SIMILAR PATTERNS OF AMINO ACIDS FOR 5LG3_G_Z80G401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE


(Bos taurus)
PF00135
(COesterase)
5 ILE A 102
ILE A 188
VAL A 139
ASP A 184
ILE A 178
None
1.23A 5lg3G-1aqlA:
0.0
5lg3G-1aqlA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aux SYNAPSIN IA

(Bos taurus)
PF02078
(Synapsin)
PF02750
(Synapsin_C)
5 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
AGS  A 800 (-3.9A)
AGS  A 800 ( 4.8A)
CA  A 801 ( 2.3A)
AGS  A 800 ( 4.4A)
AGS  A 800 (-4.3A)
1.27A 5lg3G-1auxA:
undetectable
5lg3G-1auxA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cr5 SEC18P (RESIDUES 22
- 210)


(Saccharomyces
cerevisiae)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
5 ILE A 119
ILE A 121
PHE A 167
GLU A 138
ASP A 135
None
1.27A 5lg3G-1cr5A:
0.0
5lg3G-1cr5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris)
PF13354
(Beta-lactamase2)
5 ILE A  29
ILE A  57
GLU A  52
ASP A  53
ILE A 290
None
1.21A 5lg3G-1hzoA:
0.1
5lg3G-1hzoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id0 PHOQ HISTIDINE
KINASE


(Escherichia
coli)
PF02518
(HATPase_c)
5 ILE A 411
ILE A 400
VAL A 474
ASN A 389
ASP A 415
None
None
None
ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
1.26A 5lg3G-1id0A:
0.0
5lg3G-1id0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger)
PF00544
(Pec_lyase_C)
5 ILE A 140
ILE A 121
VAL A 169
THR A 171
ILE A 156
None
1.21A 5lg3G-1idjA:
undetectable
5lg3G-1idjA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE


(Bacillus
circulans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
5 ILE A 215
PHE A 136
VAL A 252
ASP A 220
ILE A 223
None
1.26A 5lg3G-1kclA:
0.6
5lg3G-1kclA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus)
PF02078
(Synapsin)
PF02750
(Synapsin_C)
5 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
1.14A 5lg3G-1pk8A:
0.0
5lg3G-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger)
PF00544
(Pec_lyase_C)
5 ILE A 140
ILE A 121
VAL A 169
THR A 171
ILE A 156
None
1.25A 5lg3G-1qcxA:
undetectable
5lg3G-1qcxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
5 ILE B 335
ILE B 326
PHE B 343
VAL B 334
GLU B 320
None
1.18A 5lg3G-1skyB:
undetectable
5lg3G-1skyB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE


(Methanocaldococcus
jannaschii)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 ILE A 225
PHE A 235
VAL A 242
ASN A 260
GLU A 304
None
None
None
None
LLP  A  83 ( 3.6A)
1.28A 5lg3G-1tufA:
undetectable
5lg3G-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj7 BIFUNCTIONAL
RELA/SPOT


(Streptococcus
dysgalactiae)
PF04607
(RelA_SpoT)
PF13328
(HD_4)
5 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
None
1.04A 5lg3G-1vj7A:
undetectable
5lg3G-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE


(Bos taurus)
PF00587
(tRNA-synt_2b)
5 ILE A 473
ILE A 197
VAL A 458
GLU A 190
ILE A 191
None
1.16A 5lg3G-1wleA:
undetectable
5lg3G-1wleA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc1 UBIQUITIN FUSION
DEGRADATION PROTEIN
1


(Saccharomyces
cerevisiae)
PF03152
(UFD1)
5 ILE A 173
ILE A 160
PHE A 151
VAL A 125
THR A 194
None
1.14A 5lg3G-1zc1A:
undetectable
5lg3G-1zc1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd0 HYPOTHETICAL PROTEIN
PF0523


(Pyrococcus
furiosus)
PF08617
(CGI-121)
5 ILE A 103
ILE A 123
VAL A  43
GLU A  98
ILE A  30
None
None
None
UNX  A 406 ( 4.4A)
None
1.29A 5lg3G-1zd0A:
undetectable
5lg3G-1zd0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjc AMINOPEPTIDASE AMPS

(Staphylococcus
aureus)
PF02073
(Peptidase_M29)
5 ILE A 351
ILE A 308
PHE A 295
VAL A 382
ILE A 280
None
1.22A 5lg3G-1zjcA:
undetectable
5lg3G-1zjcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE


(Phanerochaete
chrysosporium)
no annotation 5 ILE A 291
ILE A 249
VAL A  89
ASN A 128
ILE A 119
None
1.08A 5lg3G-2cl2A:
undetectable
5lg3G-2cl2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE


(Phanerochaete
chrysosporium)
no annotation 5 ILE A 291
ILE A 249
VAL A  89
TRP A 103
ILE A 119
None
1.14A 5lg3G-2cl2A:
undetectable
5lg3G-2cl2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE


(Homo sapiens)
PF05158
(RNA_pol_Rpc34)
5 ILE A  28
ILE A  37
VAL A  25
ASN A  54
TRP A  38
None
1.14A 5lg3G-2dk5A:
undetectable
5lg3G-2dk5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE


(Homo sapiens)
PF05158
(RNA_pol_Rpc34)
5 ILE A  28
ILE A  37
VAL A  25
TRP A  38
ILE A  53
None
1.25A 5lg3G-2dk5A:
undetectable
5lg3G-2dk5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 ILE A 392
ILE A 370
PHE A 448
ASP A 365
ILE A 455
None
1.08A 5lg3G-2hckA:
undetectable
5lg3G-2hckA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ILE A 370
ILE A 348
PHE A 426
ASP A 343
ILE A 433
None
1.18A 5lg3G-2hk5A:
1.3
5lg3G-2hk5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hl7 CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
CCMH


(Pseudomonas
aeruginosa)
PF03918
(CcmH)
5 ILE A  61
ILE A  48
PHE A  16
ASP A  43
ILE A  33
None
1.23A 5lg3G-2hl7A:
undetectable
5lg3G-2hl7A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxd DCTP DEAMINASE,
DUMP-FORMING


(Methanocaldococcus
jannaschii)
PF00692
(dUTPase)
5 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
None
0.98A 5lg3G-2hxdA:
undetectable
5lg3G-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k49 UPF0339 PROTEIN
SO_3888


(Shewanella
oneidensis)
PF07411
(DUF1508)
5 ILE A 106
ILE A  43
PHE A  17
THR A 103
ASN A 100
None
1.23A 5lg3G-2k49A:
undetectable
5lg3G-2k49A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv4 PUTATIVE OUTER
MEMBRANE OR EXPORTED
PROTEIN


(Salmonella
enterica)
PF16583
(ZirS_C)
5 ILE A 258
ILE A 272
VAL A 219
ASN A 223
GLU A 254
None
0.84A 5lg3G-2lv4A:
undetectable
5lg3G-2lv4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ILE A 370
ILE A 348
PHE A 426
ASP A 343
ILE A 433
None
1.06A 5lg3G-2og8A:
undetectable
5lg3G-2og8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohg GLUTAMATE RACEMASE

(Streptococcus
pyogenes)
PF01177
(Asp_Glu_race)
5 ILE A 137
ILE A 104
VAL A 112
THR A 178
ILE A 204
None
1.27A 5lg3G-2ohgA:
undetectable
5lg3G-2ohgA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU


(Mycobacterium
tuberculosis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 ILE A 274
ILE A 286
VAL A 278
THR A 296
ILE A 298
None
1.24A 5lg3G-2qkxA:
undetectable
5lg3G-2qkxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus)
PF00423
(HN)
5 ILE A 306
VAL A 367
THR A 369
ASP A 347
ILE A 427
None
1.16A 5lg3G-2rkcA:
undetectable
5lg3G-2rkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE


(Thermotoga
maritima)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 ILE A 180
PHE A 190
VAL A 197
ASN A 210
GLU A 246
None
None
None
None
PLP  A 401 (-3.6A)
1.29A 5lg3G-2yxxA:
undetectable
5lg3G-2yxxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2


(Methanocaldococcus
jannaschii)
PF00155
(Aminotran_1_2)
5 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
None
1.02A 5lg3G-2z61A:
undetectable
5lg3G-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE


(Pyrococcus
furiosus)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5)
5 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
None
1.12A 5lg3G-2zj8A:
undetectable
5lg3G-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE


(Pyrococcus
horikoshii)
PF09488
(Osmo_MPGsynth)
5 ILE A  82
ILE A 112
PHE A 104
VAL A  57
ILE A  74
None
1.07A 5lg3G-2zu8A:
undetectable
5lg3G-2zu8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE


(Pyrococcus
horikoshii)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
5 ILE A  76
ILE A  90
PHE A  95
VAL A   9
GLU A  32
None
1.26A 5lg3G-2zufA:
undetectable
5lg3G-2zufA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycolicibacterium
smegmatis)
PF01083
(Cutinase)
5 ILE A 172
ILE A 189
VAL A 204
THR A 261
ASN A 259
None
1.28A 5lg3G-3ajaA:
undetectable
5lg3G-3ajaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1


(Symbiobacterium
toebii)
PF00551
(Formyl_trans_N)
5 ILE A   4
ILE A 182
VAL A   6
ASN A  14
GLU A 174
None
1.25A 5lg3G-3aufA:
undetectable
5lg3G-3aufA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6y GAMMA-INTERFERON-IND
UCIBLE PROTEIN
IFI-16


(Homo sapiens)
PF02760
(HIN)
5 PHE A  41
VAL A  74
THR A  78
ASP A   6
ILE A  62
None
1.19A 5lg3G-3b6yA:
undetectable
5lg3G-3b6yA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Thermoanaerobacterium
thermosulfurigenes)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
5 ILE A 216
PHE A 137
VAL A 253
ASP A 221
ILE A 224
None
1.14A 5lg3G-3bmwA:
undetectable
5lg3G-3bmwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Thermoanaerobacterium
thermosulfurigenes)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
5 ILE A 247
ILE A 216
PHE A 137
VAL A 253
ILE A 224
None
1.18A 5lg3G-3bmwA:
undetectable
5lg3G-3bmwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE


(Enterococcus
faecalis)
PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2)
5 ILE A 165
ILE A 171
VAL A 139
THR A 125
ILE A 127
None
0.96A 5lg3G-3cj8A:
undetectable
5lg3G-3cj8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cta RIBOFLAVIN KINASE

(Thermoplasma
acidophilum)
PF01982
(CTP-dep_RFKase)
PF13545
(HTH_Crp_2)
5 ILE A 196
ILE A 134
VAL A 182
ASP A 192
ILE A  95
None
1.07A 5lg3G-3ctaA:
undetectable
5lg3G-3ctaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C)
5 ILE C 532
ILE C 537
VAL C 481
THR C 499
ASN C 503
None
A  A  67 ( 4.8A)
None
None
None
1.21A 5lg3G-3degC:
undetectable
5lg3G-3degC:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY


(Trichormus
variabilis)
PF08241
(Methyltransf_11)
5 ILE A  98
ILE A  37
VAL A 126
THR A 124
ASN A  30
None
1.21A 5lg3G-3egeA:
undetectable
5lg3G-3egeA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh0 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE


(Escherichia
coli)
PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2)
5 ILE A 231
ILE A 225
VAL A 249
THR A 247
ILE A 261
None
1.14A 5lg3G-3eh0A:
undetectable
5lg3G-3eh0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5q NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae)
no annotation 5 ILE B1271
ILE B1275
PHE B1311
VAL B1268
ASP B1298
None
1.10A 5lg3G-3i5qB:
undetectable
5lg3G-3i5qB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2


(Homo sapiens)
PF01401
(Peptidase_M2)
5 ILE A 223
VAL A 226
ASP A 206
TRP A 203
ILE A 513
None
1.20A 5lg3G-3kbhA:
1.6
5lg3G-3kbhA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6


(Geobacillus
stearothermophilus)
PF00331
(Glyco_hydro_10)
5 ILE A 223
ILE A 274
PHE A 275
ASP A 243
ILE A 239
None
1.23A 5lg3G-3msgA:
undetectable
5lg3G-3msgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE


(Mycobacterium
tuberculosis)
PF01053
(Cys_Met_Meta_PP)
5 ILE A 387
ILE A 401
PHE A 286
VAL A 389
ASP A 396
None
1.25A 5lg3G-3ndnA:
undetectable
5lg3G-3ndnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
5 ILE A 648
ILE A 657
VAL A 700
THR A 697
ILE A 680
None
1.23A 5lg3G-3ob8A:
undetectable
5lg3G-3ob8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE


(Klebsiella
pneumoniae)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
5 ILE A 101
ILE A 127
VAL A  97
THR A  94
ILE A 119
None
1.21A 5lg3G-3plrA:
undetectable
5lg3G-3plrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE


(Plasmodium
falciparum)
PF00342
(PGI)
5 ILE A 303
ILE A 128
PHE A 285
ASP A 133
ILE A 308
None
1.21A 5lg3G-3qkiA:
undetectable
5lg3G-3qkiA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Campylobacter
jejuni)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ILE A  95
ILE A 108
VAL A  64
THR A  50
ILE A  52
None
0.95A 5lg3G-3r0sA:
undetectable
5lg3G-3r0sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2


(Rattus
norvegicus)
PF01070
(FMN_dh)
5 ILE A  72
ILE A 298
THR A  61
GLU A 274
ILE A  63
None
1.27A 5lg3G-3sgzA:
undetectable
5lg3G-3sgzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7y YOP PROTEINS
TRANSLOCATION
PROTEIN U


(Chlamydia
trachomatis)
PF01312
(Bac_export_2)
5 ILE A 270
ILE A 282
VAL A 333
THR A 329
GLU A 318
None
1.19A 5lg3G-3t7yA:
undetectable
5lg3G-3t7yA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uiz CHIMERA PROTEIN OF
SEFD AND SEFA


(Salmonella
enterica)
PF05775
(AfaD)
5 ILE A 138
ILE A 103
PHE A  97
VAL A 136
ILE A  67
None
1.26A 5lg3G-3uizA:
undetectable
5lg3G-3uizA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
None
1.11A 5lg3G-3uvjA:
1.7
5lg3G-3uvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA


(Cellvibrio
japonicus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 274
PHE A 301
THR A 284
ASP A 269
ILE A 298
None
1.29A 5lg3G-3v4bA:
undetectable
5lg3G-3v4bA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE


(Ascaris suum)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
5 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
None
1.02A 5lg3G-3vrbB:
undetectable
5lg3G-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9y DISKS LARGE HOMOLOG
1


(Homo sapiens)
PF00625
(Guanylate_kin)
5 ILE A 909
ILE A 848
VAL A 906
ASN A 750
ILE A 741
None
1.25A 5lg3G-3w9yA:
undetectable
5lg3G-3w9yA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA


(Staphylococcus
aureus)
PF02491
(SHS2_FTSA)
PF14450
(FtsA)
5 ILE A  56
VAL A  16
THR A  38
ASP A  48
ILE A  41
None
1.27A 5lg3G-3wquA:
undetectable
5lg3G-3wquA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA


(Staphylococcus
aureus)
PF02491
(SHS2_FTSA)
PF14450
(FtsA)
5 ILE A  56
VAL A  16
THR A  38
ASP A  48
ILE A  41
None
1.24A 5lg3G-3wt0A:
undetectable
5lg3G-3wt0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT


(Pseudonaja
textilis)
PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3)
5 ILE V1339
ILE V1407
GLU V1288
ASP V1332
ILE V1284
None
1.23A 5lg3G-4bxsV:
undetectable
5lg3G-4bxsV:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1


(Saccharomyces
cerevisiae)
PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P)
5 ILE A 411
VAL A 414
GLU A 351
ASP A 352
ILE A 376
None
1.13A 5lg3G-4c0hA:
undetectable
5lg3G-4c0hA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE


(Pectobacterium
carotovorum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 276
PHE A 303
THR A 286
ASP A 271
ILE A 300
None
1.18A 5lg3G-4e4fA:
undetectable
5lg3G-4e4fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE


(Saccharomyces
cerevisiae)
PF07992
(Pyr_redox_2)
5 ILE A 336
PHE A 208
VAL A 233
ASP A 249
ILE A 268
ILE  A 336 ( 0.7A)
PHE  A 208 ( 1.3A)
VAL  A 233 ( 0.6A)
ASP  A 249 ( 0.6A)
ILE  A 268 ( 0.7A)
1.24A 5lg3G-4g9kA:
undetectable
5lg3G-4g9kA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis)
PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C)
5 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
None
1.06A 5lg3G-4gaaA:
2.4
5lg3G-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE


(Bacteroides
thetaiotaomicron)
PF14488
(DUF4434)
PF17134
(DUF5109)
5 ILE A 273
ILE A 225
PHE A 268
GLU A 249
TRP A 252
None
1.21A 5lg3G-4h41A:
undetectable
5lg3G-4h41A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il2 STARVATION SENSING
PROTEIN RSPA


(Escherichia
coli)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 287
PHE A 314
THR A 297
ASP A 282
ILE A 311
None
1.21A 5lg3G-4il2A:
undetectable
5lg3G-4il2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lua N-ACETYLTRANSFERASE

(Staphylococcus
aureus)
PF13420
(Acetyltransf_4)
5 ILE A  44
ILE A  41
PHE A  12
VAL A  54
THR A  66
None
1.27A 5lg3G-4luaA:
undetectable
5lg3G-4luaA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6


(Saccharomyces
cerevisiae)
PF01423
(LSM)
5 ILE D  41
ILE D  19
PHE D  15
VAL D  47
ASN D  25
None
1.19A 5lg3G-4m75D:
undetectable
5lg3G-4m75D:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ILE A 164
ILE A 173
VAL A 160
ASN A 178
ASP A 176
None
1.25A 5lg3G-4mn8A:
undetectable
5lg3G-4mn8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzu WXCM-LIKE PROTEIN

(Shewanella
denitrificans)
PF00132
(Hexapep)
PF05523
(FdtA)
5 ILE A  67
ILE A  61
VAL A  99
THR A  97
ILE A 111
None
1.23A 5lg3G-4mzuA:
undetectable
5lg3G-4mzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
None
EDO  A 702 (-3.8A)
EDO  A 702 ( 3.0A)
None
None
1.19A 5lg3G-4ni2A:
1.7
5lg3G-4ni2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oca UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF01041
(DegT_DnrJ_EryC1)
5 ILE A 181
ILE A 158
VAL A 198
THR A 200
ASN A 202
None
1.25A 5lg3G-4ocaA:
undetectable
5lg3G-4ocaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis)
PF00496
(SBP_bac_5)
5 ILE A 140
ILE A 154
THR A  88
ASN A  92
ASP A 152
None
1.28A 5lg3G-4oerA:
undetectable
5lg3G-4oerA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
None
0.99A 5lg3G-4oyaA:
undetectable
5lg3G-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
5 ILE A 117
VAL A 122
THR A 125
ASN A 129
ILE A 160
None
1.10A 5lg3G-4s3jA:
undetectable
5lg3G-4s3jA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL


(Dickeya
chrysanthemi)
PF02931
(Neur_chan_LBD)
6 ILE A  20
ILE A  23
PHE A 126
ASP A 158
TRP A 160
ILE A 162
None
0.67A 5lg3G-4twfA:
32.6
5lg3G-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 1


(Drosophila
melanogaster)
PF00004
(AAA)
PF09079
(Cdc6_C)
5 ILE A 612
VAL A 608
THR A 605
GLU A 685
ILE A 716
None
1.18A 5lg3G-4xgcA:
undetectable
5lg3G-4xgcA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y68 PUTATIVE
NISIN-RESISTANCE
PROTEIN


(Streptococcus
agalactiae)
no annotation 5 ILE C 228
PHE C 245
THR C 234
ASN C 168
ASP C 164
None
1.20A 5lg3G-4y68C:
undetectable
5lg3G-4y68C:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y68 PUTATIVE
NISIN-RESISTANCE
PROTEIN


(Streptococcus
agalactiae)
no annotation 5 ILE C 296
PHE C 245
THR C 234
ASN C 168
ASP C 164
None
1.25A 5lg3G-4y68C:
undetectable
5lg3G-4y68C:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  20
ILE A  23
PHE A 126
ASP A 158
TRP A 160
None
0.50A 5lg3G-4yeuA:
29.4
5lg3G-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  20
ILE A  23
PHE A 126
TRP A 160
ILE A 162
None
0.70A 5lg3G-4yeuA:
29.4
5lg3G-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  20
ILE A  23
PHE A 126
VAL A 147
TRP A 160
None
0.56A 5lg3G-4yeuA:
29.4
5lg3G-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  23
PHE A 126
THR A 149
ASP A 158
TRP A 160
None
1.28A 5lg3G-4yeuA:
29.4
5lg3G-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  23
PHE A 126
THR A 149
TRP A 160
ILE A 162
None
0.88A 5lg3G-4yeuA:
29.4
5lg3G-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 ILE A  23
PHE A 126
VAL A 147
THR A 149
TRP A 160
None
1.22A 5lg3G-4yeuA:
29.4
5lg3G-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN


(Campylobacter
jejuni)
PF01497
(Peripla_BP_2)
5 ILE A 244
ILE A 236
VAL A 246
THR A 192
ILE A 262
None
1.24A 5lg3G-5advA:
undetectable
5lg3G-5advA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL


(Homo sapiens)
PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3)
5 ILE A 281
ILE A 259
VAL A 278
THR A 300
ILE A 261
None
1.26A 5lg3G-5dotA:
undetectable
5lg3G-5dotA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esc HUPZ

(Streptococcus
sp. 'group A')
PF01243
(Putative_PNPOx)
5 ILE A  64
ILE A 110
VAL A  17
THR A  19
ILE A  56
None
1.29A 5lg3G-5escA:
undetectable
5lg3G-5escA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT


(Thermus
thermophilus)
PF00437
(T2SSE)
5 ILE A 250
ILE A 247
THR A 139
ASP A 242
ILE A 273
None
1.17A 5lg3G-5fl3A:
undetectable
5lg3G-5fl3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fof LEUCYL-TRNA
SYNTHETASE


(Plasmodium
knowlesi)
no annotation 5 ILE A 314
ILE A 377
VAL A 277
THR A 421
ILE A 433
None
1.25A 5lg3G-5fofA:
undetectable
5lg3G-5fofA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE


(Clostridium
perfringens)
PF13320
(DUF4091)
5 ILE A 338
ILE A 281
ASP A 260
TRP A 262
ILE A 267
None
1.22A 5lg3G-5fqeA:
undetectable
5lg3G-5fqeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae)
PF03446
(NAD_binding_2)
5 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
None
1.06A 5lg3G-5g6rA:
undetectable
5lg3G-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN


(Bacillus
thuringiensis)
PF03318
(ETX_MTX2)
5 ILE A 183
VAL A 254
THR A  94
ASN A 137
GLU A 113
None
1.11A 5lg3G-5hd2A:
undetectable
5lg3G-5hd2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihy UNCHARACTERIZED
PROTEIN


(Bacillus
subtilis)
PF01966
(HD)
5 ILE A  97
ILE A  94
VAL A  57
THR A  53
ASP A  89
None
1.14A 5lg3G-5ihyA:
undetectable
5lg3G-5ihyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum)
PF00400
(WD40)
5 ILE A  67
ILE A  87
THR A  60
ASN A  95
ILE A 113
None
1.27A 5lg3G-5tqrA:
undetectable
5lg3G-5tqrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4)
no annotation 5 ILE B 323
ILE B 269
VAL B 318
THR B 314
ASN B 285
None
1.28A 5lg3G-6c2jB:
0.7
5lg3G-6c2jB:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpb CARBON MONOXIDE
OXIDATION SYSTEM
TRANSCRIPTION
REGULATOR COOA-1


(Carboxydothermus
hydrogenoformans)
no annotation 5 ILE A  78
VAL A  49
THR A  98
GLU A  27
ILE A 106
None
1.27A 5lg3G-6cpbA:
undetectable
5lg3G-6cpbA:
13.36