SIMILAR PATTERNS OF AMINO ACIDS FOR 5LG3_I_Z80I401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 PHE A 363
VAL A 393
THR A 389
ILE A  88
 None
 1.00A 5lg3I-1fw8A:
undetectable		 5lg3I-1fw8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Escherichia
coli) 		PF02668
(TauD) 		4 PHE A  46
ASP A 249
TRP A 128
ILE A 247
 None
 1.02A 5lg3I-1gy9A:
undetectable		 5lg3I-1gy9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 PHE A   8
VAL A  81
ASN A  12
ASP A 214
 None
 0.97A 5lg3I-1k1xA:
0.2		 5lg3I-1k1xA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 ILE A  68
PHE A 142
THR A 244
ILE A 446
 None
None
NAD  A 900 (-4.6A)
None
 0.88A 5lg3I-1la2A:
0.0		 5lg3I-1la2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 ILE A 261
VAL A 169
ASP A 256
ILE A 244
 None
 1.04A 5lg3I-1lnzA:
undetectable		 5lg3I-1lnzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m39 CALTRACTIN, ISOFORM
1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 ILE A 121
PHE A 110
VAL A 129
ASP A 116
 None
 0.75A 5lg3I-1m39A:
undetectable		 5lg3I-1m39A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny1 PROBABLE
POLYSACCHARIDE
DEACETYLASE PDAA

(Bacillus
subtilis) 		PF01522
(Polysacc_deac_1) 		4 PHE A  97
VAL A 150
THR A 154
ASP A 116
 None
 0.84A 5lg3I-1ny1A:
undetectable		 5lg3I-1ny1A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 PHE A  19
VAL A  49
THR A  45
ILE A 159
 None
 0.95A 5lg3I-1qpgA:
0.0		 5lg3I-1qpgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		4 VAL A 232
THR A 246
ASP A 119
ILE A 301
 None
 1.02A 5lg3I-1qwyA:
0.0		 5lg3I-1qwyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ILE E 440
PHE E 453
VAL E 370
THR E 373
 None
 0.91A 5lg3I-1skyE:
0.0		 5lg3I-1skyE:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq7 TRIOSEPHOSPHATE
ISOMERASE

(Gallus gallus) 		PF00121
(TIM) 		4 ILE A  59
THR A  37
ASN A 245
ILE A 244
 None
 1.05A 5lg3I-1sq7A:
undetectable		 5lg3I-1sq7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 ILE A 350
VAL A 256
ASP A 330
ILE A 269
 None
 1.00A 5lg3I-1su7A:
undetectable		 5lg3I-1su7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 225
PHE A 235
VAL A 242
ASN A 260
 None
 0.93A 5lg3I-1tufA:
undetectable		 5lg3I-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umr CONVULXIN BETA

(Crotalus
durissus) 		PF00059
(Lectin_C) 		4 ILE C 268
VAL C 254
THR C 257
TRP C 267
 None
 0.82A 5lg3I-1umrC:
undetectable		 5lg3I-1umrC:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Borreliella
burgdorferi) 		PF02127
(Peptidase_M18) 		4 ILE A  29
PHE A  28
THR A 440
ILE A 258
 None
 0.94A 5lg3I-1y7eA:
undetectable		 5lg3I-1y7eA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 ILE A 146
PHE A 211
VAL A 165
THR A 177
 None
 0.94A 5lg3I-2awaA:
undetectable		 5lg3I-2awaA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ILE C  39
VAL C  54
ASN C  46
ILE C 253
 None
 1.00A 5lg3I-2d3tC:
undetectable		 5lg3I-2d3tC:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE

(Homo sapiens) 		PF05158
(RNA_pol_Rpc34) 		4 ILE A  37
VAL A  25
ASN A  54
TRP A  38
 None
 1.01A 5lg3I-2dk5A:
undetectable		 5lg3I-2dk5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 ILE A 332
VAL A 310
THR A   5
ILE A 303
 None
 0.78A 5lg3I-2e28A:
undetectable		 5lg3I-2e28A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyu TWITCHING MOTILITY
PROTEIN PILT

(Aquifex
aeolicus) 		PF00437
(T2SSE) 		4 ILE A 253
THR A 142
ASP A 248
ILE A 276
 None
 1.04A 5lg3I-2eyuA:
undetectable		 5lg3I-2eyuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g18 PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Anabaena sp.) 		PF05996
(Fe_bilin_red) 		4 ILE A  57
VAL A 222
THR A 219
ILE A  83
 None
 1.00A 5lg3I-2g18A:
undetectable		 5lg3I-2g18A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		4 VAL A 343
ASN A 367
ASP A 374
ILE A 244
 None
 0.96A 5lg3I-2gjmA:
undetectable		 5lg3I-2gjmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		4 ILE A 201
THR A 191
ASN A 214
ILE A  18
 TUX  A 901 (-4.7A)
TUX  A 901 (-2.9A)
None
TUX  A 901 ( 4.9A)
 0.98A 5lg3I-2go4A:
undetectable		 5lg3I-2go4A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq7 ENDOPOLYGALACTURONAS
E

(Colletotrichum
lupini) 		PF00295
(Glyco_hydro_28) 		4 ILE A 204
VAL A 188
ASN A 152
ASP A 233
 None
 0.86A 5lg3I-2iq7A:
undetectable		 5lg3I-2iq7A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1

(Rattus
norvegicus) 		PF01161
(PBP) 		4 ILE A 137
VAL A  90
ASN A 132
ASP A 134
 None
 1.04A 5lg3I-2iqxA:
undetectable		 5lg3I-2iqxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mng POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 4

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 ILE A 623
VAL A 642
THR A 644
ILE A 661
 None
 1.06A 5lg3I-2mngA:
undetectable		 5lg3I-2mngA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxx AMYLASE-BINDING
PROTEIN ABPA

(Streptococcus
gordonii) 		no annotation 4 ILE A  61
PHE A 103
VAL A 111
ASN A  51
 None
 1.00A 5lg3I-2mxxA:
2.3		 5lg3I-2mxxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 ILE A 250
PHE A 205
VAL A 274
THR A 288
 None
 1.04A 5lg3I-2oajA:
undetectable		 5lg3I-2oajA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF08241
(Methyltransf_11) 		4 ILE A 113
THR A  97
ASP A  28
ILE A  79
 None
GOL  A 213 ( 4.0A)
None
GOL  A 213 ( 4.6A)
 1.04A 5lg3I-2p8jA:
undetectable		 5lg3I-2p8jA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ILE A  10
VAL A  78
THR A  82
ILE A 104
 None
 0.75A 5lg3I-2v0sA:
undetectable		 5lg3I-2v0sA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 4 ILE A 416
VAL A 505
THR A 537
ASN A 548
 None
 0.82A 5lg3I-2vf1A:
undetectable		 5lg3I-2vf1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p
AQUAPORIN PIP2-7 7

(Komagataella
pastoris) 		PF00230
(MIP) 		4 ILE A 131
PHE A 128
VAL A 120
THR A 116
 None
 1.06A 5lg3I-2w1pA:
undetectable		 5lg3I-2w1pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		4 ILE A 452
ASN A 495
ASP A 455
ILE A 450
 None
 0.90A 5lg3I-2xa7A:
1.1		 5lg3I-2xa7A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Prochlorococcus
marinus) 		PF00142
(Fer4_NifH) 		4 VAL A 206
THR A 175
ASN A 177
ILE A 217
 None
None
EPE  A1297 (-4.0A)
None
 0.97A 5lg3I-2ynmA:
undetectable		 5lg3I-2ynmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 180
PHE A 190
VAL A 197
ASN A 210
 None
 0.93A 5lg3I-2yxxA:
undetectable		 5lg3I-2yxxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 ILE A 673
PHE A 667
VAL A 654
ILE A 687
 None
 0.84A 5lg3I-2zj8A:
3.4		 5lg3I-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ILE A 216
VAL A 253
ASP A 221
ILE A 224
 None
 1.03A 5lg3I-3bmwA:
undetectable		 5lg3I-3bmwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpo INTERLEUKIN 13
INTERLEUKIN-13
RECEPTOR ALPHA-1
CHAIN

(Homo sapiens) 		PF03487
(IL13)
PF09240
(IL6Ra-bind) 		4 ILE C  78
ASP A  87
TRP A  35
ILE A  90
 ILE  C  78 ( 0.7A)
ASP  A  87 ( 0.6A)
TRP  A  35 ( 0.5A)
ILE  A  90 ( 0.7A)
 1.05A 5lg3I-3bpoC:
2.5		 5lg3I-3bpoC:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 186
VAL A 199
THR A 218
ASN A 216
 None
 1.04A 5lg3I-3db2A:
undetectable		 5lg3I-3db2A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE

(Neisseria
meningitidis) 		PF00701
(DHDPS) 		4 ILE A  28
VAL A   7
THR A  36
ASN A  34
 None
None
None
GOL  A 299 (-3.1A)
 1.01A 5lg3I-3fluA:
undetectable		 5lg3I-3fluA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 ILE A 230
PHE A 259
ASN A 407
ILE A 196
 None
 1.02A 5lg3I-3fn9A:
undetectable		 5lg3I-3fn9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwr YQZB PROTEIN

(Bacillus
subtilis) 		PF00571
(CBS) 		4 ILE A 175
VAL A 123
THR A 149
ASN A 153
 ADP  A 221 (-3.7A)
None
ADP  A 221 (-3.7A)
None
 0.78A 5lg3I-3fwrA:
undetectable		 5lg3I-3fwrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxq LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 ILE A  94
PHE A  96
VAL A 280
ILE A 288
 None
 0.98A 5lg3I-3fxqA:
undetectable		 5lg3I-3fxqA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4e ISOCITRATE LYASE

(Burkholderia
pseudomallei) 		PF00463
(ICL) 		4 VAL A 180
THR A 224
ASP A 218
ILE A 173
 None
 0.92A 5lg3I-3i4eA:
undetectable		 5lg3I-3i4eA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		4 ILE A 243
VAL A 110
THR A 108
ILE A 238
 None
 1.05A 5lg3I-3jskA:
undetectable		 5lg3I-3jskA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ILE A 122
VAL A  62
ASP A  10
ILE A 108
 None
 1.02A 5lg3I-3kjrA:
undetectable		 5lg3I-3kjrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kls EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 ILE X 169
PHE X 153
VAL X 138
ASN X 176
 None
 1.06A 5lg3I-3klsX:
undetectable		 5lg3I-3klsX:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 ILE A 111
VAL A 144
ASP A 117
ILE A 126
 None
 1.04A 5lg3I-3l0gA:
undetectable		 5lg3I-3l0gA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncm PROTEIN (NEURAL CELL
ADHESION MOLECULE,
LARGE ISOFORM)

(Rattus
norvegicus) 		PF13927
(Ig_3) 		4 ILE A  21
VAL A  52
ASP A  24
ILE A  33
 None
 1.00A 5lg3I-3ncmA:
undetectable		 5lg3I-3ncmA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nep MALATE DEHYDROGENASE

(Salinibacter
ruber) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE X 227
PHE X 175
VAL X 212
THR X 206
 None
 0.96A 5lg3I-3nepX:
undetectable		 5lg3I-3nepX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0k ALDO/KETO REDUCTASE

(Brucella
abortus) 		PF00248
(Aldo_ket_red) 		4 PHE A 187
THR A 203
ASN A 179
ILE A 181
 None
None
None
EDO  A 301 ( 4.3A)
 0.93A 5lg3I-3o0kA:
undetectable		 5lg3I-3o0kA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5a PERIPLASMIC NITRATE
REDUCTASE

(Cupriavidus
necator) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PHE A 765
VAL A 740
ASN A 776
ILE A 775
 None
None
MGD  A1803 (-2.9A)
None
 0.90A 5lg3I-3o5aA:
undetectable		 5lg3I-3o5aA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg7 NEUROFIBROMIN

(Homo sapiens) 		PF13716
(CRAL_TRIO_2) 		4 ILE A1658
VAL A1665
THR A1627
ASP A1623
 PTY  A 400 ( 4.8A)
None
None
None
 0.91A 5lg3I-3pg7A:
undetectable		 5lg3I-3pg7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py6 BETA-LACTAMASE-LIKE

(Brucella
abortus) 		PF12706
(Lactamase_B_2) 		4 ILE A  61
PHE A 178
THR A 240
ASP A 188
 None
None
None
MN  A 300 (-2.5A)
 0.98A 5lg3I-3py6A:
undetectable		 5lg3I-3py6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 PHE A 269
VAL A 286
ASP A 242
ILE A 240
 None
 1.04A 5lg3I-3qdqA:
undetectable		 5lg3I-3qdqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7k PROBABLE ACYL COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 206
VAL A 191
THR A 160
ASN A 172
 None
 0.95A 5lg3I-3r7kA:
4.5		 5lg3I-3r7kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 ILE A 330
VAL A 308
THR A   4
ILE A 301
 None
 0.66A 5lg3I-3t05A:
undetectable		 5lg3I-3t05A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE

(Coxiella
burnetii) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 341
PHE A 296
VAL A 361
ILE A 304
 None
 1.04A 5lg3I-3uwcA:
undetectable		 5lg3I-3uwcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9o DIHYDRONEOPTERIN
ALDOLASE

(Burkholderia
thailandensis) 		PF02152
(FolB) 		4 ILE A  87
VAL A  45
THR A 114
ASP A  95
 EDO  A 144 (-4.5A)
None
None
None
 0.95A 5lg3I-3v9oA:
undetectable		 5lg3I-3v9oA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		4 PHE A  15
VAL A  63
ASP A  25
ILE A  40
 None
 1.05A 5lg3I-3vseA:
undetectable		 5lg3I-3vseA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbx PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		4 PHE A 172
THR A 188
ASN A 164
ILE A 166
 None
 0.88A 5lg3I-3wbxA:
undetectable		 5lg3I-3wbxA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 VAL B 340
ASP B 126
TRP B 129
ILE B 131
 None
 1.01A 5lg3I-4cakB:
undetectable		 5lg3I-4cakB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 VAL A 381
THR A 379
ASP A 330
ILE A 404
 None
 0.93A 5lg3I-4cvcA:
undetectable		 5lg3I-4cvcA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		4 PHE A 314
VAL A 407
THR A  54
ASN A 318
 None
None
DDZ  A  51 ( 4.4A)
CA  A1528 (-2.7A)
 1.07A 5lg3I-4cxkA:
undetectable		 5lg3I-4cxkA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei0 UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF14725
(DUF4466) 		4 ILE A 292
VAL A 303
THR A 253
ILE A 216
 None
 1.04A 5lg3I-4ei0A:
3.6		 5lg3I-4ei0A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		4 PHE A 199
VAL A 203
THR A  25
ILE A 184
 None
 0.97A 5lg3I-4fidA:
undetectable		 5lg3I-4fidA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ILE A 174
VAL A 181
TRP A  99
ILE A  97
 None
 1.07A 5lg3I-4iugA:
undetectable		 5lg3I-4iugA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 ILE A 206
VAL A 243
ASP A 211
ILE A 214
 None
 1.01A 5lg3I-4jcmA:
undetectable		 5lg3I-4jcmA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9q ARF-LIKE GTPASE

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		4 ILE A  39
VAL A  91
ASN A 128
ASP A 170
 None
None
GNP  A 301 (-3.3A)
None
 0.98A 5lg3I-4m9qA:
undetectable		 5lg3I-4m9qA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 173
VAL A 160
ASN A 178
ASP A 176
 None
 1.04A 5lg3I-4mn8A:
undetectable		 5lg3I-4mn8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 ILE A  48
VAL A 396
THR A 405
ILE A 407
 None
 0.90A 5lg3I-4oyaA:
undetectable		 5lg3I-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ILE A 565
PHE A 202
VAL A 424
ASN A 572
ILE A 305
 None
None
None
EDO  A 612 ( 4.5A)
None
 1.31A 5lg3I-4ph9A:
undetectable		 5lg3I-4ph9A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plf LACTATE
DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 213
VAL A 197
THR A 194
ASP A 219
 None
 0.93A 5lg3I-4plfA:
undetectable		 5lg3I-4plfA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 ILE A 525
PHE A 459
THR A 412
ILE A 442
 None
 0.95A 5lg3I-4qawA:
undetectable		 5lg3I-4qawA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb1 XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6) 		4 ILE A 136
PHE A  70
THR A  23
ILE A  53
 None
 1.03A 5lg3I-4qb1A:
undetectable		 5lg3I-4qb1A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 ILE A 481
PHE A 431
VAL A  57
ASP A 476
 None
 0.97A 5lg3I-4s3pA:
undetectable		 5lg3I-4s3pA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		4 ILE A 219
VAL A 262
THR A 229
ILE A 214
 SO4  A 302 ( 4.9A)
None
None
None
 1.06A 5lg3I-4twbA:
undetectable		 5lg3I-4twbA:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		4 ILE A  23
PHE A 126
ASP A 158
TRP A 160
 None
 0.45A 5lg3I-4twfA:
32.6		 5lg3I-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 ILE A 128
PHE A 117
VAL A 136
ASP A 123
 None
 0.97A 5lg3I-4wpxA:
undetectable		 5lg3I-4wpxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE L 610
PHE L 589
ASP L 597
TRP L 600
 None
 1.02A 5lg3I-4xr7L:
2.6		 5lg3I-4xr7L:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 ILE A 245
VAL A 141
ASP A 251
ILE A 426
 None
 1.05A 5lg3I-4y23A:
undetectable		 5lg3I-4y23A:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		4 ILE A  23
PHE A 126
ASP A 158
TRP A 160
 None
 0.52A 5lg3I-4yeuA:
29.4		 5lg3I-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		4 ILE A  23
PHE A 126
VAL A 147
TRP A 160
 None
 0.64A 5lg3I-4yeuA:
29.4		 5lg3I-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 PHE A 224
VAL A 255
ASP A 195
ILE A 197
 None
 0.88A 5lg3I-4yv2A:
undetectable		 5lg3I-4yv2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 4 ILE A  36
VAL A  76
ASP A  42
ILE A  58
 None
 1.01A 5lg3I-5affA:
4.8		 5lg3I-5affA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomyces
pombe) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 ILE I 373
VAL I 345
THR I 348
ILE I 350
 None
 1.01A 5lg3I-5b04I:
undetectable		 5lg3I-5b04I:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8w CGMP-DEPENDENT
PROTEIN KINASE 2

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 ILE A 225
VAL A 252
THR A 254
ILE A 195
 None
 1.03A 5lg3I-5c8wA:
undetectable		 5lg3I-5c8wA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di3 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
13B

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		4 ILE B  39
VAL B  91
ASN B 128
ASP B 170
 None
None
GNP  B 301 (-3.2A)
None
 1.04A 5lg3I-5di3B:
undetectable		 5lg3I-5di3B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4o CAPSID PROTEIN VP1

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 VAL A 391
ASN A 239
ASP A 247
ILE A 449
 None
 1.00A 5lg3I-5f4oA:
undetectable		 5lg3I-5f4oA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 ILE A 249
VAL A 292
THR A 294
ILE A 130
 None
 1.00A 5lg3I-5g4iA:
undetectable		 5lg3I-5g4iA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		4 ILE A 393
VAL A 365
THR A 382
ILE A 355
 None
 1.04A 5lg3I-5gtkA:
undetectable		 5lg3I-5gtkA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1u GERMACRADIEN-4-OL
SYNTHASE

(Streptomyces
citricolor) 		no annotation 4 ILE A 185
PHE A 182
VAL A 193
ASP A 294
 None
 1.07A 5lg3I-5i1uA:
4.3		 5lg3I-5i1uA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihy UNCHARACTERIZED
PROTEIN

(Bacillus
subtilis) 		PF01966
(HD) 		4 ILE A  94
VAL A  57
THR A  53
ASP A  89
 None
 1.06A 5lg3I-5ihyA:
3.2		 5lg3I-5ihyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 297
VAL A 311
THR A 235
ASN A 289
 None
None
None
NAG  A 508 (-1.9A)
 0.95A 5lg3I-5l6fA:
undetectable		 5lg3I-5l6fA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m04 GTPASE OBGE/CGTA

(Escherichia
coli) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 ILE A  88
PHE A  65
VAL A  96
THR A  94
 None
 0.97A 5lg3I-5m04A:
undetectable		 5lg3I-5m04A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		4 PHE A  43
ASP A 252
TRP A 127
ILE A 250
 None
 1.01A 5lg3I-5vn6A:
undetectable		 5lg3I-5vn6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 PHE A 394
VAL A 385
THR A   6
ILE A 349
 None
 0.80A 5lg3I-5wu7A:
3.2		 5lg3I-5wu7A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbq PEROXIREDOXIN

(Pyrococcus
horikoshii) 		no annotation 4 PHE A  42
VAL A  97
THR A  16
ILE A  82
 None
 1.06A 5lg3I-5xbqA:
undetectable		 5lg3I-5xbqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S1E

(Leishmania
donovani) 		no annotation 4 ILE A 214
VAL A 127
THR A 125
ILE A 170
 None
 0.97A 5lg3I-6az1A:
undetectable		 5lg3I-6az1A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 4 PHE A 174
ASN A 146
ASP A 263
TRP A 264
 None
0X9  A 407 (-3.9A)
None
SO4  A 406 (-3.8A)
 1.02A 5lg3I-6f79A:
undetectable		 5lg3I-6f79A:
undetectable