SIMILAR PATTERNS OF AMINO ACIDS FOR 5LG3_F_Z80F401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		5 ILE A 102
ILE A 188
VAL A 139
ASP A 184
ILE A 178
 None
 1.30A 5lg3F-1aqlA:
0.0		 5lg3F-1aqlA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 204
ILE A 189
VAL A 202
ASN A 197
GLU A  66
 None
 1.29A 5lg3F-1ebdA:
0.0		 5lg3F-1ebdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 ILE A  17
ILE A  51
PHE A  95
VAL A   8
GLU A  47
 None
 1.30A 5lg3F-1ef9A:
0.0		 5lg3F-1ef9A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxh COLICIN E8 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		5 ILE A   7
ILE A  70
VAL A  42
ASN A  35
ILE A  18
 None
 1.31A 5lg3F-1gxhA:
undetectable		 5lg3F-1gxhA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		5 ILE A  29
ILE A  57
GLU A  52
ASP A  53
ILE A 290
 None
 1.27A 5lg3F-1hzoA:
0.0		 5lg3F-1hzoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id0 PHOQ HISTIDINE
KINASE

(Escherichia
coli) 		PF02518
(HATPase_c) 		5 ILE A 411
ILE A 400
VAL A 474
ASN A 389
ASP A 415
 None
None
None
ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
 1.27A 5lg3F-1id0A:
0.0		 5lg3F-1id0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 ILE A 140
ILE A 121
VAL A 169
THR A 171
ILE A 156
 None
 1.20A 5lg3F-1idjA:
0.0		 5lg3F-1idjA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 ILE A 215
PHE A 136
VAL A 252
ASP A 220
ILE A 223
 None
 1.28A 5lg3F-1kclA:
1.5		 5lg3F-1kclA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		5 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
 1.19A 5lg3F-1pk8A:
undetectable		 5lg3F-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		5 ILE A 140
ILE A 121
VAL A 169
THR A 171
ILE A 156
 None
 1.23A 5lg3F-1qcxA:
undetectable		 5lg3F-1qcxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ILE B 335
ILE B 326
PHE B 343
VAL B 334
GLU B 320
 None
 1.21A 5lg3F-1skyB:
undetectable		 5lg3F-1skyB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urx BETA-AGARASE A

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		5 ILE A 116
ILE A 249
VAL A 120
TRP A 138
ILE A 148
 None
None
None
GLA  A1292 ( 3.4A)
None
 1.30A 5lg3F-1urxA:
undetectable		 5lg3F-1urxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj7 BIFUNCTIONAL
RELA/SPOT

(Streptococcus
dysgalactiae) 		PF04607
(RelA_SpoT)
PF13328
(HD_4) 		5 ILE A 322
ILE A 268
VAL A 315
THR A 313
ILE A 285
 None
 1.05A 5lg3F-1vj7A:
undetectable		 5lg3F-1vj7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE

(Entamoeba
histolytica) 		PF05770
(Ins134_P3_kin) 		5 ILE X 224
ILE X 216
VAL X 223
ASP X 207
ILE X 151
 None
 1.32A 5lg3F-1z2oX:
undetectable		 5lg3F-1z2oX:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Lactococcus
lactis) 		PF01634
(HisG) 		5 PHE E  57
VAL E  68
THR E  72
ASN E  76
ILE E  55
 None
 1.11A 5lg3F-1z7mE:
undetectable		 5lg3F-1z7mE:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjc AMINOPEPTIDASE AMPS

(Staphylococcus
aureus) 		PF02073
(Peptidase_M29) 		5 ILE A 351
ILE A 308
PHE A 295
VAL A 382
ILE A 280
 None
 1.18A 5lg3F-1zjcA:
undetectable		 5lg3F-1zjcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 5 ILE A 291
ILE A 249
VAL A  89
ASN A 128
ILE A 119
 None
 1.09A 5lg3F-2cl2A:
undetectable		 5lg3F-2cl2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 5 ILE A 291
ILE A 249
VAL A  89
TRP A 103
ILE A 119
 None
 1.16A 5lg3F-2cl2A:
undetectable		 5lg3F-2cl2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE

(Homo sapiens) 		PF05158
(RNA_pol_Rpc34) 		5 ILE A  28
ILE A  37
VAL A  25
ASN A  54
TRP A  38
 None
 1.13A 5lg3F-2dk5A:
undetectable		 5lg3F-2dk5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dk5 DNA-DIRECTED RNA
POLYMERASE III 39
KDA POLYPEPTIDE

(Homo sapiens) 		PF05158
(RNA_pol_Rpc34) 		5 ILE A  28
ILE A  37
VAL A  25
TRP A  38
ILE A  53
 None
 1.23A 5lg3F-2dk5A:
undetectable		 5lg3F-2dk5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmz INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  79
ILE A  48
VAL A  74
ASP A  69
ILE A  31
 None
 1.00A 5lg3F-2dmzA:
undetectable		 5lg3F-2dmzA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eke SUMO-CONJUGATING
ENZYME UBC9

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		5 ILE A  60
ILE A  45
PHE A  24
VAL A  75
ILE A 112
 None
 1.26A 5lg3F-2ekeA:
undetectable		 5lg3F-2ekeA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 370
ILE A 348
PHE A 426
ASP A 343
ILE A 433
 None
 1.18A 5lg3F-2hk5A:
undetectable		 5lg3F-2hk5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hl7 CYTOCHROME C-TYPE
BIOGENESIS PROTEIN
CCMH

(Pseudomonas
aeruginosa) 		PF03918
(CcmH) 		5 ILE A  61
ILE A  48
PHE A  16
ASP A  43
ILE A  33
 None
 1.24A 5lg3F-2hl7A:
undetectable		 5lg3F-2hl7A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxd DCTP DEAMINASE,
DUMP-FORMING

(Methanocaldococcus
jannaschii) 		PF00692
(dUTPase) 		5 ILE A  42
ILE A  59
VAL A  96
ASP A  38
ILE A  65
 None
 1.01A 5lg3F-2hxdA:
undetectable		 5lg3F-2hxdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv4 PUTATIVE OUTER
MEMBRANE OR EXPORTED
PROTEIN

(Salmonella
enterica) 		PF16583
(ZirS_C) 		5 ILE A 258
ILE A 272
VAL A 219
ASN A 223
GLU A 254
 None
 0.93A 5lg3F-2lv4A:
undetectable		 5lg3F-2lv4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 370
ILE A 348
PHE A 426
ASP A 343
ILE A 433
 None
 1.06A 5lg3F-2og8A:
undetectable		 5lg3F-2og8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohg GLUTAMATE RACEMASE

(Streptococcus
pyogenes) 		PF01177
(Asp_Glu_race) 		5 ILE A 137
ILE A 104
VAL A 112
THR A 178
ILE A 204
 None
 1.27A 5lg3F-2ohgA:
undetectable		 5lg3F-2ohgA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 ILE A 274
ILE A 286
VAL A 278
THR A 296
ILE A 298
 None
 1.28A 5lg3F-2qkxA:
undetectable		 5lg3F-2qkxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus) 		PF00423
(HN) 		5 ILE A 306
VAL A 367
THR A 369
ASP A 347
ILE A 427
 None
 1.13A 5lg3F-2rkcA:
undetectable		 5lg3F-2rkcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 5 ILE A  66
ILE A  68
VAL A  33
THR A   7
ILE A 104
 None
 1.08A 5lg3F-2wteA:
undetectable		 5lg3F-2wteA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		5 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
 None
 1.03A 5lg3F-2z61A:
undetectable		 5lg3F-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		5 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
 None
 1.12A 5lg3F-2zj8A:
undetectable		 5lg3F-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Pyrococcus
horikoshii) 		PF09488
(Osmo_MPGsynth) 		5 ILE A  82
ILE A 112
PHE A 104
VAL A  57
ILE A  74
 None
 1.13A 5lg3F-2zu8A:
undetectable		 5lg3F-2zu8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 ILE A  76
ILE A  90
PHE A  95
VAL A   9
GLU A  32
 None
 1.28A 5lg3F-2zufA:
1.7		 5lg3F-2zufA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01083
(Cutinase) 		5 ILE A 172
ILE A 189
VAL A 204
THR A 261
ASN A 259
 None
 1.25A 5lg3F-3ajaA:
undetectable		 5lg3F-3ajaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1

(Symbiobacterium
toebii) 		PF00551
(Formyl_trans_N) 		5 ILE A   4
ILE A 182
VAL A   6
ASN A  14
GLU A 174
 None
 1.26A 5lg3F-3aufA:
undetectable		 5lg3F-3aufA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		5 ILE A  42
ILE A  59
PHE A  62
THR A  97
ILE A  94
 None
 1.17A 5lg3F-3axiA:
0.2		 5lg3F-3axiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6y GAMMA-INTERFERON-IND
UCIBLE PROTEIN
IFI-16

(Homo sapiens) 		PF02760
(HIN) 		5 PHE A  41
VAL A  74
THR A  78
ASP A   6
ILE A  62
 None
 1.21A 5lg3F-3b6yA:
undetectable		 5lg3F-3b6yA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 ILE A 216
PHE A 137
VAL A 253
ASP A 221
ILE A 224
 None
 1.16A 5lg3F-3bmwA:
1.4		 5lg3F-3bmwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		5 ILE A  30
ILE A  69
VAL A  26
GLU A  94
ASP A  72
 None
 1.13A 5lg3F-3c3kA:
undetectable		 5lg3F-3c3kA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE

(Enterococcus
faecalis) 		PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2) 		5 ILE A 165
ILE A 171
VAL A 139
THR A 125
ILE A 127
 None
 0.94A 5lg3F-3cj8A:
undetectable		 5lg3F-3cj8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cta RIBOFLAVIN KINASE

(Thermoplasma
acidophilum) 		PF01982
(CTP-dep_RFKase)
PF13545
(HTH_Crp_2) 		5 ILE A 196
ILE A 134
VAL A 182
ASP A 192
ILE A  95
 None
 1.08A 5lg3F-3ctaA:
undetectable		 5lg3F-3ctaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		5 ILE C 532
ILE C 537
VAL C 481
THR C 499
ASN C 503
 None
A  A  67 ( 4.8A)
None
None
None
 1.20A 5lg3F-3degC:
undetectable		 5lg3F-3degC:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		5 ILE A  98
ILE A  37
VAL A 126
THR A 124
ASN A  30
 None
 1.20A 5lg3F-3egeA:
undetectable		 5lg3F-3egeA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh0 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2) 		5 ILE A 231
ILE A 225
VAL A 249
THR A 247
ILE A 261
 None
 1.14A 5lg3F-3eh0A:
undetectable		 5lg3F-3eh0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5q NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B1271
ILE B1275
PHE B1311
VAL B1268
ASP B1298
 None
 1.12A 5lg3F-3i5qB:
undetectable		 5lg3F-3i5qB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 ILE A 251
ILE A 241
VAL A 285
ASP A 261
ILE A 265
 None
 1.28A 5lg3F-3jurA:
undetectable		 5lg3F-3jurA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		5 ILE A 223
ILE A 274
PHE A 275
ASP A 243
ILE A 239
 None
 1.20A 5lg3F-3msgA:
undetectable		 5lg3F-3msgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF01053
(Cys_Met_Meta_PP) 		5 ILE A 387
ILE A 401
PHE A 286
VAL A 389
ASP A 396
 None
 1.24A 5lg3F-3ndnA:
undetectable		 5lg3F-3ndnA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		5 ILE A 648
ILE A 657
VAL A 700
THR A 697
ILE A 680
 None
 1.22A 5lg3F-3ob8A:
undetectable		 5lg3F-3ob8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A 101
ILE A 127
VAL A  97
THR A  94
ILE A 119
 None
 1.20A 5lg3F-3plrA:
0.8		 5lg3F-3plrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		5 ILE A 303
ILE A 128
PHE A 285
ASP A 133
ILE A 308
 None
 1.20A 5lg3F-3qkiA:
undetectable		 5lg3F-3qkiA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ILE A  95
ILE A 108
VAL A  64
THR A  50
ILE A  52
 None
 0.92A 5lg3F-3r0sA:
undetectable		 5lg3F-3r0sA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 5 ILE A  86
ILE A  39
VAL A  79
ASP A  33
ILE A  49
 None
 1.26A 5lg3F-3tdgA:
undetectable		 5lg3F-3tdgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uat DISKS LARGE HOMOLOG
1

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 ILE A 894
ILE A 833
VAL A 891
ASN A 735
ILE A 726
 None
 1.31A 5lg3F-3uatA:
undetectable		 5lg3F-3uatA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		5 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
 1.07A 5lg3F-3uvjA:
undetectable		 5lg3F-3uvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA

(Cellvibrio
japonicus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 274
PHE A 301
THR A 284
ASP A 269
ILE A 298
 None
 1.28A 5lg3F-3v4bA:
undetectable		 5lg3F-3v4bA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF13085
(Fer2_3)
PF13534
(Fer4_17) 		5 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
 None
 1.04A 5lg3F-3vrbB:
undetectable		 5lg3F-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9y DISKS LARGE HOMOLOG
1

(Homo sapiens) 		PF00625
(Guanylate_kin) 		5 ILE A 909
ILE A 848
VAL A 906
ASN A 750
ILE A 741
 None
 1.24A 5lg3F-3w9yA:
undetectable		 5lg3F-3w9yA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 ILE A  56
VAL A  16
THR A  38
ASP A  48
ILE A  41
 None
 1.32A 5lg3F-3wquA:
undetectable		 5lg3F-3wquA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 ILE A  56
VAL A  16
THR A  38
ASP A  48
ILE A  41
 None
 1.29A 5lg3F-3wt0A:
undetectable		 5lg3F-3wt0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a42 ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		5 ILE A1547
ILE A1618
PHE A1539
ASP A1551
ILE A1564
 None
 1.10A 5lg3F-4a42A:
undetectable		 5lg3F-4a42A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 ILE V1339
ILE V1407
GLU V1288
ASP V1332
ILE V1284
 None
 1.20A 5lg3F-4bxsV:
undetectable		 5lg3F-4bxsV:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1

(Saccharomyces
cerevisiae) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		5 ILE A 411
VAL A 414
GLU A 351
ASP A 352
ILE A 376
 None
 1.18A 5lg3F-4c0hA:
undetectable		 5lg3F-4c0hA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4f MANNONATE
DEHYDRATASE

(Pectobacterium
carotovorum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 276
PHE A 303
THR A 286
ASP A 271
ILE A 300
 None
 1.21A 5lg3F-4e4fA:
undetectable		 5lg3F-4e4fA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		5 ILE A 336
PHE A 208
VAL A 233
ASP A 249
ILE A 268
 ILE  A 336 ( 0.7A)
PHE  A 208 ( 1.3A)
VAL  A 233 ( 0.6A)
ASP  A 249 ( 0.6A)
ILE  A 268 ( 0.7A)
 1.25A 5lg3F-4g9kA:
undetectable		 5lg3F-4g9kA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
 None
 1.06A 5lg3F-4gaaA:
3.4		 5lg3F-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2y AMINOACYL CARRIER
PROTEIN

(Agrobacterium
fabrum) 		PF00550
(PP-binding) 		5 ILE C  66
ILE C  69
PHE C  63
THR C   4
ILE C   8
 None
 1.28A 5lg3F-4h2yC:
undetectable		 5lg3F-4h2yC:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il2 STARVATION SENSING
PROTEIN RSPA

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 287
PHE A 314
THR A 297
ASP A 282
ILE A 311
 None
 1.23A 5lg3F-4il2A:
undetectable		 5lg3F-4il2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k68 GH10 XYLANASE

(soil metagenome) 		PF00331
(Glyco_hydro_10) 		5 ILE A 253
ILE A 320
PHE A 321
ASP A 273
ILE A 269
 None
 1.18A 5lg3F-4k68A:
undetectable		 5lg3F-4k68A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lua N-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF13420
(Acetyltransf_4) 		5 ILE A  44
ILE A  41
PHE A  12
VAL A  54
THR A  66
 None
 1.30A 5lg3F-4luaA:
undetectable		 5lg3F-4luaA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6

(Saccharomyces
cerevisiae) 		PF01423
(LSM) 		5 ILE D  41
ILE D  19
PHE D  15
VAL D  47
ASN D  25
 None
 1.24A 5lg3F-4m75D:
undetectable		 5lg3F-4m75D:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 164
ILE A 173
VAL A 160
ASN A 178
ASP A 176
 None
 1.25A 5lg3F-4mn8A:
undetectable		 5lg3F-4mn8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzu WXCM-LIKE PROTEIN

(Shewanella
denitrificans) 		PF00132
(Hexapep)
PF05523
(FdtA) 		5 ILE A  67
ILE A  61
VAL A  99
THR A  97
ILE A 111
 None
 1.21A 5lg3F-4mzuA:
undetectable		 5lg3F-4mzuA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		5 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
EDO  A 702 (-3.8A)
EDO  A 702 ( 3.0A)
None
None
 1.17A 5lg3F-4ni2A:
undetectable		 5lg3F-4ni2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oca UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01041
(DegT_DnrJ_EryC1) 		5 ILE A 181
ILE A 158
VAL A 198
THR A 200
ASN A 202
 None
 1.27A 5lg3F-4ocaA:
undetectable		 5lg3F-4ocaA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		5 ILE A  79
ILE A  48
VAL A 396
THR A 405
ILE A 407
 None
 0.98A 5lg3F-4oyaA:
undetectable		 5lg3F-4oyaA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pay SIDC, INTERAPTIN

(Legionella
pneumophila) 		no annotation 5 ILE A  34
ILE A 151
VAL A  35
THR A  48
ASN A  44
 None
 1.31A 5lg3F-4payA:
undetectable		 5lg3F-4payA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2

(Blattella
germanica) 		PF00026
(Asp) 		5 ILE A 123
ILE A 165
VAL A 121
THR A  29
ILE A  91
 None
 1.29A 5lg3F-4rldA:
undetectable		 5lg3F-4rldA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		5 ILE A 117
VAL A 122
THR A 125
ASN A 129
ILE A 160
 None
 1.12A 5lg3F-4s3jA:
undetectable		 5lg3F-4s3jA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 ILE A  20
ILE A  23
ASP A 158
TRP A 160
ILE A 162
 None
 0.72A 5lg3F-4twfA:
32.7		 5lg3F-4twfA:
99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		5 ILE A  20
ILE A  23
PHE A 126
ASP A 158
TRP A 160
 None
 0.45A 5lg3F-4twfA:
32.7		 5lg3F-4twfA:
99.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		5 ILE A 612
VAL A 608
THR A 605
GLU A 685
ILE A 716
 None
 1.26A 5lg3F-4xgcA:
undetectable		 5lg3F-4xgcA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y68 PUTATIVE
NISIN-RESISTANCE
PROTEIN

(Streptococcus
agalactiae) 		no annotation 5 ILE C 228
PHE C 245
THR C 234
ASN C 168
ASP C 164
 None
 1.22A 5lg3F-4y68C:
undetectable		 5lg3F-4y68C:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y68 PUTATIVE
NISIN-RESISTANCE
PROTEIN

(Streptococcus
agalactiae) 		no annotation 5 ILE C 296
PHE C 245
THR C 234
ASN C 168
ASP C 164
 None
 1.23A 5lg3F-4y68C:
undetectable		 5lg3F-4y68C:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 ILE A  20
ILE A  23
PHE A 126
TRP A 160
ILE A 162
 None
 0.74A 5lg3F-4yeuA:
29.4		 5lg3F-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		6 ILE A  20
ILE A  23
PHE A 126
VAL A 147
ASP A 158
TRP A 160
 None
 0.65A 5lg3F-4yeuA:
29.4		 5lg3F-4yeuA:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 ILE A  23
PHE A 126
THR A 149
TRP A 160
ILE A 162
 None
 0.89A 5lg3F-4yeuA:
29.4		 5lg3F-4yeuA:
71.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		5 ILE A 244
ILE A 236
VAL A 246
THR A 192
ILE A 262
 None
 1.26A 5lg3F-5advA:
undetectable		 5lg3F-5advA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT

(Thermus
thermophilus) 		PF00437
(T2SSE) 		5 ILE A 250
ILE A 247
THR A 139
ASP A 242
ILE A 273
 None
 1.22A 5lg3F-5fl3A:
undetectable		 5lg3F-5fl3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fof LEUCYL-TRNA
SYNTHETASE

(Plasmodium
knowlesi) 		no annotation 5 ILE A 314
ILE A 377
VAL A 277
THR A 421
ILE A 433
 None
 1.28A 5lg3F-5fofA:
undetectable		 5lg3F-5fofA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		5 ILE A 338
ILE A 281
ASP A 260
TRP A 262
ILE A 267
 None
 1.21A 5lg3F-5fqeA:
undetectable		 5lg3F-5fqeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 ILE A  63
ILE A   5
VAL A  89
THR A  87
ILE A 145
 None
 1.07A 5lg3F-5g6rA:
undetectable		 5lg3F-5g6rA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjk SWI/SNF COMPLEX
SUBUNIT SMARCC1

(Homo sapiens) 		PF04433
(SWIRM) 		5 ILE A 448
ILE A 450
ASN A 491
ASP A 458
ILE A 494
 None
 1.24A 5lg3F-5gjkA:
undetectable		 5lg3F-5gjkA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 ILE A 315
ILE A 268
VAL A 311
GLU A  15
ASP A  18
 None
 1.24A 5lg3F-5hn4A:
undetectable		 5lg3F-5hn4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihy UNCHARACTERIZED
PROTEIN

(Bacillus
subtilis) 		PF01966
(HD) 		5 ILE A  97
ILE A  94
VAL A  57
THR A  53
ASP A  89
 None
 1.13A 5lg3F-5ihyA:
2.0		 5lg3F-5ihyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 ILE A  67
ILE A  87
THR A  60
ASN A  95
ILE A 113
 None
 1.30A 5lg3F-5tqrA:
undetectable		 5lg3F-5tqrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnc -

(-) 		no annotation 5 ILE A  28
ILE A  37
ASN A  66
TRP A  35
ILE A 307
 None
 1.31A 5lg3F-5xncA:
undetectable		 5lg3F-5xncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cpb CARBON MONOXIDE
OXIDATION SYSTEM
TRANSCRIPTION
REGULATOR COOA-1

(Carboxydothermus
hydrogenoformans) 		no annotation 5 ILE A  78
VAL A  49
THR A  98
GLU A  27
ILE A 106
 None
 1.22A 5lg3F-6cpbA:
undetectable		 5lg3F-6cpbA:
13.36