LEU A 219
 None
 1.31A 5ljbA-1sq4A:
undetectable		 5ljbA-1sq4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		5 PHE A  11
SER A 216
PHE A 438
TYR A 180
ILE A 176
 None
 1.36A 5ljbA-1tdkA:
undetectable		 5ljbA-1tdkA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to9 THI-4 PROTEIN

(Bacillus
subtilis) 		PF03070
(TENA_THI-4) 		5 ALA B 212
SER B 106
TYR B 112
MET B 116
LEU B  48
 None
None
None
None
HMH  B 302 ( 4.9A)
 1.09A 5ljbA-1to9B:
undetectable		 5ljbA-1to9B:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 PHE A 128
TYR A  36
LEU A 120
ALA A 127
LEU A   8
 None
 1.40A 5ljbA-1ufaA:
undetectable		 5ljbA-1ufaA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 PHE A 263
LEU A 177
ALA A 267
TYR A 191
ILE A 189
 None
 1.22A 5ljbA-2c4mA:
undetectable		 5ljbA-2c4mA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7l PHYCOERYTHROCYANIN
BETA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		5 LEU B  59
ALA B  55
MET B 105
ILE B 131
LEU B 160
 None
 1.30A 5ljbA-2c7lB:
undetectable		 5ljbA-2c7lB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwb METHICILLIN
RESISTANCE MECR1
PROTEIN

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		5 LEU A 432
PHE A 402
TYR A 396
ILE A 395
LEU A 482
 None
 1.29A 5ljbA-2iwbA:
undetectable		 5ljbA-2iwbA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mh9 BLOOM SYNDROME
PROTEIN

(Homo sapiens) 		PF09382
(RQC) 		5 PHE A  80
LEU A  53
ALA A  76
ILE A  64
LEU A 107
 None
 1.17A 5ljbA-2mh9A:
undetectable		 5ljbA-2mh9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		5 PHE A 133
LEU A 268
ALA A 137
PHE A 194
LEU A 285
 None
 0.97A 5ljbA-2qvlA:
undetectable		 5ljbA-2qvlA:
18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
ALA A  33
SER A  55
ARG A  58
LEU A 117
 None
None
None
None
SO4  A 152 (-3.1A)
None
 0.91A 5ljbA-2rcqA:
23.9		 5ljbA-2rcqA:
53.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
SER A  55
PHE A  57
ARG A  58
LEU A 117
 None
None
None
None
SO4  A 152 (-3.1A)
None
 0.93A 5ljbA-2rcqA:
23.9		 5ljbA-2rcqA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wab ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00657
(Lipase_GDSL) 		5 LEU A  78
PHE A  67
TYR A 155
MET A 156
ILE A  58
 GOL  A1345 (-4.3A)
GOL  A1345 (-4.2A)
GOL  A1343 (-4.5A)
GOL  A1343 (-3.8A)
None
 1.26A 5ljbA-2wabA:
undetectable		 5ljbA-2wabA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A 414
ALA A 423
PHE A 407
TYR A 495
LEU A 435
 None
 1.41A 5ljbA-2xpzA:
undetectable		 5ljbA-2xpzA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7b ACTIN-BINDING
PROTEIN ANILLIN

(Homo sapiens) 		PF00169
(PH) 		5 PHE A1056
ALA A1089
TYR A1016
ILE A 992
LEU A1034
 None
 1.19A 5ljbA-2y7bA:
undetectable		 5ljbA-2y7bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 PHE A 471
LEU A 466
PRO A 138
PHE A 478
LEU A 134
 None
 1.31A 5ljbA-2ycbA:
undetectable		 5ljbA-2ycbA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		5 PHE A 411
PRO A 381
SER A 398
TYR A 385
ILE A 392
 None
 1.37A 5ljbA-3a3cA:
undetectable		 5ljbA-3a3cA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 PHE A 166
PRO A 167
MET A 116
ILE A 137
LEU A 148
 None
 1.39A 5ljbA-3b2dA:
undetectable		 5ljbA-3b2dA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		5 TYR A 101
LEU A 129
ALA A 385
PHE A 384
ILE A 392
 None
 1.40A 5ljbA-3ez6A:
undetectable		 5ljbA-3ez6A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmp ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU B 168
PRO B 163
TYR B 196
ILE B 215
LEU B 192
 None
 1.41A 5ljbA-3fmpB:
undetectable		 5ljbA-3fmpB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 PHE A  97
LEU A1415
ALA A1419
PHE A  21
LEU A 245
 None
 1.41A 5ljbA-3h0gA:
undetectable		 5ljbA-3h0gA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		5 LEU A 322
ALA A 366
PRO A 358
PHE A 362
ILE A 306
 None
 1.40A 5ljbA-3h6eA:
undetectable		 5ljbA-3h6eA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmf PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PHE A 208
ALA A 273
SER A 267
PHE A 270
TYR A 262
 None
 1.21A 5ljbA-3hmfA:
undetectable		 5ljbA-3hmfA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks2 CHAPERONE PROTEIN
IPGC

(Shigella
flexneri) 		PF07720
(TPR_3) 		5 PHE A 127
ALA A 123
TYR A  93
MET A  74
LEU A 139
 None
 1.39A 5ljbA-3ks2A:
undetectable		 5ljbA-3ks2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		5 PHE A 328
TYR A 164
ALA A 219
ILE A 139
LEU A 310
 None
EDO  A 347 (-4.6A)
None
None
None
 1.22A 5ljbA-3kydA:
undetectable		 5ljbA-3kydA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 PHE A 260
LEU A 304
TYR A 233
ILE A 266
LEU A 168
 None
 1.33A 5ljbA-3m07A:
undetectable		 5ljbA-3m07A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		5 ALA A 145
SER A 202
PHE A 205
TYR A 134
LEU A  52
 None
 1.36A 5ljbA-3nfvA:
undetectable		 5ljbA-3nfvA:
17.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
PRO A  39
SER A  56
PHE A  58
 None
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-3.7A)
None
 0.97A 5ljbA-3nr3A:
19.8		 5ljbA-3nr3A:
35.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A 108
PHE A 105
ARG A 290
TYR A 288
LEU A 374
 None
 1.32A 5ljbA-3nzgA:
undetectable		 5ljbA-3nzgA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		5 TYR A 494
LEU A 243
ALA A 246
ILE A 276
LEU A 259
 None
 1.31A 5ljbA-3nztA:
undetectable		 5ljbA-3nztA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppb PUTATIVE TETR FAMILY
TRANSCRIPTION
REGULATOR

(Shewanella
loihica) 		PF00440
(TetR_N) 		5 PHE A 187
LEU A  81
ALA A  85
MET A 124
ILE A 135
 PG4  A 216 (-4.7A)
None
PG4  A 216 ( 4.1A)
None
None
 1.13A 5ljbA-3ppbA:
undetectable		 5ljbA-3ppbA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		5 PHE A 150
TYR A 153
LEU A 129
ALA A 245
LEU A 156
 None
 1.36A 5ljbA-3tqoA:
undetectable		 5ljbA-3tqoA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		5 PHE A 919
LEU A 507
ALA A 508
SER A 926
PHE A 511
 None
 1.33A 5ljbA-3u6nA:
undetectable		 5ljbA-3u6nA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF00089
(Trypsin) 		5 LEU A 242
ALA A 209
SER A 198
ILE A 234
LEU A 180
 None
 1.24A 5ljbA-3ureA:
undetectable		 5ljbA-3ureA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		5 TYR A  10
ALA A  38
PRO A 201
PHE A  37
ILE A 297
 None
 1.37A 5ljbA-3vywA:
undetectable		 5ljbA-3vywA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Bacteroides
fragilis) 		PF04041
(Glyco_hydro_130) 		5 LEU A 357
PRO A 259
PHE A 307
TYR A 339
LEU A 134
 None
 1.33A 5ljbA-3wauA:
undetectable		 5ljbA-3wauA:
15.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		6 PHE A  16
TYR A  19
ALA A  33
PRO A  38
SER A  55
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 (-4.8A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.2A)
None
 0.93A 5ljbA-3wbgA:
20.3		 5ljbA-3wbgA:
32.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 PHE A 902
LEU A 793
PHE A 777
ILE A 759
LEU A 906
 None
 1.28A 5ljbA-3welA:
2.2		 5ljbA-3welA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		5 TYR A  59
ALA A  56
PHE A 325
TYR A 331
ILE A 287
 None
 1.23A 5ljbA-3wx7A:
undetectable		 5ljbA-3wx7A:
16.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  17
TYR A  20
ALA A  34
PRO A  39
SER A  56
 None
None
NA  A1132 ( 4.0A)
None
NA  A1132 (-2.9A)
 0.79A 5ljbA-4a60A:
19.3		 5ljbA-4a60A:
32.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE

(Pyrococcus
furiosus) 		PF00697
(PRAI) 		5 LEU A 149
ALA A 115
PRO A 105
SER A 108
ARG A 145
 None
 1.31A 5ljbA-4aajA:
undetectable		 5ljbA-4aajA:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
TYR A  22
LEU A  32
ALA A  36
SER A  58
 None
None
A9M  A1136 ( 4.1A)
A9M  A1136 (-3.4A)
A9M  A1136 ( 4.1A)
 0.98A 5ljbA-4azpA:
20.6		 5ljbA-4azpA:
34.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04153
(NOT2_3_5) 		5 PHE B 170
TYR B 168
ALA B 145
ILE B 190
LEU B 184
 None
 1.39A 5ljbA-4by6B:
undetectable		 5ljbA-4by6B:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqb SPERMIDINE/PUTRESCIN
E ABC SUPERFAMILY
ATP BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		5 LEU A  37
ALA A 277
PHE A 280
TYR A  40
LEU A 102
 None
 1.36A 5ljbA-4eqbA:
undetectable		 5ljbA-4eqbA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct) 		PF00977
(His_biosynth) 		5 LEU A 112
ALA A 116
MET A  62
ILE A  83
LEU A  77
 None
 1.33A 5ljbA-4evzA:
undetectable		 5ljbA-4evzA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 5 PHE A 129
LEU A 699
PRO A  63
SER A  55
PHE A 188
 None
 1.34A 5ljbA-4fyeA:
undetectable		 5ljbA-4fyeA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g19 GLUTATHIONE
TRANSFERASE GTE1

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		5 LEU A 118
ALA A  89
PRO A  74
TYR A  30
ILE A 207
 None
None
GSH  A 302 (-4.4A)
None
None
 1.36A 5ljbA-4g19A:
undetectable		 5ljbA-4g19A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 LEU A  37
ALA A 278
PHE A 281
TYR A  40
LEU A 102
 None
 1.35A 5ljbA-4gl0A:
undetectable		 5ljbA-4gl0A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 LEU B 355
SER B 132
PHE B 136
TYR B  77
LEU B  80
 None
 1.13A 5ljbA-4gnkB:
undetectable		 5ljbA-4gnkB:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		5 PHE A 346
LEU A 277
ALA A 279
PRO A 282
ARG A 318
 None
 1.16A 5ljbA-4hh1A:
undetectable		 5ljbA-4hh1A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis) 		PF07155
(ECF-ribofla_trS)
PF02361
(CbiQ) 		5 LEU T 161
ALA S  62
SER S  80
PHE S  65
LEU S  39
 None
 1.35A 5ljbA-4hzuT:
undetectable		 5ljbA-4hzuT:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld6 PWWP
DOMAIN-CONTAINING
PROTEIN 2B

(Homo sapiens) 		PF00855
(PWWP) 		5 PHE A 547
LEU A 585
ALA A 571
PRO A 505
ARG A 564
 None
 1.30A 5ljbA-4ld6A:
undetectable		 5ljbA-4ld6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Klebsiella
pneumoniae) 		PF02826
(2-Hacid_dh_C) 		5 ALA A 284
SER A  46
TYR A  44
ILE A   4
LEU A 300
 None
 1.25A 5ljbA-4n18A:
undetectable		 5ljbA-4n18A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		5 TYR A  63
ALA A  60
PHE A 329
TYR A 335
ILE A 291
 None
 1.28A 5ljbA-4nz5A:
undetectable		 5ljbA-4nz5A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pn0 MRNA-CAPPING ENZYME
SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF02940
(mRNA_triPase) 		5 ALA A 147
SER A 138
PHE A 135
ILE A 239
LEU A 290
 None
 1.34A 5ljbA-4pn0A:
undetectable		 5ljbA-4pn0A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sbv SOUTHERN BEAN MOSAIC
VIRUS COAT PROTEIN

(Southern bean
mosaic virus) 		PF00729
(Viral_coat) 		5 ALA A 182
ARG A 116
TYR A 117
ILE A 185
LEU A  78
 None
 1.13A 5ljbA-4sbvA:
undetectable		 5ljbA-4sbvA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 PHE A 330
LEU A 337
ALA A 334
TYR A 235
ILE A 266
 None
 1.42A 5ljbA-4u33A:
undetectable		 5ljbA-4u33A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrw URACIL-DNA
GLYCOSYLASE

(Mycobacterium
tuberculosis) 		PF03167
(UDG) 		5 LEU A  79
ALA A  52
PHE A  55
ILE A  64
LEU A 179
 None
None
GOL  A 305 ( 4.8A)
None
None
 1.22A 5ljbA-4wrwA:
undetectable		 5ljbA-4wrwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		5 PHE A 377
LEU A 357
ALA A 356
SER A 339
ILE A 215
 None
 1.37A 5ljbA-4z43A:
undetectable		 5ljbA-4z43A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 PHE A 633
ARG A 702
TYR A 701
ILE A 705
LEU A 321
 None
 1.17A 5ljbA-4zlgA:
2.6		 5ljbA-4zlgA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PHE A  58
ALA A 103
PRO A  54
SER A 222
ILE A  93
 None
 1.38A 5ljbA-4zyjA:
undetectable		 5ljbA-4zyjA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 5 TYR A 583
LEU A 556
ALA A 464
PHE A 465
TYR A 458
 None
 1.21A 5ljbA-5aa6A:
undetectable		 5ljbA-5aa6A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		5 LEU A1086
ALA A1101
PRO A1067
SER A1051
ILE A1076
 None
 1.17A 5ljbA-5csaA:
undetectable		 5ljbA-5csaA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		5 PHE A  34
LEU A 433
ALA A 437
PHE A 137
LEU A  39
 MPG  A 602 (-4.6A)
None
MPG  A 602 ( 3.7A)
None
None
 1.22A 5ljbA-5f15A:
undetectable		 5ljbA-5f15A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		5 PRO A 543
SER A 126
PHE A 560
ILE A 573
LEU A 583
 None
 1.15A 5ljbA-5feiA:
undetectable		 5ljbA-5feiA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		5 PHE A 113
PRO A 410
PHE A 463
MET A 509
LEU A 407
 HEM  A 601 (-4.7A)
None
HEM  A 601 (-4.4A)
VOR  A 602 ( 4.2A)
None
 1.28A 5ljbA-5hs1A:
undetectable		 5ljbA-5hs1A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		5 LEU A1086
ALA A1101
PRO A1067
SER A1051
ILE A1076
 None
 1.20A 5ljbA-5i6eA:
undetectable		 5ljbA-5i6eA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 669
ALA A 681
PHE A 684
ILE A 785
LEU A 900
 None
 1.35A 5ljbA-5im3A:
undetectable		 5ljbA-5im3A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PHE A  76
LEU A 118
ALA A 295
ILE A 332
LEU A   5
 None
 1.38A 5ljbA-5kufA:
undetectable		 5ljbA-5kufA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		5 PHE S 309
ALA S 270
SER S 277
PHE S 273
ILE S 297
 None
 1.35A 5ljbA-5mpdS:
undetectable		 5ljbA-5mpdS:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 LEU A 196
ALA A 155
SER A 147
ILE A 188
LEU A 132
 None
 1.19A 5ljbA-5mrrA:
undetectable		 5ljbA-5mrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6u UNCHARACTERIZED
PROTEIN

(Shewanella
putrefaciens) 		no annotation 5 LEU C  89
PRO C 131
SER C 130
ILE C 112
LEU C 247
 None
None
U  A  18 ( 4.6A)
None
None
 1.28A 5ljbA-5o6uC:
undetectable		 5ljbA-5o6uC:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6u UNCHARACTERIZED
PROTEIN

(Shewanella
putrefaciens) 		no annotation 5 PRO C 131
SER C 130
ARG C 117
ILE C 112
LEU C 247
 None
U  A  18 ( 4.6A)
A  A  20 ( 3.4A)
None
None
 1.26A 5ljbA-5o6uC:
undetectable		 5ljbA-5o6uC:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 5 PHE A 559
LEU A 405
ALA A 558
TYR A 507
LEU A 222
 None
None
79M  A 711 ( 4.3A)
None
None
 1.37A 5ljbA-5oc9A:
undetectable		 5ljbA-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 5 PHE A 965
TYR A 962
PRO A 997
SER A 998
LEU A 946
 None
 1.19A 5ljbA-5yimA:
undetectable		 5ljbA-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 LEU A 665
SER A 661
PHE A 572
MET A 702
LEU A 706
 None
 1.30A 5ljbA-6byiA:
undetectable		 5ljbA-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 5 TYR E 347
SER E 439
ARG E 387
TYR E 177
ILE E 384
 None
 1.16A 5ljbA-6d04E:
undetectable		 5ljbA-6d04E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 5 PHE A 188
ALA A 285
PHE A 272
TYR A 288
ILE A 394
 None
 1.41A 5ljbA-6eo5A:
undetectable		 5ljbA-6eo5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 5 PHE A 388
LEU A 403
ALA A 218
PRO A 221
TYR A 191
 None
 1.36A 5ljbA-6f4eA:
undetectable		 5ljbA-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 5 PHE A 388
LEU A 403
ALA A 218
PRO A 221
TYR A 373
 None
 1.27A 5ljbA-6f4eA:
undetectable		 5ljbA-6f4eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 5 PHE A 169
LEU A 123
ALA A 165
ILE A 119
LEU A 176
 None
 1.40A 5ljbA-6fwhA:
undetectable		 5ljbA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		4 LEU A   9
LEU A  97
ILE A 114
THR A 112
 None
 0.90A 5ljbA-1e19A:
undetectable		 5ljbA-1e19A:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  20
LEU A  36
LYS A  40
THR A  53
TRP A 106
 None
 0.46A 5ljbA-1gglA:
23.1		 5ljbA-1gglA:
54.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6f T-BOX TRANSCRIPTION
FACTOR TBX3

(Homo sapiens) 		PF00907
(T-box) 		4 LEU A 107
LEU A 112
ILE A 259
THR A 121
 None
 1.06A 5ljbA-1h6fA:
undetectable		 5ljbA-1h6fA:
17.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		4 LEU A  36
LYS A  40
THR A  53
GLN A 108
 None
 0.87A 5ljbA-1kqxA:
24.6		 5ljbA-1kqxA:
58.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		4 LYS A  40
THR A  53
TRP A 106
GLN A 108
 None
 0.46A 5ljbA-1kqxA:
24.6		 5ljbA-1kqxA:
58.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6n GAG POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00540
(Gag_p17)
PF00607
(Gag_p24) 		4 LEU A 152
LEU A 188
ILE A 247
THR A 180
 None
 0.93A 5ljbA-1l6nA:
undetectable		 5ljbA-1l6nA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  36
LYS A  40
ILE A  51
THR A  53
TRP A 106
MET A 119
 None
 0.56A 5ljbA-1lpjA:
24.4		 5ljbA-1lpjA:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mx8 CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 LEU A  20
LEU A  36
LYS A  40
ILE A  51
 RTL  A 135 ( 4.7A)
RTL  A 135 ( 4.6A)
RTL  A 135 ( 4.4A)
RTL  A 135 ( 4.6A)
 0.85A 5ljbA-1mx8A:
19.7		 5ljbA-1mx8A:
96.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 LEU A 537
LEU A 275
ILE A 289
THR A 285
 None
 0.93A 5ljbA-1ps9A:
undetectable		 5ljbA-1ps9A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzx N UTILIZATION
SUBSTANCE PROTEIN B
HOMOLOG

(Thermotoga
maritima) 		PF01029
(NusB) 		4 LEU A  64
LEU A  85
ILE A  98
THR A 103
 None
 1.06A 5ljbA-1tzxA:
undetectable		 5ljbA-1tzxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1
SISTER CHROMATID
COHESION PROTEIN 1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF02463
(SMC_N)
PF04824
(Rad21_Rec8) 		4 LEU E 532
LEU A1218
ILE A1186
THR A  29
 None
 1.07A 5ljbA-1w1wE:
undetectable		 5ljbA-1w1wE:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 LEU C 240
LEU C 269
ILE C 322
THR C 274
 None
 0.96A 5ljbA-1wa5C:
undetectable		 5ljbA-1wa5C:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we1 HEME OXYGENASE 1

(Synechocystis
sp. PCC 6803) 		PF01126
(Heme_oxygenase) 		4 LEU A  74
LEU A 129
ILE A  65
MET A  57
 None
HEM  A 300 ( 4.4A)
None
IPA  A1005 (-4.8A)
 1.01A 5ljbA-1we1A:
undetectable		 5ljbA-1we1A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xup GLYCEROL KINASE

(Enterococcus
casseliflavus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU O 146
LEU O 162
ILE O  53
GLN O  83
 None
 0.87A 5ljbA-1xupO:
undetectable		 5ljbA-1xupO:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		4 LEU A  72
LEU A  66
THR A  60
MET A 126
 None
 1.02A 5ljbA-1y8pA:
undetectable		 5ljbA-1y8pA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU I 118
LEU I 298
ILE I 107
THR I 303
 None
 1.05A 5ljbA-1yveI:
undetectable		 5ljbA-1yveI:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8g AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		4 LEU A  49
LEU A   6
ILE A 117
THR A  95
 None
 1.04A 5ljbA-2a8gA:
3.2		 5ljbA-2a8gA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 127
LEU A  75
ILE A 167
GLN A 145
 None
 1.03A 5ljbA-2akpA:
undetectable		 5ljbA-2akpA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4i AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		4 LEU A 128
LEU A  85
ILE A  62
THR A  40
 None
 0.98A 5ljbA-2c4iA:
undetectable		 5ljbA-2c4iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4i AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		4 LEU A 249
LEU A 206
ILE A 183
THR A 161
 None
 0.98A 5ljbA-2c4iA:
undetectable		 5ljbA-2c4iA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		4 LEU A  19
ILE A  63
THR A  61
TRP A 109
 None
 0.99A 5ljbA-2cbrA:
20.2		 5ljbA-2cbrA:
41.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1i CARBOXYLESTERASE

(Bacillus cereus) 		PF02230
(Abhydrolase_2) 		4 LEU A 125
LEU A  20
ILE A  73
THR A  76
 None
 1.06A 5ljbA-2h1iA:
undetectable		 5ljbA-2h1iA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE

(Sulfolobus
solfataricus) 		PF00102
(Y_phosphatase) 		4 LEU A  55
LEU A  93
ILE A  67
GLN A  77
 None
 0.94A 5ljbA-2i6jA:
undetectable		 5ljbA-2i6jA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus) 		PF02541
(Ppx-GppA) 		4 LEU A 290
LEU A 209
ILE A 165
THR A 147
 None
 1.05A 5ljbA-2j4rA:
undetectable		 5ljbA-2j4rA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5t GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01472
(PUA) 		4 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 0.89A 5ljbA-2j5tA:
undetectable		 5ljbA-2j5tA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgs CIRCULAR PERMUTANT
OF AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		4 LEU A   7
LEU A  98
ILE A  75
THR A  53
 None
 1.05A 5ljbA-2jgsA:
3.0		 5ljbA-2jgsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		4 LEU A  52
LEU A  69
ILE A 137
THR A 113
 None
 1.03A 5ljbA-2kdyA:
2.0		 5ljbA-2kdyA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o62 HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		PF12204
(DUF3598) 		4 LEU A 167
LEU A 239
ILE A 198
GLN A 210
 GOL  A 274 (-4.7A)
None
None
GOL  A 277 (-3.2A)
 0.99A 5ljbA-2o62A:
8.2		 5ljbA-2o62A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsx PUTATIVE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Vibrio
parahaemolyticus) 		PF03466
(LysR_substrate) 		4 LEU A 211
LEU A  31
THR A  23
GLN A 112
 None
None
SO4  A 216 ( 3.2A)
SO4  A 216 ( 4.4A)
 1.03A 5ljbA-2qsxA:
undetectable		 5ljbA-2qsxA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 LEU A 162
LEU A 238
ILE A 284
THR A 288
 None
 0.98A 5ljbA-2quqA:
undetectable		 5ljbA-2quqA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 LEU A 527
LEU A 222
ILE A 313
GLN A 382
 None
 0.97A 5ljbA-2qveA:
undetectable		 5ljbA-2qveA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r41 UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06124
(DUF960) 		4 LEU A  75
LEU A  31
ILE A  41
GLN A  64
 None
 1.04A 5ljbA-2r41A:
undetectable		 5ljbA-2r41A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5v PCZA361.1

(Amycolatopsis
orientalis) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 LEU A 303
ILE A 216
THR A 214
GLN A 240
 None
None
HHH  A4114 (-3.1A)
None
 0.97A 5ljbA-2r5vA:
undetectable		 5ljbA-2r5vA:
15.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LYS A  40
THR A  53
TRP A 106
GLN A 108
 None
 0.59A 5ljbA-2rcqA:
23.9		 5ljbA-2rcqA:
53.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		4 LEU A 240
LYS A 243
ILE A 257
THR A 259
 None
 0.84A 5ljbA-2rhzA:
undetectable		 5ljbA-2rhzA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		4 LEU A 297
LEU A  57
ILE A 267
THR A  52
 None
 0.95A 5ljbA-2rinA:
undetectable		 5ljbA-2rinA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 LEU A 166
ILE A 188
THR A 253
MET A 214
 None
 0.92A 5ljbA-2w21A:
undetectable		 5ljbA-2w21A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1

(Homo sapiens) 		PF01380
(SIS) 		4 LEU A 529
LYS A 635
ILE A 627
THR A 633
 None
 1.05A 5ljbA-2zj4A:
undetectable		 5ljbA-2zj4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5o CADD-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF12981
(DUF3865) 		4 LEU A 171
LEU A 152
ILE A  49
GLN A  46
 None
 1.05A 5ljbA-3b5oA:
undetectable		 5ljbA-3b5oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 117
LEU A  86
ILE A  71
GLN A  48
 None
 1.01A 5ljbA-3d5tA:
undetectable		 5ljbA-3d5tA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU A 118
LEU A 298
ILE A 107
THR A 303
 None
 0.99A 5ljbA-3fr8A:
undetectable		 5ljbA-3fr8A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 LEU A 201
LEU A 342
ILE A 333
THR A 331
 LEU  A 201 ( 0.6A)
LEU  A 342 ( 0.5A)
ILE  A 333 ( 0.4A)
THR  A 331 ( 0.8A)
 0.93A 5ljbA-3gnrA:
undetectable		 5ljbA-3gnrA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 4 LEU A  51
LEU A  97
ILE A 334
GLN A 352
 None
 1.00A 5ljbA-3hkaA:
undetectable		 5ljbA-3hkaA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE

(Mus musculus) 		PF00266
(Aminotran_5) 		4 LEU A 115
LEU A  96
ILE A 215
GLN A 220
 None
None
None
EDO  A 507 ( 4.7A)
 1.01A 5ljbA-3kgwA:
undetectable		 5ljbA-3kgwA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		4 LEU A 375
LEU A  27
ILE A  89
THR A  32
 None
None
None
FMT  A 387 ( 4.5A)
 1.01A 5ljbA-3pmmA:
undetectable		 5ljbA-3pmmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		4 LEU A 168
ILE A 301
THR A 235
TRP A 278
 None
 1.07A 5ljbA-3qwtA:
undetectable		 5ljbA-3qwtA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		4 LEU A 374
LEU A  26
ILE A  88
THR A  31
 None
 0.98A 5ljbA-3qwtA:
undetectable		 5ljbA-3qwtA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		4 LEU A 259
LEU A 217
ILE A 170
TRP A 201
 None
 1.02A 5ljbA-3rmjA:
undetectable		 5ljbA-3rmjA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc3 UV DAMAGE
ENDONUCLEASE

(Sulfolobus
acidocaldarius) 		PF03851
(UvdE) 		4 LEU A  45
ILE A  63
THR A  62
MET A 132
 None
 1.05A 5ljbA-3tc3A:
undetectable		 5ljbA-3tc3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE

(Leptospirillum
rubarum) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 LEU A 227
LEU A 211
ILE A 288
THR A 290
 None
None
CL  A 336 ( 4.6A)
None
 0.90A 5ljbA-3ttgA:
undetectable		 5ljbA-3ttgA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		4 LEU A 146
ILE A 200
THR A 196
TRP A 170
 NAP  A 552 (-4.2A)
None
NAP  A 552 (-3.5A)
None
 1.04A 5ljbA-3up4A:
undetectable		 5ljbA-3up4A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Streptomyces
coelicolor) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 LEU A 323
ILE A 236
THR A 234
GLN A 260
 None
RMN  A1369 ( 4.8A)
RMN  A1369 (-3.2A)
RMN  A1369 ( 4.7A)
 0.98A 5ljbA-3zgjA:
undetectable		 5ljbA-3zgjA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 LEU A 369
LEU A 391
ILE A 304
THR A 303
 None
 0.99A 5ljbA-4d4lA:
undetectable		 5ljbA-4d4lA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 183
ILE A 292
TRP A 173
GLN A 172
 None
 0.94A 5ljbA-4dd5A:
undetectable		 5ljbA-4dd5A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkv ALCOHOL
DEHYDROGENASE,
PROPANOL-PREFERRING

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 311
LEU A  56
ILE A 122
MET A   1
 None
 1.07A 5ljbA-4gkvA:
undetectable		 5ljbA-4gkvA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A 606
LEU A 599
THR A 551
GLN A 694
 None
 1.04A 5ljbA-4h6yA:
undetectable		 5ljbA-4h6yA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 LEU M 285
LEU M 361
ILE M  78
THR M  81
 None
 0.98A 5ljbA-4heaM:
undetectable		 5ljbA-4heaM:
13.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i9r CELLULAR RETINOIC
ACID-BINDING PROTEIN
2

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  19
ILE A  63
TRP A 109
MET A 123
 None
RET  A 201 ( 4.7A)
RET  A 201 (-3.7A)
RET  A 201 (-4.6A)
 1.00A 5ljbA-4i9rA:
19.5		 5ljbA-4i9rA:
43.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 LEU A 124
LEU A 362
ILE A 388
THR A 243
 None
 0.95A 5ljbA-4ictA:
undetectable		 5ljbA-4ictA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		4 LEU A 331
ILE A 321
TRP A 263
GLN A 260
 None
 0.99A 5ljbA-4il5A:
undetectable		 5ljbA-4il5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		4 LEU A 386
LEU A 379
THR A 375
MET A 357
 None
 0.81A 5ljbA-4k17A:
undetectable		 5ljbA-4k17A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		4 LEU A  50
LEU A 153
ILE A  38
THR A  41
 None
 1.05A 5ljbA-4mwzA:
undetectable		 5ljbA-4mwzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		4 LEU A   9
LEU A  83
ILE A 104
TRP A  97
 None
 1.00A 5ljbA-4n7tA:
undetectable		 5ljbA-4n7tA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR
PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM

(Gallus gallus;
Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2)
PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 139
LEU A  94
TRP A 144
GLN C  75
 None
 0.73A 5ljbA-4pbvA:
undetectable		 5ljbA-4pbvA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 LEU A 458
LEU A  67
ILE A 922
THR A 139
 None
 1.06A 5ljbA-4q73A:
undetectable		 5ljbA-4q73A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 LEU A 144
LEU A 100
ILE A  90
THR A  95
 None
 0.98A 5ljbA-4r85A:
undetectable		 5ljbA-4r85A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		5 LEU A 193
LEU A 134
ILE A 176
THR A  86
GLN A 173
 None
 1.45A 5ljbA-4rgyA:
undetectable		 5ljbA-4rgyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryk LMO0325 PROTEIN

(Listeria
monocytogenes) 		PF01381
(HTH_3) 		4 LEU A 181
LEU A 200
ILE A 250
GLN A 247
 None
 1.04A 5ljbA-4rykA:
undetectable		 5ljbA-4rykA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryk LMO0325 PROTEIN

(Listeria
monocytogenes) 		PF01381
(HTH_3) 		4 LEU A 181
LEU A 200
THR A 205
GLN A 247
 None
 0.99A 5ljbA-4rykA:
undetectable		 5ljbA-4rykA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0h T-BOX TRANSCRIPTION
FACTOR TBX5

(Homo sapiens) 		PF00907
(T-box) 		4 LEU A  58
LEU A  63
ILE A 212
THR A  72
 None
 1.05A 5ljbA-4s0hA:
undetectable		 5ljbA-4s0hA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trk C. ELEGANS HIM-3

(Caenorhabditis
elegans) 		PF02301
(HORMA) 		4 LEU A 182
LEU A  51
ILE A 225
MET A 179
 None
 0.89A 5ljbA-4trkA:
undetectable		 5ljbA-4trkA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 4
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14629
(ORC4_C)
PF13191
(AAA_16)
PF14630
(ORC5_C) 		4 LEU E 102
LEU E 148
ILE D  85
GLN D 245
 None
 1.04A 5ljbA-4xgcE:
undetectable		 5ljbA-4xgcE:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 LEU A 622
LEU A 666
ILE A 448
TRP A 145
 None
 1.04A 5ljbA-4xwhA:
undetectable		 5ljbA-4xwhA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 LEU A  47
ILE A 286
THR A 289
GLN A  36
 None
 1.06A 5ljbA-4zwjA:
undetectable		 5ljbA-4zwjA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 LEU A 228
LEU A 202
ILE A 194
THR A 196
 None
 0.96A 5ljbA-4zzhA:
undetectable		 5ljbA-4zzhA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 LEU A 369
LEU A 391
ILE A 304
THR A 303
 None
 0.98A 5ljbA-5ajzA:
undetectable		 5ljbA-5ajzA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 LEU A 665
ILE A 719
THR A 717
GLN A 699
 None
U  C   7 ( 3.9A)
U  C   7 ( 2.9A)
None
 0.89A 5ljbA-5aorA:
undetectable		 5ljbA-5aorA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		4 LEU A 171
LEU A 178
ILE A 116
THR A 123
 None
None
SAH  A 301 ( 4.6A)
None
 1.00A 5ljbA-5bp7A:
undetectable		 5ljbA-5bp7A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		4 LEU A   4
LEU A 384
ILE A 236
THR A 240
 None
 0.95A 5ljbA-5bq2A:
undetectable		 5ljbA-5bq2A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii;
Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		4 LEU B  19
LEU A 584
GLN A 609
MET A 612
 None
 0.95A 5ljbA-5c6gB:
undetectable		 5ljbA-5c6gB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgz 4-OXALMESACONATE
HYDRATASE

(Pseudomonas
putida) 		PF02585
(PIG-L) 		4 LEU A 115
LEU A 177
ILE A 190
TRP A  20
 None
 1.06A 5ljbA-5cgzA:
undetectable		 5ljbA-5cgzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN

(Thermococcus
kodakarensis) 		PF02900
(LigB) 		4 LEU A  64
LEU A  44
ILE A  52
THR A 137
 None
 0.96A 5ljbA-5heeA:
undetectable		 5ljbA-5heeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 LEU A 302
LEU A 279
THR A 367
GLN A 417
 None
 0.81A 5ljbA-5hxaA:
undetectable		 5ljbA-5hxaA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 LEU A 195
ILE A 206
THR A 202
MET A 323
 None
 0.98A 5ljbA-5hyhA:
undetectable		 5ljbA-5hyhA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 LEU A1088
LEU A1135
ILE A1057
GLN A1126
 None
 0.94A 5ljbA-5ja1A:
undetectable		 5ljbA-5ja1A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 117
ILE A  69
GLN A  -2
MET A   1
 None
 1.01A 5ljbA-5k1sA:
undetectable		 5ljbA-5k1sA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		4 LEU A 270
LEU A 231
ILE A 318
GLN A 283
 BU1  A 520 (-4.1A)
None
None
None
 1.04A 5ljbA-5kc9A:
undetectable		 5ljbA-5kc9A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 LEU A 250
LEU A 259
ILE A 202
THR A 201
 None
 1.03A 5ljbA-5kodA:
undetectable		 5ljbA-5kodA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU B 254
LEU B 166
ILE B 160
THR B 162
 None
None
None
CL  B 806 ( 4.7A)
 1.05A 5ljbA-5ldrB:
undetectable		 5ljbA-5ldrB:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 4 LEU A  41
ILE A  52
GLN A  65
MET A  69
 None
 0.68A 5ljbA-5nn7A:
undetectable		 5ljbA-5nn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 4 LEU A 217
LEU A 214
ILE A 115
TRP A 187
 None
 0.92A 5ljbA-5nn7A:
undetectable		 5ljbA-5nn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt RIBOSOMAL PROTEIN
S19, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 4 LEU o 127
LEU o 117
ILE o 108
GLN o  65
 None
 0.92A 5ljbA-5opto:
undetectable		 5ljbA-5opto:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr0 SEED LINOLEATE
13S-LIPOXYGENASE-1

(Glycine max) 		no annotation 4 LEU A 546
LEU A 496
ILE A 704
THR A 709
 None
 1.04A 5ljbA-5tr0A:
undetectable		 5ljbA-5tr0A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 LEU A 814
LEU A 721
ILE A 689
THR A 690
 None
 1.04A 5ljbA-5vanA:
undetectable		 5ljbA-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LEU A  76
ILE A 430
THR A 427
MET A  70
 None
 1.00A 5ljbA-5xapA:
undetectable		 5ljbA-5xapA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LEU A 393
LEU A  82
ILE A 293
THR A 272
 None
 1.06A 5ljbA-5xh9A:
undetectable		 5ljbA-5xh9A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 LEU A 432
LEU A 405
ILE B 585
THR A 400
 None
 1.06A 5ljbA-5y58A:
undetectable		 5ljbA-5y58A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 4 LEU A 325
LEU A 297
ILE A 407
THR A 284
 None
 0.97A 5ljbA-6cipA:
undetectable		 5ljbA-6cipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 4 LEU A   4
LEU A 384
ILE A 236
THR A 240
 None
 1.03A 5ljbA-6cn1A:
undetectable		 5ljbA-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 LEU A1293
LEU A1142
ILE A1087
GLN A1083
 None
 0.98A 5ljbA-6ez8A:
undetectable		 5ljbA-6ez8A:
undetectable