SIMILAR PATTERNS OF AMINO ACIDS FOR 5LG3_H_Z80H401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)


(Allochromatium
vinosum)
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
5 ILE A  80
ILE A 261
VAL A  87
THR A  89
ILE A  33
None
FAD  A 699 (-3.7A)
None
None
FAD  A 699 (-4.7A)
1.09A 5lg3H-1fcdA:
undetectable
5lg3H-1fcdA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris)
PF13354
(Beta-lactamase2)
5 ILE A  29
ILE A  57
GLU A  52
ASP A  53
ILE A 290
None
1.20A 5lg3H-1hzoA:
0.0
5lg3H-1hzoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id0 PHOQ HISTIDINE
KINASE


(Escherichia
coli)
PF02518
(HATPase_c)
5 ILE A 411
ILE A 400
VAL A 474
ASN A 389
ASP A 415
None
None
None
ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
1.25A 5lg3H-1id0A:
0.0
5lg3H-1id0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger)
PF00544
(Pec_lyase_C)
5 ILE A 140
ILE A 121
VAL A 169
THR A 171
ILE A 156
None
1.20A 5lg3H-1idjA:
0.0
5lg3H-1idjA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE


(Bacillus
circulans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
5 ILE A 215
PHE A 136
VAL A 252
ASP A 220
ILE A 223
None
1.26A 5lg3H-1kclA:
0.4
5lg3H-1kclA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus)
PF02078
(Synapsin)
PF02750
(Synapsin_C)
5 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
1.17A 5lg3H-1pk8A:
0.0
5lg3H-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger)
PF00544
(Pec_lyase_C)
5 ILE A 140
ILE A 121
VAL A 169
THR A 171
ILE A 156
None
1.23A 5lg3H-1qcxA:
undetectable
5lg3H-1qcxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq0 CARBONIC ANHYDRASE

(Methanosarcina
thermophila)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
5 ILE A 161
ILE A 167
VAL A 144
THR A 131
ILE A 133
None
1.01A 5lg3H-1qq0A:
undetectable
5lg3H-1qq0A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
5 ILE B 335
ILE B 326
PHE B 343
VAL B 334
GLU B 320
None
1.18A 5lg3H-1skyB:
0.1
5lg3H-1skyB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj7 BIFUNCTIONAL
RELA/SPOT


(Streptococcus
dysgalactiae)
PF04607
(RelA_SpoT)
PF13328
(HD_4)
5 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
None
1.04A 5lg3H-1vj7A:
undetectable
5lg3H-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A


(Pyrococcus
horikoshii)
PF00117
(GATase)
5 ILE A 106
ILE A 108
VAL A 124
GLU A 177
ILE A 178
None
1.11A 5lg3H-1wl8A:
undetectable
5lg3H-1wl8A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE


(Bos taurus)
PF00587
(tRNA-synt_2b)
5 ILE A 473
ILE A 197
VAL A 458
GLU A 190
ILE A 191
None
1.17A 5lg3H-1wleA:
undetectable
5lg3H-1wleA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE


(Lactococcus
lactis)
PF01634
(HisG)
5 PHE E  57
VAL E  68
THR E  72
ASN E  76
ILE E  55
None
1.10A 5lg3H-1z7mE:
undetectable
5lg3H-1z7mE:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc1 UBIQUITIN FUSION
DEGRADATION PROTEIN
1


(Saccharomyces
cerevisiae)
PF03152
(UFD1)
5 ILE A 173
ILE A 160
PHE A 151
VAL A 125
THR A 194
None
1.15A 5lg3H-1zc1A:
undetectable
5lg3H-1zc1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd0 HYPOTHETICAL PROTEIN
PF0523


(Pyrococcus
furiosus)
PF08617
(CGI-121)
5 ILE A 103
ILE A 123
VAL A  43
GLU A  98
ILE A  30
None
None
None
UNX  A 406 ( 4.4A)
None
1.26A 5lg3H-1zd0A:
undetectable
5lg3H-1zd0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjc AMINOPEPTIDASE AMPS

(Staphylococcus
aureus)
PF02073
(Peptidase_M29)
5 ILE A 351
ILE A 308
PHE A 295
VAL A 382
ILE A 280
None
1.20A 5lg3H-1zjcA:
undetectable
5lg3H-1zjcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE


(Phanerochaete
chrysosporium)
no annotation 5 ILE A 291
ILE A 249
VAL A  89
ASN A 128
ILE A 119
None
1.10A 5lg3H-2cl2A:
undetectable
5lg3H-2cl2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE


(Phanerochaete
chrysosporium)
no annotation 5 ILE A 291
ILE A 249
VAL A  89
TRP A 103
ILE A 119
None
1.15A 5lg3H-2cl2A:
undetectable
5lg3H-2cl2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE


(Homo sapiens)
PF05158
(RNA_pol_Rpc34)
5 ILE A  28
ILE A  37
VAL A  25
ASN A  54
TRP A  38
None
1.10A 5lg3H-2dk5A:
undetectable
5lg3H-2dk5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE


(Homo sapiens)
PF05158
(RNA_pol_Rpc34)
5 ILE A  28
ILE A  37
VAL A  25
TRP A  38
ILE A  53
None
1.22A 5lg3H-2dk5A:
undetectable
5lg3H-2dk5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmz INAD-LIKE PROTEIN

(Homo sapiens)
PF00595
(PDZ)
5 ILE A  79
ILE A  48
VAL A  74
ASP A  69
ILE A  31
None
1.01A 5lg3H-2dmzA:
undetectable
5lg3H-2dmzA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ILE A 370
ILE A 348
PHE A 426
ASP A 343
ILE A 433
None
1.17A 5lg3H-2hk5A:
undetectable
5lg3H-2hk5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hl7 CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
CCMH


(Pseudomonas
aeruginosa)
PF03918
(CcmH)
5 ILE A  61
ILE A  48
PHE A  16
ASP A  43
ILE A  33
None
1.18A 5lg3H-2hl7A:
undetectable
5lg3H-2hl7A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxd DCTP DEAMINASE,
DUMP-FORMING


(Methanocaldococcus
jannaschii)
PF00692
(dUTPase)
5 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
None
0.95A 5lg3H-2hxdA:
undetectable
5lg3H-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv4 PUTATIVE OUTER
MEMBRANE OR EXPORTED
PROTEIN


(Salmonella
enterica)
PF16583
(ZirS_C)
5 ILE A 258
ILE A 272
VAL A 219
ASN A 223
GLU A 254
None
0.82A 5lg3H-2lv4A:
undetectable
5lg3H-2lv4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohg GLUTAMATE RACEMASE

(Streptococcus
pyogenes)
PF01177
(Asp_Glu_race)
5 ILE A 137
ILE A 104
VAL A 112
THR A 178
ILE A 204
None
1.25A 5lg3H-2ohgA:
undetectable
5lg3H-2ohgA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus)
PF00423
(HN)
5 ILE A 306
VAL A 367
THR A 369
ASP A 347
ILE A 427
None
1.13A 5lg3H-2rkcA:
undetectable
5lg3H-2rkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE


(Thermotoga
maritima)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 ILE A 180
PHE A 190
VAL A 197
ASN A 210
GLU A 246
None
None
None
None
PLP  A 401 (-3.6A)
1.27A 5lg3H-2yxxA:
undetectable
5lg3H-2yxxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2


(Methanocaldococcus
jannaschii)
PF00155
(Aminotran_1_2)
5 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
None
1.02A 5lg3H-2z61A:
undetectable
5lg3H-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE


(Pyrococcus
furiosus)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5)
5 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
None
1.12A 5lg3H-2zj8A:
undetectable
5lg3H-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE


(Pyrococcus
horikoshii)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
5 ILE A  76
ILE A  90
PHE A  95
VAL A   9
GLU A  32
None
1.23A 5lg3H-2zufA:
3.6
5lg3H-2zufA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2


(Homo sapiens)
PF06920
(DHR-2)
5 ILE A1534
PHE A1579
VAL A1535
TRP A1575
ILE A1577
None
1.17A 5lg3H-3b13A:
1.0
5lg3H-3b13A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6y GAMMA-INTERFERON-IND
UCIBLE PROTEIN
IFI-16


(Homo sapiens)
PF02760
(HIN)
5 PHE A  41
VAL A  74
THR A  78
ASP A   6
ILE A  62
None
1.22A 5lg3H-3b6yA:
undetectable
5lg3H-3b6yA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Thermoanaerobacterium
thermosulfurigenes)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
5 ILE A 216
PHE A 137
VAL A 253
ASP A 221
ILE A 224
None
1.15A 5lg3H-3bmwA:
0.4
5lg3H-3bmwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Thermoanaerobacterium
thermosulfurigenes)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
5 ILE A 247
ILE A 216
PHE A 137
VAL A 253
ILE A 224
None
1.18A 5lg3H-3bmwA:
0.4
5lg3H-3bmwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE


(Enterococcus
faecalis)
PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2)
5 ILE A 165
ILE A 171
VAL A 139
THR A 125
ILE A 127
None
0.97A 5lg3H-3cj8A:
undetectable
5lg3H-3cj8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Cryptosporidium
parvum)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ILE A  22
ILE A  47
VAL A  44
ASP A  80
ILE A  83
None
1.24A 5lg3H-3cpsA:
undetectable
5lg3H-3cpsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cta RIBOFLAVIN KINASE

(Thermoplasma
acidophilum)
PF01982
(CTP-dep_RFKase)
PF13545
(HTH_Crp_2)
5 ILE A 196
ILE A 134
VAL A 182
ASP A 192
ILE A  95
None
1.04A 5lg3H-3ctaA:
undetectable
5lg3H-3ctaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C)
5 ILE C 532
ILE C 537
VAL C 481
THR C 499
ASN C 503
None
A  A  67 ( 4.8A)
None
None
None
1.20A 5lg3H-3degC:
undetectable
5lg3H-3degC:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY


(Trichormus
variabilis)
PF08241
(Methyltransf_11)
5 ILE A  98
ILE A  37
VAL A 126
THR A 124
ASN A  30
None
1.20A 5lg3H-3egeA:
undetectable
5lg3H-3egeA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh0 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE


(Escherichia
coli)
PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2)
5 ILE A 231
ILE A 225
VAL A 249
THR A 247
ILE A 261
None
1.14A 5lg3H-3eh0A:
undetectable
5lg3H-3eh0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE


(Arthrobacter
globiformis)
PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M)
5 ILE A  10
ILE A 210
VAL A 199
GLU A 350
ILE A 214
None
1.12A 5lg3H-3gsiA:
undetectable
5lg3H-3gsiA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5q NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae)
no annotation 5 ILE B1271
ILE B1275
PHE B1311
VAL B1268
ASP B1298
None
1.13A 5lg3H-3i5qB:
undetectable
5lg3H-3i5qB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2


(Homo sapiens)
PF01401
(Peptidase_M2)
5 ILE A 223
VAL A 226
ASP A 206
TRP A 203
ILE A 513
None
1.18A 5lg3H-3kbhA:
2.4
5lg3H-3kbhA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kin KINESIN HEAVY CHAIN

(Rattus
norvegicus)
PF00225
(Kinesin)
5 ILE A 184
ILE A 109
VAL A 180
ASP A 115
ILE A 211
None
1.25A 5lg3H-3kinA:
undetectable
5lg3H-3kinA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxi GTP-BINDING PROTEIN
(HFLX)


(Sulfolobus
solfataricus)
PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M)
5 ILE A  17
PHE A  63
VAL A  27
GLU A  92
ILE A  61
None
1.09A 5lg3H-3kxiA:
undetectable
5lg3H-3kxiA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6


(Geobacillus
stearothermophilus)
PF00331
(Glyco_hydro_10)
5 ILE A 223
ILE A 274
PHE A 275
ASP A 243
ILE A 239
None
1.25A 5lg3H-3msgA:
undetectable
5lg3H-3msgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE


(Mycobacterium
tuberculosis)
PF01053
(Cys_Met_Meta_PP)
5 ILE A 387
ILE A 401
PHE A 286
VAL A 389
ASP A 396
None
1.22A 5lg3H-3ndnA:
undetectable
5lg3H-3ndnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
5 ILE A 648
ILE A 657
VAL A 700
THR A 697
ILE A 680
None
1.22A 5lg3H-3ob8A:
undetectable
5lg3H-3ob8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oix DIHYDROOROTATE
OXIDASE
PUTATIVE
DIHYDROOROTATE
DEHYDROGENASE


(Streptococcus
mutans)
PF01180
(DHO_dh)
5 ILE A 218
VAL A 223
THR A 226
ASN A 230
ILE A 193
None
1.14A 5lg3H-3oixA:
undetectable
5lg3H-3oixA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otm CARBONIC ANHYDRASE

(Methanosarcina
thermophila)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
5 ILE A 161
ILE A 167
VAL A 144
THR A 131
ILE A 133
None
0.99A 5lg3H-3otmA:
undetectable
5lg3H-3otmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE


(Klebsiella
pneumoniae)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
5 ILE A 101
ILE A 127
VAL A  97
THR A  94
ILE A 119
None
1.17A 5lg3H-3plrA:
undetectable
5lg3H-3plrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE


(Plasmodium
falciparum)
PF00342
(PGI)
5 ILE A 303
ILE A 128
PHE A 285
ASP A 133
ILE A 308
None
1.19A 5lg3H-3qkiA:
undetectable
5lg3H-3qkiA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Campylobacter
jejuni)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  95
ILE A 108
VAL A  64
THR A  50
ILE A  52
None
0.96A 5lg3H-3r0sA:
undetectable
5lg3H-3r0sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2


(Rattus
norvegicus)
PF01070
(FMN_dh)
5 ILE A  72
ILE A 298
THR A  61
GLU A 274
ILE A  63
None
1.27A 5lg3H-3sgzA:
undetectable
5lg3H-3sgzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7y YOP PROTEINS
TRANSLOCATION
PROTEIN U


(Chlamydia
trachomatis)
PF01312
(Bac_export_2)
5 ILE A 270
ILE A 282
VAL A 333
THR A 329
GLU A 318
None
1.18A 5lg3H-3t7yA:
undetectable
5lg3H-3t7yA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uiz CHIMERA PROTEIN OF
SEFD AND SEFA


(Salmonella
enterica)
PF05775
(AfaD)
5 ILE A 138
ILE A 103
PHE A  97
VAL A 136
ILE A  67
None
1.24A 5lg3H-3uizA:
undetectable
5lg3H-3uizA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
None
1.09A 5lg3H-3uvjA:
undetectable
5lg3H-3uvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)


(Bacteroides
thetaiotaomicron)
PF07494
(Reg_prop)
PF07495
(Y_Y_Y)
5 ILE A 640
ILE A 621
PHE A 660
THR A 361
ASN A 670
None
1.19A 5lg3H-3v9fA:
undetectable
5lg3H-3v9fA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9o DIHYDRONEOPTERIN
ALDOLASE


(Burkholderia
thailandensis)
PF02152
(FolB)
5 ILE A  32
ILE A  87
VAL A  45
THR A 114
ASP A  95
None
EDO  A 144 (-4.5A)
None
None
None
1.15A 5lg3H-3v9oA:
undetectable
5lg3H-3v9oA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
5 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
None
1.05A 5lg3H-3vrbB:
undetectable
5lg3H-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9y DISKS LARGE HOMOLOG
1


(Homo sapiens)
PF00625
(Guanylate_kin)
5 ILE A 909
ILE A 848
VAL A 906
ASN A 750
ILE A 741
None
1.23A 5lg3H-3w9yA:
undetectable
5lg3H-3w9yA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT


(Pseudonaja
textilis)
PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3)
5 ILE V1339
ILE V1407
GLU V1288
ASP V1332
ILE V1284
None
1.21A 5lg3H-4bxsV:
undetectable
5lg3H-4bxsV:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE


(Pectobacterium
carotovorum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 276
PHE A 303
THR A 286
ASP A 271
ILE A 300
None
1.20A 5lg3H-4e4fA:
undetectable
5lg3H-4e4fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE


(Saccharomyces
cerevisiae)
PF07992
(Pyr_redox_2)
5 ILE A 336
PHE A 208
VAL A 233
ASP A 249
ILE A 268
ILE  A 336 ( 0.7A)
PHE  A 208 ( 1.3A)
VAL  A 233 ( 0.6A)
ASP  A 249 ( 0.6A)
ILE  A 268 ( 0.7A)
1.25A 5lg3H-4g9kA:
undetectable
5lg3H-4g9kA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis)
PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C)
5 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
None
1.05A 5lg3H-4gaaA:
0.3
5lg3H-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE


(Bacteroides
thetaiotaomicron)
PF14488
(DUF4434)
PF17134
(DUF5109)
5 ILE A 273
ILE A 225
PHE A 268
GLU A 249
TRP A 252
None
1.19A 5lg3H-4h41A:
undetectable
5lg3H-4h41A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il2 STARVATION SENSING
PROTEIN RSPA


(Escherichia
coli)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 287
PHE A 314
THR A 297
ASP A 282
ILE A 311
None
1.22A 5lg3H-4il2A:
undetectable
5lg3H-4il2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1


(Physcomitrella
patens)
PF01156
(IU_nuc_hydro)
5 ILE A 194
PHE A 196
VAL A 151
ASP A  23
ILE A 164
None
1.21A 5lg3H-4kpnA:
undetectable
5lg3H-4kpnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6


(Saccharomyces
cerevisiae)
PF01423
(LSM)
5 ILE D  41
ILE D  19
PHE D  15
VAL D  47
ASN D  25
None
1.21A 5lg3H-4m75D:
undetectable
5lg3H-4m75D:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ILE A 164
ILE A 173
VAL A 160
ASN A 178
ASP A 176
None
1.25A 5lg3H-4mn8A:
undetectable
5lg3H-4mn8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzu WXCM-LIKE PROTEIN

(Shewanella
denitrificans)
PF00132
(Hexapep)
PF05523
(FdtA)
5 ILE A  67
ILE A  61
VAL A  99
THR A  97
ILE A 111
None
1.22A 5lg3H-4mzuA:
undetectable
5lg3H-4mzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
None
EDO  A 702 (-3.8A)
EDO  A 702 ( 3.0A)
None
None
1.18A 5lg3H-4ni2A:
undetectable
5lg3H-4ni2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oca UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF01041
(DegT_DnrJ_EryC1)
5 ILE A 181
ILE A 158
VAL A 198
THR A 200
ASN A 202
None
1.25A 5lg3H-4ocaA:
undetectable
5lg3H-4ocaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
None
0.97A 5lg3H-4oyaA:
0.1
5lg3H-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2


(Blattella
germanica)
PF00026
(Asp)
5 ILE A 123
ILE A 165
VAL A 121
THR A  29
ILE A  91
None
1.27A 5lg3H-4rldA:
undetectable
5lg3H-4rldA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
5 ILE A 117
VAL A 122
THR A 125
ASN A 129
ILE A 160
None
1.10A 5lg3H-4s3jA:
undetectable
5lg3H-4s3jA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL


(Dickeya
chrysanthemi)
PF02931
(Neur_chan_LBD)
5 ILE A  20
ILE A  23
ASP A 158
TRP A 160
ILE A 162
None
0.71A 5lg3H-4twfA:
32.5
5lg3H-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL


(Dickeya
chrysanthemi)
PF02931
(Neur_chan_LBD)
5 ILE A  20
ILE A  23
PHE A 126
ASP A 158
TRP A 160
None
0.40A 5lg3H-4twfA:
32.5
5lg3H-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 1


(Drosophila
melanogaster)
PF00004
(AAA)
PF09079
(Cdc6_C)
5 ILE A 612
VAL A 608
THR A 605
GLU A 685
ILE A 716
None
1.12A 5lg3H-4xgcA:
undetectable
5lg3H-4xgcA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y68 PUTATIVE
NISIN-RESISTANCE
PROTEIN


(Streptococcus
agalactiae)
no annotation 5 ILE C 228
PHE C 245
THR C 234
ASN C 168
ASP C 164
None
1.19A 5lg3H-4y68C:
undetectable
5lg3H-4y68C:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  20
ILE A  23
PHE A 126
ASP A 158
TRP A 160
None
0.54A 5lg3H-4yeuA:
29.4
5lg3H-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  20
ILE A  23
PHE A 126
TRP A 160
ILE A 162
None
0.75A 5lg3H-4yeuA:
29.4
5lg3H-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  20
ILE A  23
PHE A 126
VAL A 147
TRP A 160
None
0.55A 5lg3H-4yeuA:
29.4
5lg3H-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  23
PHE A 126
THR A 149
TRP A 160
ILE A 162
None
0.89A 5lg3H-4yeuA:
29.4
5lg3H-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  23
PHE A 126
VAL A 147
THR A 149
TRP A 160
None
1.22A 5lg3H-4yeuA:
29.4
5lg3H-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN


(Schizosaccharomyces
pombe)
no annotation 5 ILE A 792
PHE A 802
VAL A 763
ASP A 799
ILE A 812
None
1.03A 5lg3H-4yhcA:
undetectable
5lg3H-4yhcA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN


(Campylobacter
jejuni)
PF01497
(Peripla_BP_2)
5 ILE A 244
ILE A 236
VAL A 246
THR A 192
ILE A 262
None
1.22A 5lg3H-5advA:
undetectable
5lg3H-5advA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL


(Homo sapiens)
PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3)
5 ILE A 281
ILE A 259
VAL A 278
THR A 300
ILE A 261
None
1.26A 5lg3H-5dotA:
undetectable
5lg3H-5dotA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT


(Thermus
thermophilus)
PF00437
(T2SSE)
5 ILE A 250
ILE A 247
THR A 139
ASP A 242
ILE A 273
None
1.20A 5lg3H-5fl3A:
undetectable
5lg3H-5fl3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fof LEUCYL-TRNA
SYNTHETASE


(Plasmodium
knowlesi)
no annotation 5 ILE A 314
ILE A 377
VAL A 277
THR A 421
ILE A 433
None
1.27A 5lg3H-5fofA:
undetectable
5lg3H-5fofA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE


(Clostridium
perfringens)
PF13320
(DUF4091)
5 ILE A 338
ILE A 281
ASP A 260
TRP A 262
ILE A 267
None
1.20A 5lg3H-5fqeA:
0.0
5lg3H-5fqeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvd NUCLEOCAPSID

(Human
metapneumovirus)
PF03246
(Pneumo_ncap)
5 ILE A 203
ILE A 206
VAL A 184
ASP A 212
ILE A 168
None
1.22A 5lg3H-5fvdA:
undetectable
5lg3H-5fvdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae)
PF03446
(NAD_binding_2)
5 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
None
1.05A 5lg3H-5g6rA:
undetectable
5lg3H-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjk SWI/SNF COMPLEX
SUBUNIT SMARCC1


(Homo sapiens)
PF04433
(SWIRM)
5 ILE A 448
ILE A 450
ASN A 491
ASP A 458
ILE A 494
None
1.24A 5lg3H-5gjkA:
undetectable
5lg3H-5gjkA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN


(Bacillus
thuringiensis)
PF03318
(ETX_MTX2)
5 ILE A 183
VAL A 254
THR A  94
ASN A 137
GLU A 113
None
1.07A 5lg3H-5hd2A:
undetectable
5lg3H-5hd2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihy UNCHARACTERIZED
PROTEIN


(Bacillus
subtilis)
PF01966
(HD)
5 ILE A  97
ILE A  94
VAL A  57
THR A  53
ASP A  89
None
1.12A 5lg3H-5ihyA:
undetectable
5lg3H-5ihyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum)
PF00400
(WD40)
5 ILE A  67
ILE A  87
THR A  60
ASN A  95
ILE A 113
None
1.24A 5lg3H-5tqrA:
undetectable
5lg3H-5tqrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdt CALPAIN-3

(Homo sapiens)
no annotation 5 ILE A 149
PHE A 165
THR A 139
ASP A 120
ILE A 135
None
None
None
CA  A 501 (-2.2A)
None
1.22A 5lg3H-6bdtA:
undetectable
5lg3H-6bdtA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4)
no annotation 5 ILE B 323
ILE B 269
VAL B 318
THR B 314
ASN B 285
None
1.27A 5lg3H-6c2jB:
undetectable
5lg3H-6c2jB:
12.12