SIMILAR PATTERNS OF AMINO ACIDS FOR 5LI8_A_KKKA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		5 THR A 592
ASN A 183
ALA A 602
ARG A 247
ASN A 593
 None
 1.36A 5li8A-2o36A:
0.9		 5li8A-2o36A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		5 THR A 593
ASN A 184
ALA A 603
ARG A 248
ASN A 594
 None
 1.40A 5li8A-2o3eA:
0.0		 5li8A-2o3eA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 THR A 743
VAL A 976
ALA A 227
SER A 749
ASN A 746
 None
 1.21A 5li8A-3opyA:
0.0		 5li8A-3opyA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 THR A 743
VAL A 976
ALA A 508
SER A 749
ASN A 746
 None
 1.41A 5li8A-3opyA:
0.0		 5li8A-3opyA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 5 THR A  54
PRO A  79
VAL A 227
ALA A 293
ASN A  57
 None
 1.40A 5li8A-3wlaA:
0.0		 5li8A-3wlaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		5 THR A 143
VAL B 374
ALA B 330
LYS B 342
ARG B 322
 None
 1.29A 5li8A-4bwcA:
0.0		 5li8A-4bwcA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f06 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 THR A 255
PRO A 257
PHE A  41
ALA A 289
SER A 305
 None
 1.35A 5li8A-4f06A:
0.0		 5li8A-4f06A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTD
CYTOCHROME C FAMILY
PROTEIN
POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 5 THR A   9
PRO D 145
VAL C 182
ALA D 134
SER A  16
 None
 1.41A 5li8A-6f0kA:
undetectable		 5li8A-6f0kA:
11.73